Your microbiome your health

Your Microbiome, Your Health

Richard SpragueApril 29, 2015

Hello, I’m Richard Sprague

What is a human?

YouWeight

Human Non-Human

Cells

Human Non-Human

Genes

Human Non-Human

3 pounds

Desulforudis audaxviator

Deinococcus radiodurans

What they want

Toxoplasma gondii

Who’s in charge?

Find which microbes you have

For hardcore experimenters

• 25-35 week program

• Weekly+ sampling• Detailed analysis• 16S (like uBiome)• Metagenomics

(very expensive)

Dynamics of the Human Microbiota

What’s in my microbiome?

Bacteroides Plebeius

Hacking my microbiome

May Jun Oct Jan Feb0

10000

20000

30000

40000

50000

60000

70000

Bifidobacterium

Did it help my sleep?

Microbiome changes over time

David et al: Host lifestyle affects human microbiota on daily timescalesGenome Biology 2014, 15:R8

My microbiome through time

May-14 Jun-14 Oct-14 Jan-15 Feb-150%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

ActinobacteriaVerrucomicrobiaProteobacteriaBacteroidetesFirmicutes

May Jun Oct Jan Feb0%

10%

20%

30%

40%

50%

60%

70%

Bacteroidetes/Firmicutes

My Microbiome after travel

Microbiome of the mouth

“treads the fine line between commensal and pathogen” Sophie C.H. Wen et al

“Good” or “Bad” ?

Helicobacter pylori

Good or Bad?

Streptococcus viridans

Obesity

Germophobia

Microbiome mania

Groom your microbiome

Thank you

@sprague