Slide 1 Evolution at the DNA level …ACGGTGCAGTTACCA… …AC----CAGTCCACCA… Mutation SEQUENCE EDITS REARRANGEMENTS Deletion Inversion Translocation Duplication Slide…

Slide 1 CS273a Lecture 8, Win07, Batzoglou Evolution at the DNA level …ACGGTGCAGTTACCA… …AC----CAGTCCACCA… Mutation SEQUENCE EDITS REARRANGEMENTS Deletion Inversion…

Slide 1 CS273a Lecture 11, Aut 08, Batzoglou Multiple Sequence Alignment Slide 2 CS273a Lecture 11, Aut 08, Batzoglou CS273a Lecture 11, Fall 2008 Index-based local alignment…

Slide 1 Some new sequencing technologies Slide 2 Molecular Inversion Probes Slide 3 Illumina Genotype Arrays Slide 4 Single Molecule Array for Genotyping—Solexa Slide 5…

Slide 1 CS273a Lecture 10, Aut 08, Batzoglou CS273a Lecture 10, Fall 2008 Local Alignments Slide 2 CS273a Lecture 10, Aut 08, Batzoglou CS273a Lecture 10, Fall 2008 After…

Slide 1 CS273a Lecture 9/10, Aut 10, Batzoglou Multiple Sequence Alignment Slide 2 CS273a Lecture 9/10, Aut 10, Batzoglou CS273a Lecture 10, Fall 2010 Evolution at the DNA…

Slide 1 CS262 Lecture 9, Win07, Batzoglou Real-world protein aligners MUSCLE  High throughput  One of the best in accuracy ProbCons  High accuracy  Reasonable…

Slide 1 Building synteny maps Recommended local aligners BLASTZ  Most accurate, especially for genes  Chains local alignments WU-BLAST  Good tradeoff of efficiency/sensitivity…

Slide 1 Short Primer on Comparative Genomics Today: Special guest lecture 12pm, Alway M108 Comparative genomics of animals and plants Adam Siepel Assistant Professor of Biological…