Mission: successfully control liver fluke, worms and liceIvermectin 6.7 g/L Clorsulon 67 g/L dosage and Administration 1.5mL / 50kg Nitromec is administered as a subcutaneous injection.

Mission: successfully control liver fluke, worms and lice

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A HIGHLY EFFECTIVE WorLd FIrsT

• Nitromecistheworld’sfirsttripleactiveinjectablecattleparasiticideandcontainsacombinationofNitroxynil,ClorsulonandIvermectin

• UsesthesynergisticeffectofClorsulonandNitroxynilforsuperiorpotencyagainst liver fluke

• Effectiveagainstallthreestagesofliverfluke,includingtheimportanttwoweekold earlyimmaturestage

• Thegreatestdamagetotheliveriscausedbyyoungmigratingstatesofliverfluke

• ControlsTriclabendazoleresistantstrainsofliverfluke

• ContainsIvermectinwhichishighlyeffectiveagainstgastrointestinalroundworms andexternalparasites

InjECT For EFFECT

NitromechasbeendevelopedinAustraliabyVirbac usingthelatestformulationtechnology.ItcontainsacombinationofNitroxynil,ClorsulonandIvermectin. ThecombinationofNitroxynilandClorsulonprovidessynergisticactivityagainstliverfluke,makingitoneof onlytwoproductsproventoeffectivelykillliverfluke assoonastwoweekspost-infection-theotheris Virbac’sFlukazole®CPlusSelenium.

AnefficacystudyhasprovenNitromeciseffective againstallthreestagesofliverfluke,includingthehighlyimportanttwoweekoldearlyimmaturestage1.

Independenttrialshaveshownthatpopularpour-onflukicides are not as effective on early immature fluke (includingtwoandfourweekoldstages)asNitromecInjection1.

Cattle flukicide efficacy trials

NitromecInjectionversuspour-ontreatment

ByinjectingNitromecyouhavetheconfidenceinknowingtheproductisinsidetheanimalandworking.Theconditionoftheanimal’scoatandweathercan’tinfluencehowwelltheproductwillwork

The strength of synergy

Manyparasitecontrolproductscontainmorethanoneactiveingredient,butalmostuniversally,theingredientsactindependentlyofeachother,providingasimplecumulativeeffect.Rarely,thechemicalsworktogethertoprovidehigherpotencythanexpectedfromthecumulativeimpactofthetwochemicals,asynergisticeffectthatprovidesoutstandingpotency.

Nitromecutilisestheprovensynergisticeffectofclorsulonandnitroxynil.Thisprovidessuperiorpotencycomparedwithnon-synergisedflukicides,includingmosttriclabendazole-basedproductsthatclaimcontrolofallthreedevelopmentalstagesoftheliverfluke.ThehigherpotencyofNitromecisparticularlyevidentagainsttheearlyimmaturestageofthefluke.NitromecisoneofonlytwoproductstohaveanAustralianPesticidesandVeterinaryMedicinesAuthority(APVMA)approvedlabelclaimspecificallyforthecontroloftwoweekoldearlyimmatureliverfluke(theotherbeingVirbac’sFlukazoleCPlusSeleniumoraldrench).

3IVERMECTIN

CLORSULON

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Age of fluke at the time of treatment 2-weeks 4-weeks

NITROMEC INJECTION POUR-ON(abamectin/triclabendazole)

99% 99%

8%

82%

Bile duct

Gall bladder

1 week

2 weeks

4 weeks

6 weeks

8 weeks

Cross section of a damaged liver

1 week old fluke – Newly arrived from gut and

4 week old early immature fluke – migratory phase, causing haemorrhage and leaving scarring

8 week old immature fluke – migratory phase completed. Ready to enter bile duct

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Adult fluke in bile duct – eggs layed approx 10-12 weeks after infection

Fluke eggs in gall bladder, ready for release into digestive tract

Visible scarringF

1 week old fluke – Newly arrived from gut and penetrating the liver capsule4 week old early immature fluke – migratory phase, causing haemorrhage and leaving scarring 8 week old immature fluke – – migratory phase completed. Ready to enter bile ductAdult fluke in bile duct – eggs layed approx 10-12 weeks after infection Fluke eggs in gall bladder, ready for release into digestive tractVisible scarring

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KnoW THE EnEmY

Cross section of a damaged liver

The scarring from immature fluke is evident on this liver.Healthy normal liver.

