Slide 1Alignment methods Introduction to global and local sequence alignment methods Global : Needleman-Wunch Local : Smith-Waterman Database Search BLAST FASTA Slide 2 Why…
Slide 1 Alignment methods June 26, 2007 Learning objectives- Understand how Global alignment program works. Understand how Local alignment program works. Slide 2 Why search…
Slide 1 Alignment methods II April 24, 2007 Learning objectives- 1) Understand how Global alignment program works using the longest common subsequence method. 2) Understand…
Slide 1 Pair-wise Sequence Alignment What happened to the sequences of similar genes? random mutation deletion, insertion Seq. 1: 515 EVIRMQDNNPFSFQSDVYSYG EVI ++ P++ ++DV+SY…
HMM for multiple sequences Pair HMM HMM for pairwise sequence alignment, which incorporates affine gap scores. “Hidden” States Match (M) Insertion in x (X) insertion…
Reminder -Structure of a genome Sequence Alignment We assume a link between the linear information stored in DNA, RNA or amino-acid sequence and the protein function determined…
SVD methods applied to wire antennae Pelagia Neocleous Kings College London IPAM, Lake Arrowhead Meeting Overview Antenna design as an inverse problem The wire antenna (Background)…
Ch 5. Profile HMMs for sequence families Biological sequence analysis: Probabilistic models of proteins and nucleic acids Richard Durbin Sean R. Eddy Anders Krogh Graeme…
Alignment methods II April 24, 2007 Learning objectives- 1) Understand how Global alignment program works using the longest common subsequence method. 2) Understand how Local…