07/05/2018
1
CURRICULUM VITAE
Name: Yu-Long Li, M.D. Ph.D.
Campus Address: DRC-I 6047, Department of Emergency Medicine, University of Nebraska Medical Center,
Omaha, NE 68198-5850, USA
Phone: 1-402-559-3016
Fax: 1-402-559-9659 or 402-559-4438
E-mail: [email protected]
EDUCATIONS:
09/1991 - 06/1994 Ph.D. Cardiovascular Physiology, Hebei Medical University, China
08/1984 - 07/1987 M.S. Cardiovascular Pharmacology, Hebei Medical University, Hebei, China
09/1979 - 07/1984 M.D. Clinical Medicine, Hebei Medical University, Hebei, China
EMPLOYMENTS:
07/2018 - present Professor, Department of Emergency Medicine, University of Nebraska Medical Center,
Omaha, NE, USA
07/2018 - present Courtesy Professor, Department of Cellular & Integrative Physiology, University of
Nebraska Medical Center, Omaha, NE, USA
07/2011 - 06/2018 Associate Professor, Department of Emergency Medicine, University of Nebraska
Medical Center, Omaha, NE, USA
07/2011 - 06/2018 Courtesy Associate Professor, Department of Cellular & Integrative Physiology,
University of Nebraska Medical Center, Omaha, NE, USA
07/2007 - 06/2011 Assistant Professor, Department of Emergency Medicine, University of Nebraska
Medical Center, Omaha, NE, USA
07/2007 - 06/2011 Courtesy Assistant Professor, Department of Cellular & Integrative Physiology,
University of Nebraska Medical Center, Omaha, NE, USA
01/2007 - 06/2007 Research Assistant Professor, Department of Cellular & Integrative Physiology,
University of Nebraska Medical Center, Omaha, NE, USA
07/2004 - 12/2006 Instructor, Department of Cellular & Integrative Physiology, University of Nebraska
Medical Center, Omaha, NE, USA
01/2003 - 06/2004 Research Associate, Department of Physiology & Biophysics, University of Nebraska
Medical Center, Omaha, NE, USA
01/2002 - 12/2002 Postdoctoral Research Associate, Department of Physiology & Biophysics, University
of Nebraska Medical Center, Omaha, NE, USA
GRANTS:
Current
07/05/2018
2
1. NIH/NHLBI, 1R01HL144146-01 (PI, Yulong Li). Potential therapies to improve ventricular vagal
function in type 2 diabetes. 07/01/2018 to 06/30/2023. Role: PI.
2. NIH/NHLBI, 1R01HL137832-01 (PI, Yulong Li). Mechanisms of cardiac sympathetic hyperactivity in
chronic heart failure. 07/01/2017 to 06/30/2022. Role: PI.
3. USAMRAA grant from Department of Defense, W81XWH-17-1-0037 (PI, Yulong Li). Optimized
liposomal dexamethasone therapy improves functional outcome of post-traumatic skeletal muscle and
neuromuscular junction. 03/01/2017-02/28/2020. Role: PI.
4. NIH/NIDDK, 1R01DK114663-01 (PI, KP Patel and H Zheng). Novel target mechanism (renal
denervation) to reduce sodium retention in chronic heart failure. 08/15/2017-04/30/2022. Role:
Co-investigator.
5. NIH/NHLBI, 1R43HL137545-01 (PI, EC Unger and TR Porter). Dodecafluoropentane prevents
ischemia reperfusion injury in contemporary acute myocardial infarction management.
04/01/2017-09/30/2018. Role: Co-investigator.
Previous
1. NIH/NHLBI, R01HL116608-01A1 (PI, IH Zucker). Molecular and cellular determinants of the
exercise pressor reflex in CHF. 08/01/2013 to 06/30/2018. Role: Co-Investigator.
2. Grant-in-Aid from American Heart Association, 15GRANT24970002 (PI, Yulong Li). Role of
ventricular vagal dysfunction in ventricular arrhythmogenesis in heart failure. 07/01/2015-06/30/2017.
Role: PI.
3. NIH/NHLBI, R01HL098503-01A1 (PI, Yulong Li). Dysfunction of baroreceptor neurons in heart
failure: cellular and molecular mechanisms. 07/01/2010 to 06/30/2015. Role: PI.
