PRACTICE GUIDELINE
Comprehensive Geriatric
Assessment (CGA)
in oncological patients
Version: 20 July 2011
This guideline was established under the auspices of the educational committee of SIOG. The guidelines are
available at the SIOG website, and are meant to become an ‘uptodate’ system where health care workers can
add new evidence or information if required. All information or questions can be addressed to SIOG at the email
address [email protected]
Concept: Cindy Kenis and Hans Wildiers
Coworkers: Ulrich Wedding, Martine Extermann, Koen Milisen, Johan Flamaing
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Content
1 Geriatric oncology ........................................................................................................................... 4
1.1 Comprehensive Geriatric Assessment ..................................................................................... 4
1.2 Methodology ........................................................................................................................... 4
1.3 Content of a CGA ..................................................................................................................... 5
2 Evaluation instruments: screening tools ......................................................................................... 6
2.1 Overview .................................................................................................................................. 6
2.2 G8 ............................................................................................................................................ 7
2.3 Flemish version of the Triage Risk Screening Tool ................................................................ 10
2.4 Groninger Frailty Indicator .................................................................................................... 14
2.5 Vulnerable Elders Survey - 13 ................................................................................................ 17
2.6 Senior Adult Oncology Program 2 ......................................................................................... 22
2.7 Abbreviated Comprehensive Geriatric Assessment .............................................................. 27
3 Evaluation instruments: CGA......................................................................................................... 32
3.1 Overview ................................................................................................................................ 32
3.2 Activities of Daily Living ......................................................................................................... 33
3.3 Barthel Index ......................................................................................................................... 38
3.4 Instrumental activities of Daily Living ................................................................................... 43
3.5 Falls ........................................................................................................................................ 52
3.6 Mini Mental State Examination ............................................................................................. 54
3.7 Clock Drawing Test ................................................................................................................ 63
3.8 Geriatric Depression Scale ..................................................................................................... 69
3.9 Mini Nutritional Assessment ................................................................................................. 74
3.9.1 Mini Nutritional Assessment (MNA).............................................................................. 74
3.9.2 Mini Nutritional Assessment – Short Form (MNA-SF) ................................................... 77
3.10 Charlson Comorbidity Index (CCI) ......................................................................................... 84
3.11 Cumulative Illness Rating Scale for Geriatrics ....................................................................... 89
4 Practical issues ........................................................................................................................... 92
4.1 Which patients to evaluate? ................................................................................................. 92
4.2 Methodology ......................................................................................................................... 93
4.3 Organizational conditions...................................................................................................... 93
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4.4 Way of reporting ................................................................................................................... 94
4.5 Interventions ......................................................................................................................... 94
4.6 Use in clinical practice ........................................................................................................... 95
5 Case presentation ....................................................................................................................... 97
6 Prediction of toxicity with geriatric assessment .................................................................... 100
7 Usefull information .................................................................................................................... 101
8 References................................................................................................................................. 102
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1 Geriatric oncology
A Comprehensive Geriatric Assessment (CGA) is the most appropriate method to obtain a view on the general
health status of an older individuals (including social situation, functionality, falls, cognitive and mood changes,
nutritional status, …). It completes history taking and physical examination. It was developed in geriatric
medicine as diagnostic tool, as tool to plan care and interventions and as tool to assess quality of care.
A CGA allows to detect multiple problems that are often unknown for the treating oncologist. It allows also to
organize specific interventions where needed.
1.1 Comprehensive Geriatric Assessment
The definition of CGA according to the Consensus Conference, supported by the
National Institute of Aging in 1989, states the following:
“CGA is a multidimensional, interdisciplinary patient evaluation that leads to the identification of patient’s
problems”.
In other words, CGA is characterized by a multidimensional evaluation of the general health status but also
functional, cognitive, social and psychological parameters of older persons.
1.2 Methodology
A screening instrument can be used initially for risk detection. If the screening indicates the presence of a
geriatric risk profile, a CGA can be performed. This ‘two-step’ approach is recommended in the guidelines of the
National Comprehensive Cancer Network (NCCN) (see figure 1).
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Figure 1: 2-step approach in geriatric assessment
Screening test
normal abnormal
stop Comprehensive Geriatric Assessment (CGA)
1.3 Content of a CGA
The CGA consists of different evaluation instruments and is generally performed by interview or by performance
tests.
During this contact (+/- 30 to 45 minutes), several core domains are evaluated:
- Demographic data
o Marital status
o Living situation
o Professional home care
o Level of education
- Functionality including falls
- Cognitive status
- Depression
- Nutritional status
Other relevant domains than can be evaluated are listed below:
- Pain
- Fatigue
- Quality of life
- …
Comorbidity and polypharmacy are also considered to be part of a CGA, but are generally available in the medical
file of the patient. However for quantification of comorbidity, validated scales can be used (see further).
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2 Evaluation instruments: screening tools
2.1 Overview
Table 1:
DOMAIN INSTRUMENT
Screening tool
- G8
- Flemish version of the Triage Risk Screening Tool (TRST)
- Groninger Frailty Indicator (GFI)
- Vulnerable Elders Survey – 13 (VES-13)
- Senior Adult Oncology Program 2 (SAOP2)
- abbreviated Comprehensive Geriatric Assessment (aCGA)
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2.2 G8
Instrument G8
Abbreviation G8
Author Soubeyran et al.
Subject Screening
Goal Detection of a geriatric risk profile
Population Older Cancer Patients
Taken by Health care professional
Number of items 8
Participation of the patient Yes
Reference Soubeyran P, Bellera CA, Gregoire F, et al. Validation of a screening test
for elderly patients in oncology. J Clin Oncol 2008; 26(suppl 20): abstr
20568.
Soubeyran P, Bellera C, Goyard J ,et al. Validation of the G8 screening tool
in geriatric oncology: the ONCODAGE project. J Clin Oncol 2011; abstr
9001.
Instrument can be found at: www.siog.org
www.eortc.be/home/NESG/history.html
Permission required No
Translations available - English
- French
- Dutch
- German
- …
Goal
The G8 is used for the identification of older persons with cancer with a geriatric risk profile where a full CGA is
required.
Target population
The G8 is meant for older persons.
Description
The G8 is a screening instrument based on the MNA, with addition of an age related component.
Method
- Interview
Scoring
- Total score = 17
Page 8
- Range total score = 0-17
- Cut-off: ≤ 14
Interpretation
- 0 - 14 = presence of a geriatric risk profile
- > 14 = absence of a geriatric risk profile
Instructions
1. Indicate the correct answer for each question.
2. Make a sum of all scores and calculate the total score.
Remarks
1. Validation
The G8 has been prospectively validated in the Oncodage study. The cutoff of 14 or lower was confirmed as the
optimal threshold, with a sensitivity of 76,6% and a specificity of 64,4%. Compared to the VES13, the G8 was
more sensitive (76.6% versus 68.7%) although its specificity was inferior (64.4% versus 74.3%).
2. User friendliness.
It takes about 2 to 3 minutes to complete the screening.
References
1. Soubeyran P, Bellera CA, Gregoire F, et al. Validation of a screening test for elderly patients in oncology. J
Clin Oncol 2008; 26(suppl 20): abstr 20568.
2. Soubeyran P, Bellera C, Goyard J ,et al. Validation of the G8 screening tool in geriatric oncology: the
ONCODAGE project. J Clin Oncol 2011; abstr 9001.
Page 9
Example
G8
Items Possible answers Score
A
Has food intake declined over the past 3
months due to loss of appetite, digestive
problems, chewing or swallowing difficulties?
0 = severe reduction in food intake
1 = moderate reduction in food intake
2 = normal food intake
………...
B
Weight loss during the last 3 months?
0 = weight loss >3kg
1 = does not know
2 = weight loss between 1 and 3 kg
3 = no weight loss
………...
C
Mobility 0 = bed or chair bound
1 = able to get out of bed/chair but does
not go out
2 = goes out
………...
E
Neuropsychological problems 0 = severe dementia or depression
1 = mild dementia or depression
2 = no psychological problems
………...
F
Body Mass Index (weight in kg/height in m2) 0 = BMI <19
1 = 19 ≤BMI < 21
2 = 21 ≤ BMI < 23
3 = BMI ≥23
………...
H Takes more than 3 medications per day 0 = yes
1 = no
………...
P
In comparison with other people of the same
age, how does the patient consider his/her
health status?
0,0 = not as good
0,5 = does not know
1,0 = as good
2,0 = better
………...
Age 0 = >85
1 = 80-85
2 = <80
………...
Total score (0-17)
………...
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2.3 Flemish version of the Triage Risk Screening Tool
Instrument Flemish version of the Triage Risk Screening Tool
Abbreviation Flemish version of the TRST
Author Deschodt et al.
Subject Screening
Goal Detection of a geriatric risk profile
Population Older Patients / Older Cancer Patients
Taken by Health care professional
Number of items 5
Participation of the patient Yes
Reference Deschodt, M., Wellens, N., Braes, T., De Vuyst, A., Boonen, S., Flamaing,
J., Moons, P., Milisen, K. (2011). Prediction of Functional Decline in Older
Hospitalized Patients: a Comparative Multicentre Study of Three Screening
Tools. Aging Clinical and Experimental Research (In press).
Instrument can be found at: /
Permission required No
Translations available - Dutch
- English
Goal
The Flemish version of the TRST is used for the identification of older persons with a geriatric risk profile where a
full CGA is required.
Target population
The Flemish version of the TRST is meant for older persons.
Description
The Flemish version of the TRST is a translation and adaptation of the Triage Risk Screening Tool (Meldon et al.,
2003) and includes the following 5 items:
1. Presence of cognitive decline
2. Living alone or no help from family / partner
3. Reduced mobility or fallen in the past 6 months
4. Hospitalized in the past 3 months
5. Polypharmacy (≥ 5 different medications)
Method
- Interview
Scoring
- Total score = 6
- Range total score = 0-6
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- Cut-off:
o ≥ 1 (in oncology)
o ≥ 2 (in geriatrics)
Interpretation
- Oncology
o Score 0: absence of a geriatric risk profile
o Score ≥ 1: presence of a geriatric risk profile
- Geriatrics
o Score 0 – 1: absence of a geriatric risk profile
o Score ≥ 2: presence of a geriatric risk profile
Instructions
- Circle the right answer on the different questions.
- Count total score by counting the scores of the different questions.
Remarks
1. User friendliness
It takes less than 1 minute to complete the screening tool.
References
1. Braes, T., Flamaing, J., Sterckx, W., Lipkens, P., Sabbe, M., de Rooij, S., Schuurmans, M., Moons, P.,
Milisen, K. (2009). Predicting the risk of functional decline in older patients admitted to the hospital: a
comparison of three screening instruments. Age and Ageing, 38 (5), 600-603.
2. Braes T, Milisen K, Vander Elst B, Van Doninck E, Pelemans W & Flamaing J. Identificatie van geriatrische
patiënten opgenomen op een niet-geriatrische afdeling: het Geriatrisch Risicoprofiel Instrument (GRP). 28th
Winter-Meeting, Belgian Association for Gerontology and Geriatrics. 4-5 March 2005, Oostende, Belgium.
3. Braes, T., Moons, P., Lipkens, P., Sterckx, W., Sabbe, M., Flamaing, J., Boonen, S., Milisen, K. (2010).
Screening for risk of unplanned readmission in older patients admitted to the hospital: predictive accuracy of
three instruments. Aging Clinical and Experimental Research, 22, 345-351.
4. Deschodt, M., Wellens, N., Braes, T., De Vuyst, A., Boonen, S., Flamaing, J., Moons, P., Milisen, K. (2011).
Prediction of Functional Decline in Older Hospitalized Patients: a Comparative Multicentre Study of Three
Screening Tools. Aging Clinical and Experimental Research (In press).
5. Kenis, C., Schuermans, H., Van Cutsem, E., Verhoef, G., Vansteenkiste, J., Vergote, I., Schöffski, P., Milisen,
K., Flamaing, J., & Wildiers, H. (2009). Screening for a geriatric risk profile in older cancer patients: a
comparative study of the predictive validity of three screening tools. Critical Reviews in
Oncology/Hematology, 72(suppl.1), 22.
Page 12
6. Meldon SW, Mion LC, Palmer RM, Drew BL, Connor JT, Lewicki LJ, Bass DM, & Emerman CL. A brief risk-
stratification tool to predict repeat emergency department visits and hospitalizations in older patients
discharged from the emergency department. Academic Emergency Medicine 2003; 10(3):224-232
Page 13
Example
Flemish version of the TRST
RISK YES NO
1. Presence of cognitive decline 2 0
2. Living alone OR no help from family / partner 1 0
3. Reduced mobility OR fallen in the past 6 months 1 0
4. Hospitalized in the past 3 months 1 0
5. Polypharmacy: ≥ 5 medications 1 0
Total score:
...............................
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2.4 Groninger Frailty Indicator
Instrument Groninger Frailty Indicator
Abbreviation GFI
Author Slaets JP.
Subject Screening
Goal Detection of a geriatric risk profile
Population Older persons
Taken by Health care professional
Number of items 15
Participation of the patient Yes
Reference Slaets JP. Vulnerability in the elderly: frailty. Medical Clinics of North
America 2006, 90:593-601.
Instrument can be found at: http://www.nardisteverink.nl/materials/GFI_lijst.pdf
Permission required No
Translations available - English
- Dutch
- …
Goal
The GFI is used for the identification of older persons with a geriatric risk profile where a full CGA is required.
Target population
The GFI is meant for older persons.
Description
The GFI is a short, easy to administer 15-item screening tool to determine a person's level of frailty, including
psycho-social components.
It screens for diminished abilities and resources in 4 domains of functioning:
• physical (mobility functions, multiple health problems, physical fatigue, vision, hearing)
• cognitive (cognitive functioning)
• social (emotional isolation)
• psychological (depressed mood and feelings of anxiety)
Method
- Interrogation of the patient / proxy
Scoring
- Total score = 15
- Range total score = 0-15
- Cut-off: ≥ 4
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Interpretation
- Score 0-3 = absence of a geriatric risk profile
- Score 4-15 = presence of a geriatric risk profile
Instructions
- Circle the answer to the question.
- Use the following scoring rules for counting total score:
- Question 1 to 4 independent (yes) =0 dependent (no) =1
- Question 5 0-6= 1 7-10 = 0
- Question 6 to 9 yes= 1 no = 0
- Question 10 no and sometimes = 0 yes = 1
- Question 11 to 15 no = 0 sometimes and yes =1
Remarks
/
References
1. Slaets JP. Vulnerability in the elderly: frailty. Medical Clinics of North America 2006, 90:593-601.
2. Steverink, N., Slaets, J.P.J., Schuurmans, H., & Lis, M. van (2001). Measuring frailty: development and
testing of the Groningen Frailty Indicator (GFI). The Gerontologist, 41, special issue 1, 236-237.
3. Schuurmans, H., Steverink, N., Lindenberg, S., Frieswijk, N., & Slaets, J.P.J. (2004). Old or frail: what tells
us more? Journals of Gerontology: Medical Sciences, 59A, 962-965.
Page 16
Example
GFI
Mobility
Is the patient able to carry out these tasks without any help? (the use of help
resources, such as walking stick, walking frame, wheelchair, is considered as
independent)
1. Shopping
2. Walking around outside (around the house or to the neighbors)
3. Dressing and undressing
4. Going to the toilet
Yes – No
Yes – No
Yes – No
Yes – No
Physical fitness
5. What mark does the patient give him/herself for physical fitness?
(Scale 0 to 10)
Mark: …………..
