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MESSAGE FROM GNIPSTGNIPST BULLETIN is the official publication of Guru Nanak
Institute of Pharmaceutical Science & Technology. All the
members of GNIPST are proud to publish the 25thVolume of
GNIPST BULLETIN. Over the last two years this bulletin
updating readers with different scientific, cultural or sports
activities and promoting knowledge of recent development in
Pharmaceutical and Biological Sciences. Students section is
informing readers about some curious facts of drug discovery,
science, sports and other relevant fields. We look forward to seeing
your submission and welcome comments and ideas you may have.
LETTER TO THE EDITOR.
NEWS UPDATE
World Environment Day,2013:THINK.EAT.SAVE
World Environment day is celebrated every year on 5th June to
aware people about their role on saving environment. The World
Environment Day celebration began in 1972 and has grown to
become one of the main vehicles through which the United
Nations stimulates worldwide awareness of the environment and
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encourages political attention and action. The theme for this years
World Environment Day is based on anti-food waste and food loss
campaign Think.Eat.Save. According to the UN Food andAgriculture Organization (FAO), every year 1.3 billion tonnes of
food is wasted. This is equivalent to the same amount produced in
the whole of sub-Saharan Africa. At the same time, 1 in every 7
people in the world go to bed hungry and more than 20,000
children under the age of 5 die daily from hunger. This years
theme inform us about our small initiative can reduces theenvironmental impact of forced food production and population
outburst.Read more
Protein drugsfrom bacteria(5th June, 2013)
Using the bacterium E. coli, researchers from the University's
Faculty of Engineering showed it was possible to vastly increase
the efficiency of the cells producing specifically modified proteins,
as well as improve its performance and stability.Read more
Alzheimer's disease Drugs Linked to Reduced
Risk of Heart Attacks(5th June, 2013)
Clinical trial shows that cholinesterase inhibitors (ChEIs), such as
donepezil, rivastigmine and galantamine, which are used for
treating mild to moderate Alzheimer's disease are linked to a
http://www.unep.org/wed/about/http://www.unep.org/wed/about/http://www.sciencedaily.com/releases/2013/06/130605104428.htmhttp://www.sciencedaily.com/releases/2013/06/130605104428.htmhttp://www.sciencedaily.com/releases/2013/06/130605104428.htmhttp://www.unep.org/wed/about/7/28/2019 Gnipst Bulletin 25.4
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reduced risk of heart attacks and death due to their beneficial
effect on the vagus nerve.Read more
PTSD patients also suffer from depression (4thJune, 2013)
About one of every two people diagnosed with posttraumatic
stress disorder (PTSD) also suffer symptoms of depression,
according to new research by Case Western Reserve University's
Department of Psychological Sciences.Read more
Genetic Editing Shows Promise in Duchenne
Muscular Dystrophy(4th June, 2013)
Using a novel genetic 'editing' technique, Duke University
biomedical engineers have been able to repair a defect responsible
for one of the most common inherited disorders, Duchenne
muscular dystrophy, in cell samples from Duchenne patients.
Read more
New treatment strategy for Neuroblastoma
(3rd
June, 2013)
A group of Swedish researcher have discovered asmall chemical
molecule that knock out MYCN protein are therefore a possible
http://www.sciencedaily.com/releases/2013/06/130605090257.htmhttp://www.sciencedaily.com/releases/2013/06/130605090257.htmhttp://www.sciencedaily.com/releases/2013/06/130604153515.htmhttp://www.sciencedaily.com/releases/2013/06/130604153515.htmhttp://www.sciencedaily.com/releases/2013/06/130604153946.htmhttp://www.sciencedaily.com/releases/2013/06/130604153946.htmhttp://www.sciencedaily.com/releases/2013/06/130604153946.htmhttp://www.sciencedaily.com/releases/2013/06/130604153515.htmhttp://www.sciencedaily.com/releases/2013/06/130605090257.htm7/28/2019 Gnipst Bulletin 25.4
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therapy option for children with neuroblastoma as well as for
other MYC-driven tumours.Read more
Statinassociatedmusculoskeletal disorder
(3rdJune, 2013)
Clinical trial reveals that Cholesterol lowering statin users are
more prone to musculoskeletal disorders.Read more
Smartphone can disrupt sleep(3rdJune, 2013)
Smartphones and tablets can disrupt our sleep. The bright light-
emitting diodes that allow the use of mobile devices in dimly lit
rooms can interfere with melatonin, a hormone that helps control
the natural sleep-wake cycle. A Mayo Clinic study suggests
dimming the smartphone or tablet brightness settings and holding
the device at least 14 inches from your face while using it willreduce its potential to interfere with melatonin and impede sleep.