4. National Institutes of Health; NIH - PPG grant. Project II (PI, PK Patel). The role of excitatory input
into the PVN on increased sympathetic drive in heart failure. 07/01/2009 to 6/30/2014. Role:
Co-Investigator.
5. Nebraska Bankers Association Equipment Grant (PI, Yulong Li). Optimize limb salvage in battlefield
medicine with tourniquet. 06/01/2012-05/31/2013. Role: PI.
6. Scientist Development Grant from American Heart Association, 0730108N (PI, Yulong Li). Blunted
excitability of baroreceptor neurons in diabetes: role of HCN channels and potential signaling
pathways. 01/01/2007-12/31/2010. Role: PI.
7. Nebraska Redox Biology Center, 3P20RR017675 (PI, HD Schultz). O2 sensing in the carotid body: in
search of membrane hemoproteic sensor that modulates K+ channel function. 03/01/2004 to
02/28/2007, Role: Co-Investigator.
TEACHING EXPERIENCE:
08/1987 - 07/1989 Assistant, Department of Pharmacology, Hebei Medical University, Hebei, China. Course
taught: Medical Pharmacology and Pharmacological Lab for Medical Students
07/1989 - 08/1991 Lecturer, Department of Pharmacology, Hebei Medical University, Hebei, China. Course
taught: Medical Pharmacology and Pharmacological Lab for Medical Students
07/05/2018
3
07/1994 - 12/1995 Associate Professor, Department of Physiology, Hebei Medical University, Hebei, China.
Course taught: Medical Physiology for Medical Students and Advanced Cardiovascular
Physiology for Graduate Student
02/2004 - 12/2010 Course 253-provided lectures to undergraduate students on respiratory physiology,
University of Nebraska Medical Center, NE, USA
02/2011 - 12/2016 Course 353-respiratory physiology, University of Nebraska Medical Center, NE
09/2011 - CIP 916 (Advanced Cardiovascular Physiology) for Ph.D. students
Primary advisor for Ph.D graduate student: 01/2018 - present Junliang Qian to pursue his Ph.D. student. Graduate Student Supervisory Committees: 09/2010 - 11/2013 Doctoral dissertation committee for Jianxun Xia (Department of Pharmacology &
Experimental Neuroscience, Mentor: Huangui, Xiong). 02/2013 - 12/2014 M.S. advisory committee for Mina E. Hanna (Department of Cellular &
Integrative Physiology). 05/2016 - present Doctoral dissertation committee for Gang Zhao (Department of Pharmaceutical
Sciences, Mentor: Dong Wang).
Junior Faculties:
Dongze Zhang Instructor (01/2017-present)
Huiyin Tu Instructor (01/2017-present)
Medical Residents:
Ryan Corrick 05/2016 - 06/2017
Mesloh Miranda 07/2017 -
Postdoctoral Fellows & Research Associate:
Huiyin Tu 2008-2013 (now professor in Department of Physiology, Zhengzhou University,
China)
Libin Zhang 2008-2010 (now associate professor in Department of Physiology, Xinxiang Medical
College, China)
Jinxu Liu 2010-2015
Dongze Zhang 2011-2016
Huiyin Tu 2016-2016
Liang Cao 2016-2017
Medical Student Fellows:
Chad Agnew (2007)
Peilin (Max) Song (2014)
Chaojun Wang (2016-2017)
Undergraduate Students:
Chad Agnew (2005, 2006)
07/05/2018
4
Katie Langenfeld (2007)
Richard Akromis (2007)
Elizabeth Spartz (2011)
Christen Badee (2013)
HONOR AND AWARD:
1990 Award of Scientific and Technological Contribution, Health Department of Hebei Province, China.
1991 Award of Scientific and Technological Contribution, Health Department of Hebei Province, China.
1995 Outstanding Youth Award, Shijiazhuang, Hebei, China.
1995 Young Physiologist Award, Chinese Physiological Society.
1997 Award of Scientific and Technological Contribution, Hebei Provincial Government, China.
2008 Neural Control and Autonomic Regulation Section Research Recognition Award, American
Physiological Society.