Vision
6. Does the patient experience problems in daily life as a result of poor
vision?
Yes – No
Hearing
7. Does the patient experience problems in daily life because of difficulty
hearing?
Yes– No
Nourishment
8. During the last 6 months has the patient lost a lot of weight unwillingly?
(3kg in 1 month or 6 kg in 2 months)
Yes – No
Morbidity
9. Does the patient take 4 or more different types of medicine?
Yes – No
Cognition
10. Does the patient have any complaints about his/her memory or is the
patient knonw to have a dementia syndrome?
No – Sometimes - Yes
Psychosocial
11. Does the patient sometimes experience an emptiness around him/her?
12. Does the patient sometimes miss people around him/her?
13. Does the patient sometimes feel abandoned?
14. Has the patient recently felt down-hearted or sad?
15. Has the patient recently felt nervous or anxious?
No – Sometimes – Yes
No – Sometimes – Yes
No – Sometimes – Yes
No – Sometimes – Yes
No – Sometimes – Yes
Total score (0-15)
………………………….
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2.5 Vulnerable Elders Survey - 13
Instrument Vulnerable Elders Survey – 13
Abbreviation VES-13
Author Saliba et al.
Subject Screening
Goal Identification of vulnerable elders
Population Older persons in the community / Older Cancer Patients
Taken by Health care professional
Number of items 13
Participation of the patient - No: when filled in by self-report
- Yes: when filled in by interview
Reference Saliba D, Elliott M, Rubenstein LZ, Solomon DH, Young RT, Kamberg CJ, et
al. The Vulnerable Elders Survey: a tool for identifying vulnerable older
people in the community. J Am Geriatr Soc 2001 Dec;49(12):1691-9.
Instrument can be found at: http://www.rand.org/health/projects/acove/survey.html - Accessed 1-18-06
Permission required - The VES can be used without charge by researchers, health care
professionals, and provider organizations.
- RAND's (cooperation) only requirement is that proper acknowledgement
be given RAND as rights owner, citing the reference noted above.
Translations available - English
- Dutch
- …
Goal
The VES-13 is used for the identification of vulnerability by older persons in the community who can have benefit
from improved detection and care of prevalent medical and geriatric conditions known to result in functional
decline and mortality.
Target population
The VES-13 is meant for older persons.
Description
The VES-13 is a simple function-based screen, which effectively and efficiently identifies older people at risk of
functional decline or death over a 2-year period. It aims to identify a group of community-dwelling older people at
risk for death or decline and who might therefore benefit from improved detection and care of prevalent medical
and geriatric conditions known to result in functional decline and mortality.
This targeting system relies on patients self-report, is easily transportable across settings, and will remain relevant
as care systems evolve. It applies across care systems regardless of the quality of administrative data, does not
require direct observations or laboratory data, and avoids reliance on utilization patterns or on the quality of
condition detection within each system.
Page 18
Method
- Self-report
- Interview
Scoring
- Total score = 10
- Range total score = 0 – 10
- Cut-off: ≥ 3
Interpretation
- Score 0 – 2: absence of vulnerability
- Score 3 – 10: presence of vulnerability
Instructions
- Cross or fill in the correct answer to the question.
- Use the following scoring rules for counting total score:
- Question 1: age
- 75-84 = 1 point
- ≥85 = 3 points
- Question 2: self-rated
health
- fair or poor = 1 point
- Question 3: difficulty with
one or more physical
activities
- stooping, crouching, or kneeling; lifting 10 pounds; reaching
above shoulder level; walking one quarter of a mile; heavy
housework; writing or grasping small objects
- 1 point for each * respons
- maximum of 2 points
- Question 4: requiring
assistance with any of five
activities
- shopping, light housework, finances, walking across room,
or bathing
- 4 points for one or more * responses
Remarks
1. User friendliness
It takes less than 5 minutes to complete.
References
1. Mohile SG, Bylow K, Dale W, Dignam J, Martin K, Petrylak DR, et al. A pilot study of the vulnerable elders
survey-13 compared with the Comprehensive Geriatric Assessment for identifying disability in older patients
with prostate cancer who receive androgen ablation. Cancer 2007 Feb 15;109(4):802-10.
Page 19
2. Saliba D, Elliott M, Rubenstein LZ, Solomon DH, Young RT, Kamberg CJ, et al. The Vulnerable Elders
Survey: a tool for identifying vulnerable older people in the community. J Am Geriatr Soc 2001
Dec;49(12):1691-9
Page 20
Example
VES-13
1. Age: …………………..
2. In general, compared to other people your age, would you say that your health is:
� Poor *
� Fair *
� Good
� Very good
� Excellent
3. How much difficulty, on average, do you have with the following physical activities:
No
difficulty
A little
difficulty
Some
difficulty
A lot of
difficulty
Unable to
do
a. stooping, crouching or kneeling?
� � � � * � *
b. lifting, or carrying objects as heavy as
10 pounds?
� � � � * � *
c. reaching or extending arms above
shoulder level?
� � � � * � *
d. writing, or handling and grasping small
objects?
� � � � * � *
e. walking a quarter of a mile?
� � � � * � *
f. heavy housework such as scrubbing
floors or washing windows?
� � � � * � *
4. Because of your health or a physical condition, do you have any difficulty:
a. shopping for personal items (like toilet items or medicines)?
� YES → Do you get help with shopping? � YES * � NO
� N
Page 21
�
DON’T DO → Is that because of your health? � YES * � NO
b. managing money (like keeping track of expenses or paying bills)?
� YES → Do you get help with managing money? � YES � NO
� NO
�
DON’T DO → Is that because of your helth? � YES * � NO
c. walking across the room? USE OF CANE OR WALKER IS OK.
� YES → Do you get help with walking? � YES * � NO
� NO
�
DON’T DO → Is that because of your health � YES * � NO
d. doing light housework (like washing dishes, straightening up, or light cleaning)?
� YES → Do you get help with light housework? � YES * � NO
� NO
�
DON’T DO → Is that because of your health? � YES * � NO
e. bathing orshowering?
� YES → Do you get help with bathing or showering? � YES * � NO
� NO
�
DON’T DO → Is that because of your health? � YES * � NO
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2.6 Senior Adult Oncology Program 2
Instrument Senior Adult Oncology Program 2 screening questionnaire
Abbreviation SAOP2
Author Extermann et al.
Subject Screening
Goal Identification of older persons for a multidisciplinary team consultation
Population Older Cancer Patients
Taken by Health care professional
Number of items 15
Participation of the patient Yes
Reference Extermann M, Green T, Tiffenberg G, Rich CJ. Validation of the Senior Adult
Oncology Program (SAOP)2 screening questionnaire. International Society
of Geriatric Oncology (SIOG) conference, Montreal, Oct 16-18, 2008. Crit
Rev Oncol Hematol 69(2): 185, 2009
Instrument can be found at: http://www.siog.org/images/SIOG_documents/geriatricassessmentsaop2.pdf
or www.moffitt.org/saoptools
Permission required No
Translations available - English
- …
Goal
The SAOP2 is used for the identification of older persons with cancer where a multidisciplinary team consultation
was required.
Target population
The SAOP2 is meant for older persons.
Description
The SAOP2 was developed by the multidisciplinary clinical team of the SAOP at Moffitt to determine when a
multidisciplinary team consultation was required in new patients. In addition to function, depression, and cognitive
screening, the screening includes questions regarding quality of life, self-rated health, falls, nutrition, sleep,
polypharmacy, and social questions (drug payment and caregiver availability).
Method
- Self-report + interview
Interpretation
- If one item is positive, the respectively specialist is called in.
- If several items are impaired, the multidisciplinary team is called in or a geriatric referral is made for a CGA.
Page 23
Instructions
- The first pages are answered by self-report (patient) and the last page is administered by the clinic staff.
Remarks
1. Validation
o After more than 5 years of clinical use, this screen has demonstrated face validity, finding that
63% of senior cancer patients needed psychosocial counseling, 40% dietary intervention, and
14% medication counseling and assistance (the latter probably underestimated).
o Its performance was validated against a Multidimensional Geriatric Assessment (MGA).
References
1. Extermann M, Green T, Tiffenberg G, Rich CJ. Validation of the Senior Adult Oncology Program (SAOP)2
screening questionnaire. International Society of Geriatric Oncology (SIOG) conference, Montreal, Oct 16-
18, 2008. Crit Rev Oncol Hematol 69(2): 185, 2009
2. Johnson D, Blair J, Balducci L, Extermann M, Crocker T, McGinnis M, Vranas P. The assessment of clinical
resources in a Senior Adult Oncology Program. European Oncology Nursing Society Meeting, Innsbruck,
Austria, April 22, 2006
Page 24
Example
SAOP2
Name: UR#: Age:
Diagnosis: MD:
1. If it was necessary, is there someone who could help take care
of you?
� Yes � No
2. Do you feel sad more days than not? � Yes � No
3. Have you lost interest in things you used to enjoy (hobbies,
food, sex, being with friends/family)?
� Yes � No
4. On a scale of 1 to 10, rate your present quality of life (10 is the best life, 1 is the worst)
1 2 3 4 5 6 7 8 9 10
worst best
5. On a scale of 1 to 10, rate your present overall health (10 is the excellent, 1 is the poor)
1 2 3 4 5 6 7 8 9 10
worst best
6. Activities of Daily Living
Can you dress yourself completely? Yes Yes but with help No
Can you feed yourself? Yes Yes but with help No
Do you use a cane, walker, or wheelchair?.. Yes Yes, occasionally No
Do you need help to get out of bed/chair?… Yes Yes but with help No
Are you incontinent of urine? Yes Occasionally No
Do you need help taking a shower or a bath? Yes Occasionally No
Have you tripped or fallen in the past year?.. Yes No
Are you able to drive? Yes Have never driven No
Are you able to prepare your own meals?… Yes Yes but with help No
Are you able to go shopping? Yes Yes but with help No
Can you take care of your finances?……… Yes Yes but with help No
Can you use the telephone? Yes Yes but with help No
Do you remember to take your medications? Yes Yes but with help No
7. Have you lost 5 or more pounds in the past 6 months without
dieting?
� Yes � No
8. Has your appetite decreased in the last 3 months? � Yes � No
9. Has there been a change in the types of foods you are able to � Yes � No
Page 25
eat?
10. Are you always able to pay for your prescription medications? � Yes � No
11. Do you feel you are sleeping well? � Yes � No
Please stop here. Thank you!
Page 26
***I am going to name 3 objects (pencil, truck, book) and ask you to repeat them now and a few minutes from now
to test your memory.
12. Spell the word “clown” backwards. n-w-o-l-c……………………….. 5 points=____
13. What is today’s date and day? Mth.___Date___Yr.___, Day_____... 4 points=____
14. Can you repeat the 3 objects I mentioned earlier? 1[ ] 2[ ] 3[ ]….... 3 points=____
Total= ______
15. How many medications/herbals/vitamins are you taking? ____________ None [ ]
Additional information:
ECOG PS:______ Usual weight=_______ Current weight=________
Nutrition: BMI______ MNAs_______ Referral: No - Yes
SW: GDS______ MMSE______ Referral: No - Yes
Page 27
2.7 Abbreviated Comprehensive Geriatric Assessment
Instrument abbreviated Comprehensive Geriatric Assessment
Abbreviation aCGA
Author Overcash et al.
Subject Screening
Goal Detection of a geriatric risk profile
Population Older Cancer Patients
Taken by Health care professional
Number of items 15
Participation of the patient Yes
Reference Overcash JA, Beckstead J, Extermann M, et al: The abbreviated
comprehensive geriatric assessment (aCGA): a retrospective analysis. Crit
Rev Oncol Hematol 54:129-36, 2005
Instrument can be found at: /
Permission required No
Translations available - English
- …
Goal
The aCGA is used for the identification of older persons with cancer with a geriatric risk profile where a full CGA is
required.
Target population
The aCGA is meant for older persons.
Description
The aCGA includes 15 items which were isolated within the findings of a MGA in a large database of older
patients with cancer who underwent a CGA as part of their oncology evaluation:
o 3 questions about ADL
o 4 questions about IADL
o 4 questions from the Mini Mental Status Examination
o 4 questions from the Geriatric Depression Scale
Method
- Interview
Scoring
- GDS:
o On each question, ‘yes’ or ‘no’ needs to be answered, according to the mood of the patient.
o Calculation of the score:
Page 28
YES NO
1. Do you feel that your life is empty? 1 0
2. Do you feel happy most of the time? 0 1
3. Do you often feel helpless? 1 0
4. Do you feel pretty worthless the way you are now? 1 0
- ADL / IADL
o Cross the correct answer
o If any impairment is present: see instructions.
- MMSE
Question Timelimit Scoring
• Serial sevens 30 sec • Score the total number of times that 7 is
substracted correctly.
• Examples:
93, 86, 79, 72, 65 = 5 points (all good)
93, 88, 81, 74, 67 = 4 points (4 good, 1 false)
92, 85, 78, 71, 64 = 4 points (4 good, 1 false)
93, 87, 80, 73, 64 = 3 points (3 good, 2 false)
92, 85, 78, 71, 63 = 3 points (3 good, 2 false)
93, 87, 80, 75, 67 = 2 points (2 good, 3 false)
93, 87, 81, 75, 69 = 1 point (1 good, 4 false)
• Spell the word “WORLD” 30 sec • The score is the number of letters in correct order,
e.g. dlrow = 5; dlorw =3.
When the patient cannot or will not perform the task with serial sevens or didn’t perform it completely correct, ask
him/her to perform the spelling exercise. Compare both scores to each other and the highest score will count for
the total result of the MMSE.
• Reading
10 sec • Score one point only if the subject closes eyes.
• The subject does not have to read aloud.
• Writing
30 sec
• Score one point for writing a sentence.
• The sentence must make sense and has to contain
a subject and a verb.
• Ignore spelling errors.
• Copying
1 min
maximum
• Score one point for a correctly copied diagram.
• The person must have drawn a four-sided figure
between two five-sided figures.
• Tremor and rotation are ignored.
Instructions
- GDS score ≥ 2: complete full 15-item GDS
- ADL: any impairment: complete full ADL
- IADL: any impairment: complete full IADL
- Cognitive screening score ≤ 6: complete full MMSE
Page 29
Remarks
/
References
1. Overcash JA, Beckstead J, Extermann M, et al: The abbreviated comprehensive geriatric assessment
(aCGA): a retrospective analysis. Crit Rev Oncol Hematol 54:129-36, 2005
2. Overcash JA, Beckstead J, Moody L, et al: The abbreviated comprehensive geriatric assessment (aCGA) for
use in the older cancer patient as a prescreen: scoring and interpretation. Crit Rev Oncol Hematol 59:205-
10, 2006
Page 30
Example
aCGA
Patient identifier:……………………….
GDS
To score the GDS (items 1 – 4) circle yes or no.
1. Do you feel that your life is empty? � Yes � No
2. Do you feel happy most of the time? � Yes � No
3. Do you often feel helpless? � Yes � No
4. Do you feel pretty worthless the way you are now? � Yes � No
ADL
To score the ADL (items 5 – 7) check which level of assistance applies.
