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Your Microbiome, Your Health
Richard SpragueApril 29, 2015
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Hello, I’m Richard Sprague
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YouWeight
Human Non-Human
Cells
Human Non-Human
Genes
Human Non-Human
3 pounds
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Desulforudis audaxviator
Deinococcus radiodurans
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Toxoplasma gondii
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Find which microbes you have
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For hardcore experimenters
• 25-35 week program
• Weekly+ sampling• Detailed analysis• 16S (like uBiome)• Metagenomics
(very expensive)
Dynamics of the Human Microbiota
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What’s in my microbiome?
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Bacteroides Plebeius
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Hacking my microbiome
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May Jun Oct Jan Feb0
10000
20000
30000
40000
50000
60000
70000
Bifidobacterium
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Did it help my sleep?
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Microbiome changes over time
David et al: Host lifestyle affects human microbiota on daily timescalesGenome Biology 2014, 15:R8
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My microbiome through time
May-14 Jun-14 Oct-14 Jan-15 Feb-150%
10%
20%
30%
40%
50%
60%
70%
80%
90%
100%
ActinobacteriaVerrucomicrobiaProteobacteriaBacteroidetesFirmicutes
May Jun Oct Jan Feb0%
10%
20%
30%
40%
50%
60%
70%
Bacteroidetes/Firmicutes
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My Microbiome after travel
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Microbiome of the mouth
“treads the fine line between commensal and pathogen” Sophie C.H. Wen et al
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“Good” or “Bad” ?
Helicobacter pylori
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Good or Bad?
Streptococcus viridans
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Groom your microbiome
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Thank you
@sprague