• Controllingtheearlyimmatureandimmaturestagesofliverflukeisimportantbecause:

• Theearlyimmatureandimmatureflukesmigratethroughtheliverleavingadevastatingtrailofdestruction

• Theycausereducedappetite,bloodandproteinlosswithliverfunctionimpairmentandscarring

• Severeinfections,wheremanyyouflukesinhabitthelivercanleadtopermanentunderperformanceorevendeath

• Evenincaseswheretheclinicalsignsofinfectionare notobvious,thedamagetothelivercanseverelylimittheproductivity

• Effectiveremovalofearlyimmatureandimmatureflukesstopsegglayingforanextendedperiodoftime

1weekoldfluke–Newlyarrivedfromgutandpenetratingthelivercapsule

4weekoldearlyimmaturefluke–migratoryphase,causinghaemorrhageandleavingscarring

8weekoldimmaturefluke––migratoryphasecompleted.Readytoenterbileduct

Adultflukeinbileduct–eggslayedapprox10-12weeksafter infection

Flukeeggsingallbladder,readyforreleaseintodigestivetract

Visiblescarring

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Ostertagia ostertagiSmallbrownstomachworms

Haemonchus placei Barber’sPoleworm

Trichostrongylus axei Stomachhairworm

Trichostrongylus colubriformis Intestinalhairworm

O. lyrata Stomachworm

Cooperia spp Smallintestinalworm

Oesophagostomum radiatum Bunostomum phlebotomum

Noduleworm

And adult stages of: Trichuris spp

Whipworm

Stongyloides papillosus Intestinalworm

Nematodirus sppThinneckedintestinalworm

Early immature (including 2-week old), Immature and Adult Liver Fluke

Fasciolahepatica

Dictyocaulus viviparous Lungworms

Thelazia spp Eyeworm

Linognathus vituli Longnosedsuckinglouse

Haematopinus eurysternus Shortnosedsuckinglouse

Solenopotes capillatus Littlebluesuckinglouse

Sarcoptes scabei var bovis Mites

Chrysomya bezziana Screwwormfly

Boophilus microplus Cattletick

Inject profit into your wallet

AweightgainstudybyindependentparasitologistDrJoeBorayhasclearlydemonstratedtheeconomicadvantageinremovingearlyimmatureflukes.Inthatstudy2, animals treatedtoremoveearlyimmatureflukes1-2weekspost-infectionhadgreaterweightgainthananimalstreated4-6or8-12weekspost-infection.Over20weeks,theaveragebodyweightoftheearlytreatedgroupwas8kgheavierthanthegrouptreated4-6weekspost-infectionand13kgheavierthanthegroupthathadtheflukeremovedwhentheyweremature.

Watch your calves TAKE oFF!

Producersshouldlookformaximumefficacyagainsttheyoungestliverflukepossiblewhenchoosingaproductforthecontrolofliverfluke.Highlevelsofefficacywillminimisetheliverdamagecausedbythemigratingyoungflukeandintheprocessminimisetheeconomiclossesresultingfromthedisease.

WEIGHT GAIN (kg) OVER 20 WEEKS

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4-6 WEEK STAGES

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13kg = an additional $23 in liveweight value3

ThelastlinkintheNitromecInjectionislvermectin.Ivermectinistheworld’smostpopulardrenchactiveforuseincattle.Itishighlyeffectiveagainstgastrointestinalroundworms,lungwormandexternalparasites.

Nitromecinjectionalsoofferspersistentcontrolofdamagingroundwormsandlungworm.4•Ostertgiaspp•Cooperiaspp•Lungworm•Screwwormfly

TheIvermectininNitromecInjectionisalsoahighlyeffectiveinsecticide.ForthisreasonNitromecInjectionisactiveagainstarangeofparasitesoncattleincludinglive,mangemitesandcattletick.

Licenumberstypicallybuildupoverthecolderwintermonthsastheanimal’scoatthickens.

NitromecInjectiongivesfullcontrolofsuckingliceandaidsinthecontrolofbitinglice

Control far more than just liver fluke

Ivermectin – the special link in the chain WO

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assistanceofDrJoeBoray,oneoftheworldsleadingauthoritiesonliverfluke,aimstolimittheeconomicimpactoftheliverflukeinahighlyeffectiveandsustainableway.

ThetwokeytreatmenttimingsintheFlukekillprogrammeareautumnandspring,withanoptionalsummertreatment(s)includedwhereflukeinfestationishigh.