Read more
New kind of antibiotic may be more effective
against Tuberculosis, Anthrax and other
diseases (3rdJune, 2013)
46 previously untested compound has shown potential activity to
disrupt the trans-translation process of different bacteria like
E.coli, Shigella, Bacillus anthracis andM. tuberculosis.Read more
http://www.sciencedaily.com/releases/2013/06/130603163753.htmhttp://www.sciencedaily.com/releases/2013/06/130603163753.htmhttp://www.sciencedaily.com/releases/2013/06/130603164145.htmhttp://www.sciencedaily.com/releases/2013/06/130603163610.htmhttp://www.sciencedaily.com/releases/2013/06/130603163610.htmhttp://www.sciencedaily.com/releases/2013/06/130603163809.htmhttp://www.sciencedaily.com/releases/2013/06/130603163809.htmhttp://www.sciencedaily.com/releases/2013/06/130603163809.htmhttp://www.sciencedaily.com/releases/2013/06/130603163610.htmhttp://www.sciencedaily.com/releases/2013/06/130603164145.htmhttp://www.sciencedaily.com/releases/2013/06/130603163753.htm7/28/2019 Gnipst Bulletin 25.4
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FDA recommends against prolonged use of
Magnesium Sulfate to stop pre-term labour dueto bone change in expossed baby Stem cell
injections improve(30thMay, 2013)
The U.S. Food and Drug Administration (FDA) is advising health
care professionals against using magnesium sulfate injection for
more than 5-7 days to stop pre-term labor in pregnant women.Administration of magnesium sulfate injection to pregnant women
longer than 5-7 days may lead to low calcium levels and bone
problems in the developing baby or fetus, including thin bones,
called osteopenia, and bone breaks.Read more
HEALTH AWARENESS
Climate Change and Human Health
Environment, human health and diseases form an essential triangle
for the survival of human race. Climate is an essential part of
environment and Changes in climate affect the average weather
conditions that we are accustomed to. The impacts of climate
change on health will depend on many factors. These factors
include age, sex, communities, geographical regions, length of
exposure to altered climate.
http://www.fda.gov/Drugs/DrugSafety/ucm353333.htm?source=govdeliveryhttp://www.fda.gov/Drugs/DrugSafety/ucm353333.htm?source=govdelivery7/28/2019 Gnipst Bulletin 25.4
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Heat waves impact:
Heat waves can lead to heat stroke and dehydration, and arethe most common cause of weather-related deaths. It has been
observed that Young children, older adults, people with medicalconditions, and the poor are more vulnerable than others to heat-related illness. Climate change will likely lead to more frequent,more severe, and longer heat waves in the summer , as well as lesssevere cold spells in the winter. The impacts of future heat wavescould be especially severe in large metropolitan areas. Forexample, in Los Angeles, annual heat-related deaths are projectedto increase two- to seven-fold by the end of the 21st century,depending on the future growth of greenhouse gas emissions.Heat
waves are also often accompanied by periods of stagnant air,leading to increases in air pollution and the associated healtheffects
Extreme weather event impact:
Extreme weather like drought, storm, tsunami, rainfall can
directly or indirectly affect the human health. These conditions
may: Reduce the availability of fresh food and water.
Interrupt communication, utility, and health care services,
specially observed after tsunami in Indian Ocean region.
Contribute to carbon monoxide poisoning from portable
electric generators used during and after storms.
Increase stomach and intestinal illness.
Contribute to mental health impacts such as depression and
post-traumatic stress disorder.
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Reduced air quality impact:
The quality of air in urban region of developing countries is not in
desired standard. Even despite significant improvements in U.S.
air quality since the 1970s, as of 2008 more than 126 million
Americans lived in counties that did not meet national air quality
standards. This can lead to several deadly diseases.
Increasing ozone impact:
Ground-level ozone can damage lung tissue and can reduce lungfunction and inflame airways. This can increase respiratorysymptoms and aggravate asthma or other lung diseases. It isespecially harmful to children, older adults, outdoor workers,and those with asthma and other chronic lung diseases.
Ozone exposure also has been associated with increasedsusceptibility to respiratory infections, medication use, doctorvisits, and emergency department visits and hospitaladmissions for individuals with lung disease. Some studies
suggest that ozone may increase the risk of prematuremortality, and possibly even the development of asthma.
Ground-level ozone is formed when certain air pollutants, suchas carbon monoxide, oxides of nitrogen (also called NOX), andvolatile organic compounds, are exposed to each other insunlight. Ground-level ozone is one of the pollutants in smog.
