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05th
September, 2014 Volume No.: 37 Issue No.: 02
Vision
TO REACH THE PINNACLE OF GLORY AS A CENTRE OF EXCELLENCE IN THE OF PHARMACEUTICAL AND BIOLOGICAL SCIENCES BY KNOWLEDGE BAS
LEARNING AND PRACTICE
ontentsMessage from PRINCIPAL
Editorial board
Historical article
News Update
Knowledge based Article
Disease Related Breaking
News
Upcoming Events
Drugs Update
Campus NewsStudents Section
Editors Note
Archive
GNIPST Photo Gallery
or your comments/contribution
For ack-Issues,
ailto:[email protected]
GURU NANAK INSTITUTE OF PHARMACEUTICAL
SCIENCE AND TECHNOLOGY
Website:http://gnipst.ac.in
https://plus.google.com/u/0/photos/111714720327580099858/albums/5897323676427099873?sort=7mailto:[email protected]:[email protected]:[email protected]://plus.google.com/u/0/photos/111714720327580099858/albums/5897323676427099873?sort=78/11/2019 GNIPST Bulletin 37.2
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MESSAGE FROM PRINCIPAL
"It can happen. It does happen.But it can't happen if you quit." Lauren Dane.
We are what we repeatedly do.
Excellence then is not an act, but a habit. Aristotle
It gives me immense pleasure to pen a few words for our e-bulletin. At the onset I would like to thank tlast years editors and congratulate the newly selected editors for the current year.
Our first consideration is always in the best interest of the students. Our goal is to promote academexcellence and continuous improvement.
I believe that excellence in education is aided by creating a learning environment in which all learners a
supported in maximizing their potential and talents. Education needs to focus on personalized learni
and instruction, while promoting an education system that is impartial, universally accessible, and meetithe needs of all students.
It is of paramount importance that our learners have sufficient motivation and encouragement in order achieve their aims. We are all very proud of you, our students, and your accomplishments and loo
forward to watching as you put your mark on the profession in the years ahead.
The call of the time is to progress, not merely to move ahead. Our progressive Management is looki
forward and wants our Institute to flourish as a Post Graduate Institute of Excellence. Steps are taken
this direction and fruits of these efforts will be received by our students in the near future. Our Teacheare committed and dedicated for the development of the institution by imparting their knowledge and pl
the role of facilitator as well as role model to our students.
The Pharmacy profession is thriving with a multitude of possibilities, opportunities and positi
challenges. At Guru Nanak Institute of Pharmaceutical Science and Technology, our focus is on holist
needs of our students.
I am confident that the students of GNIPST will recognize all the possibilities, take full advantage of t
opportunities and meet the challenges with purpose and determination.
Excellence in Education is not a final destination, it is a continuous walk. I welcome you to join us this path.
My best wishes to all.
Dr. A. Sengupta
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EDITORIAL BOARD
CHIEF EDITOR DR. ABHIJIT SENGUPTAEDITOR MS. JEENATARA BEGUM
ASSOCIATE EDITOR MR. DIPANJAN MANDAL
HISTORICAL ARTICLE
History of Teachers Day in India:While the world celebrates international Teachers Day on the 15th
of October, India celebrates it on the 5th of September, which is
also the birthday of the famous teacher, academic philosopher and
the second President of India, Mr. Sarvepalli Radhakrishan.Dr. Sarvepalli Radhakrishnan was born in the year 1888 in a well-known religious state in Chennai, then called Madras. He was thesecond son of Veera Samayya, a tehsildar in a zamindari. It was amiddle-class, respectable Hindu Brahmin family.He graduated with a Masters Degree in Arts from MadrasUniversity. In partial fulfillment for his M.A. degree,Radhakrishnan wrote a thesis on the ethics of the Vedanta titled
The Ethics of the Vedanta and Its Metaphysical Presuppositions,which was a reply to the charge that the Vedanta system had noroom for ethics.The Origin of Teachers Day: Since 1962, 5th of September has been
celebrated as Teachers Day in India. Dr. Sarvepalli
Radhakhrishnan was a philosopher and a teacher par excellence.
Some of his students and friends approached him and requested
him to allow them to celebrate his birthday. In reply, Dr,
Radhakrishnan said, Instead of celebrating my birthdayseparately, it would be my proud privilege if September 5th is
observed as Teachers day. The request showed
Dr.Radhakrishnans love for the teaching profession. From then
onwards, his birthday is observed as Teachers Day in India.
