Slide 1Why Align Sequences? DNA sequences (4 letters in alphabet) – GTAAACTGGTACT… Amino acid (protein) sequences (20 letters) – SSHLDKLMNEFF… Align them so we can…

Slide 1Early experiences in amplicon sequencing using the Roche GS-FLX massively parallel DNA sequencer and its application within a diagnostic laboratory Louise Stanley…

Slide 1An Introduction to Bioinformatics 2. Comparing biological sequences: sequence alignment (cont’d) Slide 2 An Introduction to Bioinformatics Outline Global Alignment…

Slide 1 Next-generation sequencing: informatics & software aspects Gabor T. Marth Boston College Biology Department Slide 2 Next-gen data Slide 3 Read length read length…

Slide 1 A Large Version of the Small Parsimony Problem Optimally reconstruct ancestral sequences given - unrooted phylogeny (hence ‘small’ parsimony p.) - multiple alignment…

Slide 1 BME 130 – Genomes Lecture 23 Genome evolution I: Mutations, repair, and recombination Slide 2 Transitions A  G C  T Transversions A  C A  T C  G…

Slide 1 1 Getting Started Download and install Haploview http://www.broad.mit.edu/mpg/haploview/index.php http://www.broad.mit.edu/mpg/haploview/index.php Slide 2 2 i.Downloading…

Slide 1 www.bioalgorithms.infoAn Introduction to Bioinformatics Algorithms Multiple Alignment Slide 2 An Introduction to Bioinformatics Algorithmswww.bioalgorithms.info Multiple…

Slide 1 The Science of Information: From Communication to DNA Sequencing TexPoint fonts used in EMF: AAAAAAAAAAAAAAAA David Tse U.C. Berkeley CUHK December 14, 2012 Research…

Slide 1 www.bioalgorithms.infoAn Introduction to Bioinformatics Algorithms Sequence Alignment Slide 2 An Introduction to Bioinformatics Algorithmswww.bioalgorithms.info Outline…