The California Institute for Telecommunications and Information
Technology
Dynamics of Your Gut Microbiome in Health and
DiseasePresentationExponential MedicineSan Diego, CAOctober 9,
2016Dr. Larry SmarrDirector, California Institute for
Telecommunications and Information TechnologyHarry E. Gruber
Professor, Dept. of Computer Science and EngineeringJacobs School
of Engineering, UCSDhttp://lsmarr.calit2.net1
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There are 100 billion stars in the Andromeda galaxyand 100
billion galaxies in theknown universe.
Its a microbial world
there are 100 million times as many bacteria on Earth as stars
in the universe. Microbiology is the ultimate Big Data science!
Most of Lifes Evolutionary Time Was in the Microbial World
You Are Here
Source: Carl Woese, et al
Tree of Life Derived from 16S rRNA Sequences
President Obama Announces National Microbiome InitiativeMay 13,
2016
Your Microbiome is YourNear-Body EnvironmentThe
MicrobiomeContains 300x as Many DNA GenesAs Your Human DNAInclusion
of the Dark Matter of the BodyWill Radically Alter Medicine
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Your Gut Microbiome Contains Hundreds of Microbial Species
Average Over 250 Healthy PeopleFrom NIH Human Microbiome
Project
Note Log ScaleClostridium difficileSource: Weizhong Li, Andrew
Prudomme, Larry Smarr, UCSD
Exploring the Gut Microbiome Time Series byCollaborating with
the UCSD Knight Lab
My Welcome Present to Rob
MouthStoolVaginaSkinSource: Knight Lab, UCSD
Source: Knight Lab, UCSD
But Microbiome Time SeriesAre Very Different in Disease
States
Fecal TransplantsFrom Healthy DonorTo C. Diff PatientsSource:
Knight Lab, UCSD
As a Model for the Precision Medicine Initiative, I Have Tracked
My Internal Biomarkers To Understand My Bodys Dynamics
My Quarterly Blood DrawCalit2 64 Megapixel VROOM
By Creating a Time Series of an Immune System BiomarkerI
Discovered I Had an Autoimmune DiseaseNormal Range