ICTR Biostatistics Research Resource
Mary LindstromProfessor, Dept. of Biostatistics and Medical Informatics
Director, ICTR Biostatistics Research Resource
Resource Faculty and Staff20 UW Faculty Biostatisticians
8 UW Staff Biostatisticians
4 Marshfield Clinic Biostatisticians
ICTR Biostatistics Resource Faculty and Staff
Clinical Research• UW Faculty: AC Andrei, T Becker, K Buhr, R Chappell, T Cook, M Detry, NM Dowling, M Fisher, P Hutson, R Gangnon, M Lindstrom, M Palta, M Rosenberg, S Wang• UW Staff: J Barnet, M Evans, S Hetzel, Z Li, V Rajamanickam, S Seo• Marshfield Clinic: R Berg, P Chyou, H Liang
Statistical Genetics • UW Faculty: K Broman, S Keles, C Kendziorski, R Mau, M Newton, S Wang, B Yandell• UW Staff: A Andrei, A Broman• Marshfield Clinic: Z Ye
Areas of Expertise
Traditional Areas• Clinical Trials• Prospective Cohort Studies• Case Control Studies• Retrospective Studies• Pre-clinical StudiesSpecial Areas (growing, unique) • Statistical Genetics• Qualitative Outcomes• Cost and Policy Issues• Pharmacokinetics & Pharmacodynamics
Biostatistics Resource Activities
ConsultingCollaborative ResearchMethodology Research
TrainingProtocol & Pilot Project Review
26%
21%39%
14%
ICTR
Departments ¢ersCollaborative grants
Methodology grants
UW - Madison Resource Funding Model
13.8 FTEs devoted to ICTR Biostatistics
Leveraging UW ICTR Resources
Funding Source
ActivityICTR
(3.7 FTE)
Departments & Centers
(2.9 FTE)
Collab. Grants(5.4 FTE)
Method. Grants(1.9 FTE)
Consulting X X
Collaboration X X X X
Methodology X X
Review X
Marshfield Clinic Funding Model
Funding Source FTEs
Collaborative Projects 2.10
Institutional Support 0.10
ICTR 0.25
2.45 FTEs devoted to ICTR Biostatistics
Prioritizing Requests
UW - MadisonWhen we have a waiting list:• New investigators over established• Projects leading to proposals for
funding• One active project per investigator• Deadlines given priority• First come, first serve Long term management:• Departments, centers, and
investigators with substantial use are asked to provide direct funding.
All requests must:• come from ICTR Members• be related to clinical
and/or translational research
Marshfield Clinic• External, large grant
proposals• Internal proposals• Deadlines given priority
Units Using Resource
Madison • Pediatrics• Population Health
Sciences• Psychiatry• Radiology• Surgery
Other Schools• Agricultural and Life
Sciences• Education• Engineering• Human Ecology• Library and
Information Studies• Letters and Science• Nursing• Pharmacy• Veterinary Medicine
Other• Waisman Center• Center for Health
Enhancement Systems Studies
• Office of Continuing Professional Development in Medicine and Public Health
• Department of Veterans Affairs
MarshfieldMedical School• Anatomy• Anesthesiology• Dermatology• Family Medicine• Medical Physics• Medicine• Neurological Surgery• Neurology• Obstetrics and
Gynecology• Ophthalmology & Visual
Sciences• Orthopedics and
Rehabilitation• Pathology and
Laboratory Medicine• Pharmacology
• Cardiology• Dermatology• Division of
Education• Internal
Medicine• Neurology• Oncology• Pediatrics• Rheumatology• Sleep Lab• Surgery
Red indicates funding forindividual statisticians
ICTR Biostatistics 2009 Activity
UW - Madison Marshfield Clinic
407 Projects 79
275 Investigators 36
90 Collaborative Publications 10
28 Collaborative Grants 56
50 ProtocolsReviewed
59
88 Pilot ProjectsReviewed
The Future
• Upgrade the Activity Tracking System to follow:– the life cycle of grants, protocols, manuscripts,– the effect of training and collaboration on
investigator success.• Increase capacity for qualitative endpoints
collaboration.• Encourage junior Biostatistics faculty to compete for
ICTR pilot grants.• Improve interaction between UW and Marshfield
Clinic Biostatistics Research Resources.
Examples of Collaboration
Clinical Trials Wisconsin Network for Health Research (WiNHR) presented by Mary Lindstrom
Stat-Gen Statistical Genetics and Genomics Program presented by Christina Kendziorski
Wisconsin Network for HealthResearch (WiNHR)
•A statewide network of clinical sites to collaborate on trials of•Diagnostic, preventative and therapeutic interventions•Comparative effectiveness
•Expands capabilities of Wisconsin researchers•More studies done faster•Population of > 3 million
•Centralizes some aspects of the research•Data management• IRB approval process•Statistical analysis
•Each site has a PI and local research staff
WiNHR Sites
Marshfield Clinic
Gundersen Lutheran
UW-Madison
Aurora Health Care
WiNHR Studies
•Protocols • come from all participating sites• are funded independently
•Studies• 9 ongoing, 1 completed• 712 patients accrued• 8 different lead investigators• 9/10 studies use 3 or 4 sites.