Jacqueline F. McGinty, Timothy W. Whitfield Jr., William J. Berglind
Chronic neurobiological disorder Detrimental effects Compulsive behavior Preoccupation
Neurological Development: Increased drug-seeking behavior Attenuation of other behaviors
Reward Pathway Learning Key areas
Cognition Goals Many connections
Executive Function Decision making Troubleshooting Novel / Dangerous / Difficult situations Overcoming strong habitual response
Neuroadaptations TrkB
Plasticity Behavioral coping Neuroprotection Associative learning
Increased BDNF Production NAc
NAc expression: Behavioral
sensitization CPP
Kristy R. Crooks, Daniel T. Kleven, Ramona M. Rodriguiz, William C. Wetsel, James O. McNamarae,
+ pTrkB in Nac dnTrkB mice
Tet-off system
bdnf
P!Cascade to mRNA
Normal TrkBdnTrkB bdn
f
No P Occurs!
DOX TAKEN FROM DIET!
TrkB expression: Sensitization CPP Feeds reward
pathway
Increased BDNF Production PFC
attenuation
PFC BDNF < drug induced NAc GLU levels
PFC BDNF normalizes NAc p-ERK
Fabio Fumagalli, Lucia Caffino, Giorgio Racagni, Marco Andrea Riva,
Chronic stress: Sensitizes behavioral
response Facilitates
reinstatement Affects BDNF
expression
Chronically stressed male rats acute cocaine
BDNF & TrkB PFC Hippocampus
Stressed rats : Restraint swim tests No habituation
BDNF neuroprotection reward pathway
BDNF Site specific use Protect executive functioning
