Mission: successfully control liver fluke, worms and lice
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A HIGHLY EFFECTIVE WorLd FIrsT
• Nitromecistheworld’sfirsttripleactiveinjectablecattleparasiticideandcontainsacombinationofNitroxynil,ClorsulonandIvermectin
• UsesthesynergisticeffectofClorsulonandNitroxynilforsuperiorpotencyagainst liver fluke
• Effectiveagainstallthreestagesofliverfluke,includingtheimportanttwoweekold earlyimmaturestage
• Thegreatestdamagetotheliveriscausedbyyoungmigratingstatesofliverfluke
• ControlsTriclabendazoleresistantstrainsofliverfluke
• ContainsIvermectinwhichishighlyeffectiveagainstgastrointestinalroundworms andexternalparasites
InjECT For EFFECT
NitromechasbeendevelopedinAustraliabyVirbac usingthelatestformulationtechnology.ItcontainsacombinationofNitroxynil,ClorsulonandIvermectin. ThecombinationofNitroxynilandClorsulonprovidessynergisticactivityagainstliverfluke,makingitoneof onlytwoproductsproventoeffectivelykillliverfluke assoonastwoweekspost-infection-theotheris Virbac’sFlukazole®CPlusSelenium.
AnefficacystudyhasprovenNitromeciseffective againstallthreestagesofliverfluke,includingthehighlyimportanttwoweekoldearlyimmaturestage1.
Independenttrialshaveshownthatpopularpour-onflukicides are not as effective on early immature fluke (includingtwoandfourweekoldstages)asNitromecInjection1.
Cattle flukicide efficacy trials
NitromecInjectionversuspour-ontreatment
ByinjectingNitromecyouhavetheconfidenceinknowingtheproductisinsidetheanimalandworking.Theconditionoftheanimal’scoatandweathercan’tinfluencehowwelltheproductwillwork
The strength of synergy
Manyparasitecontrolproductscontainmorethanoneactiveingredient,butalmostuniversally,theingredientsactindependentlyofeachother,providingasimplecumulativeeffect.Rarely,thechemicalsworktogethertoprovidehigherpotencythanexpectedfromthecumulativeimpactofthetwochemicals,asynergisticeffectthatprovidesoutstandingpotency.
Nitromecutilisestheprovensynergisticeffectofclorsulonandnitroxynil.Thisprovidessuperiorpotencycomparedwithnon-synergisedflukicides,includingmosttriclabendazole-basedproductsthatclaimcontrolofallthreedevelopmentalstagesoftheliverfluke.ThehigherpotencyofNitromecisparticularlyevidentagainsttheearlyimmaturestageofthefluke.NitromecisoneofonlytwoproductstohaveanAustralianPesticidesandVeterinaryMedicinesAuthority(APVMA)approvedlabelclaimspecificallyforthecontroloftwoweekoldearlyimmatureliverfluke(theotherbeingVirbac’sFlukazoleCPlusSeleniumoraldrench).
3IVERMECTIN
CLORSULON
NITROXYNIL1
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Age of fluke at the time of treatment 2-weeks 4-weeks
NITROMEC INJECTION POUR-ON(abamectin/triclabendazole)
99% 99%
8%
82%
Bile duct
Gall bladder
1 week
2 weeks
4 weeks
6 weeks
8 weeks
Cross section of a damaged liver
1 week old fluke – Newly arrived from gut and
4 week old early immature fluke – migratory phase, causing haemorrhage and leaving scarring
8 week old immature fluke – migratory phase completed. Ready to enter bile duct
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Adult fluke in bile duct – eggs layed approx 10-12 weeks after infection
Fluke eggs in gall bladder, ready for release into digestive tract
Visible scarringF
1 week old fluke – Newly arrived from gut and penetrating the liver capsule4 week old early immature fluke – migratory phase, causing haemorrhage and leaving scarring 8 week old immature fluke – – migratory phase completed. Ready to enter bile ductAdult fluke in bile duct – eggs layed approx 10-12 weeks after infection Fluke eggs in gall bladder, ready for release into digestive tractVisible scarring
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KnoW THE EnEmY
Cross section of a damaged liver
The scarring from immature fluke is evident on this liver.Healthy normal liver.