2011 New Investigator Award, University of Nebraska Medical Center.
ASSOCIATION:
2002- present Member, American Physiological Society
2002- present Member, Nebraska Physiological Society
2008- present Member, American Heart Association
CONSULTING POSITIONS
Reviewer for journals:
1993 - 1995 Acta Pharmacologica Sinica
2001 - present Cardiovascular Research
2005 - present Am J Physiol-Cell Physiol
2005 - present Am J Physiol-Heart Physiol
2006 - present Hypertension
2008 - present Int J Biomed Sci
2009 - present Am J Physiol-Regu Phsyiol
2010 - present Eur J Pharmacol
2010 - present J Neurophysiol
2010 - present Clin Exp Pharmacol Physiol
2010 - present J Diabetes & Metabolism
2011 - present Pflug Arch - Eur J Physiol
2012 - present Mol Neurodegner
2012 - present Plos ONE
2012 - present Clin Pharmacol Curr Res
2012 - present J Vasc Res
07/05/2018
5
2012 - present CNS Neurosci Ther
2013 - present Cardiovasc Diabetol
2013 - present J Appl Physiol
2013 - present Acta Physiologica
2014 - present Cell Mol Neurobiol
2014 - present Life Science
2014 - present J Clin Invest
2014 - present Am J Hypert
2015 - present Neuropharmacol
2015 - present Oxid Med Cell Longev
2017 - present Auton Neurosci
2017 - present J Renin Angiotensin Aldosterone Syst
Editorial boards:
2010 - present J Diabetes & Metabolism
2013 - present Eur J Pharmacol
2014 - present World J Cardiol
2015 - present Associate Editor, Section of Autonomic Neuroscience, Frontiers in Neuroscience, Frontiers in
Neurology, and Frontiers in Physiology (3 Journals)
2017 - Guest Editor in Special Issue on neural mechanisms of autonomic dysfunction in neurological
diseases, Neural Plasticity
2018 - Guest Editor in Special Issue on regulation of autonomic nervous system, Neuroscience Bulletin
Member of review committees:
Nebraska Cardiovascular Research Symposium (UNMC, 2006)
Reviewer for UNMC graduate student’s fellowship (UNMC, 2011)
Reviewer for UNMC graduate student’s fellowship (UNMC, 2015)
Reviewer for UNMC graduate student’s fellowship (UNMC, 2017)
Reviewer for UNMC graduate student’s fellowship (UNMC, 2018)
Ad hoc reviewer, NIH, ESTA study section (2016/02)
Ad hoc reviewer, Al Jalila Foundation (2017/06)
PUBLICATIONS:
Original papers
1. Li YL, Fu SX, Li YS. Prophylactic effects of m-nisoldipine and nisoldipine on reperfusion arrhythmia in
hearts of rats. Acta Pharmacol Sin 1988; 9: 542-547.
2. Li YL, Fu SX, Li YS. Prophylactic effects of m-nisoldipine and nisoldipine on reperfusion arrhythmias
exacerbated by free radical generating system in Langendorff heart of rat. Acta Pharmacol Sin 1989;
07/05/2018
6
10: 310-315.
3. Li YL, Fu SX, Li YS. Influences of perfusate ion concentration on reperfusion arrhythmias in
Langendorff heart of rats. Chin Pharmacol Bull 1989; 5: 95-97.
4. Li YL, Fu SX, Li YS. Investigation on experimental model of reperfusion arrhythmias in rats. Chin J
Pharmacol Toxicol 1990; 4: 159-160.
5. Li YL, He RR. Hemodynamic effects of adenosine and its analogue 2-chloroadenosine in anesthetized
rats. Chin J Physiol Sci 1993; 9: 31-43.
6. Li YL, He RR. Electrophysiological effects of N6-cyclopentyladenosine and
[-]-N6-phenylisopropyladenosine on pacemaker cells in sinoatrial node of guinea pigs. Acta Pharmacol
Sin 1993; 14: 414-417.
7. Li YL, He RR. Effects of 8-phenyltheophylline and glibenclamide on cardiovascular responses to
adenosine and [-]-N6(phenylisopropyl)-adenosine in anesthetized rats. Chin J Physiol Sci 1994; 10:
97-104.
8. Wu HY, Li YL. Recording and application of action potential in sino-atrial node of guinea-pigs. J Hebei
Medical University (Acta Acad Med Hebei) 1994; 15: 167-168.