Because warm, stagnant air tends to increase the formation of
ozone, climate change is likely to increase levels of ground-level
ozone in already-polluted areas of the United States and increase
the number of days with poor air quality. If emissions of air
pollutants remain fixed at today's levels until 2050, warming from
climate change alone could increase the number of Red Ozone
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Alert Days (when the air is unhealthy for everyone) by 68% in the
50 largest eastern U.S. cities.
Changes in suspended Particulate Matter:
Inhaling fine particles can lead to a broad range of adverse health
effects, including premature mortality, aggravation of
cardiovascular and respiratory disease, development of chronic
lung disease, exacerbation of asthma, and decreased lung function
growth in children. Sources of fine particle pollution include
power plants, gasoline and diesel engines, wood combustion, high-temperature industrial processes such as smelters and steel mills,
and forest fires. Due to the variety of sources and components of
fine particulate matter, scientists do not yet know whether
climate change will increase or decrease particulate matter
concentrations. However Climate change will also affect
particulates through changes in wildfires, which are expected to
become more frequent and intense in a warmer climate.
Changes in Allergens:Climate change may affect allergies and respiratory health. it is
mainly due to increased spring pollen season, increased carbon
dioxide and temperature.
Food-borne Diseases:Higher air temperatures can increase cases of salmonella and other
bacteria-related food poisoning because bacteria grow more
rapidly in warm environments. These diseases can cause
gastrointestinal distress and, in severe cases, death.
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Flooding and heavy rainfall can cause overflows from sewage
treatment plants into fresh water sources. Overflows could
contaminate certain food crops with pathogen-containing feces.
Vector borne diseases:
Malaria is a classic example of vector borne disease, the intensity
of which hugely altered with climate changes. The malaria
modelling shows that small temperature increases can greatly
affect transmission potential. Globally, temperature increases of 2-
3C would increase the number of people who, in climatic terms,
are at risk of malaria by around 3-5%, i.e. several hundred million.
Further, the seasonal duration of malaria would increase in manycurrently endemic areas.
For better quality of health it is essential to save environment for
further abrupt change in the climate.
DISEASE OUTBREAK NEWS
Poliovirus detected from environmental samples
in Israel(3rdJune, 2013)
Wild poliovirus type 1 (WPV1) was isolated from sewage samples
collected on 9 April 2013 in Rahat, southern Israel. The virus has
been detected in sewage only; no case of paralytic polio has been
reported.Read more
http://www.who.int/csr/don/2013_06_03/en/index.htmlhttp://www.who.int/csr/don/2013_06_03/en/index.htmlhttp://www.who.int/csr/don/2013_06_03/en/index.htmlhttp://www.who.int/csr/don/2013_06_03/en/index.html7/28/2019 Gnipst Bulletin 25.4
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Middle East respiratory syndrome coronavirus
(MERS-CoV) (1st June, 2013)
The Ministry of Health in Italy, through the European Unions
Early Warning Response System, has notified WHO of a
laboratory-confirmed case with Middle East respiratory syndrome
coronavirus (MERS-CoV) in a resident in the country.Read more
FORTHCOMING EVENTS
Two short-term (2 weeks each) AICTE-sponsored refresher
courses on: Innovation and excellence in Pharmaceutical Sciences for
teaching staffs of the Indian Universities and colleges in QIP
Nodal Cell (Pharmacy), Department of Pharmaceutical
Technology, Jadavpur University, Kolkata-700 032 from 2ndJuly to
29th July,2013Read more
AICTE Sponsored Quality Improvement Program on Production
to Prescription - Opportunities for Innovation on MCOPS,
Manipal University from 1-13th July, 2013Read more
DRUGS UPDATES
FDA approves two drugs, companion diagnostic
test for advanced skin cancer(29 MAY 2013)
http://www.who.int/csr/don/2013_06_01_ncov/en/index.htmlhttp://www.who.int/csr/don/2013_06_01_ncov/en/index.htmlhttp://www.who.int/csr/don/2013_06_01_ncov/en/index.htmlhttp://www.jaduniv.edu.in/upload_files/asc_info/1368622884-1.pdfhttp://www.jaduniv.edu.in/upload_files/asc_info/1368622884-1.pdfhttp://www.manipal.edu/Institutions/Pharmacy/MCOPSManipal/Documents/events/QIP%20on%20Production%20to%20Prescription-%20Opportunities%20for%20Innovation.pdfhttp://www.manipal.edu/Institutions/Pharmacy/MCOPSManipal/Documents/events/QIP%20on%20Production%20to%20Prescription-%20Opportunities%20for%20Innovation.pdfhttp://www.manipal.edu/Institutions/Pharmacy/MCOPSManipal/Documents/events/QIP%20on%20Production%20to%20Prescription-%20Opportunities%20for%20Innovation.pdfhttp://www.manipal.edu/Institutions/Pharmacy/MCOPSManipal/Documents/events/QIP%20on%20Production%20to%20Prescription-%20Opportunities%20for%20Innovation.pdfhttp://www.jaduniv.edu.in/upload_files/asc_info/1368622884-1.pdfhttp://www.who.int/csr/don/2013_06_01_ncov/en/index.html7/28/2019 Gnipst Bulletin 25.4
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The U.S. FDAapproved approved two new drugs, Tafinlar
(dabrafenib) and Mekinist (trametinib), for patients with
advanced (metastatic) or unresectable (cannot be removed by
surgery) melanoma, the most dangerous type of skin cancer.Readmore
FDA clears first blood tracking device that uses
Radio Frequency Identification technology(28 MAY
2013)iTrace for Blood Centers, (Version 1.0.924.0), the first applicationto use Radio Frequency Identification (RFID) technology in blood
establishments to assist in enhancing blood safety by preventing
the release of unsuitable blood components, was cleared today by
the U.S. Food and Drug Administration.Read more.