• Controllingtheearlyimmatureandimmaturestagesofliverflukeisimportantbecause:
• Theearlyimmatureandimmatureflukesmigratethroughtheliverleavingadevastatingtrailofdestruction
• Theycausereducedappetite,bloodandproteinlosswithliverfunctionimpairmentandscarring
• Severeinfections,wheremanyyouflukesinhabitthelivercanleadtopermanentunderperformanceorevendeath
• Evenincaseswheretheclinicalsignsofinfectionare notobvious,thedamagetothelivercanseverelylimittheproductivity
• Effectiveremovalofearlyimmatureandimmatureflukesstopsegglayingforanextendedperiodoftime
1weekoldfluke–Newlyarrivedfromgutandpenetratingthelivercapsule
4weekoldearlyimmaturefluke–migratoryphase,causinghaemorrhageandleavingscarring
8weekoldimmaturefluke––migratoryphasecompleted.Readytoenterbileduct
Adultflukeinbileduct–eggslayedapprox10-12weeksafter infection
Flukeeggsingallbladder,readyforreleaseintodigestivetract
Visiblescarring
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Ostertagia ostertagiSmallbrownstomachworms
Haemonchus placei Barber’sPoleworm
Trichostrongylus axei Stomachhairworm
Trichostrongylus colubriformis Intestinalhairworm
O. lyrata Stomachworm
Cooperia spp Smallintestinalworm
Oesophagostomum radiatum Bunostomum phlebotomum
Noduleworm
And adult stages of: Trichuris spp
Whipworm
Stongyloides papillosus Intestinalworm
Nematodirus sppThinneckedintestinalworm
Early immature (including 2-week old), Immature and Adult Liver Fluke
Fasciolahepatica
Dictyocaulus viviparous Lungworms
Thelazia spp Eyeworm
Linognathus vituli Longnosedsuckinglouse
Haematopinus eurysternus Shortnosedsuckinglouse
Solenopotes capillatus Littlebluesuckinglouse
Sarcoptes scabei var bovis Mites
Chrysomya bezziana Screwwormfly
Boophilus microplus Cattletick
Inject profit into your wallet
AweightgainstudybyindependentparasitologistDrJoeBorayhasclearlydemonstratedtheeconomicadvantageinremovingearlyimmatureflukes.Inthatstudy2, animals treatedtoremoveearlyimmatureflukes1-2weekspost-infectionhadgreaterweightgainthananimalstreated4-6or8-12weekspost-infection.Over20weeks,theaveragebodyweightoftheearlytreatedgroupwas8kgheavierthanthegrouptreated4-6weekspost-infectionand13kgheavierthanthegroupthathadtheflukeremovedwhentheyweremature.
Watch your calves TAKE oFF!
Producersshouldlookformaximumefficacyagainsttheyoungestliverflukepossiblewhenchoosingaproductforthecontrolofliverfluke.Highlevelsofefficacywillminimisetheliverdamagecausedbythemigratingyoungflukeandintheprocessminimisetheeconomiclossesresultingfromthedisease.
WEIGHT GAIN (kg) OVER 20 WEEKS
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1-2 WEEK STAGES
4-6 WEEK STAGES
8-12 WEEK STAGES
13kg = an additional $23 in liveweight value3
ThelastlinkintheNitromecInjectionislvermectin.Ivermectinistheworld’smostpopulardrenchactiveforuseincattle.Itishighlyeffectiveagainstgastrointestinalroundworms,lungwormandexternalparasites.
Nitromecinjectionalsoofferspersistentcontrolofdamagingroundwormsandlungworm.4•Ostertgiaspp•Cooperiaspp•Lungworm•Screwwormfly
TheIvermectininNitromecInjectionisalsoahighlyeffectiveinsecticide.ForthisreasonNitromecInjectionisactiveagainstarangeofparasitesoncattleincludinglive,mangemitesandcattletick.
Licenumberstypicallybuildupoverthecolderwintermonthsastheanimal’scoatthickens.
NitromecInjectiongivesfullcontrolofsuckingliceandaidsinthecontrolofbitinglice
Control far more than just liver fluke
Ivermectin – the special link in the chain WO
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assistanceofDrJoeBoray,oneoftheworldsleadingauthoritiesonliverfluke,aimstolimittheeconomicimpactoftheliverflukeinahighlyeffectiveandsustainableway.
ThetwokeytreatmenttimingsintheFlukekillprogrammeareautumnandspring,withanoptionalsummertreatment(s)includedwhereflukeinfestationishigh.
Autumnandsummertreatmentsmustcontrolallthreestagesofthefluke(earlyimmature,immatureandadult).Nitromec® andFlukazole®CPlusSeleniumarethemosteffectiveproductsavailableforuseatthesetimes.
