by :Fariborz Amoozgar Email:[email protected]
APPLICATION OF 3D PRINTING IN ANALYTICAL CHEMISTRY AND SEPRATION
Supervisor:
Presented by:
Fariborz Amoozgar
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Application
How 3D printer works?
History
Contents
Introduction
Conclusion
Methods & Technologies
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3D printing or additive manufacturing is a process of making three dimensional solid
objects from a digital file. The creation of a 3D printed object is achieved using additive
processes.
INTROUCTION :
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Has been around since the early 80’s modern 3D Printing by:
Charles W .Hull , stereolithography technique.
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Methods and technologies of 3D Printing:
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SLA (Stereolithography):
the laser beam traces a cross-section of the part pattern on the surface of the
liquid resin. Exposure to the ultraviolet laser light cures and solidifies the pattern
traced on the resin and joins it to the layer below.
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SLS(Selective laser sintering):
The laser selectively fuses the powdered material by scanning the cross-sections
(or layers) generated by the 3D modeling program on the surface of a powder bed.
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FDM (Fused deposition modeling):
The FDM technology works using a plastic filament or metal wire which is unwound
from a coil and supplies material to an extrusion nozzle .The nozzle is heated to melt
the material by a numerically controlled mechanism. The object is produced by
extruding melted material to form layers as the material hardens immediately after
extrusion from the nozzle.
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LOM(Laminated object manufacturing):
after the first layer of a sheet material is loaded onto a stage, a laser or razor traces the
designed cross-section to define the pattern on the layer. After the excess material of the
sheet is removed, a second layer covers the previous layer and the laser or knife tracing will
define the next pattern based on information in the .STL file. Adjacent layers are combined
by use of adhesives or welding for paper or metal, respectively. These steps are repeated to
generate a layered 3D model.
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Production companies:
1)Objet Geometrise
2) Z-Corporation
3) Stratasys
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RepRap Version 1.0 RepRap Version 2.0
Household 3D printers :
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The cost of 3D Printers:
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3D Printing
Food
Industries
APPLICATIONS Medical
ARCHITECTURE
Weaponry &
Archaeology and
paleontology
Household uses
Mathematics
&Robotics
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Physicians can use 3D printing to
make hearing aids, artificial teeth, and bone
grafts.
• 3D printed Jaw
• 3D printed Ear
• 3D Printed bone
MEDICAL INDUSTRY
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Artists can create models of their projects.
ARCHITECTURE
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Designers use 3D printers to quickly create product models
and prototypes.
INDUSTRIAL DESIGN
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FIRST EVER 3D PRINTED CAR
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Building
24
This printer is built by Pro . Behrokh Khoshnevis.It can build a 200 square meter house in only 24 hours.
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25
Chemistry
Printing Lab On Chip (LOC) devices and interconnect
Printing Biosensors and electrodes for electrochemical reaction
Printing chromatography columns
Printing flow – cells
Printing mili fluidic devices and micro fluidic devices
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The interconnect, a flexible polymer gasket co-printed with, rigid clamps, elim-inatesadhesives and additional assembly by direct multi-material 3D, printing from a computer-aideddesign model.
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The maximum pressure that the system can not tolerate:
Ffluid >Ffriction Leakage
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Schematic of the fluidic circuit for the
durability tests and modified dead-end
channel experiments .
Experimental setup used to conduct long-term reliability testing.
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Interconnects delivering three different fluids, via adhesive-free connections, into separate
channels have also been demonstrated.
3D printed porous media columns with fine control of column packing morphology:
The three bed geometric designs: 1- simple cubic beads, 2- straight channels, 3- herringbone channels
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Illustration of the flow distributor templates:
(a) radial flow distributor, (b) fractal flow distributor
where Ѳ is the dimensionless time defined in terms of the theoret-ical residence time, estimated from the designed geometry of the lattice structure.
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The SC coloumn is better than the other due to have a Ѳ close to one.
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Comparison of 2 ml columns with radial and fractal flow distributors for (a) PC columns
(b) SC columns.
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3D-printedand CNC milled flow-cells for chemiluminescence detection:
CNC milling:A model of each flow-cell was drawn using the Auto
Desk Inventor And the models were converted Intomachine code using Edge CAM software.