9. Li YL, He RR. Endogenous adenosine and ATP-sensitive potassium channel modulate anoxia-induced
electrophysiological changes of pacemaker cells in sinoatrial node of guinea pigs. Acta Pharmacol Sin
1995; 16: 42-46.
10. Li YL, He RR. Effects of N6-cyclopentyladenosine on afterdepolarizations and triggered activity induced
by isoproterenol in guinea pig papillary muscle. Acta Pharmacol Sin 1995; 16: 163-168.
11. Li YL, He RR. Protective effect of preconditioning on ischemic heart and characterization of adenosine
receptors in ischemic rabbit hearts. Acta Pharmacol Sin 1995; 16: 505-508.
12. Wei YJ, Tian Q, Li QH, Li YL, Chang JK, Tang J, Ho SY. Hemodynamic effects of centrally
administered adrenomedullin (13-52) in anesthetized rats. Biological Signals 1995; 4: 338-344.
13. Zhang Z, Li YL, Ho SY. Effects of endothelin on the electrical activity of sino-atrial pacemaker cells of
rabbit. Acta Physiol Sin 1996; 48: 53-58.
14. Zhang Z, Sun GQ, Li YL, He RR. Endothelin and ATP-sensitive potassium channel mediate
electrophysiological changes induced by hypoxia in rabbit sinoatrial node. Acta Physiol Sin 1996; 48:
235-42.
15. Ding YF, Li YL, Ho SY. Ischemic preconditioning and exogenous L-arginine reduce infarct size in rabbit
heart. Acta Physiol Sin 1996; 48: 564-70.
16. Zhang Z, Li YL, He RR. Effects of endothelin on electrophysiological and contractile activity of guinea
pig papillary muscles. Chin J Physiol Sci 1996; 12: 129-134.
17. Zhang Z, Li YL, He RR. Effects of endothelin on electrophysiological and contractile activity of guinea
pig papillary muscles. Acta Physiol Sin 1997; 49: 146-52.
18. Peng YX, Ma SP, Li YL, Yang LM. Changes of -adrenoreceptors in peripheral lymphocytes in patients
with essential hypertension. Chin J Hypertension 1998; 6: 39-41.
19. Peng YX, Ma SP, Li YL, Yang LM, Li CY. Regulative characteristics of -adrenoreceptor subtypal
07/05/2018
7
function in patients with essential hypertension by chronic -selective antagonist. Chin J Cardiol 1998;
26: 337-339.
20. Peng YX, Ma SP, Li YL, Yang LM. Changes of left ventricular mass and beta-adrenoreceptors of
peripheral lymphocytes in patients with hypertension. Chin J Pathophysiol 1998; 14: 771-773.
21. Peng YX, Ma SP, Li YL, Yang LM, Bian SH, Zhang SJ. Changes of -adrenoreceptors in peripheral
lymphocytes at different stages of essential hypertension and their clinical significance. Chin J Cardiol
1999; 27: 48-50.
22. Peng YX, Ma SP, Li YL, Yang LM. Correlative study on left ventricular mass and -adrenoreceptor
density of peripheral lymphocytes in patients with essential hypertension. Med J Chin People’s
Liberation Army 1999; 24: 33-34.
23. Li YL, Sato T, Arita M. Bepridil blunts the shortening of action potential duration caused by metabolic
inhibition via blockade of ATP-sensitive K+ channels and Na+-activated K+ channels. J Pharmacol Exp
Ther 1999; 292: 562-68.
24. Peng YX, Ma SP, Zhang SJ, Li YL, Yang LM. Selective -adrenoreceptor blocker blunts the sensitivity
of -adrenoreceptor in patients with hypertension. Chin J Hypertension 2000; 8: 131-133.
25. Zhu Z, Li YL, Li DP, He RR. Effect of anoxic preconditioning on ATP- sensitive Potassium channels in
guinea-pig ventricular myocytes. Pflugers Archiv 2000; 439: 808-13.
26. Ito K, Shigematsu S, Sato T, Abe T, Li YL, Arita M. JTV-519, a novel cardioprotective agent, improves
the contractile recovery after ischemia-reperfusion in coronary perfused guinea-pig ventricular muscles.
Br J Pharmacol 2000; 130: 767-76.