5. Bathing (Sponge bath, tub
bath or shower)
� Receive no assistance (gets into and out of tub by self if tub is
the usual means of bathing)
� Receives assistance in bathing only one part of the body (such
as back or a leg)
� Receives assistance in bathing more than one part of the body
(or not bathed)
6. Transfer � Moves into and out bed as well as into and out of chair without
assistance (May use object such as cane or walker for support)
� Moves into or out of bed or chair with assistance
� Doesn’t get out of bed
7. Continence � Controls urination and bowel movement completely by self
� Has occasional accidents
� Supervision helps keep control of urination or bowel movement or
catheter is used or is incontinence
IADL
To score the IADL (items 8 – 11) circle the number which reflects the ability.
8. Can you go shopping for groceries? � Without help
� With some help
� Are you completely unable to do any shopping?
3
2
1
9. Can you prepare your own meals? � Without help
� With some help
� Are you completely unable to prepare any meals?
3
2
1
10. Can you do your own housework? � Without help 3
Page 31
� With some help
� Are you completely unable to do any housework?
2
1
11. Can you do your own laundry? � Without help
� With some help
� Are you completely unable to do any laundry at all?
3
2
1
MMSE
Score as indicated on each item.
12. Attention and calculation - Begin with 100 and count backward by 7 (stop after 5
answers): 93-86-79-72-65. Score one point for each
correct answer.
- If the patient will not perform this task, ask the person
to spell ‘WORLD’ backwards (DLROW). Record the
patients spelling. Score one point for each correctly
placed letter.
Score:
13. Reading Read and obey the following: Close your eyes (show the
patient the item on the attached paper)
Circle the score:
1 / 0
14. Writing Write a sentence (on the attached paper) Circle the score:
1 / 0
15. Copying Copy the design of the intersecting pentagons
Circle the score:
1 / 0
.
Page 32
3 Evaluation instruments: CGA
3.1 Overview
Table 2:
DOMAIN EVALUATION INSTRUMENTS
Functional status
- Activities of Daily Living (ADL) (Katz et al., 1963)
- Barthel Index (BI) (Barthel et al., 1969)
- Instrumental Activities of Daily Living (IADL) (Lawton & Brody, 1969)
Falls
- Falls (Lamb et al., 2005)
Cognitive status
- Mini Mental State Examination (MMSE) (Folstein et al., 1975)
- Clock Drawing Test (Sunderland et al., 1989)
Depression
- Geriatric Depression Scale (GDS) (Yesavage et al., 1983)
Nutrition
- Mini Nutritional Assessment (MNA) (Guigoz et al., 1997)
- Mini Nutritional Assessment – Short Form (MNA-SF) (Guigoz et al.,
1997)
Comorbidity
- Charlson Comorbidity Index (CCI) (Charlson et al, 1997)
- Cumulative Illness Rating Scale – Geriatrics (Linn et al., 1968)
Page 33
3.2 Activities of Daily Living
Instrument Katz index of Independance in Activities of Daily Living
Abbreviation KATZ or ADL
Author Katz et al.
Subject Functional evaluation
Goal Evaluation of the capacities of daily living
Population Mainly older persons
Taken by Health care professional
Number of items 6
Participation of the patient Yes
Reference Katz S, Ford AB, Moskowitz RW, et al. Studies of illness in the aged. The
Index of the ADL: a standardized measure of biological and psychosocial
function. JAMA 1963;185:914-919.
Instrument can be found at: http://www.geronurseonline.org
Permission required No
Translations - English
- French
- Dutch
- …
Goal
The Katz-scale is used for the objective evaluation of the functional condition by measuring the level of autonomy
for the performance of daily activities. This index wants to measure the physical functioning of older individuals
and individuals with chronic diseases.
Target population
The Katz-scale is mainly used for the functional evaluation of older individuals.
Description
This scale is used for the detection of problems with functionality, and for establishing a care plan for the different
topics.
The Katz-index measures the performance in 6 functions:
• Bathing
• Dressing
• Toileting
• Transferring
• Continence
• Feeding
Page 34
In the original version, the scoring is binary, with score 0 for dependence and 1 for indepence. A low score
indicates a strong dependence. More recently, there are scores with more specification (3 item: 0-0.5-1 per item;
4 item: 1-2-3-4 per item, eg. Belgian Katz scale).
Method
- Interview
- Observation
Scoring
For 2-item:
- Range total score = 0 – 6
- For each domain (6) there are 2 levels of dependency with specific criteria.
• Score 1 if the patient can perform the task with no supervision.
• Score 0 if the patient can only perform the task with supervision.
• The patient receives a score for each of the 6 domains.
Interpretation
- The scores of the different domains are added to obtain the total score
- Original version: score 0 was completely dependent, and score 6 completely independent.
- In contrast: adapted versions where interpretation score is often opposite.
Instructions
- The 6 items are assessed one by one by the health care worker based on observation or interview of the
patient or relative.
Remarks
1. User friendliness
- The performance of the Katz-scale is very simple.
- It is based on observations while the patient performs activities of daily living or taken by interview.
2. General remarks
- The Katz-scale is the most commonly used scale for decades to evaluate the functional condition of
the older population. Validity and reliability data for the original version of the Katz were not found
in the literature.
- The Katz-scale has undergone multiple changes during the years, depending on the domain where
it is used.
- The way of scoring is also changed in different versions, so it is important to use the rules that are
relevant for the version used.
- Results may differ because patients tent to overestimate their abilities.
References
1. Asberg KH. Disability as a predictor of outcome for the elderly in a department of internal medicine. Scand J
Soc Med 1987;15:261-265.
Page 35
2. Daem, M., Piron, C., Lardennois, M., Gobert, M., Folens, B., Vanderwee, K., Grypdonck, M., & Defloor T.
(2007). Opzetten van een databank met gevalideerde meetinstrumenten: BEST-project. Brussel, Federale
Overheidsdienst Volksgezondheid, Veiligheid van de voedselketen en Leefmilieu.
http://www.best.ugent.be
3. Katz S, Vignos PJ, Moskowitz RW, et al. Comprehensive outpatient care in rheumatoid arthritis: a controlled
study. JAMA 1986;206:1249-1254.
4. Katz S, Ford AB, Chinn AB, et al. Prognosis after strokes: II. Long-term course of 159 patients with stroke.
Medicine 1966;45:236-246.
5. Katz S, Ford AB, Moskowitz RW, et al. Studies of illness in the aged. The Index of the ADL: a standardized
measure of biological and psychosocial function. JAMA 1963;185:914-919.
6. Katz. S. Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily
living. J.Am.Geriatr.Soc. 31 (12):721-727, 1983.
7. Reijneveld SA. Spijker J. Dijkshoorn H. Katz' ADL index assessed functional performance of Turkish,
Moroccan, and Dutch elderly. [Journal Article. Research Support, Non-U.S. Gov't] Journal of Clinical
Epidemiology. 60(4):382-8, 2007 Apr
Page 36
Example 2-item ADL
ACTIVITIES
POINTS (1 OR 0)
INDEPENDENCE:
(1 POINT)
NO supervision, direction or personal
assistance
DEPENDENCE:
(0 POINTS)
WITH supervision, direction, personal
assistance or total care
BATHING
POINTS:___________
(1 POINT) Bathes self completely or
needs help in bathing only a single part of
the body such as the back, genital area
or disabled extremity.
(0 POINTS) Needs help with bathing
more than one part of the body, getting in
or out of the tub or shower. Requires total
bathing.
DRESSING
POINTS:___________
(1 POINT) Gets clothes from closets and
drawers and puts on clothes and outer
garments complete with fasteners. May
have help tying shoes.
(0 POINTS) Needs help with dressing self
or needs to be completely dressed.
TOILETING
POINTS:___________
(1 POINT) Goes to toilet, gets on and off,
arranges clothes, cleans genital area
without help.
(0 POINTS) Needs help transferring to
the toilet, cleaning self or uses bedpan or
commode.
TRANSFERRING
POINTS:___________
(1 POINT) Moves in and out of bed or
chair unassisted. Mechanical transferring
aides are acceptable.
(0 POINTS) Needs help in moving from
bed to chair or requires a complete
transfer.
CONTINENCE
POINTS:___________
(1 POINT) Exercises complete self
control over urination and defecation.
(0 POINTS) Is partially or totally
incontinent of bowel or bladder.
FEEDING
POINTS:___________
(1 POINT) Gets food from plate into
mouth without help. Preparation of food
may be done by another person.
(0 POINTS) Needs partial or total help
with feeding or requires parenteral
feeding.
TOTAL POINTS =
______
6 = High (patient independent)
0 = Low (patient very dependent )
Page 37
Example 3-item ADL
Bathing (sponge, shower, or tub):
� I: receives no assistance (gets in and out of tub if tub is the usual means of bathing)
� A: receives assistance in bathing ony one part of the body (such as the back or leg)
� D: receives assistance in bathing more than one part of the body (or not bathed)
Dressing:
� I: gets clothes and gets completely dressed without assistance
� A: gets clothes and gets dressed without assistance except in tying shoes
� D: receives assistance in getting clothes or in getting dressed or stays partly or completely
underdressed
Toileting:
� I: goes to "toilet room", cleans self, and arranges clothes without assistance (may use object for
support such as cane, walker, or wheelchair and my manage night bedpan or commode,
emptying in the morning)
� A: receives assistance in going to "toilet room" or in cleansing self or in arranging clothes after
elimination or in use of night bedpan or commode
� D: doesn't go to room termed "toilet" for the elimination process
Transferring:
� I: moves in and out of bed as well as in and out of chair without assistance (may be using object
for support such as cane or walker)
� A: moves in and outof bed or chair with assistance
� D: doesn't get out of bed
Continence:
� I: controls urination and bowel movement completely by self
� A: has occasional "accidents"
� D: supervision helps keep urine or bowel control; catheter is used, or is incontinent
Feeding:
� I: feeds self without assistance
� A: feeds self except for getting assistance in cutting meat or buttering bread
� D: receives assistance in feeding or is fed partly or completely by using tubes or intravenous fluids
Page 38
3.3 Barthel Index
Instrument Barthel Index
Abbreviation BI
Author Mahoney & Barthel
Subject Functional evaluation
Goal Evaluation of daily activities
Population - Chronically ill patients
- Older persons
Taken by Health care worker
Number of items - Original version: 10 items - 5-item is also existing
Participation of the patient No
Reference Mahoney, F. I. and Barthel, D. W. 1965. "Functional evaluation: the Barthel
Index." Md State Med.J. 1461-65.
Instrument can be found at: Mahoney, F. I. and Barthel, D. W. 1965. "Functional evaluation: the Barthel
Index." Md State Med.J. 1461-65.
http://www.strokecenter.org/trials/scales/barthel.pdf
Permission required - The Maryland State Medical Society holds the copyright for the
Barthel Index. It may be used freely for noncommercial purposes with
the following citation:
Mahoney FI, Barthel D. “Functional evaluation: the Barthel Index.”
Maryland State Med Journal 1965;14:56-61. Used with permission.
- Permission is required to modify the Barthel Index or to use it for
commercial purposes.
Translations - English
- …
Goal
The Barthel Index (BI) is developed to assess basic problems in chronically ill patients according to daily
activities.
Target population
Originally the BI was used to assess the functional condition of patients with all chronic diagnosis. Currently the
BI is used as indicator in persons with a decline in mobility, more specific older persons.
Description
The BI consists of 10 items that measure a person's daily functioning specifically the activities of daily living and
mobility:
• Feeding
• Bathing
Page 39
• Grooming
• Dressing
• Bowels
• Bladder
• Toilet use
• Transfers (bed to chair and back)
• Mobility (on lever surfaces)
• Stairs
The assessment can be used to determine a baseline level of functioning and can be used to monitor
improvement in activities of daily living over time. The items are weighted according to a scheme developed by
the authors.
Method
- Interview
- Observation
Scoring
- Total score = 100
- Range total score = 0 - 100
Interpretation
A score of 100 indicates independency for ADL
Lower scores indicate increasing deficiencies in ADL.
Instructions
- The index should be used as a record of what a patient does, not as a record of what a patient could do.
- The main aim is to establish degree of independence from any help, physical or verbal, however minor and
for whatever reason.
- The need for supervision renders the patient not independent.
- A patient's performance should be established using the best available evidence. Asking the patient,
friends/relatives and nurses are the usual sources, but direct observation and common sense are also
important. However direct testing is not needed.
- Usually the patient's performance over the preceding 24-48 hours is important, but occasionally longer
periods will be relevant.
- Independence means that the person needs no assistance at any part of the task.
- Middle categories imply that the patient supplies over 50% of the effort.
- Use of aids to be independent is allowed.
- The scores for each of the items are summed to create a total score.
- The higher the score the more "independent" the person.
Remarks
1. Reliability
- The internal consistency is sufficient, expressed as a Cronbach alpha of 0,84 (Hsueh et al.2002).
Page 40
- The stability of the BI is demonstrated by Ganger et al. by estimating the correlation of two
measurements of the BI performed by the same investigator. The Test-Retest result was 0;89 which
stands for a good stability.
- Ganger et al. has also defined the interobserver reliability with a correlation coefficient of 0,95. This
results indicates comparable scores with multiple investigators (Equivalence).
2. Validation
- The Concurrent Validity has been demonstrated in several studies. It was verified by comparing the
BI with other evaluation instruments like the FIM. Hsueh et al. (2002) showed a good correlation
coefficient by comparing the FIM motor subscale and the BI (r= 0,92). Another study (2001) showed
also a good correlation with the FIM (r= 0,93) and a moderate correlation coefficient with SF-36 (r =
0,22) (Hobart & Thompson, 2001).
3. User friendliness
- It takes about 5 to 10 minutes to complete the BI.
- Each question includes specific definitions which facilitate the scoring.
4. Variants
- Different versions of the BI exist, for example the 5-item (BI-5).
- The BI-5 is derived from the original BI with 10 items. This simplifies the test and less time is
needed to complete (Hsueh et al.2002). The 5 items of the BI-5 are: transfer, grooming, toilet use,
stairs and mobility. The internal consistency of the BI-5 ( 0,71) is less in comparison with the BI
(0,92) but stays correct (Hsueh et al.2002).
- The BI-5 shows a strong correlation with the original BI (0,96) what expresses the validity of the
selected items in the BI-5 (Hobart and Thompson2001). This study (2001) shows also a good
correlation of the BI-5 with the FIM (r = 0,92) and has, just like the BI from which it is derived, a
moderate correlation coefficient with the SF-36 (r= 0,22) (Hobart and Thompson2001).
5. General remarks
- Some authors (Formiga, Mascaro, and Pujol, 2005) suggest to foresee a training in the use of the BI
for investigators. This would result in a better Equivalence of the index.
- Depending on the version of the BI that is used, there are different rules for scoring. It is important
to keep this in mind if the BI is included in the geriatric evaluation.
References
1. Calmels, P., Bethoux, F., Le-Quang, B., Chagnon, P. Y., and Rigal, F. 2001. "[Functional Assessment Scales
and Lower Limb Amputation]." Ann.Readapt.Med.Phys. 44(8):499-507.
2. Collin C, Wade DT, Davies S, Horne V. “The Barthel ADL Index: a reliability study.” Int Disability
Study.1988;10:61-63.
