Slide 1 Drug metabolism Refers to enzyme-mediated biotransformations (detoxication) that alter the pharmacological activity of both endogenous and exogenous compounds. Slide…

Slide 1 Slide 2 Phase-II Drug Metabolism Reactions which conjugate the drug or its phase-I metabolite with a hydrophilic, endogenous species (conjugation reactions). These…

Slide 1 Modeling the Effects of Mutants and Drugs on the Ras Signaling Pathway RuleBenders Gianluca Arianna Lyle Kingsbury Piotr Gauza Lehman College CMACS Workshop, 2014…

Slide 1 Slide 2 ABO & Rh(D) Blood Groups Slide 3 ABO & Rh(D)2 The ABO System Discovered in 1901 by Dr. Karl Landsteiner 4 Main Phenotypes (A, B, AB, O) ABO gene located…

Introduction to drug metabolism Phase-II Drug Metabolism Phase-II Drug Metabolism Reactions which conjugate the drug or its phase-I metabolite with a hydrophilic, endogenous…

Modification of the K-Ras Signaling Pathway The Model Pathway Self-Sufficiency is a Hallmark of Cancer Uncontrolled cell proliferation Cells acquire ability to sustain growth…

Introduction to drug metabolism Drug metabolism Refers to enzyme-mediated biotransformations (detoxication) that alter the pharmacological activity of both endogenous and…