27. Peng YX, Ma SP, Zhang SJ, Li YL, Yang LM, Bian SH. Clinical significance of changes in
beta-adrenoreceptors in peripheral lymphocytes in patients with essential hypertension. Chin Med J
2000; 113: 1064-67.
28. Peng YX, Xue H, Ma SP, Li YL, Yang LM. Regulating characteristics of selective -adrenoreceptor
blocker on the function of -adrenoreceptor subtype in patients with essential hypertension. Chin Med J
2001; 114: 62-66.
29. Peng YX, Xue H, Ma SP, Li YL, Yang LM. Regulatory characteristics of -adrenoreceptor subtype
function in patients with essential hypertension and given a chronic 1-selective blocker. Chin Med J
2001; 114: 117-125.
30. Li YL, Sato T. Dual signaling via protein kinase C and phosphatidylinositol-3’-kinase contributes to
bradykinin B2 receptor-induced cardioprotection in guinea-pig hearts. J Mol Cell Cardiol 2001; 33:
2047-53.
31. Li YL, Sun SY, Overholt JJ, Prabhakar NR, Rozanski GJ, Zucker IH, Schultz HD. Attenuated outward
potassium currents in carotid body glomus cells of heart failure rabbit: involvement of nitric oxide. J
Physiol 2004; 555: 219-229.
32. Sato T, Li YL, Saito T, Nakaya H. Minoxidil opens mitochondrial KATP channels and confers
cardioprotection. Br J Pharmacol 2004; 141: 360-366 (Featured in comment, Br J Pharmacol
141:197-198; 2004).
07/05/2018
8
33. Gao L, Wang W, Li YL, Schultz HD, Liu D, Cornish KG, Zucker IH. Superoxide mediates
sympathoexcitation in heart failure: roles of angiotensin II and NAD(P)H oxidase. Circ Res 2004; 95(9):
937-44.
34. Gao L, Wang W, Li YL, Schultz HD, Liu D, Cornish KG, Zucker IH. Sympatho-excitation by central
Ang II: The roles for AT1 receptor upregulation and NAD(P)H oxidase in the RVLM. Am J Physiol
Heart Circ Physiol. 2005; 288: H2271-H2279.
35. Li YL, Li YF, Liu DM, Cornish KG, Patel KP, Zucker IH, Channon KM, Schultz HD. Gene transfer of
neuronal nitric oxide synthase to carotid body reverses enhanced chemoreceptor function in heart failure
rabbits. Circ Res 2005; 97(3): 260-267 (Featured in editorial, Circ Res 97: 201-203; 2005).
36. Gao L, Wang W, Li Y L, Schultz HD, Liu D, Cornish KG, Zucker IH. Simvastatin therapy normalizes
sympathetic neural control in experimental heart failure: the roles of AT1 receptors and NAD(P)H oxidase.
Circulation 2005; 112: 1763-1770.
37. Takebayashi S, Li YL, Kaku T, Inagaki S, Hashimoto Y, Kimura K, Miyamoto S, Hadama, T, Ono K.
Remodeling excitation-contraction coupling of hypertrophied ventricular myocytes is dependent on
T-type calcium channels expression. Biochem Biophys Res Commun 2006; 345: 766-773.
38. Li YL, Xia XH, Zheng H, Gao L, Li YF, Liu D, Patel KP, Wang W, Schultz HD. Angiotensin II enhances
carotid body chemoreflex control of sympathetic outflow in chronic heart failure rabbits. Cardiovasc Res
2006; 71: 129-138.
39. Li YL, Schultz HD. Enhanced sensitivity of Kv channels to hypoxia in the carotid body in heart failure:
role of angiotensin II. J Physiol 2006; 575: 215-227 (Featured in perspectives, J Physiol 575: 4; 2006).
40. Gao L, Pan YX, Wang W, Li YL, Schulz HD, Zucker IH, Wang W. Cardiac Sympathetic Afferent
Stimulation Augments the Arterial Chemoreceptor Reflex in Anesthetized Rats. J Appl Physiol. 2007;
102: 37-43.
41. Li S, Li X, Li YL, Shao CH, Bidasee KR, Rozanski GJ. Insulin regulation of glutathione and contractile
phenotype in diabetic rat ventricular myocytes. Am J Physiol Heart Circ Physiol 2007; 292: 1619-1629.