3. Daem, M., Piron, C., Lardennois, M., Gobert, M., Folens, B., Vanderwee, K., Grypdonck, M., & Defloor T.
(2007). Opzetten van een databank met gevalideerde meetinstrumenten: BEST-project. Brussel, Federale
Overheidsdienst Volksgezondheid, Veiligheid van de voedselketen en Leefmilieu.
http://www.best.ugent.be
Page 41
4. Formiga, F., Mascaro, J., and Pujol, R. 2005. "Inter-Rater Reliability of the Barthel Index." Age Ageing
34(6):655-56.
5. Gresham GE, Phillips TF, Labi ML. “ADL status in stroke: relative merits of three standard indexes.” Arch
Phys Med Rehabil. 1980;61:355-358.
6. Hobart, J. C. and Thompson, A. J. 2001. "The Five Item Barthel Index." J.Neurol.Neurosurg.Psychiatry
71(2):225-30.
7. Hsueh, I. P., Lin, J. H., Jeng, J. S., and Hsieh, C. L. 2002. "Comparison of the Psychometric Characteristics
of the Functional Independence Measure, 5 Item Barthel Index, and 10 Item Barthel Index in Patients With
Stroke." J.Neurol.Neurosurg.Psychiatry 73(2):188-90.
8. Loewen SC, Anderson BA. “Predictors of stroke outcome using objective measurement scales.” Stroke.
1990;21:78-81.
9. Mahoney, F. I. and Barthel, D. W. 1965. "Functional Evaluation: The Barthel Index." Md State Med.J. 1461-
65.
Page 42
Example Barthel Index
Page 43
3.4 Instrumental activities of Daily Living
Instrument The Lawton Instrumental Activities of Daily Living Scale
Abbreviation IADL
Author Lawton, M.P. & Brody, E.M.
Subject Functional evaluation
Goals Evaluation of the performance in instrumental activities of daily living
Population General population
Taken by Health care professional
Number of items - First version: 5 items for men, 8 items for women
- Subsequent versions: 9 items
Participation of the patient Yes
Reference Lawton, M. P. and Brody, E. M. 1969. "Assessment of Older People: Self-
Maintaining and Instrumental Activities of Daily Living." Gerontologist
9(3):179-86.
Instrument can be found at: http://www.geronurseonline.org
Permission required No
Translations - English
- French
- Dutch
- German
- …
Goal
The IADL is an instrument that can be used for the evaluation of more complex activities that require cognitive
functions.
Target population
This instrument is developed for use by older individuals and can be used in the hospital.
Description
The evaluation of the instrumental activities of daily living relates to the evaluation of complex activities (meaning
that they require certain skills, a certain autonomy, an appropriate judgment, and the capability of structuring
tasks) mainly driven by cognitive functions.
The scale describes a dimension of physical, mental and social functioning by evaluating different activities:
• Ability to use telephone
• Shopping
• Food preparation
• Housekeeping
• Laundry
• Mode of transportation
Page 44
• Responsibility for own medication
• Ability to handle finances
In the original version, 8 instrumental activities are evaluated with score 0 or 1 depending on whether the tasks
can be performed independently. Score 1 indicates an autonomy, and score 0 indicates a certain dependence.
The total score can vary from 0 to 5 for men, and 0 to 8 for women. Laundry, housekeeping and cooking were
considered to be not relevant for males, and were not counted in the score. In more recent versions, the
distinction between male and female was abandoned. In some subsequent versions, a ninth item was added
(doing handyman work). Most recent versions quote each item on 4 levels, some score from 0 to 3, others give 0
or 1 for the 4 levels with a certain cutoff.
In the latest version, it was suggested to indicate for every item whether that item was considered relevant for that
particular individual, and then only count the scores for the relevant items.
The example below is the original IADL version (scores from 0 (completely dependent) to 8 (completely
independent)) and the IADL version used by EORTC.
Methodology
- Interview
- (Observation)
Scoring
- Original version (women)
o Total score = 8
o Range total score = 0 – 8
- Original version (men)
o Total score = 5
o Range total score = 0 – 5
Interpretation
- Score 0 = completely dependent
o Low score = higher dependence
- Score 5 or 8 = completely independent
o High score = higher independence
Instructions
- The items are assessed one by one by the health care worker based on observation or interview of the
patient or relative.
Remarks
1. Reliability
- Literature does not give information on the internal consistency and stability of the IADL scale.
- Reliability of the test has been demonstrated by an inter observer reliability of 0,85.
- In 2003, Cromwell et al found an internal consistency of the IADL, expressed as Cronbach alpha of
0,70 – 0,74.
2. Validation
Page 45
- The validity of the IADL has been shown by correlating it to other scales in the functiontal domains.
This validity has been expressed as a correlation coefficient of 0.38 and 0.61 according to the parts
of the scale that were judged.
- The IADL can be used for the evaluation of cognitive functions, with very good diagnostic validity,
expressed as a sensitivity of 62% and specificity of 80% for the diagnosis of cognitive problems.
3. User friendliness
- It takes about 10 minutes to do the test, but training is required for the health care worker.
4. General remarks
- There are very few studies that looked at psychometric properties of the IADL from Lawton.
- This evaluation instrument is widely used in research and clinical practice.
Note: IADL of the EORTC
Interpretation
- The difficulty with IADL is that some domains
may not be informative for all people.
- For example some men (for cultural reasons)
may not do the laundry.
- Therefore it has been suggested that each
question is preceded by a screening question, to assess relevance.
Instructions
- Register the number of domains that cannot be scored since the person has never performed this kind of
activities.
- Score the number of remaining domains according to the level at which the patient functions (score 0 – 1)
- Calculate the total score based on the number of items that are relevant for that particular individual.
- The score can be indicated as a percentage, based on the score divided by the number of items taken into
account.
References
1. Barberger-Gateau, P. , Commenges, D. , Gagnon, M. , Letenneur, L. , Sauvel, C. , Dartigues, J.-F.
Instrumental Activities of Daily Living as a screening tool for cognitive impairment and dementia in elderly
community dwellers Journal of the American Geriatrics Society Volume 40, Issue 11, 1992, Pagina’s 1129-
1134
2. Cromwell, D. A., Eagar, K., and Poulos, R. G. 2003. "The Performance of Instrumental Activities of Daily
Living Scale in Screening for Cognitive Impairment in Elderly Community Residents." J.Clin.Epidemiol.
56(2):131-37.
3. Daem, M., Piron, C., Lardennois, M., Gobert, M., Folens, B., Vanderwee, K., Grypdonck, M., & Defloor T.
(2007). Opzetten van een databank met gevalideerde meetinstrumenten: BEST-project. Brussel, Federale
Overheidsdienst Volksgezondheid, Veiligheid van de voedselketen en Leefmilieu.
Page 46
http://www.best.ugent.be
4. Guelfi J.D., L'évaluation clinique standardisée en psychiatrie, éditions médicales Pierre Fabre, tome II, 1996.
Article de L. Israël, Évaluation de l'autonomie, Les activités instrumentales de la vie quotidienne, IADL, p
477-480.
5. Lawton, M. P. and Brody, E. M. 1969. "Assessment of Older People: Self-Maintaining and Instrumental
Activities of Daily Living." Gerontologist 9(3):179-86.
Page 47
Example – original version
IADL
Score
ABILITY TO USE TELEPHONE
� Operates telephone on own initiative, looks up and dials numbers, etc.
� Dials a few well known-numbers
� Answers telephone but does not dial
� Does not use telephone at all
1
1
1
0
SHOPPING
� Takes care of all shopping needs independently
� Shops independently for small purchases
� Needs to be accompanied on any shopping trip
� Completely unable to shop
1
0
0
0
FOOD PREPARATION
� Plans, prepares and serves adequate meals independently
� Prepares adequate meals if supplied with ingredients
� Heats, serves, and prepares meals but does not maintain adequate diet
� Needs to have meals prepared and served
1
0
0
0
HOUSEKEEPING
� Maintains house alone or with occasional assistance (e.g. “heavy work domestic help”)
� Performs light daily tasks such as dish-washing, bed-making
� Performs light daily tasks but cannot maintain acceptable level of cleanliness
� Needs help with all home maintenance tasks
� Does not participate in any housekeeping tasks
1
1
1
1
0
Page 48
LAUNDRY
� Does personal laundry completely
� Launders small items-rinses socks, stocking, etc.
� All laundry must be done by others
1
1
0
MODE OF TRANSPORTATION
� Travels independently on public transportation or drives own car
� Arranges own travel via taxi, but does not otherwise use public transportation
� Travels on public transportation when accompanied by other
� Travel limited to taxi or automobile with assistance of another
� Does not travel at all
1
1
1
0
0
RESPONSIBILITY FOR OWN MEDICATION
� Is responsible for taking medication in correct dosages at correct time
� Takes responsibility if medication is prepared in advance in separate dosage
� Is not capable of dispensing own medication
1
0
0
ABILITY TO HANDLE FINANCES
� Manages financial matters independently (budgets, writes checks, pays rent, bills, goes to
the bank), collects and keeps track of income
� Manages day to day purchases, but needs help with banking, major purchases, etc.
� Incapable of handling money
1
1
0
Total score (0-8)
Total score women (0-8)
Total score men (0-5) without food preparation, housekeeping, laundry
……......
………..
………...
Page 49
Example – EORTC version
IADL
Page 50
Score
ABILITY TO USE TELEPHONE
Has never used the telephone
� Operates telephone on own initiative, looks up and dials numbers, etc.
� Dials a few well known-numbers
� Answers telephone but does not dial
� Does not use telephone at all
N/R
1
1
1
0
SHOPPING
Has never done the shopping
� Takes care of all shopping needs independently
� Shops independently for small purchases
� Needs to be accompanied on any shopping trip
� Completely unable to shop
N/R
1
0
0
0
FOOD PREPARATION
Has never done the food preparation
� Plans, prepares and serves adequate meals independently
� Prepares adequate meals if supplied with ingredients
� Heats, serves, and prepares meals but does not maintain adequate diet
� Needs to have meals prepared and served
N/R
1
0
0
0
HOUSEKEEPING
Has never done the housekeeping
� Maintains house alone or with occasional assistance (e.g. “heavy work domestic help”)
� Performs light daily tasks such as dish-washing, bed-making
� Performs light daily tasks but cannot maintain acceptable level of cleanliness
� Needs help with all home maintenance tasks
� Does not participate in any housekeeping tasks
N/R
1
1
1
1
0
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LAUNDRY
Has never done the laundry
� Does personal laundry completely
� Launders small items-rinses socks, stocking, etc.
� All laundry must be done by others
N/R
1
1
0
MODE OF TRANSPORTATION
Has never travelled independently
� Travels independently on public transportation or drives own car
� Arranges own travel via taxi, but does not otherwise use public transportation
� Travels on public transportation when accompanied by other
� Travel limited to taxi or automobile with assistance of another
� Does not travel at all
N/R
1
1
1
0
0
RESPONSIBILITY FOR OWN MEDICATION
Does not take tablets currently
� Is responsible for taking medication in correct dosages at correct time
� Takes responsibility if medication is prepared in advance in separate dosage
� Is not capable of dispensing own medication
N/R
1
0
0
ABILITY TO HANDLE FINANCES
Never handled the finances
� Manages financial matters independently (budgets, writes checks, pays rent, bills, goes to
the bank), collects and keeps track of income
� Manages day to day purchases, but needs help with banking, major purchases, etc.
� Incapable of handling money
N/R
1
1
0
Total domains which are not relevant (N/R) (0-8)
Total domains which are relevant (0-8)
Domains in which the patient is dependent for the relevant domains (0-X)
………
………
………
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3.5 Falls
Falls can be evaluated by asking the presence of falls during the last year.
Definition of ‘fall’:
‘‘an unexpected event in which the older person comes to rest on the ground, floor, or lower level..”
If presence of falls is detected, also the nature of injuries is evaluated.
Minor injury is defined as:
- scratches
- bruises
- superficial wounds that do not/minimally require medical care
Major injury is defined as:
- sprains
- severe soft tissue bruises
- severe wounds of the head
- distortion or dislocation of joints
- cuts
- loss of conscience
- fractures
Page 53
• Did you have a fall last year?
IF YES: how often?:………………………………………………………………………
YES
NO
• Did you encounter injuries after the fall?
IF YES: which injuries?
- ‘Minor’ injuries
Definition: scratches, bruises, superficial wounds that do
not/minimally require medical care.
- ‘Major’ injuries
Definition: sprains, severe soft tissue bruises, severe wounds
of the head, distortion or dislocation of joints, cuts, loss of
conscience, fractures
YES
NO
References
1. Lamb SE, Jørstad-Stein EC, Hauer K, Becker C. 2005. Development of a common outcome data set for fall
injury prevention trials: the Prevention of Falls Network Europe consensus; Prevention of Falls Network
Europe and Outcomes Consensus Group. J Am Geriatr Soc. 53(9):1618-22.
Page 54
3.6 Mini Mental State Examination
Instrument Mini Mental State Examination
Abbreviation MMSE
Author Folstein et al.
Subject Cognition / desorientation
Goals Investigation of cognitive functions
Population Main categories, mainly older population
Taken by Trained health care worker
Number of items 30
Participation of the patient Yes
Reference Folstein MM, Folstein SE, Mc Hugh PR (1975), « Mini-Mental State»: a
pratical method for grading the cognitive state of patients for the clinical. J
Psychiatr Res 1975 Nov; 12(3): 189-98
Evaluation instrument can be
found at:
Folstein MM, Folstein SE, Mc Hugh PR (1975), ‘Mini-Mental State‘: a
pratical method for grading the cognitive state of patients for the clinical. J
Psychiatr Res 1975 Nov; 12(3): 189-98
Permission required No
Translations - English
- French
- Dutch
- …
Goal
The MMSE aims to screen orientation, memory, concentration, language, apraxia (cognitive functions). It is not
specifically meant for measuring the degree of desorientation or fluctuations in orientation.
Target population
The MMSE is meant for all categories of patients. It was originally used only in patients with psychiatric
pathologies, but later also more and more used in the general older population or in cancer patients.
Description
The MMSE consists of a series of questions and tests addressing different topics:
- Orientation in time
- Orientation in space
- Registration
- Calculation and attention
- Memory
- Language
- Constructive ability
The test is not meant for measuring changes in mood, mental disturbance, or reasoning. The items of the
questionnaire are addressed one by one, and a score for each item is immediately given. In order to have the
Page 55
patient collaboration, the patient should be comfortable and should be encouraged. It is important not to influence
the replies and avoid to put pressure on items where the patient encouters difficulties.
The MMSE consists of 2 parts. The first part requires oral replies and the maximum score is 21. The second item
requires reading and writing. Patients with visual problems could encounter difficulties with this part. The
maximum score for the second part is 9. The maximum score of part 1 and 2 together, is 30. A score below 24
indicates a cognitive problem (5 % false-negatives).
Methodology
- Interview
Scoring
- Total score = 30
- Range total score = 0 – 30
- Cut-offs:
o ≤ 23
o ≤ 17
Interpretation
- 24 – 30 = normal cognitive status
- 18 – 23 = mild cognitive decline
- 0 – 17 = severe cognitive decline
Instructions
• Basic information
o The timelimits noted by each question are guidelines. They are not compelling.
o The scoring rules are compelling.
