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Regenerasi Sel dan
Penyembuhan Lukadr. Sari Eka Pratiwi
Departemen Patologi Anatomi
Program Studi Pendidikan DokterFakultas Kedokteran Universitas Tanjungpura
2014
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Sebelum Mulai, kita senam dulu
http://localhost/var/www/apps/conversion/tmp/scratch_3/Senam%20Otak-atik%20(%20otak%20tengah%20)%20by%20Angga.mp4http://localhost/var/www/apps/conversion/tmp/scratch_3/Senam%20Otak-atik%20(%20otak%20tengah%20)%20by%20Angga.mp48/10/2019 Regenerasi Sel Dan Penyembuhan Luka
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Inflammation
Stimulus
Tissue
Reaction
Repair
Cell
ChemicalVascular
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Causes
Physical agentsMechanical
Thermal
Chemicals & drugs
Microbiologic agents
Immunologic reactions Radiation
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Repair & Regeneration
Repair : process of recovering the damagedtissue :
Initial tissue cells
Other cells
Regeneration : process of recovering by
initial tissue cells
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Regeneration
Two processes :
Proliferation of surviving cells
Migration of surviving cells
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Three groups of cells
Labile cells
Stable cells
Permanent cells
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Role of the extracellularmatrix in regenerationand repair. Liverregeneration with
restoration of normaltissue after injuryrequires an intact cellularmatrix. If the matrix is
damaged the injury isrepaired by fibrous tissuedeposition and scarformation.
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Mechanisms
regulating cell
populations
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Signaling Cell Growth
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Healing Processes
Induction of an inflammatory process
Proliferation and migration of parenchymaland connective tissue cells
Angiogenesis and granulation tissue Synthesis of ECM proteins and collagen
deposition
Tissue remodelling Wound contraction
Acquisition of wound strength
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Wound healing
Superficial regeneration
Deep repair
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Healing Processes
The main components :
- ANGIOGENESIS
- SCAR FORMATION
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ANGIOGENESIS
Definition :The process of blood vessel formation in adultor NEOVASCULARIZATION
Mechanisms :- Angiogenesis from Endothelial Precursor Cells- Angiogenesis from Pre-Existing Vessels
- Growth Factors and Receptors Involved inAngiogenesis
- ECM Proteins as Regulators of Angiogenesis
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Angiogenesis by mobilization of endothelial precursor cells
(EPCs) from the bone marrow and from preexisting vessels
(capillary growth).
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Two patterns of healing
Healing by first intention
(primary union = repair perprimam)
Healing by second intention
(secondary union = repair persekundam)
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Healing of skin ulcers. A, Pressure ulcer of the skin, commonly found in diabetic patients. The
histologic slides show: B, a skin ulcer with a large gap between the edges of the lesion; C, a
thin layer of epidermal re-epithelialization and extensive granulation tissue formation in thedermis; and D, continuing re-epithelialization of the epidermis and wound contraction
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A, Granulation tissue showing numerous blood vessels, edema, and a loose ECM containingoccasional inflammatory cells. Collagen is stained blue by the trichrome stain; minimal mature
collagen can be seen at this point. B, Trichrome stain of mature scar, showing dense collagen,
with only scattered vascular channels.
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Multiple roles of macrophages in wound healing. Macrophages participate in wound
debridement, have antimicrobial activity, stimulate chemotaxis and the activation of
inflammatory cells and fibroblasts, promote angiogenesis, and stimulate matrix remodelingand synthesis. ROS, reactive oxygen species
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SCAR FORMATION
Processes of Scar Formation :
1. Emigration and Proliferation of
Fibroblast in the site of injury
2. Deposition of ECM
3. Tissue Remodeling
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Scar Formation
Net collagen depends on increasedcollagen synthesis and decreaseddegradation
Scar compossed of spindle-shapedfibroblasts, dense collagen, fragmentsof elastic tissue and ECM components
Vascular regression --- pale, avascularscar
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Tissue Remodeling
Granulation tissue to Scar --- involvestransitions in the composition of TheECM
The Balance between ECM synthesis anddegradation results in remodeling ofthe connective tissue framework
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Keloid. A, Excess collagen deposition in the skin forming a raised scar known as keloid. B,
Note the thick connective tissue deposition in the dermis
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Development of fibrosis in chronic inflammation. The persistent stimulus of chronic
inflammation activates macrophages and lymphocytes, leading to the production of growth
factors and cytokines, which increase the synthesis of collagen. Deposition of collagen isenhanced by decreased activity of metalloproteinases.
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THANK YOU
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Tugas
Kelainan melanosit
Benign epithelial tumor
Premalignant and Malignant Epidermal
Tumors
Chronic Inflammatory Dermatoses
Infeksi virus dan jamur