Slide 1Chapter 12 Topics Chapter 12 Topics Models of Replication Prokaryotic and Eukaryotic Replication Models of Recombination: read pp 339-342 Slide 2 Three Models of DNA…

Slide 1 Learning goals: Students will understand that 1) molecular mechanisms that preserve the fidelity of the genetic sequence have been favored by natural selection, 2)…

Slide 1 Repair of DNA and XP Errol C. Friedberg (2003) DNA damage and repair. Nature 421: 436-440. Slide 2 Xeroderma Pigmentosum (XP) Symptoms include: --- Extreme sensitivity…

Slide 1 Lecture 15: DNA Organization, Replication and Repair Reading Assignment: Chapter 38, pgs. 412-434; Harper’s Biochemistry (25 th edition). Objective: To understand…

Slide 1 The Mutability and Repair of DNA Slide 2 1. Switch of one base for another: purine pyrimidine (transition) (transversion) 2. insertion or deletion of a nucleotide…

Slide 1 Definitions: ★ replication errors ★ spontaneous DNA damage ★ DNA mutations ★ double-strand break (DSB) repair pathway Slide 2 Questions to be addressed …

Slide 1 Microbial Genetics (Micr340) Lecture 14 DNA Repair and Mutagenesis Slide 2 Definitions Lesion: chemical damage in DNA Mutagens: chemical compounds that cause lesions…