• Specific information
a. Orientation in time and place
Question Timelimit Scoring
- What year is this? 10 sec • Accept exact answer only
- What season is this? 10 sec • Accept either: last week of the old season or first
week of a new season
- What month is this? 10 sec • Accept either: the first day of a new month or the
last day of the previous month
- What is today’s date? 10 sec • Accept previous or next date
- What day of the week is this? 10 sec • Accept exact answer only
- What country are we in? 10 sec • Accept exact answer only
- What province are we in? 10 sec • Accept exact answer only
- What city/town are we in? 10 sec • Accept exact answer only
- What is the name of this building? 10 sec • Accept exact name of institution only
- What floor of the building are we
on?
10 sec • Accept exact answer only
Page 56
b. Registration
Question Timelimit Scoring
• Repeating and remembering the
names of three unrelated objects
20 sec • Score one point for each correct reply on the first
attempt.
• If the person did not repeat all three, repeat until
they are learned or up to a maximum of five times
(but only score first attempt).
c. Calculation and attention
Question Timelimit Scoring
• Serial sevens 30 sec • Score the total number of times that 7 is
substracted correctly.
• Examples:
93, 86, 79, 72, 65 = 5 points (all good)
93, 88, 81, 74, 67 = 4 points (4 good, 1 false)
92, 85, 78, 71, 64 = 4 points (4 good, 1 false)
93, 87, 80, 73, 64 = 3 points (3 good, 2 false)
92, 85, 78, 71, 63 = 3 points (3 good, 2 false)
93, 87, 80, 75, 67 = 2 points (2 good, 3 false)
93, 87, 81, 75, 69 = 1 point (1 good, 4 false)
• Spell the word “WORLD” 30 sec • The score is the number of letters in correct order,
e.g. dlrow = 5; dlorw =3.
When the patient cannot or will not perform the task with serial sevens or didn’t perform it completely correct, ask
him/her to perform the spelling exercise. Compare both scores to each other and the highest score will count for
the total result of the MMSE.
d. Memory / Recall
Question Timelimit Scoring
• Repetition of the three objects that
were previously asked to the
patient to remember
10 sec • Score one point for each correct answer regardless
of order.
e. Language and constructive ability
Question Timelimit Scoring
• Naming:
o “watch”
o “pencil”
10 sec
• Score one point for correct response
• Repetition of phrase
10 sec
• Score one point for a correct repetition.
• Must be completely exact.
• 3-stage command
30 sec
• Score one point for each instruction executed
correctly.
• Reading
10 sec • Score one point only if the subject closes eyes.
• The subject does not have to read aloud.
Page 57
• Writing
30 sec
• Score one point for writing a sentence.
• The sentence must make sense and has to contain
a subject and a verb.
• Ignore spelling errors.
• Copying
1 min
maximum
• Score one point for a correctly copied diagram.
• The person must have drawn a four-sided figure
between two five-sided figures.
• Tremor and rotation are ignored.
Remarks
1. Reliability
- The internal consistenty is sufficient and expressed as a Cronbach’s alpha between 0,54-0,96.
- The reliability of the MMSE is shown by repeating the test after 24h and 28 days.
- The Test-Retest (Stability) is excellent. If the MMSE is taken twice in the same person with 24h
interval, the correlation coefficient between the 2 measurements is 0,887. There is no significant
difference after 28 days.
- The interobserver reliability is excellent, the correlation coefficient is 0,827.
- These results resemble the scores with multiple investigators (Equivalence).
2. Validation
- The MMSE is a valid test for measuring cognitive function. The obtained scores are comparable
with the Weschler Adult Intelligence Scale (WAIS). The Pearson correlation-coefficients (Concurrent
Validity) between the MMSE and the WAIS are 0,776 (p<0,001) for the first part and 0,660 (p<0,001)
for the second part.
- The MMSE is used for the estimation of severe cognitive deficits, but also for changes in cognitive
function. The obtained values of the MMSE correspond with the clinical opinion on presence of
cognitive deficits (Convergent Validity).
- The obtained means in patients below or above age 60 years, are not different in patients within the
same disease category.
- The validity of the MMSE decreases slightly if the patient has low level education or low literacy, or if
the patient has aphasia, hearing problems or visual problems. The language barrier can also
decrease the validity of the instrument.
- The MMSE has become one of the most frequently used neurophychological tests. It is easy to use
and has an excellent validity but low diagnostic value.
- The MMSE has become a ‘gold standard’ and is very popular, but compared to other evaluation
instruments, it does not have superior psychometric capacities.
- The MMSE can have low sensitivity in some types of cognitive dysfunction, which can induce ‘false
negatives’.
3. User friendliness
- It takes +/- 10 minutes to complete the questionnaire.
4. General remarks
- The MMSE is frequently used as a reference for the validation of other evaluation instruments.
- There are several derived versions of the MMSE:
o Short version: the MMSE-12 (a version with 12 items, maximum score 12), the MMSE-ALFI
(version with 14 items, maximum score 22).
o Longer version: the Modified Mini Mental Test (3MS)
Page 58
References
1. Daem, M., Piron, C., Lardennois, M., Gobert, M., Folens, B., Vanderwee, K., Grypdonck, M., & Defloor T.
(2007). Opzetten van een databank met gevalideerde meetinstrumenten: BEST-project. Brussel, Federale
Overheidsdienst Volksgezondheid, Veiligheid van de voedselketen en Leefmilieu.
http://www.best.ugent.be
2. Fayers, P. M., Hjermstad, M. J., Ranhoff, A. H., Kaasa, S., Skogstad, L., Klepstad, P., and Loge, J. H. 2005.
"Which Mini-Mental State Exam Items Can Be Used to Screen for Delirium and Cognitive Impairment?"
J.Pain Symptom.Manage. 30(1):41- 50.
3. Folstein, M. F., Folstein, S. E., and McHugh, P. R. 1975. ""Mini-Mental State". A Practical Method for
Grading the Cognitive State of Patients for the Clinician." J.Psychiatr.Res. 12(3):189-98.
4. Smith, M. J., Breitbart, W. S., and Platt, M. M. 1995. "A Critique of Instruments and Methods to Detect,
Diagnose, and Rate Delirium." J.Pain Symptom.Manage. 10(1):35-77.
5. Song, J. A., Algase, D. L., Beattie, E. R., Milke, D. L., Duffield, C., and Cowan, B. 2003. "Comparison of
U.S., Canadian, and Australian Participants' Performance on the Algase Wandering Scale-Version 2 (AWS-
V2)." Res.Theory.Nurs.Pract. 17(3):241-56.
Page 59
Example
Maximum
score
Score
ORIENTATION
- What year is this? 1
- What season is this? 1
- What month is this? 1
- What is today’s date? 1
- What day of the week is this? 1
- What country are we in? 1
- What province are we in? 1
- What city/town are we in? 1
- What is the name of this building? 1
- What floor of the building are we on? 1
REGISTRATION
Ask the patient if you may test his memory. Name 3 objects: house, bread,
cat (1 second to say each). Then ask the patient all 3 after you named
them. Give 1 point for each correct answer. Then repeat them until he
learns all 3.
(house / bread / cat)
3
Count trials
and record:
CALCULATION AND ATTENTION
Ask the patient to begin with 100 and count backwards by 7. Stop after 5
subtraction. Score the total number of correct answers.
(93 86 79 72 65) … … … … …
5
If the patient cannot or will not perform this task, ask him to spell the word
“W O R L D” backwards. The score is the number of the letters in correct
order.
D L R O W
… … … … …
5
MEMORY
Ask for the three objects repeated above. Give 1 point for each one.
3
Page 60
(house, bread, cat)
LANGUAGE
- Name a watch. 1
- Name a pencil. 1
- Repeat the following “No ifs, ands or buts”. 1
- Follow a three stage command: “take a paper in your right hand (1), fold it
in half (2), and put it on the floor”.
3
- Read and obey the following: “Close your eyes” 1
- Write a sentence. 1
CONSTRUCTIVE ABILITY
- Copy the following drawing. 1
Total score (0 – 30)
………………
Page 61
Close your eyes
Page 62
WRITE A SENTENCE
COPY THIS FIGURE
Page 63
3.7 Clock Drawing Test
Instrument Clock Drawing Test
Abbreviation CDT
Author - Sunderland et al. (1989)
- Wolf-Klein et al. (1989)
- Watson et al. (1993)
- Manos & Wu (1994)
- Freund et al. (2005)
Subject Cognitive evaluation
Goal Evaluation of cognitive decline, memory and constructive capacity
Population - Older persons
- Persons with dementia
- Persons with cognitive disorders
Taken by Health care worker
Number of items Depending on the method used
Participation of the patient Yes
Reference Original:
Sunderland, T., Hill, J. L., Mellow, A. M., Lawlor, B. A., Gundersheimer, J.,
Newhouse, P. A., and Grafman, J. H. 1989. "Clock Drawing in Alzheimer's
Disease. A Novel Measure of Dementia Severity." J.Am.Geriatr.Soc.
37(8):725-29.
Instrument can be found at: - /
Permission required No
Translations - Not applicable
Goal
The CDT is used for the investigation of cognitive decline, disorders in orientation in time and neglect. Originally
it was used for the assessment of visual constructive capacities but was later generalized for all cognitive
impairments.
Target population
Older persons, persons with dementia and persons with cognitve disorders are the target population for the CDT.
The test can be performed by persons of different cultures and nationalities (Philpot, 2004). Some authors
indicate the correlation between the score and the age / level of education of the patient (Seigerschmidt et al.,
2002).
Description
The CDT can be performed in different ways and the way of scoring has to be adapted to the version that is used.
Some versions show the patient a circle on a paper. The circle is standing for a clock. The patient receives
verbal instructions for the performance of the test. The instructions are also different depending on the version
Page 64
that is used. The instructions can be repeated if necessary. In other versions the patient has to drawn the circle
himself and then complete according to the instructions of the investigator.
The performance of the test requires verbal insight, memory, visuo-spatial abilities and constructive qualifications
of the patient. Level of education, age and mood can influence the test results (Agrell & Dehlin, 1998).
Method
- Performance by patient
Scoring
- See ‘Variants’
Interpretation
- See ‘Variants’
Instructions
- See ‘Variants’
Variants
1. Clock Drawing Test by Freund (Freund et al.2005)
- Instructions:
The patient receives a drawn circle which is standing for a clock. The requested hour is 11.10.
11.10 is acknowledged as the hour with the best sensitivity for detecting neurocognitive
impairments.
- Scoring:
o Total score = 7
o Range total score = 0 to 7
o The scoring system of this version is based on 7 points:
� Indicating the hour (3 points)
• One of the hands of the clock is pointing number 2.
• The two hands of the clock are standing completely correct.
• There is no intrusion (writing, wrong hands of the clock, one of the
hands is pointing number 10, the hour is written in text,…)
� Numbers (2 points)
• The numbers are outside the circle.
• All numbers are present (1 – 12). None of numbers is standing double
and none of the numbers is forgotten.
� Interspace (2 points)
• The numbers have the same or almost equal interspaces.
• The numbers have the same or almost equal interspaces in comparison
with the circle edge.
2. Clock Drawing Test by Manos (Manos & Wu, 1994)
- Instructions:
Page 65
The patient receives a drawn circle.
- Scoring:
o Total score = 10
o Range total score = 0 – 10
o One point is given for the correct position of the numbers 1, 2, 4, 5, 7, 8, 10 en 11 and for
the position of the hands of the clock.
- Interpretation:
A high score is standing for a good performance.
3. Clock Drawing Test by Sunderland (Sunderland et al.,1989)
- Instructions:
The test is running in 3 steps:
o Step 1. Ask the patient to draw a circle on a piece of paper. This first part is standing on 2
points depending on the completeness of the circle.
o Step 2. The following task to perform is putting the numbers of the clock into the circle.
This part is standing on 4 points, depending on the presence and composition of all
numbers.
o Step 3. The patient receives a third instruction: ‘put the hands of the clock on the hour
11.10’. this part is also standing on 4 points.
All instructions may be repeated if the patients doesn’t understand the request. There is no timeline
for the performance of the test.
- Scoring:
o Total score = 10
o Range score = 0 - 10
o The first 5 points are given for the drawing of the circle and the correctly filled in numbers.
The following 5 points are given for the proper positioning of the hands of the clock.
- Interpretation:
o A high score is standing for a good performance.
o A cut-off point of 6 is considered as standard (Shulman, 2000).
4. Clock Drawing Test by Watson (Watson, Arfken, and Birge,1993)
- Instructions:
The patient receives a circle to perform the test. The patient has to put the numbers into the circle
but doesn’t have to place the hands of the clock.
- Scoring:
o Total score = 7
o Range total score = 0 - 7
o Divide the circle in 4 equal quadrants by drawing a line through the center of the circle and
the number 12 and a second line through the center of the circle and the number 3.
o Count the amount of numbers in each quadrant of the circle clockwise, starting with the
number corresponding number 12. Each number is just counted once. If a number is
falling on the reference lines, it is counted with the quadrant that is following clockwise. A
total of three number in each quadrant is considered correct.
Page 66
o For faults in the amount of numbers in the first, second or third quadrant of the circle, is
counted 1 point (the amount of faults is not important). The faults in the amount of
numbers in the fourth quadrant is counting for 4 points.
- Interpretation:
o Normal score is ranging from 0 to 3.
o In persons with dementia the score is ranging from 4 to 7.
o In this version a high score is standing for a severe cognitive impairment.
5. Clock Drawing Test by Pfizer Inc. and Eisai Inc.
- Instructions:
The patient has to draw a circle which is standing for a clock. Afterwards he has to place the hands
of the clock on 10.10.
- Scoring:
o Total score = 4
o Range total score = 0 - 4
o Scoring rules:
� 1 point: drawing a closed circle
� 1 point: putting the numbers on the right place
� 1 point: completing the proper 12 numbers
� 1 point: placing the hands of the clock in the right position
- Interpretation:
A high score is standing for a good performance.
6. Clock Drawing Test by Wolf-Klein (Wolf-Klein et al., 1989)
- Instructions:
The patient receives a drawn circle and has to put the numbers to complete.
- Interpretation:
The cut-off score is 7. A score ≥ 7 means a good performance. A score < 7 means presence of a
cognitive impairment (Shulman, 2000).
Remarks
1. Reliability
- The reported correlation coefficients for repeated measures (test retest) in patients with Alzheimer
dementia was between 0,70 and 0,78 (Stability) without adaptation for cognitive capacities of the
patient. Manos et Wu describe a correlation coefficient for ‘test-retest’ at 2 days (r = 0,87 tot 0,94);
for a ‘test-retest’ at 4 days, Tuokko reports results of r=0,70; Mendez et al report a result of 0,78 at 3
months.
- The clock drawing test shows a good correlation between the different items with a coëfficiënt r=
0,91 – 0,97 (Powlishta et al.2002).
- South and coworkers determined inter – class coëfficiënts (ICC) vfor 3 versions of the clock test and
obtained very good coefficients(Shulman 2000): Libon Revises system ICC: r = 0,59 – 0,90;
Rouleau & al. ICC: r= 0,70-0,93; Freedman & al. ICC: r= 0,52-0,91.
- If the test is taken by different observers (Equivalence), Sunderland et al. Found an excellent result
with a Spearman coëfficiënt between 0,86 and 0,97; Mendez et al: 0,94.; Tuokko: from 0,94 to 0,97.
Page 67
- Seigerschmidt et al. Studied the ‘inter rater reliability’ in 4 versions of the clock test an obtained high
correlation coefficients: Manos & Wu: r= 0,95; Watson & al.: r=0,90; Wolf-Klein & al.: r = 0,82;
Shulman & al. r= 0,85 (Seigerschmidt et al.2002)
- Sunderland et al found no difference between clinical and non-clinical observers (with respective
Spearman coëfficiënt of 0,84 and 0,86).