Thespringtreatmentisapreventativetreatment,removinganyadultflukesremainingafterwintertominimisepasturecontaminationwithflukeeggsatthebeginningoftheflukeseason.VirbamecPlusisrecommendedforthistreatment.
TriclabendazolehasbeenontheAustralianmarketforover20yearsandisusedrepeatedlyasthemainactiveconstituenttocontrolliverfluke.SuspectedcasesoftriclabendazoleresistanceareemerginginregionsaroundAustraliawhichcouldbeattributedtotheover-useofproductscontainingtriclabendazole.
Nitromecprovidesasuitablerotationawayfromtriclabendazoleforautumnandsummerfluketreatments.
FlukeKillA INITIATIVE
TM
Use
Nit
rom
ec In
ject
ion
or
Fluk
azol
e C
Plu
s Se
leni
um.
Use
Vir
bam
ec P
lus Autumn Treatment Late winter/spring
The autumn treatment must control early immature, immature and adult fluke.
An optimal mid summer. treatment may be required for heavily infested properties.
Optimal time for the late spring treatment is August/September. This is important to remove all remaining fluke & stop pasture contamination of fluke eggs.
Use
Nit
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ion
or
Fluk
azol
e C
Plu
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mArKET LEAdErsHIp
Liver fluke is serious and so is Virbac.
VirbacrecognisesthatliverflukediseaseincattleisamajorongoingproductivityissuecostingAustralia’sbeefindustrymillionsofdollarsinlostproductioneachyear.Virbachasinvestedheavilyinliverflukeresearchtohelpgainanin-depthunderstandingofthisparasiteanditsimpacts.Virbac’spassionfordevelopingtherightproductsolutionshasproducedauniquerangeofcutting-edgeproductsthatprovidescattleproducerswitheffective,flexibleandeconomicalcontrolofliverfluke.YoucanbeconfidentthattheVirbacNitromecwillgiveyouthecontrolyouneed.
InITIATIVE – 360˚ FLuKE ConTroL
Liverflukeisacomplexparasite,butitscontroliseasilyachievedwheretailoredcontrolprogrammesareemployed.TheFlukekillprogramme,aVirbacinitiative,guidesfarmersthroughtreatmenttimingandproductchoice.Theprogramme,whichwasdesignedwiththe
FlukeKill
produCT spECIFICATIons
Active Constituents
Nitroxynil 340g/L Ivermectin 6.7g/L Clorsulon 67g/L
dosage and Administration
1.5mL/50kg Nitromecisadministeredasasubcutaneousinjection.
pack sizes
1 Litre 2.5Litre
Witholding periods
A Meat: 56 days(calvesborntocowsthathavebeentreatedwithNitromecInjectionduringpregnancymustnotbeslaughteredforhumanconsumptionfor56daysaftertreatmentofthedam.
B Milk: Donotuseincattlewhichareproducingmilkormayinthefutureproducemilkwherethemilkormilkproductsmaybeusedforhumanconsumption.
C ESI:Cattle:120 days.Donotuselessthan120daysbeforeslaughterforexport.CalvesborntocowsthathavebeentreatedwithNitromecInjectionduringpregnancy,mustnotbeslaughteredforexportfor 120daysafterthetreatmentofthedam.
Liveweight Kg dose Volume mLCattle Treated
1L pack 2.5L pack
50-75 2.25 444 1111
75-100 3 333 833
101-150 4.5 222 555
151-200 6 166 416
201-250 7.5 133 333
251-300 9 111 277
301-350 10.5 95 238
351-400 12 83 208
401-450 13.5 74 185
451-500 15 66 166
501-550 16.5 60 151
551-600 18 55 138
601-650 19.5 51 128
Cattleheavierthan650kgshouldbedosedat1.5mL/50kg
Customer support Tel: 1800 009 847 www.virbac.com.au
• Upto100%controlof2-weekoldfluke
• Controlstriclabendazoleresistantfluke
• Broadspectrumcontrolofinternalandexternalparasites
• PartoftheVirbac’sFlukeKillprogramme
Nitromec,FlukazoleandVirbamecareregisteredtrademarksofVirbac(Australia)PtyLimited.FlukeKillisatrademarkofVirbac(Australia)PtyLimited.
1.Dataonfile–Virbac(Australia)Pty.Limited2.JCBoray(1982)ChemotherapyoffaciolosisNewSouthWalesVeterinaryProceedings,p42-47r3.Calculationbasedonaliveweightmarketpriceof$1.75perKg4.Seeproductlabelfordetails