Slide 1Comparative genomics Why humans have big heads and language Slide 2 Genome Projects etc Genome browser: http://genome.cse.ucsc.edu/ http://genome.cse.ucsc.edu/ Homologene:…

Slide 1Evolution and proteins You can see the effects of evolution, not only in the whole organism, but also in its molecules - DNA and protein For a mutation to have an…

Slide 1Quick Lesson on dN/dS Neutral Selection Codon Degeneracy Synonymous vs. Non-synonymous dN/dS ratios Why Selection? The Problem Slide 2 What does selection “look”…

1.Towards Personal Genomics Tools for Navigating theGenome of an Individual Saul A. Kravitz J. Craig Venter Institute Rockville, MD Bio-IT World 20082. Personal Genomics:The…

Slide 1 Are we still evolving? Mapping sites of selection in the human genome Simon Myers Slide 2 Targets of selection are important Humans Other species What makes us human?…

Slide 1 Adaptive Molecular Evolution Nonsynonymous vs Synonymous Slide 2 Reading for today Li and Graur chapter (PDF on website) Evolutionary EST paper (PDF on website) Page…

Slide 1 Population genetics, comparative genomics, and natural selection Simon Myers Slide 2 Overview Identifying selection through –Use of comparative genomic data (FOXP2)…

Jianfeng Xu, M.D., Dr.PH Professor of Public Health and Cancer Biology Director, Program for Genetic and Molecular Epidemiology of Cancer Associate Director, Center for Human…

Detection of positive selection in humane genome Introduction Introduction Before and after genome sequencing Detection Methods 1.- High proportion of function-altering mutations…

One way to test these theories is to look at th number of silent vs. non-synonymous substitutions over a given region of DNA   are silent point mutations in DNA (no effect…