Slide 1Cao et al. (2000) Gene Phylogeny of Mammals a good example where molecular sequences have led to a big improvement of our understanding of evolution. Slide 2 rRNA…

Slide 1Ligand Substitution Reactions kinetics Slide 2 Water Exchange Reactions M n+ log k (sec -1 ) Cr 3+ -6 V 2+ -2 Cr 2+ 9 Cu 2+ 9 SLOW FAST 15 orders of magnitude increase!…

1.Phylogeny-based methods for analysing uncultured microbial communities Presented by Aaron Darling 2. OTUs for ecology Operational Taxonomic Unit: a grouping of similar…

Statistical methods in Bioinformatics Dot Matrix First described by Gibbs and McIntyre (1970) Dot matrix analysis of DNA sequence (W=11, S=7) Phage P22 c2 repressor Phage…

Slide 1 The Concept of Functional Constraint Slide 2 The intensity of purifying selection is determined by the degree of intolerance characteristic of a site or a genomic…

Slide 1 Chapter 23 - Molecular evolution: Types of questions: How do genomes, DNA, and protein sequences evolve? Dynamics and mode of change. Rates of change. How are genes…

Slide 1 Probabilistic methods for phylogenetic trees (Part 2) Sushmita Roy BMI/CS 576 www.biostat.wisc.edu/bmi576/ [email protected] Oct 7 th, 2014 Slide 2 RECAP Probabilistic…

Slide 1 Alcohol reactions Slide 2 Alcohols – reactions Addition of alkene to form alcohol. Elimination of alcohol to form alkene. Halogenation (substitution) of alcohol…

Slide 1 Basic Local Alignment Search Tool Presented by Mei Liu August 7, 2008 Slide 2 Introduction BLAST Finds regions of local similarity between sequences Assesses which…

Slide 1 Adaptive Molecular Evolution Nonsynonymous vs Synonymous Slide 2 Reading for today Li and Graur chapter (PDF on website) Evolutionary EST paper (PDF on website) Page…