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Documents Alignment methods Introduction to global and local sequence alignment methods Global :...

Slide 1Alignment methods Introduction to global and local sequence alignment methods Global : Needleman-Wunch Local : Smith-Waterman Database Search BLAST FASTA Slide 2 Why…

Documents SNU BioIntelligence Lab. () 1 Ch 5. Profile HMMs for sequence families Biological sequence analysis:...

Slide 1 SNU BioIntelligence Lab. (http://bi.snu.ac.kr) 1 Ch 5. Profile HMMs for sequence families Biological sequence analysis: Probabilistic models of proteins and nucleic…

Documents Alignment methods June 26, 2007 Learning objectives- Understand how Global alignment program works.....

Slide 1 Alignment methods June 26, 2007 Learning objectives- Understand how Global alignment program works. Understand how Local alignment program works. Slide 2 Why search…

Documents Alignment methods II April 24, 2007 Learning objectives- 1) Understand how Global alignment program....

Slide 1 Alignment methods II April 24, 2007 Learning objectives- 1) Understand how Global alignment program works using the longest common subsequence method. 2) Understand…

Documents Pair-wise Sequence Alignment What happened to the sequences of similar genes? random mutation...

Slide 1 Pair-wise Sequence Alignment What happened to the sequences of similar genes? random mutation deletion, insertion Seq. 1: 515 EVIRMQDNNPFSFQSDVYSYG EVI ++ P++ ++DV+SY…

Documents HMM for multiple sequences. Pair HMM HMM for pairwise sequence alignment, which incorporates affine....

HMM for multiple sequences Pair HMM HMM for pairwise sequence alignment, which incorporates affine gap scores. “Hidden” States Match (M) Insertion in x (X) insertion…

Documents Reminder -Structure of a genome Human 3x10 9 bp Genome: ~30,000 genes ~200,000 exons ~23 Mb coding.....

Reminder -Structure of a genome Sequence Alignment We assume a link between the linear information stored in DNA, RNA or amino-acid sequence and the protein function determined…

Documents SVD methods applied to wire antennae Pelagia Neocleous Kings College London IPAM, Lake Arrowhead...

SVD methods applied to wire antennae Pelagia Neocleous Kings College London IPAM, Lake Arrowhead Meeting Overview Antenna design as an inverse problem The wire antenna (Background)…

Documents Ch 5. Profile HMMs for sequence families

Ch 5. Profile HMMs for sequence families Biological sequence analysis: Probabilistic models of proteins and nucleic acids Richard Durbin Sean R. Eddy Anders Krogh Graeme…

Documents Alignment methods II

Alignment methods II April 24, 2007 Learning objectives- 1) Understand how Global alignment program works using the longest common subsequence method. 2) Understand how Local…