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He showed how western philosophers, despite all claims to
objectivity, were biased by theological influences from their wider
culture. In one of his major works he also showed that Indian
philosophy, once translated into standard academic jargon, is
worthy of being called philosophy by western standards. His main
contribution to Indian thought, therefore, is that he placed it on
the map, thereby earning Indian philosophy a respect that it had
not had before.
Dr. Radhakrishnan was of the opinion that only the right kind ofeducation could solve many ills of the society and the country. Hewanted to bring in a change in the educational system by
improving the quality of education and building up a strongrelationship between the teacher and the taught. In his opinion,teachers should be the best minds of the country; they should notmerely instruct but should gain the true affection of pupils, and therespect for teachers cannot be ordered but it should be earned.After 1946, his philosophical career was cut short when hiscountry needed him as ambassador to UNESCO and later toMoscow. He was later to become the first Vice-President andfinally the President (1962-1967) of India. He was awarded theBharat Ratna in 1954. The University of Oxford instituted theRadhakrishnan Chevening Scholarships and the RadhakrishnanMemorial Award in his memory. He also received the Peace Prizeof the German Book Trade in 1961.Even as the president Sarvepalli remained a humble man. It was anopen house at the Rashtrapati Bhavan and people from all sectionsof society were welcome to meet him. In addition he accepted onlyRs. 2,500 out of his salary of Rs. 10,000 and donated the remaining
amount to the Prime Ministers National Relief Fund every month.He remained a teacher in many ways and even adopted theauthoritative tone of a headmaster in many of his letters to hisministers. Sarvepalli Radhakrishnan passed away on April 17, 1975.
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NEWS UPDATE
Use of dengue vaccine may cause short-term
spikes in its prevalence: (5thSeptember, 2014)As researchers continue to work toward vaccines for serioustropical diseases such as dengue fever, experts caution in a newreport that such vaccines will probably cause temporary butsignificant spikes in the disease in the years after they are firstused.
First international standards for growth of
developing babies, size of newborns: (5
th
September, 2014)The first international standards for fetal growth and newborn sizehave been developed by a global team led by scientists. Now, forthe first time, all 120 million babies born each year across theworld can be assessed using a common set of standards, reflectinghow babies should grow when mothers have adequate health,nutrition, medical care and socioeconomic status.
One in five child deaths in England preventable,as are many other types, study shows: (5th
September, 2014)A new series of articles highlights the substantial number ofpreventable deaths in England. For example, 20% of child deathsreviewed between 2010 and 2011 (800 of 4601) were frompreventable causes including accidents, suicide, abuse, and neglect.Moreover, the series reveals that death rates vary widely between
and within high income countries and between different agegroups. At an international level, a higher proportion of deaths inolder children in the USA, Australia, and New Zealand are due toexternal causes.
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New blood test could offer more tailored
treatment of ovarian cancer: (5th September,
2014)A new blood test allowing doctors to predict which ovarian cancerpatients will respond to particular types of treatment is a stepcloser following a new study. Researchers say the test could bedeveloped and used in hospitals within the next few years.
Caffeine therapy for apnea of prematurity does
not have long-term harmful effects on sleep:
(5thSeptember, 2014)
Caffeine therapy for apnea of prematurity has no long-termharmful effects on sleep or control of breathing, according to a newstudy of 201 preterm children assessed at ages 5-12, the first studyin humans to examine the long-term effects of neonatal caffeinetreatment on sleep regulation and ventilatory control.
Novel microneedle patch for faster, effective
delivery of painkiller, collagen: (5th September,
2014)A simple technique has been developed to encapsulate lidocaine, acommon painkiller, or collagen in the tiny needles attached to anadhesive patch. When applied to the skin, the microneedles deliverthe drug or collagen rapidly into the skin without any discomfortto the user.
Potassium-rich foods cut stroke, death risks
among older women: (4thSeptember, 2014)
Older women who eat foods with higher amounts of potassiummay be at lower risk of stroke and death than women whoconsume less potassium-rich foods. The health benefits frompotassium-rich foods are greater among older women who do nothave high blood pressure. Most older American women do not eatthe recommended amounts of potassium from foods.
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Rare stem cells hold potential for infertility
treatments: (4thSeptember, 2014)Rare stem cells in testis that produce a biomarker protein called
PAX7 help give rise to new sperm cells -- and may hold a key torestoring fertility, research suggests. Infertility, which the Centersfor Disease Control estimates affects as many as 4.7 million men inthe United States, is a key complication of cancer treatments, suchas chemotherapy and radiation therapy.
