Your Microbiome, Your Health
Richard SpragueApril 29, 2015
Hello, I’m Richard Sprague
YouWeight
Human Non-Human
Cells
Human Non-Human
Genes
Human Non-Human
3 pounds
Desulforudis audaxviator
Deinococcus radiodurans
Toxoplasma gondii
Find which microbes you have
For hardcore experimenters
• 25-35 week program
• Weekly+ sampling• Detailed analysis• 16S (like uBiome)• Metagenomics
(very expensive)
Dynamics of the Human Microbiota
What’s in my microbiome?
Bacteroides Plebeius
Hacking my microbiome
May Jun Oct Jan Feb0
10000
20000
30000
40000
50000
60000
70000
Bifidobacterium
Did it help my sleep?
Microbiome changes over time
David et al: Host lifestyle affects human microbiota on daily timescalesGenome Biology 2014, 15:R8
My microbiome through time
May-14 Jun-14 Oct-14 Jan-15 Feb-150%
10%
20%
30%
40%
50%
60%
70%
80%
90%
100%
ActinobacteriaVerrucomicrobiaProteobacteriaBacteroidetesFirmicutes
May Jun Oct Jan Feb0%
10%
20%
30%
40%
50%
60%
70%
Bacteroidetes/Firmicutes
My Microbiome after travel
Microbiome of the mouth
“treads the fine line between commensal and pathogen” Sophie C.H. Wen et al
“Good” or “Bad” ?
Helicobacter pylori
Good or Bad?
Streptococcus viridans
Groom your microbiome
Thank you
@sprague