42. Li YL, Gao L, Zucker IH, Schultz HD. NADPH oxidase-derived superoxide mediates angiotensin
II-enhanced carotid body chemoreceptor sensitivity in heart failure rabbits. Cardiovasc Res 2007; 75:
646-554.
43. Ding YF, Li YL, Schultz HD. Downregulation of carbon monoxide as well as nitric oxide contributes to
peripheral chemoreflex hypersensitivity in chronic heart failure rabbits. J Appl Physiol 2008; 105: 14-23
(Featured in editorial, J Appl Physiol 105:1-2; 2008).
44. Li YL, Tran TP, Muelleman R, Schultz HD. Blunted excitability of aortic baroreceptor neurons in
diabetic rats: involvement of hyperpolarization-activated channels. Cardiovasc Res 2008; 79: 715-721.
45. Li YL, Ding Y, Agnew C, Schultz HD. Exercise training improves peripheral chemoreflex function in
chronic heart failure rabbits. J Appl Physiol 2008; 105: 782-790 (Featured in editorial, J Appl Physiol
105:779-781; 2008).
46. Xiong W, Mactaggart J, Knispel R, Worth J, Zhu Z, Li YL, Sun Y, Baxter BT, Johanning J. Inhibition of
reactive oxygen species attenuates aneurysm formation in a murine model. Atherosclerosis 2009; 202:
07/05/2018
9
128-134.
47. Ding Y, Li YL, Zimmerman MC, Davisson RL, Schultz HD. Role of CuZn-superoxide dismutase on
carotid body function in heart failure rabbits. Cardiovasc Res 2009; 81: 678-685 (Featured in editorial,
Cardiovasc Res 81: 633-634; 2009).
48. Tu H, Zhang L, Tran TP, Muelleman RL, Li YL. Diabetes alters protein expression of
hyperpolarization-activated cyclic nucleotide-gated channel subunits in rat nodose ganglion cells.
Neuroscience 2010; 165: 39-52.
49. Zhang L, Tu H, Li YL. Angiotensin II enhances hyperpolarization-activated currents in rat aortic
baroreceptor neurons: involvement of superoxide. Am J Physiol Cell Physiol 2010; 298: C98-C106.
50. Ding Y, Li YL, Zimmerman MC, Schultz HD. Elevated mitochondrial superoxide contributes to enhanced
chemoreflex in heart failure rabbits. Am J Physiol Regul Integr Comp Physiol 2010; 298: R303-R311
(Article commentary in editorial focus, Am J Physiol Regul Integr Comp Physiol 2010, 298: R301-R302).
51. Gao L, Li YL, Schultz HD, Wang WZ, Wang W, Finch M, Smith L, Zucker IH. Down regulated Kv4.3
expression in the RVLM as a potential mechanism of sympatho-excitation in chronic heart failure rats. Am
J Physiol Heart Circ Physiol 2010; 298: H945-H955.
52. Marcus N, Li YL, Bird C, Schultz HD, Morgan B. Chronic intermittent hypoxia augments chemoreflex
control of sympathetic activity: role of the angiotensin II type 1 receptor. Resp Physiol Neurobi 2010; 171:
36-45.
53. Yin JX, Yang RF, Li S, Renshaw A, Li YL, Schultz HD, Zimmerman MC. Mitochondria-produced
superoxide mediates angiotensin II-induced inhibition of neuronal potassium current. Am J Physiol Cell
Physiol 2010; 298: C857-C865.
54. Li YL, Zheng H, Ding Y, Schultz HD. Expression of neuronal nitric oxide synthase in rabbit carotid body
glomus cells regulates Ca++ dependent potassium currents. J Neurophysiol 2010; 103: 3027-3033.
55. Tu H, Zhang L, Tran TP, Muelleman RL, Li YL. Reduced expression and activation of voltage-gated
sodium channels contributes to blunted baroreflex sensitivity in heart failure rats. J Neurosci Res 2010; 88:
3337-3349.
56. Wang HJ, Li YL, Gao L, Zucker IH, Wang W. Alteration in skeletal muscle afferents in rats with
chronic heart failure. J Physiol 2010; 588: 5033-5047.
