Recall Performance For High Value Words Correlates With White Matter Integrity PRESENTED BY NICCO REGGENTE FOR COGNITIVE FORUM (DATA BLITZ) ON 9/27/13
Feb 23, 2016
Recall Performance For High Value Words Correlates With White Matter Integrity
PRESENTED BY NICCO REGGENTE FOR COGNITIVE FORUM (DATA BLITZ) ON 9/27/13
Tasks
Value Directed Remembering Task Monetary Incentive Delay Task
Behavioral Results
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Average Recall Performance Across 5 Lists
High Value
Low Value
5 List Average
Prop
orti
on R
ecal
led
Value Directed Remembering Task Monetary Incentive Delay Task
fMRI Results
Cue Period: Classic VTA localizer
Value Directed Remembering Task Monetary Incentive Delay Task
ROIs VTA, Nucleus Accumbens, Uncinate Fasciculus
Methodology
Fractional Anisotropy Indicative of white matter integrity
Probabilistic Tractography Nucleus Accumbens VTA
Uncinate Fasciculus Results
0.28 0.3 0.32 0.34 0.36 0.38 0.40
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4
6
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10
12
14
R² = 0.557167782487299
Fractional Anisotropy Along Left Un-cinate
# H
igh
Valu
e W
ords
Rec
alle
d
0.28 0.3 0.32 0.34 0.36 0.38 0.40
2
4
6
8
10
12
14
R² = 0.048058852458864
Low Value Recall vs. UF FA
Fractional Anisotropy Along Left Uncinate
# L
ow V
alue
Wor
ds R
ecal
led
High Value Recall vs. UF FA
Nacc VTA Results
300 350 400 450 500 550 600 650 700 750 8000.1
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R² = 0.194467357005302
Number of Tractable Voxels to Left VTA from
Left Nucleus Accumbens
Sele
ctiv
ity
Inde
x
Tractography vs. Selectivity
Participants Score – Chance Score
“Selectivity Index” = _____________________________________
Optimal Score – Chance Score
Left NaccLeft VTA
The Authors: Michael S. Cohen (Amy) Zhong Sheng Zheng Natalie G. DeShetler Alan D. Castel Barbara J. Knowlton Jesse Rissman
Memory recall for high value words correlates with individual differences in white matter pathways associated with reward processing and fronto-temporal communication