CAMPUS NEWS
The following B.Pharm. final year students have qualified, GPAT-
2013. We congratulate them all.
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STUDENTS SECTION
WHO CAN ANSWER FIRST???
Name of which medical device is derived from the name of dentist Charles Stent?
Which drug was first synthesized by AlbertHofmann in 1938?
Answer of Previous Issue Question:A) Petridish B)Micropipette
Send yourthoughts/ Quiz/Puzzles/games/write-ups or any other contributions for Students Section
& answers of this Section [email protected]
mailto:[email protected]:[email protected]:[email protected]7/28/2019 Gnipst Bulletin 25.4
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EDITORS NOTE
I am honored to become the new editor of the official bulletin of our
prestigious institute and proud to publish the 4
th
issue of 25
th
VolumeofGNIPST BULLETIN. On behalf of the entire GNIPST members,
contributors and the valuable readers ofGNIPST BULLETIN I want
to thankMr. Debabrata Ghosh Dastidar who edited the bulletin last
one year with excellence.
GNIPST BULLETIN now connected globally through facebook
account GNIPST bulletin
I want to convey my thanks to all the GNIPST members and the
readers for their valuable comments, encouragement& supports.
I am thankful to Dr. Abhijit Sengupta, Director of GNIPST and
Prof. Dipankar Chakraborty, Registrar of GNIPST for their
valuable advice and encouragement. Special thanks toDr. Prerona
Saha and Mr. Debabrata Ghosh Dastidar for their kind co-
operation and technical supports.
An important part of the improvement of the bulletin is the
contribution of the readers. You are invited to send in your write ups,
notes, critiques or any kind of contribution for the forthcoming
special and regular issue
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ARCHIVE
The general body meeting of APTI, Bengal Branch has been
conducted at GNIPST on 15
th
June, 2012. The program startedwith a nice presentation by Dr. Pulok Kr. Mukherjee, School of
Natural Products, JU on the skill to write a good manuscript for
publication in impact journals. It was followed by nearly two hour
long discussion among more than thirty participants on different
aspects of pharmacy education. Five nonmember participants
applied for membership on that very day.
GNIPST is now approved by AICTE and affiliated to WBUT for
conducting the two years post graduate course (M.Pharm) in
PHARMACOLOGY. The approved number of seat is 18.
The number of seats in B.Pharm. has been increased from 60 to
120.
2nd World Congress on Ga-68 (Generators and Novel Radiopharmaceuticals),
Molecular Imaging (PET/CT), Targeted Radionuclide Therapy, and
Dosimetry (SWC-2013) : On the Way to Personalized Medicine
Dates 28 Feb 2013
02 Mar 2013Location: Chandigarh, India.Details.
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AICTE has sanctioned a release of grant under Research
Promotion Scheme (RPS) during the financial year 2012-
13to GNIPST as per the details below:
a. Beneficiary Institution: Guru Nanak Institution of
Pharmaceutical Science & Technology.
b. Principal Investigator: Dr. Lopamudra Dutta.
c. Grant-in-aid sanctioned :Rs. 16,25000/- only
d.Approved duration: 3 years
e. Title of the project: Screening and identification ofpotential medicinal plant ofPurulia& Bankura districts of West
Bengal with respect to diseases such as diabetes, rheumatism,
Jaundice, hypertension and developing biotechnological tools for
enhancing bioactive molecules in these plants.