Knowing how bacteria take out trash could lead
to new antibiotics: (4thSeptember, 2014)A team of scientists has reconstructed how bacteria tightly control
their growth and division, the cell cycle, by destroying specificproteins through regulated protein degradation. All organisms usecontrolled protein degradation to alter cell behavior in response tochanging environment. A process as reliable and stable as celldivision also has to be flexible, to allow the organism to grow andrespond. But little has been known about the molecular mechanicsof how this works.
Minimally invasive, high-performance intervention
for staging lung cancer: (4thSeptember, 2014)Endoscopic biopsy of lymph nodes between the two lungs(mediastinum) is a sensitive and accurate technique that canreplace mediastinal surgery for staging lung cancer in patientswith potentially resectable tumors. The new study shows that it isnot necessary to perform surgery to confirm negative resultsobtained through the endoscopic approach during the pre-operative evaluation of patients with this type of cancer. This
discovery has many advantages for both the patients and thehealth-care system.
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Important regulators of immune cell response
identified: (4thSeptember, 2014)A more effective method to determine how T cells differentiate
into specialized cell types has been identified by researchers. Thenew approach could help accelerate laboratory research and thedevelopment of potential therapeutics, including vaccines. Themethod may also be used to identify the genes that underlie tumorcell development.
Avian influenza virus isolated in harbor seals
poses a threat to humans: (4th September,
2014)The avian influenza A H3N8 virus that killed harbor seals alongthe New England coast can spread through respiratory dropletsand poses a threat to humans, scientists have found. The findingsreinforce the need for continued surveillance of flu virusescirculating in wild and domestic animals to understand the riskthe viruses pose to humans, said the study's first author.
For detail mail toeditor
KNOWLEDGE BASED ARTICLE
Edible vaccines
Plants offer enormous potential as production platform for
vaccines. Stable integration of a gene into the plant nuclear or
chloroplast genome can transform higher plants (tobacco, potato,
tomato, and banana) into bioreactors for the production of subunit
vaccines. From here, the existence of edible vaccines comes into
being. This plant derived vaccines present an alternative to
conventional vaccines by facilitating safe and effective oral delivery
through the consumption of edible plant tissue.
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Owing to its low cost, it would suitable for developing countries
like India. Edible vaccines are mucosal targeted vaccines which
causes stimulation of both systemic and mucosal immune
response. Todays development of novel vaccines stresses the need
for edible vaccines that are inexpensive and easily administered.
The production of recombinant vaccines in plants may overcome
some of the major difficulties encountered while using traditional
or sub-unit vaccines. In developing countries, difficulties include
vaccine affordability, the need for cold chain from producer to
the site of use of the vaccine and also on dependence on injections
whereas plant derived vaccines do not face these issues. The offer
increased safety, envisaged low cost of programme for massvaccination and wider use of vaccination for veterinary use. Thus,
the use of plant vaccine may overcome some of the major diseases
like measles, cholera, hepatitis B, hey may also help to suppress
auto immune disorders like type I diabetes, diarrhoea, multiple
sclerosis and rheumatoid arthritis. They also offer a unique
opportunity and a convenient tool against the threat against
bioterrorism.
Advantages-
Potential advantages of plant based vaccines are-
Edible means of administration
Reduced need for medical personnel and sterile injection
conditions
Economical in mass production and transportation
Therapeutic proteins are free from pathogens and toxins
Storage near the site of use
Heat stable, eliminating the need for refrigeration.
Subunit vaccine(not attenuated pathogens) means improved safety
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This pocket is filled with a cluster of B-cells, T-cells andmacrophages.
M-cells express class II MHC molecules and antigenstransported across the mucous membrane by M-cells can activate
B-cells within these lymphoid follicles. The activated B-cells leave the lymphoid follicles and migrate to
diffuse mucosal associated lymphoid tissue(MALT) where theydifferentiate into plasma cells that secrete the IgA calss ofantibodies.
These IgA antibodies are transported across the epithelial cellsinto secretions of the lumen where they can interact with theantigens present in the lumen.
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Oral delivery, mucosal and systemic antibody responses:
Plant-derived vaccines have demonstrated the ability to induce
both systemic and mucosal immune responses. The major obstacle to oral vaccination is the digestion of the
antigenic protein in the stomach.
Vaccines derived and delivered by plant cells have been shown toovercome this problem through the protective effect of the plantcell wall.
Like liposome and microcapsules, the plant cell wall allowsgradual release of the antigen onto the vast surface area of the
lower digestive tract. Further problems may be associated with poor immunogenicity or
the induction of tolerance.
Binding to a targeting molecule or carrier peptide, such as HbsAg,has been shown to overcome poor immunogenicity of orallydelivered subunit vaccines.
