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Slide 1Institut Curie - HJ Brisse – Oncology & Nuclear Medicine – Neuroblastoma IDRF IPR - Chicago – May 2016 INRG Staging System • Numerous prognostic factors and treatment options • Risk-based treatment approach Institut Curie - HJ Brisse – Oncology & Nuclear Medicine – Neuroblastoma IDRF IPR - Chicago – May 2016 Local disease staging 2A R2 N0 N0 3 « Unresectable » Crossing midline N0 N+ N0 N+ Monclair T, et al. JCO 2009 Brodeur GM, et al. JCO 1988 & 1993 Stage Image Defined Risk Monclair T, et al. Ped Blood Cancer 2015 Simon T et al. Ped Blood Cancer 2008 IDRFs are • based on radiological criteria • defined by international consensus IDRFs are NOT • Contraindication for surgery Institut Curie - HJ Brisse – Oncology & Nuclear Medicine – Neuroblastoma IDRF IPR - Chicago – May 2016 Monclair T, et al. JCO 2009 Brisse HJ et al. Radiology 2011 Günther P et al. Eur J Pediatr Surg 2011 Pohl A et al. Klinishe Padiatrie 2016 INRG Imaging Committee – Beth McCarville1 – Claudio Granata5 – Sandra Wooton-George1 – Barabara Krug2 – Kimio Kanegawa4 Institut Curie - HJ Brisse – Oncology & Nuclear Medicine – Neuroblastoma IDRF IPR - Chicago – May 2016 IDRF Check-list Institut Curie - HJ Brisse – Oncology & Nuclear Medicine – Neuroblastoma IDRF IPR - Chicago – May 2016 NB NB Contact Institut Curie - HJ Brisse – Oncology & Nuclear Medicine – Neuroblastoma IDRF IPR - Chicago – May 2016 « Contact » « Encasement » Institut Curie - HJ Brisse – Oncology & Nuclear Medicine – Neuroblastoma IDRF IPR - Chicago – May 2016 Chest Institut Curie - HJ Brisse – Oncology & Nuclear Medicine – Neuroblastoma IDRF IPR - Chicago – May 2016 IDRF + IDRF + IDRF + Institut Curie - HJ Brisse – Oncology & Nuclear Medicine – Neuroblastoma IDRF IPR - Chicago – May 2016 IDRF + IDRF + Institut Curie - HJ Brisse – Oncology & Nuclear Medicine – Neuroblastoma IDRF IPR - Chicago – May 2016 IDRF + IDRF + Surgeons : risk of complication or incomplete removal Statisticans : standardization / trials comparison