2. Validation
- The clock test is a good test for the determination of cognitive capacities. It shows an acceptable
correlation coefficient with the MMSE (r= 0,32 to r= 0,69) and with other tests that evaluate cognitive
dysfunction (Concurrent Validity).
- The test has good diagnostic validity. The sensitivity in the version of Sunderland is 78% and the
specificity 96 % (Sunderland et al.1989).
- According to the scoring system of Watson, a score of 4 or more has a sensitivity of 87 % and a
specificity of 82 % (Watson, Arfken, and Birge1993). For the detection of Alzheimer disease, a
sensitivity of 86,7 % and specificity of 92,7 % were reached (Wolf-Klein et al.1989).
- Powloski showed a negative association between dementia and the score of the clock test, with a
Spearman correlation coefficient between -0,69 and -0,74. (Powlishta et al.2002). (Divergent
validity)
- Nishiwaki et al. showed that if the test is done by a nurse, and with a cutoff of 1 or lower, the
sensitivity and specificity are 46,3 % and 96,2 %, which is a lower sensitivity than the MMSE
(sensitivity 76 %; specificity 87,1 %).
- With a cutoff of 3 or lower, the sensitivity and specificity are 92,7 % and 68,1 %, which means a
lower specificity and more ‘false positives’. (Nishiwaki et al.2004)
- The different versions of the ‘Clock drawing test’ show similar psychometric properties.(Powlishta et
al.2002)
- The interrater reliability (Equivalence) is high (0,97) and does not depend on clinical and non-clincal
health care workers (Freund et al.2005).
3. User friendliness
- Regardless the version that is used, the CDT takes less than 5 minutes to complete. The CDT is
easy in use and there is no training necessary for the investigator (Powlishta et al., 2002).
- As an evaluation instrument for the detection of cognitive impairments the CDT is considered as a
quick, easy and reliable instrument (Nishiwaki et al.2004).
4. General remarks
- /
References
1. Agrell B. and Dehlin O. 1998. "The Clock-Drawing Test." Age and Ageing 27399-403.
2. Daem, M., Piron, C., Lardennois, M., Gobert, M., Folens, B., Vanderwee, K., Grypdonck, M., & Defloor T.
(2007). Opzetten van een databank met gevalideerde meetinstrumenten: BEST-project. Brussel, Federale
Overheidsdienst Volksgezondheid, Veiligheid van de voedselketen en Leefmilieu.
http://www.best.ugent.be
Page 68
3. Freund, B., Gravenstein, S., Ferris, R., Burke, B. L., and Shaheen, E. 2005. "Drawing Clocks and Driving
Cars." J Gen.Intern.Med. 20(3):240-244.
4. Manos, P. J. and Wu, R. 1994. "The Ten Point Clock Test: a Quick Screen and Grading Method for Cognitive
Impairment in Medical and Surgical Patients." Int.J.Psychiatry Med. 24(3):229-44.
5. Nishiwaki, Y., Breeze, E., Smeeth, L., Bulpitt, C. J., Peters, R., and Fletcher, A. E. 15-10-2004. "Validity of
the Clock-Drawing Test As a Screening Tool for Cognitive Impairment in the Elderly." Am J Epidemiol.
160(8):797-807.
6. Philpot, M. 2004. "The Clock-Drawing Test: a Critique." Int.Psychogeriatr. 16(3):251-56.
7. Powlishta, K. K., Von Dras, D. D., Stanford, A., Carr, D. B., Tsering, C., Miller, J. P., and Morris, J. C. 24-9-
2002. "The Clock Drawing Test Is a Poor Screen for Very Mild Dementia." Neurology 59(6):898-903.
8. Seigerschmidt, E., Mosch, E., Siemen, M., Forstl, H., and Bickel, H. 2002. "The Clock Drawing Test and
Questionable Dementia: Reliability and Validity." Int.J.Geriatr.Psychiatry 17(11):1048-54.
9. Shulman, K. I. 2000. "Clock-Drawing: Is It the Ideal Cognitive Screening Test?" Int.J.Geriatr.Psychiatry
15(6):548-61.
10. Sunderland, T., Hill, J. L., Mellow, A. M., Lawlor, B. A., Gundersheimer, J., Newhouse, P. A., and Grafman, J.
H. 1989. "Clock Drawing in Alzheimer's Disease. A Novel Measure of Dementia Severity." J.Am.Geriatr.Soc.
37(8):725-29.
11. Tuokko, H., Hadjistavropoulos, T., Miller, J. A., and Beattie, B. L. 1992. "The Clock Test: a Sensitive Measure
to Differentiate Normal Elderly From Those With Alzheimer Disease." J.Am.Geriatr.Soc. 40(6):579-84.
12. Watson, Y. I., Arfken, C. L., and Birge, S. J. 1993. "Clock Completion: an Objective Screening Test for
Dementia." J.Am.Geriatr.Soc. 41(11):1235-40.
13. Wolf-Klein, G. P., Silverstone, F. A., Levy, A. P., and Brod, M. S. 1989. "Screening for Alzheimer's Disease
by Clock Drawing." J.Am.Geriatr.Soc. 37(8):730-734.
Page 69
3.8 Geriatric Depression Scale
Instrument Geriatric Depression Scale
Abbreviation GDS
Author Yesavage et al
Subject Psycho-social evaluation
Goal Evaluation of depression
Population General population
Taken by Health care worker
Number of items - Different version available: 4 – 10 – 15 – 30
- Most commonly used: GDS-15
Participation of the patient
Yes
Some versions are to be filled in by the patient independently.
Reference Yesavage, J. A., Brink, T. L., Rose, T. L., Lum, O., Huang, V., Adey, M., and
Leirer, V. O. (1982). "Development and Validation of a Geriatric Depression
Screening Scale: a Preliminary Report." J.Psychiatr.Res. 17(1):37-49.
Instrument can be found at: www.stanford.edu/~yesavage
Permission required No
Translations - Arab
- Chinese
- Creole
- Danish
- Dutch
- Farsi
- French
- German
- Greek
- Hebrew
- Hindi
- Hungarian
- Icelandic
- Italian
- Japanese
- Korean
- Lithuania
- Malay
- Maltse
- Norwegian
- Portuguese
- Rumanian
- Russian
- Ukraine.
- Serbian
- Spanish
- Swedish
- Thai
- Turkish
- Vietnamese
- Yiddish
Goal
The GDS has been developed to detect whether a person is (possibly) depressive.
Target population
The GDS can be used in healthy populations and in patient groups with illnesses, and even in populations with
mild to severe cognitive deficits.
Description
The original version consists of 30 questions. A score from 0 to 9 is considered normal, 10-19 indicates presence
of a moderate depression, 20-30 indicates severe depression. Since fatigue or lack of concentration can
sometimes make it difficult for older individuals to reply 30 questions, the authors propose a shorter version with
Page 70
15 items. This 15 item scale is the most commonly used version, and details on scoring and interpretation are
below.
Methodology
- Self report
- Interview
Scoring (GDS-15)
- Total score = 15
- Range total score = : 0 – 15
- Cut-off: ≥ 5
Interpretation (GDS-15)
- Score 0 – 4 = not at risk for depression
- Score 5 – 15 = at risk for depression
Instructions
- On each question, ‘yes’ or ‘no’ needs to be answered, according to the mood of the patients.
- Calculation of the score:
YES NO
1. Are you basically satisfied with your life? 0 1
2. Have you dropped many of your activities and interests? 1 0
3. Do you feel that your life is empty? 1 0
4. Do you often get bored? 1 0
5. Are you in good spirits most of the time? 0 1
6. Are you afraid that something bad is going to happen to you? 1 0
7. Do you feel happy most of the time? 0 1
8. Do you often feel helpless? 1 0
9. Do you prefer to stay at home, rather than going out and doing new things? 1 0
10. Do you feel you have more problems with memory than most? 1 0
11. Do you think it is wonderful to be alive? 0 1
12. Do you feel pretty worthless the way you are now? 1 0
13. Do you feel full of energy? 0 1
14. Do you feel your situation is hopeless? 1 0
15. Do you think that most people are better off than you are? 1 0
Remarks
1. Reliability
- The reliability of the GDS-15 is shown by a good internal consistency expressed by Chronbach
alpha of 0.8.
2. Validation
- The diagnostic validity of the GDS-15 is moderate: sensitivy is 67% and specificity 73%.
- The validity of the test is shown by looking at the correlation between GDS-15 and other evaluation
instruments of depression.
Page 71
- The results are excellent with correlation coefficients of 0.88 with the Zung Rating Scale and 0,77
with the Hamilton Rating Scale. On the other hand, the correlation between GDS and the Cornell
Scale is moderate (r= 0,37).
3. User friendliness
- The GDS-15 can be taken in 5 to 7 minutes.
- When patients are asked about their experience after having done a GDS evaluation, 87.6% find
this test acceptable, 3.6% experienced it as difficult or stressing.
4. Variants
- Other shorter versions have been proposed by other authors (GDS-10; GDS-5; GDS-4; GDS-1).
- The correlation between the different variants of the test is very good.
5. General remarks
- At the initial development of the test, there were 100 items.
- For the original version, the 30 questions with the best correlations with the total score were
selected to make the final GDS.
- The GDS has been translated into many languages.
References
6. Agrell, B. and Dehlin, O. 1989. "Comparison of Six Depression Rating Scales in Geriatric Stroke Patients."
Stroke 20(9):1190-1194.
7. D'Ath, P., Katona, P., Mullan, E., Evans, S., and Katona, C. 1994. "Screening, Detection and Management
of Depression in Elderly Primary Care Attenders. I: The Acceptability and Performance of the 15 Item
Geriatric Depression Scale (GDS15) and the Development of Short Versions." Fam.Pract. 11(3):260-266.
8. Daem, M., Piron, C., Lardennois, M., Gobert, M., Folens, B., Vanderwee, K., Grypdonck, M., & Defloor T.
(2007). Opzetten van een databank met gevalideerde meetinstrumenten: BEST-project. Brussel, Federale
Overheidsdienst Volksgezondheid, Veiligheid van de voedselketen en Leefmilieu.
http://www.best.ugent.be
9. Hammond, M. F. 2004. "Doctors' and Nurses' Observations on the Geriatric Depression Rating Scale." Age
Ageing 33(2):189-92.
10. Meara, J., Mitchelmore, E., and Hobson, P. 1999. "Use of the GDS-15 Geriatric Depression Scale As a
Screening Instrument for Depressive Symptomatology in Patients With Parkinson's Disease and Their
Carers in the Community." Age Ageing 28(1):35-38.
11. Salamero, M. and Marcos, T. 1992. "Factor Study of the Geriatric Depression Scale." Acta Psychiatr.Scand.
86(4):283-86. [abstract]
12. Van Marwijk, H. W., Wallace, P., de Bock, G. H., Hermans, J., Kaptein, A. A., and Mulder, J. D. 1995.
"Evaluation of the Feasibility, Reliability and Diagnostic Value of Shortened Versions of the Geriatric
Depression Scale." Br.J.Gen.Pract. 45(393):195- 99.
Page 72
13. Wancata, J., Alexandrowicz, R., Marquart, B., Weiss, M., and Friedrich, F. 2006. "The Criterion Validity of
the Geriatric Depression Scale: a Systematic Review." Acta Psychiatr.Scand. 114(6):398-410.
14. Yesavage, J. A., Brink, T. L., Rose, T. L., Lum, O., Huang, V., Adey, M., and Leirer, V. O. 1982.
"Development and Validation of a Geriatric Depression Screening Scale: a Preliminary Report."
J.Psychiatr.Res. 17(1):37-49.
Page 73
Example
GDS-15
YES NO
1. Are you basically satisfied with your life?
2. Have you dropped many of your activities and interests?
3. Do you feel that your life is empty?
4. Do you often get bored?
5. Are you in good spirits most of the time?
6. Are you afraid that something bad is going to happen to you?
7. Do you feel happy most of the time?
8. Do you often feel helpless?
9. Do you prefer to stay at home, rather than going out and doing new things?
10. Do you feel you have more problems with memory than most?
11. Do you think it is wonderful to be alive now?
12. Do you feel pretty worthless the way you are now?
13. Do you feel full of energy?
14. Do you feel that your situation is hopeless?
15. Do you think that most people are better off than you are?
Total score
…………….
Page 74
3.9 Mini Nutritional Assessment
The MNA® is a validated nutrition screening and assessment tool that can identify geriatric patients age 65 and
above who are malnourished or at risk of malnutrition. Recent research has resulted in the launch of a new,
revised MNA®-Short Form. First the original MNA is presented, followed by the revised MNA® – Short Form.
3.9.1 Mini Nutritional Assessment (MNA)
Instrument Mini Nutritional Assessment
Abbreviation MNA®
Author Guigoz et al.
Subject Malnutrition
Goals Detection of malnutrition
Population Older persons
Taken by Health care worker
Number of items 18
Participation of the patient Yes
Reference Guigoz Y., Vellas B. & Garry P.J. (1994) Mini Nutritional Assessment: a
practical assessment tool for grading the nutritional state of elderly patients.
Nutrition, Facts and research in gerontology, supplement no.2.
Evaluation instrument can be
found at:
http://www.mna-elderly.com/mna_forms.html
Permission required Yes
Explanation: The MNA® form is protected by copyright laws and MNA is also a
registered trademark of Société des Produits Nestlé S.A. By downloading the MNA®
form you agree to keep the original form downloaded unchanged. This means that you
are not entitled to modify at all the external appearance of the form nor the order of the
questions. In addition, all references and logos may not be altered in any way nor
removed.
Translations - English
- Arabic
- Chinese
- Chinese simplified
- Czech
- Danish
- Dutch
- Farsi
- Finnish
- French
- German
- Greek
- Hungarian
- Italian
- Japanese
- Latvian
- Norwegian
- Portuguese
- Sinhala
- Slovenian
- Spanish
- Swedish
- Turkish
- Thai
Goal
Page 75
The goal of the MNA® is to evaluate the risk of malnutrition and to identify persons who can have benefit from
early intervention.
Target population
The MNA® has been developed for older persons and for different settings:
- home care (for older individuals who live independently, for the general practitioner)
- psychogeriatric setting (for instance patients with Alzheimer disease)
- hospitals and other institutions (long term stay institutions)
Description
The MNA® consists of 18 questions divided in 4 topics:
- Antropometric parameters: weight, length, Body Mass Index (BMI), calf and upper arm
circumference, and weight loss
- General judgement in relation to life style, medication, physicial and mental status.
- Nutritional evaluation: number of meals per day, eating problems
- Subjective evaluation: a question about self perception and a question about health status
Method
- Interview
Scoring
- Total score = 30
- Range total score = 0 – 30
- Cut-offs:
o < 24
o < 17
Interpretation
- 24-30: no risk / normal nutritional status
- 17-23.5: risk of malnutrition
- < 17: malnutrition / bad nutritional status
Instructions
- Complete the MNA-SF en count the screening score.
o Score 12-14 = normal nutritional status
o Score ≤ 11 = risk of malnutrition
- If the score is 11 or less, proceed with the completion of the full MNA.
- Count total score (sum of MNA-SF and full assessment).