A unique opportunity against the threat of bio-weapons:
A number of infectious diseases, including smallpox, anthrax andplague have recently raised concern for their possible use inactions of bio-terrorism.
Nations at risk are now faced with the need to be ready tovaccinate part or all of their population within limited periods oftime.
This means that millions of vaccine doses have to be prepared,
stored and renewed at intervals of time. The economic and technical benefits offered by plant-derived
vaccines propose these vaccines as ideal substitutes fortraditional vaccines.
Research on plants that produce antigens against major pathogensfeared in case of bio-terrorism is already under way.
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Dosage:To explain the concept of oral therauptic protein delivery,
hepatitis B surface antigen(HBsAg) was used for oralimmunisation. No primary immune response was detected aftertwo 300microgram doses of yeast derived HBsAg. However aprimary response began after two servings of transgenic potatoescontaining, 85-300microgram of HBsAg.
Side effects:
A research by National Institute Of Allergy & Infectious Diseases(NIAID), National Institutes of Health (NIH) and University of
Maryland School Of Medicine showed no significant side effects.
Limitations:
Development of immune tolerance to vaccine peptide or protein
Consistency of dosage form fruit to fruit, plant to plant , and from
generation to generation is not similar Stability of vaccine in fruit is not known
Selection of best plant is difficult
Certain foods like potato are not eaten raw, and cooking the food
might weaken the medicine present in it.
Anurag Chanda
Student, GNIPST
B.Pharm, 4thYear
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DISEASE RELATED BREAKING NEWS
Human infection with avian influenza A (H7N9)
virus: (4thSeptember, 2014)On 2 September 2014, the National Health and Family Planning
Commission of China notified WHO of 2 additional laboratory-
confirmed cases of human infection with avian influenza A(H7N9)
virus.Read more
UPCOMING EVENTS
5thInternational Conference on Stem Cells and Cancer 2014, JNU
Convention Centre, New Delhi, India from 8-10 November, 2014
DRUGS UPDATES
FDA Approves Keytruda (pembrolizumab) for
Advanced Melanoma:(4thSeptember, 2014)The U.S. Food and Drug Administration granted accelerated
approval toKeytruda (pembrolizumab) for treatment of patients
with advanced or unresectable melanoma who are no longer
responding to other drugs.Read more
CAMPUS NEWS
Today, on 5th September, 2014 the students of GNIPST havearranged a wonderful Teachers Day Programme. On behalf of all
the teachers of GNIPST I would like to thank our beloved
students.
The Freshers welcome programme was held on 14thAugust, 2014.Welcome 1styear students.
We congratulate the following M.Pharm. final year students whohave made their positions in different pharmaceutical companies.
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http://www.who.int/csr/don/2014_09_04_avian_influenza/en/http://www.who.int/csr/don/2014_09_04_avian_influenza/en/http://d/Jeenat/Bulletin%2034.3_1/New%20Folder/UPCOMING%20EVENTS.docxhttp://www.drugs.com/keytruda.htmlhttp://www.drugs.com/newdrugs/fda-approves-keytruda-pembrolizumab-advanced-melanoma-4079.htmlhttp://www.drugs.com/newdrugs/fda-approves-keytruda-pembrolizumab-advanced-melanoma-4079.htmlhttp://www.drugs.com/newdrugs/fda-approves-keytruda-pembrolizumab-advanced-melanoma-4079.htmlhttp://www.drugs.com/newdrugs/fda-approves-keytruda-pembrolizumab-advanced-melanoma-4079.htmlhttp://www.drugs.com/keytruda.htmlhttp://d/Jeenat/Bulletin%2034.3_1/New%20Folder/UPCOMING%20EVENTS.docxhttp://www.who.int/csr/don/2014_09_04_avian_influenza/en/8/11/2019 GNIPST Bulletin 37.2
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Anirban Banerjee (Emami Ltd.)
Mahender Roy (Stadmed private Ltd.)
We congratulate the following B.Pharm. final year students for
their success.Samadrita Mukherjee (Abbott India Ltd.)
Suman Sarkar (Tata Medical Centre-Apollo Pharmacy)
Shrewashee Mukherjee (Fresenius Kabi-Parenteral Nutrition)
Avishek Naskar (Glaxo SmithKline-Marketing)
Bappaditya Manik (USV Limited)
Sarbani Das (Nutri Synapzz-Marketing)
Ankita Roy (Nutri Synapzz-Marketing)
Rahul Mitra (B M Pharmaceuticals-Production)
The following B.Pharm. final year students have qualified, GPAT-2014. We congratulate them all.