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(i) flow-cell A (ii) flow-cell A with a mirror against the back face (iii) flow-cell A in the purpose-built holder(iv) flow cell F in the same holder by :Fariborz Amoozgar Email:[email protected]
A: coiled tubing
B: 3D-printed
transparent polycarbonate milled
F: white Acetal milled
reaction of morphine with the permanganate reagent:
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a) Dual detection zone flow-cell
b) conventional T-piece splitting to two separate flow-cells
O: octopamine S: synephrineT: tyramineH: hordenine
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Low cost lab-on-a- chip prototyping with a consumer grade 3D printer:
In this work, affordable 3D printed LOC devices have been demonstrated. Complex geometries,
directly created in 3D printed structures, enable transference of demanding fabrication tasks to the
printer, thus maximizing reliability and removing the influence of user fabrication skills from the
prototypes.
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For H2O2 detection with ULOC, connectors were assembled with silicon tubing:C) control solution S) 0.1μM (sample)H)1μM (high level)
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Preparation:
1- Pumping MPs and anchored by external magnet2- Washing Extra3- modified with biotinyled Glycan4- Washing Extra5- Binding of HA-CdS on to biotinyled Glycan 6-Washing Extra7-immerseing the chip in an ultra sonic bath to fractionaing to MPs-Glycan-HA-Cds complex
3D printed chip for electrochemical detection of influenza virus labeled with CdS
quantum dots:
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a) Injection (influx) was used for dispensing the
samples , buffer and electrolyte
a) Reaction cell,where whole process of isolation and
magnetic pad,(d)was placed.
c) Three electrod setup,with working glassy carbon
microelectrode,andefflux
e) For removing of reactants from the reaction
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Effect of isolation and detection procedure on the Real sample detection.Real sample is inactivated influenzavirusH5N1
S1-S4 are the same samples and k1 and k2 are the negative controls
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Configurable 3D-Printed millifluidic and microfluidic ‘lab on a chip’ reactionware devices:
An overview of the time and cost associated with the
fabrication of each of the three reactors, along with
their overall dimensions
R1; A two inlet device, (top right), R2; a three-inlet
device, (below) R3; a one-inlet device with two
‘‘silos’’: one filled with sodium molybdate
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R2: The actual set-up of the devices, with three inlets each
connected to a pump, and the in-line ATR-IR and/or UV-Vis flow-cells connected to the outlet.
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R1 : Flow synthesis of the imine derived from benzaldehyde and
benzylamine, as characterised by in-line ATR-IR spectroscopy.
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A 3D Printed Fluidic Device that Enables Integrated Features:
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Rapid prototyping
Clean process
Complex shape
Easy to use
Reduce design complexity
Cheap in massive production
Remote location fabrication
ADVANTAGES
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Process is slow
Components do not have enough strength.
Cost of raw materials
3-D printers are still expensive.
Misuse of technology
Although 3-D printers have the potential of creating many jobs and opportunities, they might also put certain jobs at risk .
DISADVANTAGES
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3D printing is rapidly maturing
Still a lot to discover
Can save lives (literally)
May disrupt property and manufacturing processes
Ethical and law questions need to be solved
Potentially very dangerous
Conclusion
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Bethany C. Gross, Jayda L. Erkal, Sarah Y. Lockwood, Chengpeng Chen, and Dana M
Spence .Anal. Chem., Just Accepted Manuscript
ringsO.H. Paydara,∗, C.N. Paredesb, Y. Hwangb, J. Pazb,c, N.B. Shahb, R.N. Candlerb,
3D printedchipforelectrochemicaldetectionofinfluenza viruslabeled with CdSquantumdots
Chen Zhao, CaiyunWang, Robert Gorkin III, Stephen Beirne, Kewei Shu, Gordon
G.Wallace Kara B.Spilstead a, JessicaJ.Learey a, EganH.Doeven a,nn, GregoryJ.Barbante a, StephanMohr b,
NeilW.Barnett a, JessicaM.Terry a, RobynneM.Hall c, PaulS.Francis Kari B. Anderson,† Sarah Y. Lockwood,† R. Scott Martin,§ and Dana M. Spence R. S.; Takayama, S.; Otsuni, E.; Ingber, D. E.; Whitesides, G. M. Biomaterials 1999, 20, 2363- 2376.Waldbaur, A.; Rapp, H.; Lange, K.; Rapp, B. E. Analytical Methods 2011, 3, 2681-2716. Germán Comina,a Anke Suskaa and Daniel Filippini Philip J. Kitson, Mali H. Rosnes, Victor Sans, Vincenza Dragone and Leroy Cronin*
REFERENCES
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