Remarks
1. Reliability
- The internal consistency of the MNA® was high (α= 0.68 - 0.865). This is also the case for the m-
MNA® (α= 0.60) (3;11) and the MNA®-SF (α =0.843).
- The values expressing equivalence are different. Under the name of interrater reliability very low to
high kappa values were noted for the MNA® (к=0.04 to 0.80). In a study from Baath et al. (2008), a
Page 76
good interrater reliability was reported for the MNA®-SF (κ= 0.531-1.000) compared to the total
MNA®-SF score.
- Finally, also the stability of the MNA® was high with a kappa value of 0.78.
- The intraclass correlation coefficient (ICC) is 0.89 for the total MNA®-score.
2. Validation
- The validation of the MNA® was initially done in 600 older persons. Concurrent validity was
demonstrated.
- A high sensitivity, an important factor for screening instruments like this one for malnutrition, was
found (mostly between 72 and 100%, but some studies showed values only between 27 en 57%).
- Altering the cut-off can change the sensitivity and specificity. The specificity is between 60 and
100%. Some studies indicated a specificity of lower than 47% (changing of the cut-off and inclusion
of different populations were mentioned as causes for the lower specificity). Studies have shown
good correlations between serum albumine and MNA® (r= 0.699 en 0.811). Low specificity ratios
indicate that too many patients are falsely classified as undernourished.
- Values of positive predictive value were variable, between 16.3 % to 77%. Also the negative
predictive value varies (47% to 98%).
- The mortality rate was significantly higher for residents who were malnourished (predictive validity).
Discriminant validity was shown compared to the cognitive score (r= -0.31). A principal component
analysis has been done, allowing to show construct validity.
3. User friendliness
- The completion of the MNA® takes 10 to 15 minutes.
- Murphy et al. (2000) indicated 30 minutes to complete the MNA®. (mainly to obtain the
anthropometric data).
4. Variants: modified-MNA (m-MNA)
The m-MNA® is suitable for older individuals with cognitive dysfunction and other specific disease
settings. This variants consists of 7 items (weight loss, mobility, BMI, number of full meals, amount of
fluid intake, modality of feeding, health status). This version has specific cut-off scores: 12,5 to 15
indicates a good nutritional status, a score between 9 and 12 indicates a risk on malnutrition and a score
below 9 indicates malnutrition.
5. General remarks
- The MNA® was not shown to be a reliable instrument for patients who are not capable of adequate
self judgment (confused patients, advanced dementia, aphasia or apraxia after CVA, or patients with
severe or acute illnesses like pneumonia).
- An adapted form of the MNA®, the m-MNA® can be a solution for such patients, since it can be used
for patients with cognitive dysfunction or other specific disease settings.
Page 77
3.9.2 Mini Nutritional Assessment – Short Form (MNA-SF)
Instrument Mini Nutritional Assessment – Short Form
Abbreviation MNA-SF®
Author Guigoz P.J., Vellas B.J. & Garry, P.J.
Subject malnutrition
Goals Detection of malnutrition
Population Older persons
Taken by Health care worker
Number of items 6
Participation of the patient Yes
Reference Guigoz Y., Vellas B. & Garry P.J. (1994) Mini Nutritional Assessment: a
practical assessment tool for grading the nutritional state of elderly patients.
Nutrition, Facts and research in gerontology, supplement no.2.
Evaluation instrument can be
found at:
http://www.mna-elderly.com/mna_forms.html
Permission required Yes
Explanation: The MNA® form is protected by copyright laws and MNA is also a
registered trademark of Société des Produits Nestlé S.A. By downloading the MNA®
form you agree to keep the original form downloaded unchanged. This means that you
are not entitled to modify at all the external appearance of the form nor the order of the
questions. In addition, all references and logos may not be altered in any way nor
removed.
Translations - English
- Arabic
- Chinese
- Chinese simplified
- Czech
- Danish
- Dutch
- Farsi
- Finnish
- French
- German
- Greek
- Hungarian
- Italian
- Japanese
- Latvian
- Norwegian
- Portuguese
- Sinhala
- Slovenian
- Spanish
- Swedish
- Turkish
- Thai
Goal
The MNA-SF® is to evaluate the risk or presence of malnutrition and to identify persons who can have benefit
from early intervention.
Target population
The MNA® has been developed for older persons and for different settings:
o home care (for older individuals who live independently, for the general practitioner)
o psychogeriatric setting (for instance patients with Alzheimer disease)
o hospitals and other institutions (long term stay institutions)
Page 78
Description
The MNA®-SF is a shortened form of the MNA® that provides an easy way to screen elderly patients for
malnutrition. The shortened MNA-SF® comprises six questions that were found to strongly correlate with the
total MNA® and clinical judgment of nutritional status. This MNA® Short Form is now validated as a stand-alone
tool. Calf circumference has been determined to be a valid alternative when BMI is not available. The MNA®
Short Form now also classifies the elderly as well-nourished, at risk, or malnourished versus completion of the
full MNA® for nutritional status classification. These changes to the MNA® Short Form facilitate its use across
care settings and make it much more user friendly.
Method
- Interview
Scoring
- Total score = 14
- Range total score = 0 – 14
Interpretation
- 12 or more: normal nutritional status
- 8 - 11: risk of malnutrition
- 0 – 7: malnourished
Instructions
- Complete the screen by filling in the boxes with the appropriate numbers.
- Total the numbers for the final screening score.
Remarks
1. Validation
- For the MNA®- SF, sensitivity was between 85.6 and 100%.
- Specificity was between 69.5% and 100%, with the exception of a study of Ranhoff et al with
specificity of 38%.
- The high sensitivity and specificity of the MNA®-SF compared with the MNA® or other nutritional
parameters indicate that the MNA®-SF is a valid screening tool for malnutrition in the older person.
2. User friendliness
- The MNA®-SF takes less than 5 minutes.
- The training time required for the use of the MNA®-SF was shown to be shorter than for the MNA®.
3. General remarks
- The MNA® is a reliable two-step screening test to assess the risk of malnutrition in the older person.
o In the first step, the MNA®-SF serves as a simple valid tool to rapidly screen patients for
risk of malnutrition.
o In the second step, the full MNA® is used to assess nutritional status and facilitate
nutritional intervention.
- The full MNA® should be used as a guide for nutritional interventions.
- It is important that the MNA® is completed at regular intervals for continuous assessment of the
patient.
Page 79
References
1 Baath, C., Hall-Lord, M., Idvall, E., Wiberg-Hedman, K., & Larsson, B. W. (2008). Interrater Reliability Using
Modified Norton Scale, Pressure Ulcer Card, Short Form-Mini Nutritional Assessment By Registered And
Enrolled Nurses In Clinical Practice. Journal Of Clinical Nursing, 17, 618-626.
2 Bauer, J. M., Vogl, T., Wicklein, S., Trogner, J., Muhlberg, W., & Sieber, C. C. (2005). Comparison Of The
Mini Nutritional Assessment, Subjective Global Assessment, And Nutritional Risk Screening (Nrs 2002) For
Nutritional Screening And Assessment In Geriatric Hospital Patients. Z.Gerontol.Geriatr., 38, 322-327.
3 Bleda, M. J., Bolibar, I., Pares, R., & Salva, A. (2002). Reliability of the mini nutritional assessment (MNA) in
institutionalized elderly people. J.Nutr.Health Aging, 6, 134-137.
4 Charlton, K. E., Kolbe-Alexander, T. L., & Nel, J. H. (2007). The Mna, But Not The Determine, Screening Tool
Is A Valid Indicator Of Nutritional Status In Elderly Africans. Nutrition, 23, 533-542.
5 Christensson, L., Unosson, M., & Ek, A. C. (2002). Evaluation Of Nutritional Assessment Techniques In
Elderly People Newly Admitted To Municipal Care. Eur.J.Clin.Nutr., 56, 810-818.
6 Cohendy, R., Rubenstein, L. Z., & Eledjam, J. J. (2001). The Mini Nutritional Assessment-short form for pre-
operative nutritional evaluation of elderly patients. Aging, 13, 293-297.
7 Daem, M., Piron, C., Lardennois, M., Gobert, M., Folens, B., Vanderwee, K., Grypdonck, M., & Defloor T.
(2007). Opzetten van een databank met gevalideerde meetinstrumenten: BEST-project. Brussel, Federale
Overheidsdienst Volksgezondheid, Veiligheid van de voedselketen en Leefmilieu.
http://www.best.ugent.be
8 De Groot, L. C. P. G. & Beck, A. M. (1998). Evaluating The Determine Your Nutrutional Health Checklist And
The Mini Nutritional Assessment.. European Journal Of Clinical Nutrition, 52, 877.
9 Ferreira, L. S., Nascimento, L. F. C., & Marucci, M. F. N. (2008). Use of the mini nutritional assessment tool
in elderly people from long-term care institutions of southeast of Brazil. The Journal of Nutrition, Health and
Aging, 12, 213-217.
10 Guigoz, Y., Vellas, B., & Garry, P. J. (1994). Mini Nutritional Assessment: a practical assessment tool for
grading the nutritional state of elderly patients. Nutrition, Facts and research in gerontology, supplement no.2.
11 Harris, D. G., Davies, C., Ward, H., & Haboubi, N. Y. (2008). An Observational Study Of Screening For
Malnutrition In Elderly People Living In Sheltered Accommodation. J.Hum.Nutr.Diet., 21, 3-9.
12 Hengstermann, S., Nieczaj, R., Steinhagen-Thiessen, E., & Schulz, R. J. (2008). Which are the most efficient
items of mini nutritional assessment in multimorbid patients? J.Nutr.Health Aging, 12, 117-122.
Page 80
13 Kaiser MJ, Bauer JM, Ramsch C et al. Validation of the mini nutritional assessment short-form (MNA-SF): a
practical tool for identification of nutritional status. J Nutr Health Aging. 2009; 13: 782-8.
14 Murphy, M. C., Brooks, C. N., & Lumbers, M. L. (2000). The Use Of The Mini-Nutritional Assessment (MNA)
Tool In Elderly Orthopaedic Patients. Eur J Clin Nutr., 54, 555-562.
15 Persson, M. D., Brismar, K. E., Katzarski, K. S., Nordenstrom, J., & Cederholm, T. E. (2002). Nutritional
Status Using Mini Nutritional Assessment And Subjective Global Assessment Predict Mortality In Geriatric
Patients. J.Am.Geriatr.Soc., 50, 1996-2002.
16 Ranhoff, A. H., Gjoen, A. U., & Mowe, M. (2005). Screening for malnutrition in elderly acute medical patients:
the usefulness of MNA-SF. J.Nutr.Health Aging, 9, 221-225.
17 Rubenstein, L. Z., Harker, J., & Guigoz, Y. V. B. (1999). Comprehensive geriatric assessment (CGA) and the
MNA: an overview of CGA, nutritional assessment, and development of a shortened version of the MNA. Mini
Nutritional Assessment (MNA): Research and Practice in the Elderly, ed B Vellas, PJ Garry & Y Guigoz,
Nestlé Workshop Series Clinical &Performance Programme.Basel Nestlé, 1, 101-116.
18 Rubenstein, L. Z., Harker, J. O., Salva, A., Guigoz, Y., & Vellas, B. (2001). Screening For Undernutrition In
Geriatric Practice: Developing The Short-Form Mini-Nutritional Assessment (Mna-Sf). J.Gerontol.A
Biol.Sci.Med.Sci., 56, M366-M372.
19 Vellas, B., Guigoz, Y., Baumgartner, M., Garry, P. J., Lauque, S., & Albarede, J. L. (2000). Relationships
Between Nutritional Markers And The Mini-Nutritional Assessment In 155 Older Persons. J.Am.Geriatr.Soc.,
48, 1300-1309.
20 Wikby, K. & Christensson, L. (2008). The Two-Step Mini Nutritional Assessment Procedure In Community
Resident Homes. Journal Of Clinical Nursing, 17, 1211-1218.
Page 81
Example: MNA
Page 82
Page 83
Example: MNA-SF
Page 84
3.10 Charlson Comorbidity Index (CCI)
Instrument Charlson Comorbidity Index
Abbreviation CCI
Author Charlson ME et al.
Subject Comorbidities
Goal Severity of comorbidities
Population General population
Taken by - Clinician
- Trained coder
Number of items 19
Participation of the patient No
References Charlson ME, Pompei P, Ales KL, Mackenzie CR: A New Method of
Classifying Prognostic Co-Morbidity in Longitudinal-Studies - Development
and Validation. Journal of Chronic Diseases 1987, 40:373-383.
Instrument can be found at: Charlson ME, Pompei P, Ales KL, Mackenzie CR: A New Method of
Classifying Prognostic Co-Morbidity in Longitudinal-Studies - Development
and Validation. Journal of Chronic Diseases 1987, 40:373-383.
Permission required No
Translations available Not available
Goal
The Charlson Comorbidity Index (CCI) assesses comorbidity level by taking into account both the number and
severity of 19 pre-defined comorbid conditions.
Target population
The CCI can be used in the general population.
Description
- The CCI provides a weighted score of a client's comorbidities which can be used to predict short- and long-
term outcomes such as function, hospital length of stay and mortality rates.
- The CCI is comprised of 19 comorbid conditions: myocardial infarct, congestive heart failure, peripheral
vascular disease, cerebrovascular disease, dementia, chronic pulmonary disease, connective tissue disease,
ulcer disease, mild liver disease, diabetes, hemiplegia, moderate or several renal disease, diabetes with end
organ damage, any tumor, leukemia, lymphoma, moderate or severe liver disease, metastatic solid tumor,
AIDS.
Page 85
- Each disease is given a different weight based on the strength of its association with 1-year mortality as
follows (2):
Assigned weights
for diseases Comorbid Conditions
1 Myocardial infarct, congestive heart failure, peripheral vascular disease, cerebrovascular
disease, dementia, chronic pulmonary disease, connective tissue disease, ulcer disease, mild
liver disease, diabetes
2 Hemiplegia, moderate or several renal diseases, diabetes with end organ damage, any tumor,
leukemia, lymphoma
3 Moderate or severe liver disease
6 Metastatic solid tumor, AIDS
Method
- medical records
- administrative databases
Scoring
- The total score in the CCI is derived by summing the assigned weights of all comorbid conditions presented
by the patient.
Interpretation
- Higher scores indicate a more severe condition and consequently, a worse prognosis (3).
Instructions
- B
asic information
o If you include a patient with metastatic colorectal carcinoma and he has in addition a metastatic
prostate cancer: this is counted as a comorbidity (= 2nd malignancy).
o The tumor type leading to inclusion in the trial is not.
- S
pecific information
Description
Myocardial infarction History of medically documented myocardial infarction
Congestive heart failure Symptomatic CHF with response to specific treatment
Peripheral vascular disease Intermittent claudication, peripheral arterial bypass for insufficiency,
gangrene, acute arterial insufficiency, untreated aneurysm (> 6 cm)
Cerebrovascular disease (except
hemiplegia)
History of TIA, or CVA with no or minor sequellae
Dementia Chronic cognitive deficit
Chronic pulmonary disease Symptomatic dyspnoea due to chronic respiratory conditions
(including asthma)
Connective tissue disease SLE, polymyositis, mixed CTD, polymyalgia rheumatica, moderate to
Page 86
severe RA
Ulcers Patients who have required treatment for PUD
Mild liver disease Cirrhosis without PHT, chronic hepatitis
Diabetes (without end-organ damage) Diabetes with medication
Diabetes (with end organ damage) Retinopathy, neuropathy, nephropathy
Hemiplegia (or paraplegia) Hemiplegia or paraplegia
Moderate or severe chronic renal
failure
Creatinine > 3 mg/dl (265 gmol/l), dialysis, transplantation, uremic
syndrome
2nd malignancy (non metastatic) Initially treated in the last 5 years.