Utsha Sinha
Satarupa Bhattacharya
Sandipan Sarkar
Purbali Chakraborty
Reminiscence, 2014(GNIPST Reunion) was held in Collegecampus on 2ndFebruary,2014.
1st Annual Sports of GNIPST was held on 3rd February,2014 inCollege campus ground.
An industrial tour and biodiversity tour was conducted in Sikkimfor B.Pharm and B.Sc. students under the supervision of Mr. Asis
Bala, Ms. Jeentara Begum and Ms. Moumita Chowdhury.
B.Pharm 3rd year won the GNIPST Football Champions trophy,2013. B.Pharm 3rdyear won the final match 1-0 against B.Pharm 2nd
year. Deep Chakrabortywas the only scorer of the final.
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STUDENTS SECTION
WHO CAN ANSWER FIRST????
Which day is celebrated as World
Teachers Day?
From which year teachers day is
celebrated in India?
Answer of Previous Issues Questions
A) DRDO
B) Afghanistan
Identify the person
Answer of Previous Issues Image
Richard Martin Willsttter
Send your thoughts/
Quiz/Puzzles/games/write-ups or any other
contributions for Students Section
answ ers of this Section at
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EDITORS NOTE
It is a great pleasure for me to publish the 2nd
issue of 37th
Volume
of GNIPST BULLETIN. All the followers of GNIPST BULLETIN
are able to avail the bulletin through facebook account GNIPSTbulletin I am very much thankful to all the GNIPST members and
readers who are giving their valuable comments, encouragements
and supports. I am also thankful to Dr. Abhijit Sengupta, Director
of GNIPST for his valuable advice and encouragement. Special
thanks to Dr. Prerona Saha, Mr. Debabrata Ghosh Dastidar
and Mr. Soumya Bhattacharya for their kind co-operation and
technical supports. Thank you Mr. Soumya Bhattacharyafor thequestionnaires of the student section. An important part of the
improvement of the bulletin is the contribution of the readers. You
are invited to send in your write ups, notes, critiques or any kind of
contribution for the forthcoming special and regular issue.
ARCHIVE
Students of GNIPST organized pre puja celebration programme,Saaranya on 7thOctober, 2013 in college Auditorium.
GNIPST organized a garment distribution programme on 28thSeptember, 2013 at Dakshineswar Kali Temple and Adyapith,
Kolkata. On this remarkable event about hundred people have
received garments. More than hundred students and most of the
faculties participated on that day with lot of enthusiasm.
GNIPST celebrated World Heart Day (29th September) andPharmacists Day (25thSeptember)on 25thand 26thSeptember,
2013 in GNIPST Auditorium. A seminar on Violence against
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recent development of Pharmacy, Genetics and Microbiology and
their correlation with Life Sciences. On the post lunch session,
Ms. Saini Setua and Ms. Sanchari Bhattacharjee explained the
recent development and career opportunities in Biotechnology
and Hospital Management. The programme was concluded with
valedictory session and certificate distribution.
About 50 Higher secondary school teachers from different
schools of Kolkata and North& South 24 Parganas district of
West Bengal participated in this programme. A good interactive
session between participants and speakers was observed in the
seminar. The seminar was a great success with the effort of
faculties, staffs and students of our Institute. It was a uniquediscussion platform for school teachers and professional of the
emerging and newer branches of Life Science.
The general body meeting of APTI, Bengal Branch has been
conducted at GNIPST on 15th June, 2012. The program started
with a nice presentation by Dr. Pulok Kr. Mukherjee, School of
Natural Products, JU on the skill to write a good manuscript for
publication in impact journals. It was followed by nearly two hourlong discussion among more than thirty participants on different
aspects of pharmacy education. Five nonmember participants
applied for membership on that very day.
GNIPST is now approved by AICTE and affiliated to WBUT for
conducting the two years post graduate course (M.Pharm)
in PHARMACOLOGY.The approved number of seat is 18.
The number of seats in B.Pharm. has been increased from 60 to
120.
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AICTE has sanctioned a release of grant under Research
Promotion Scheme (RPS) during the financial year 2012-13to
GNIPST as per the details below:
a. Beneficiary Institution:Guru Nanak Institution of PharmaceuticalScience & Technology.
b.Principal Investigator:Dr. LopamudraDutta.
c. Grant-in-aid sanctioned:Rs. 16,25000/- only
d.Approved duration: 3 years
e. Title of the project: Screening and identification of potential
medicinal plant of Purulia & Bankura districts of West Bengal
with respect to diseases such as diabetes, rheumatism, Jaundice,hypertension and developing biotechnological tools for enhancing
bioactive molecules in these plants.
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