Autumnandsummertreatmentsmustcontrolallthreestagesofthefluke(earlyimmature,immatureandadult).Nitromec® andFlukazole®CPlusSeleniumarethemosteffectiveproductsavailableforuseatthesetimes.

Thespringtreatmentisapreventativetreatment,removinganyadultflukesremainingafterwintertominimisepasturecontaminationwithflukeeggsatthebeginningoftheflukeseason.VirbamecPlusisrecommendedforthistreatment.

TriclabendazolehasbeenontheAustralianmarketforover20yearsandisusedrepeatedlyasthemainactiveconstituenttocontrolliverfluke.SuspectedcasesoftriclabendazoleresistanceareemerginginregionsaroundAustraliawhichcouldbeattributedtotheover-useofproductscontainingtriclabendazole.

Nitromecprovidesasuitablerotationawayfromtriclabendazoleforautumnandsummerfluketreatments.

FlukeKillA INITIATIVE

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The autumn treatment must control early immature, immature and adult fluke.

An optimal mid summer. treatment may be required for heavily infested properties.

Optimal time for the late spring treatment is August/September. This is important to remove all remaining fluke & stop pasture contamination of fluke eggs.

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mArKET LEAdErsHIp

Liver fluke is serious and so is Virbac.

VirbacrecognisesthatliverflukediseaseincattleisamajorongoingproductivityissuecostingAustralia’sbeefindustrymillionsofdollarsinlostproductioneachyear.Virbachasinvestedheavilyinliverflukeresearchtohelpgainanin-depthunderstandingofthisparasiteanditsimpacts.Virbac’spassionfordevelopingtherightproductsolutionshasproducedauniquerangeofcutting-edgeproductsthatprovidescattleproducerswitheffective,flexibleandeconomicalcontrolofliverfluke.YoucanbeconfidentthattheVirbacNitromecwillgiveyouthecontrolyouneed.

InITIATIVE – 360˚ FLuKE ConTroL

Liverflukeisacomplexparasite,butitscontroliseasilyachievedwheretailoredcontrolprogrammesareemployed.TheFlukekillprogramme,aVirbacinitiative,guidesfarmersthroughtreatmenttimingandproductchoice.Theprogramme,whichwasdesignedwiththe

FlukeKill

produCT spECIFICATIons

Active Constituents

Nitroxynil 340g/L Ivermectin 6.7g/L Clorsulon 67g/L

dosage and Administration

1.5mL/50kg Nitromecisadministeredasasubcutaneousinjection.

pack sizes

1 Litre 2.5Litre

Witholding periods

A Meat: 56 days(calvesborntocowsthathavebeentreatedwithNitromecInjectionduringpregnancymustnotbeslaughteredforhumanconsumptionfor56daysaftertreatmentofthedam.

B Milk: Donotuseincattlewhichareproducingmilkormayinthefutureproducemilkwherethemilkormilkproductsmaybeusedforhumanconsumption.

C ESI:Cattle:120 days.Donotuselessthan120daysbeforeslaughterforexport.CalvesborntocowsthathavebeentreatedwithNitromecInjectionduringpregnancy,mustnotbeslaughteredforexportfor 120daysafterthetreatmentofthedam.

Liveweight Kg dose Volume mLCattle Treated

1L pack 2.5L pack

50-75 2.25 444 1111

75-100 3 333 833

101-150 4.5 222 555

151-200 6 166 416

201-250 7.5 133 333

251-300 9 111 277

301-350 10.5 95 238

351-400 12 83 208

401-450 13.5 74 185

451-500 15 66 166

501-550 16.5 60 151

551-600 18 55 138

601-650 19.5 51 128

Cattleheavierthan650kgshouldbedosedat1.5mL/50kg

Customer support Tel: 1800 009 847 www.virbac.com.au

• Upto100%controlof2-weekoldfluke

• Controlstriclabendazoleresistantfluke

• Broadspectrumcontrolofinternalandexternalparasites

• PartoftheVirbac’sFlukeKillprogramme

Nitromec,FlukazoleandVirbamecareregisteredtrademarksofVirbac(Australia)PtyLimited.FlukeKillisatrademarkofVirbac(Australia)PtyLimited.

1.Dataonfile–Virbac(Australia)Pty.Limited2.JCBoray(1982)ChemotherapyoffaciolosisNewSouthWalesVeterinaryProceedings,p42-47r3.Calculationbasedonaliveweightmarketpriceof$1.75perKg4.Seeproductlabelfordetails