Exclude: non-melanomatous skin cancers and in situ cervical
carcinoma.
Leukaemia CML, CLL, AML, ALL, PV
Lymphoma Non-Hodgkin's lymphoma (NHQ, Hodgkin's, Waldenstrom, multiple
myeloma)
Moderate or severe liver disease Cirrhosis with PHT + /- variceal bleeding
2nd metastatic malignancy Self-explaining
AIDS AIDS and AIDS-related complex
Suggested: as defined in latest definition
Abbrevations:
• CHF: congestive heart failure
• TIA: transient ischemic attack
• CVA: cerebro-vascular accident
• SLE: systemic lupus erythematosus
• CTD: connective tissue disease
• RA: rheumatoid arthritis
• PUD: peptic ulcer disease
• PHT: portal hypertension
• CML: chronic myeloid leukaemia
• CLL: chronic lymphoid leukaemia
• AML: acute myeloid leukaemia
• ALL: acute lymphoblastic leukaemia
• PV: polycythemia vera.
Remarks
- The CCI is the most widely used scoring system for comorbities used by researchers and clinicians.
- The CCI has a weighted age version, two adaptations to be used with ICD-9 databases, and one version to
be used with clients with amputations.
References
1. B
ravo, G., Dubois, M.F., Hebert, R., De Wals, P., & Messier, L. (2002). A perspective evaluation of the
Charlson Comorbidity Index for use in long-term care patients. JAGS, 50, 740-745.
Page 87
2. Charlson ME, Pompei P, Ales KL, Mackenzie CR: A New Method of Classifying Prognostic Co-Morbidity in
Longitudinal-Studies - Development and Validation. Journal of Chronic Diseases 1987, 40:373-383.
3. Charlson, M., Szatrowski, T.P., Peterson, J., & Gold, J. (1994). Validation of a Combined Comorbidity Index.
Journal of Clinical Epidemiology, 47(11), 1245-1251.
4. Deyo, R.A., Cherkin, D.C., & Ciol, M.A. (1992). Adapting a clinical comorbidity index for use with ICD-9-CM
administrative databases. Journal Clinical Epidemiology, 45, 613-619.
5. Elixhauser, A., Steiner, C., Harris, D.R., & Coffey, R.M. (1998). Comorbidity measures for use with
administrative data. Medical Care, 36(1), 8-27.
6. Launay-Vacher V, et al; International Society of Geriatric Oncology. Renal insufficiency in elderly cancer
patients: International Society of Geriatric Oncology clinical practice recommendations. Ann Oncol. 2007
Aug;18(8):1314-21.
7. Romano, P.S., Roos, L.L., & Jollis, J.G. (1993). Adapting a clinical comorbidity index for use with ICD-9-CM
administrative data: differing perspectives. Journal of clinical epidemiology, 46 (10) 1075-1079.
Page 88
Example
Charlson Comorbidity Index (CCI)
Co-morbidities
Present
Points
1. Myocardial infarction 1
2. Congestive cardiac
failure
1
3. Peripheral vascular disease 1
4. Cerebrovascular disease (except hemiplegia) 1
5. Dementia 1
6. Chronic obstructive pulmonary disease 1
7. Connective tissue disease 1
8. Ulcers 1
9. Mild liver disease 1
10. Diabetes Mellitus (without end-organ damage) 1
11. Diabetes Mellitus (with end-organ damage) 2
12. Hemiplegia 2
13. Moderate / Severe chronic renal failure 2
14. Second malignancy (non metastatic) 2
15. Leukaemia 2
16. Lymphoma 2
17. Moderate / Severe liver disease 3
18. Second malignancy (metastatic) 6
19. AIDS 6
Total score (0-37)
…………….
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3.11 Cumulative Illness Rating Scale for Geriatrics
Instrument Cumulative Illness Rating Scale for Geriatrics
Abbreviation CIRS-G
Author Linn et al (1968)
Subject Comorbidities
Goal Severity of comorbidities
Population General population
Taken by - Clinician
- Trained coder
Number of items 14 items
Participation of the patient No
Reference Linn BS, Linn MW & Gurel L: Cumulative illness rating scale. Journal of the
American Geriatric Society 1968; 16:622-626.
Instrument can be found at: …
Permission required …
Translations - English
- French
- Dutch
- …
Goal
Target population
Description
- The CIRS-G is developed to meet the need for a brief, comprehensive and reliable instrument for assessing
physical impairment.
- It classifies comorbidities by organ systems and grades each condition from 0 (no problem) to 4 (Extremely
Severe / immediate treatment required / end organ failure / severe impairment in function).
Method
- medical records
- administrative databases
Scoring
- See scoring manual: the scoring, interpretation, and instructions are very complex, and can be found in detail
in a specific manual (hopefully soon available online)
Interpretation
- See scoring manual
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Instructions
- See scoring manual
Remarks
/
References
1. Linn BS, Linn MW & Gurel L: Cumulative illness rating scale. Journal of the American Geriatric Society
1968; 16:622-626.
2. Miller MD, Paradis CF, Houck PR, Mazumdar S, Stack JA, Rifai AH, Mulsant B & Reynolds CF. Rating
chronic medical illness burden in geropsychiatric practice and research: application of the Cumulative
Illness Rating Scale. Psychiatry Research 1992; 41(3): 237-248.
3. Salvi F, Miller MD, Grilli A, Giorgi R, Towers AL, Morichi V, Spazzafumo L, Mancinelli L, Espinosa E,
Rappelli A, Dessì-Fulgheri P. A manual of guidelines to score the modified cumulative illness rating scale
and its validation in acute hospitalized elderly patients. J Am Geriatr Soc. 2008 Oct;56(10):1926-31.
Page 91
Example
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4 Practical issues
This chapter will describe the practical issues for starting the implemention of a screening +/- CGA by oncological
patients.
4.1 Which patients to evaluate?
In the guidelines of SIOG, the National Comprehensive Cancer Network (NCCN) and the EORTC-Task Force
Cancer in the Elderly, it has recommended that all patients 70 years or older, with diagnosis of cancer, should
undergo some form of geriatric assessment.
Besides that, it is also reasonable to perform a geriatric evaluation in patients with known cancers, but where
treatment decisions need to be taken. Here below are some situations where a geriatric evaluation can be
considered. Of course, there can be specific/acute situations where such an evaluation is not appropriate.
Which patients to evaluate?
- Patients with an oncological diagnosis (solid malignant tumor / haematological malignancy)
o New diagnosis
o Progressive after/under a certain form of therapy
� Surgery
� Chemotherapy
� Radiotherapy
� Hormonal therapy
� Targeted therapy
� …
o Relapse
- Patients 70 years or older
- Patients present in the hospital
o Ambulatory
o Hospitalized
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4.2 Methodology
- Screening:
o Depending on the screening tool that is chosen, screening is performed by self-report or
interview.
- CGA:
o In clinical practice it is recommended to perform the CGA by interview.
4.3 Organizational conditions
Individual level
- Education and training for developing expertise in performing a CGA
- Presence of care givers when performing the screening +/-CGA
o The presence of care givers (partner / children / family members / others) is accepted during
the performance of a CGA.
o Clear instructions of the health care professional are required in view of the fact that certain
evaluation instruments can be fulfilled by the older person only (eg. MMSE).
o In some situations, eg. older person with Alzheimer, the presence of a care giver is required to
receive correct information concerning the actual condition of the older person.
- Language barrier
o The screening +/- CGA can be performed best in mother language of the older person unless
the necessary knowledge of the other language is present. If this isn’t the case, an interpreter
can be required.
Institutional level
- Requirements for the performance of a CGA:
o Room where the necessary privacy can be foreseen during the interview
o Computer
- Material necessary for the performance of a CGA:
o Paper and pen
o Measuring tape
o Watch
o Pencil
o Clipmap
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- Organizational information sessions to the involved physicians and health care professionals for information
and sensibilisation
4.4 Way of reporting
When screening +/- CGA are performed, the results should be made available to the treating physician. It is
advised to make a short summary and to mention advices for intervention and follow-up.
Because the treating physician / health care worker will not always be known with the geriatric evaluation
instruments that are used, it is important to mention:
- Full name of the evaluation instrument
- Total score of each instrument + range of the score
- Scores identifying problems/deficits
- Number of scores identifying problems
- Subareas + specific subscore (eg. items of the ADL)
- Interpretation of the score
4.5 Interventions
Based on the implementation of a CGA, there are often problems detected by the older person that were not
previously known. After detection, specific interventions can be planned like involvement of other health care
workers or referral to specific services. If possible the patients situation should be discussed in a team
conference.
- Involvement other health care workers
o Social worker
o Occupational therapist
o Physical therapist
o Dietician
o Psychologist
o Geronto-psychiatrist
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o General practitioner
o …
- Referral
o Geriatric day clinic
o Fall clinic
o …
4.6 Use in clinical practice
The CGA offers the best way of working to provide an excellent view on the general condition of the older person.
The algorithm below shows how you can use the screening +/- CGA in daily practice in the treatment decision
plan of the older person (see figure 1).
Figure 1 : Algoritm for CGA
Page 96
Adaptation of Balducci, L. (2003). Geriatric oncology. Critical Reviews in Oncology / Hematology, 46, 211-220.
Page 97
5 Case presentation
General information
- Age: 80 years
- Gender: Female
- ECOG-PS or Karnofsky-PS
- Diagnosis:
o New diagnosis breast cancer 07/2010, cT3N1M0, for which she receives:
� mastectomy and axillary dissection
� Pathological analysis show a pT1cN2aM0 grade III tumor
• ER/PR negative
• HER2 negative
- Indication for CGA:
o New oncological diagnosis
o Older than 70 years
o Ambulant setting: patient is seen at the consultation unit
Results
Screening + CGA
Methodology
SCREENING
- G8 (0-17): 14/17
o < of = 14: presence of a geriatric risk profile
o > 14: absence of a geriatric risk profile
Interview
PAIN
- VAS (0-10): 3/10
o 0: no pain
o 1-10: presence of pain increasingly
Interview
DEMOGRAPHIC DATA
- Marital status: Married
- Living situation: At home with partner
- Education: Higher secondary education
- Profession: Teacher Physical Activity
Interview
FUNCTIONALITY
- ADL (0-6): 5/6
* Bathing: 1/1
* Dressing: 1/1
Interview
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* Transferring: 1/1
* Toileting: 1/1
* Continence: 0/1
* Feeding: 1/1
o 6: independent
o 0-5: dependent in x activities of daily living
FUNCTIONALITY
- IADL (0-8): 8/8
* Ability to use telephone: 1/1
* Shopping: 1/1
* Food preparation: 1/1
* Housekeeping: 1/1
* Laundry: 1/1
* Mode of transportation: 1/1
* Responsability for own medication: 1/1
* Ability to handle finances: 1/1
o 8: independent
o 0-7: dependent in x instrumental activities of daily living
Interview
FALLS
- Falls: NO
* Injuries: NO
- Minor: NO
- Major: NO
Interview
COGNITIVE STATUS
- MMSE (0-30): 30/30
* Orientation in time: 5/5
* Orientation in place: 5/5
* Registration: 3/3
* Calculation and attention: 5/5
* Memory: 3/3
* Language: 8/8
* Constructive ability: 1/1
o 24 – 30 = normal cognitive situation
o 18 – 23 = mild cognitive deterioration
o 0 – 17 = severe cognitive deterioration
Interview
DEPRESSION
- GDS (0-15): 1/15
o 0-4: no depression
o 5-15: at risk for depression
Interview
NUTRITIONAL STATUS
- MNA screening (0-14): 11/14
o 12 or more: no risk / normal nutritional status
o 11 or less: risk of malnutrition
- MNA full assessment (0-30): 25.5/30
o 24-30: no risk / normal nutritional status
Interview
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o 17-23.5: risk of malnutrition
o < 17: malnutrition / bad nutritional status
SUMMARY
- Screening: presence of a geriatric risk profile
- CGA: pain, ADL dependent (incontinence), IADL independent, no falls, normal cognitive
situation, no depression, normal nutritional status
Treatment decision for this patient
1. What would be your oncological treatment proposal in case the patient was 55 years without other
comorbidity?
o Surgery
o Radiotherapy
o Chemotherapy: FEC - Taxotere
2. Is this different from your oncological treatment proposal for this patient according to the age of the patient
without information of the geriatric assessment?
YES: Only surgery and radiotherapy
3. Is this different from your current oncological treatment proposal for this patient according to the age of the
patient with the knowledge of geriatric assessment?
YES: Surgery / Radiotherapy / Chemotherapy: Taxotere - Cyclofosfamide
WHY? Very good assessment, good life expectancy (not taking into account breast tumor), with
relevant risk of dying of breast cancer in the next few years.
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6 Prediction of toxicity with geriatric assessment
CRASH Score Calculator
This score stratifies patients in 4 risk categories of severe toxicity for older patients receiving chemotherapy. The
tool includes chemotherapy risk (0-1-2 depending on MAX-2 score), hematologic risk factors (diastolic blood
pressure, IADL, LDH) and non-hematologic risk factors (ECOG PS, MMS, MNA), and allows to predict toxicity of
a specific chemotherapy regimen. Formal clinical applications of the score still need to be studied.
The calculator is available at www.moffitt.org/saoptools
Reference for derivation and validation results: Extermann et al. Proc Am Soc Clin Oncol. Vol 28, abstr 9000,
2010.
Page 101
7 Usefull information
International websites:
www.siog.org
Belgian websites:
www.best.ugent.be
www.geriatrie.be
www.valpreventie.be
Scientifical journals:
• Journal of Geriatric Oncology
• Critical Reviews in Oncology / Hematology
• European Journal of Cancer
• Journal of Clinical Oncology
Books:
ESMO Handbook of Cancer in the Senior Patient
By D. Schrijvers, M. Aapro, B. Zakotnik, R. Audisio, H. van Halteren, A. Hurria
ISBN: 978-184184708-5
Page 102
8 References
Carreca I, Balducci L, Extermann M. Cancer in the older person. Cancer Treatment Reviews 2005 Aug;31(5):380-
402.
Extermann M. Geriatric Oncology: An Overview of Progresses and Challenges. Cancer Res Treat 2010 Jun;
42(2), 61-68.
Extermann M, Hurria A. Comprehensive geriatric assessment for older patients with cancer. Journal of Clinical
Oncology 2007; 25: 1824-1831.
Extermann M, Meyer J, McGinnis M, et al. A comprehensive geriatric intervention detects multiple problems in
older breast cancer patients. Critical Reviews in Oncology Hematology 2004 Jan,49(1), 69-75.
Lekan-Rutledge D. Functional assessment. In: Matteson MA, McConnel ES, Linton AD, editors. Gerontological
nursing: concepts and practice. 2nd edition. Philadelphia: WB Saunders 1997; 67–111.
Stuck AE, Slu AL, Wieland GD, Adams J, Rubenstein LZ. Comprehensive geriatric assessment: a meta-analysis
of controlled trials. Lancet 1993; 342: 1032-1036.