1. Sequence alignment Paul Gardner March 19, 2015 Paul Gardner Sequence alignment 2. What is homology? A homologous trait is any characteristic of organisms that is derived…

Slide 1 SNU BioIntelligence Lab. (http://bi.snu.ac.kr) 1 Ch 5. Profile HMMs for sequence families Biological sequence analysis: Probabilistic models of proteins and nucleic…

HMM for multiple sequences Pair HMM HMM for pairwise sequence alignment, which incorporates affine gap scores. “Hidden” States Match (M) Insertion in x (X) insertion…

Ch 5. Profile HMMs for sequence families Biological sequence analysis: Probabilistic models of proteins and nucleic acids Richard Durbin Sean R. Eddy Anders Krogh Graeme…

HMM for multiple sequences Pair HMM HMM for pairwise sequence alignment, which incorporates affine gap scores. “Hidden” States Match (M) Insertion in x (X) insertion…