Slide 1Institut Curie - HJ Brisse – Oncology & Nuclear Medicine – Neuroblastoma IDRF IPR - Chicago – May 2016
INRG Staging System
• Numerous prognostic factors and treatment options
• Risk-based treatment approach
Institut Curie - HJ Brisse – Oncology & Nuclear Medicine – Neuroblastoma IDRF IPR - Chicago – May 2016
Local disease staging
2A R2 N0 N0
3 « Unresectable » Crossing midline
N0 N+ N0 N+
Monclair T, et al. JCO 2009 Brodeur GM, et al. JCO 1988 & 1993
Stage Image Defined Risk
Monclair T, et al. Ped Blood Cancer 2015
Simon T et al. Ped Blood Cancer 2008
IDRFs are
• based on radiological criteria
• defined by international consensus
IDRFs are NOT
• Contraindication for surgery
Institut Curie - HJ Brisse – Oncology & Nuclear Medicine – Neuroblastoma IDRF IPR - Chicago – May 2016
Monclair T, et al. JCO 2009
Brisse HJ et al. Radiology 2011
Günther P et al. Eur J Pediatr Surg 2011
Pohl A et al. Klinishe Padiatrie 2016
INRG Imaging Committee
– Beth McCarville1
– Claudio Granata5
– Sandra Wooton-George1
– Barabara Krug2
– Kimio Kanegawa4
Institut Curie - HJ Brisse – Oncology & Nuclear Medicine – Neuroblastoma IDRF IPR - Chicago – May 2016
IDRF Check-list
Institut Curie - HJ Brisse – Oncology & Nuclear Medicine – Neuroblastoma IDRF IPR - Chicago – May 2016
NB
NB
Contact
Institut Curie - HJ Brisse – Oncology & Nuclear Medicine – Neuroblastoma IDRF IPR - Chicago – May 2016
« Contact » « Encasement »
Institut Curie - HJ Brisse – Oncology & Nuclear Medicine – Neuroblastoma IDRF IPR - Chicago – May 2016
Chest
Institut Curie - HJ Brisse – Oncology & Nuclear Medicine – Neuroblastoma IDRF IPR - Chicago – May 2016
IDRF +
IDRF +
IDRF +
Institut Curie - HJ Brisse – Oncology & Nuclear Medicine – Neuroblastoma IDRF IPR - Chicago – May 2016
IDRF +
IDRF +
Institut Curie - HJ Brisse – Oncology & Nuclear Medicine – Neuroblastoma IDRF IPR - Chicago – May 2016
IDRF + IDRF +
Surgeons : risk of complication or incomplete removal
Statisticans : standardization / trials comparison