1. Trio Exome Sequencing: Improving the Chance of a Genetic Diagnosis in Rare Disorders Anna De Grassi -- Dept. Biosciences, Biotechnologies and Biopharmaceutics, University…

1. Synonymous mutations - from bacterial evolution to somatic changes in human cancer Fran Supek 1) Lehner group, CRG/EMBL Systems Biology Unit, Barcelona 2) Division of…

Slide 1 NGS Workshop Variant Calling and Structural Variants from Exomes/WGS Ramesh Nair May 31, 2013 Slide 2 Outline Types of genetic variation Framework for variant discovery…

Slide 1 NGS Cancer Systems Biology Workshop Variant Calling and Structural Variants from Exomes/WGS Ramesh Nair May 30, 2014 Slide 2 Outline Types of genetic variation Framework…

PowerPoint Presentation Neutral theory: The vast majority of observed sequence differences between members of a population are neutral (or close to neutral). These differences…

Keri Massie and Emily Williamson Biology 425, Spring 2009 Introduction many theories about the evolution of hibernation (Kemp, 2005) None have extra-ordinary evidence supporting…

Robustness the ability of a system to perform consistently under a variety of conditions competition degeneracy modularity feedback Elements of robustness: Feedback Feedback…

PowerPoint Presentation ATPase dataset -> muscle -> phyml (with ASRV)– re-rooted ATPase dataset -> parsimony – re-rooted gaps excluded ATPase dataset -> muscle…

Ejercicios de alineamiento de secuencias: CLUSTALW insertar secuencias de FASTA Pedir alineamiento múltiple Analizar resultado Regiones conservadas y variables en proteinas…

PowerPoint Presentation Comparative computational biology Positive selection What is positive selection? Positive selection is selection of a particular trait - and the increased…