57. Tran TP, Tu H, Pipinos II, Muelleman RL, Albadawi H, Li YL. Tourniquet-induced acute
ischemia-reperfusion injury in mouse skeletal muscles: involvement of superoxide. Eur J Pharmacol
2011; 650: 328-334. PMID: 21036124
58. Yang RF, Yin JX, Li YL, Zimmerman MC, Schultz HD. Angiotensin-(1-7) increases neuronal
potassium current via a nitric oxide-dependent mechanism. Am J Physiol Cell Physiol 2011; 300:
C58-64.
59. Ding YF, Li YL, Schultz HD. Role of blood flow in carotid body chemoreflex function in heart failure. J
Physiol 2011; 589: 245-258.
07/05/2018
10
60. Wang HJ, Li YL, Zhang LB, Zucker IH, Gao L, Zimmerman MC, Wang W. Endogenous reactive oxygen
species modulates voltage-gated sodium channels in dorsal root ganglia of rats. J Appl Physiol 2011; 110:
1439-1447.
61. Li YL. Elevated angiotensin II in rat nodose ganglia primes diabetes-blunted arterial baroreflex
sensitivity: involvement of NADPH oxidase-derived superoxide. J Diabetes & Metabolism 2011; 2(6):
135 (1-5). pii: 1000135. PMID: 22308229
62. Li YL, Zheng H. Angiotensin II-NADPH oxidase-derived superoxide mediates diabetes-attenuated cell
excitability of aortic baroreceptor neurons. Am J Physiol Cell Physiol 2011; 301: C1368-1377. PMID:
21940665
63. Tu H, Liu J, Zhu Z, Pipinos II, Li YL. Mitochondria-derived superoxide and voltage-gated sodium
channels in baroreceptor neurons from chronic heart failure rats. J Neurophysiol 2012; 107: 591-602.
PMID: 22072507
64. Liu J, Zhang L, Tu H, Li YL. Angiotensin II induces protein overexpression of
hyperpolarization-activated cyclic nucleotide-gated channels in primary cultured nodose neurons.
Neurosci Lett 2012; 515: 168-173. PMID: 22465246
65. Liu J, Tu H, Zheng H, Zhang L, Tran TP, Muelleman RL, Li YL. Alterations of calcium channels and cell
excitability in intracardiac ganglion neurons from type 2 diabetic rats. Am J Physiol Cell Physiol 2012;
302: C1119-C1127. PMID: 22189553
66. Wang HJ, Li YL, Zucker IH, Wang W. Exercise training reverses skeletal muscle afferent sensitization in
rats with chronic heart failure. Am J Physiol Regul Integr Comp Physiol 2012; 302: R1260-R1270. PMID:
22496362
67. Liu J, Tu H, Zhang D, Li YL. Changes of calcium channel mRNA, protein and current in NG108-15 cells
after cell differentiation. Biochem Biophys Res Commun 2012; 423: 55-59. PMID: 22627136
68. Marcus NJ, Philippi NR, Bird CE, Li YL, Schultz HD, Morgan BJ. Effect of AT1 receptor blockade on
intermittent hypoxia-induced endothelial dysfunction. Respir Physiol Neurobiol 2012; 183: 67-74. PMID:
22728949
69. Tran TP, Tu H, Liu J, Muelleman RL, Li YL. Mitochondria-derived superoxide links to
tourniquet-induced apoptosis in mouse skeletal muscle. PLoS One 2012; 7: e43410. PMID: 22912870
70. Liu J, Tu H, Zhang D, Zheng H, Li YL. Voltage-gated sodium channel expression and action potential
generation in differentiated NG108-15 cells. BMC Neurosci 2012; 13: 129. PMID: 23095258
71. Tu H, Liu J, Zhang D, Zheng H, Patel KP, Cornish KG, Wang WZ, Muelleman RL, Li YL. Heart
failure-induced changes of voltage-gated Ca++ channels and cell excitability in rat cardiac postganglionic
neurons. Am J Physiol Cell Physiol 2014; 306: C132-C142. PMID: 24025863 (Topic of an Editorial
Focus, Am J Physiol Cell Physiol, 2014: 306: C121-C122).
72. Zhang D, Liu J, Tu H, Muelleman RL, Cornish KG, Li YL. In vivo transfection of manganese superoxide
dismutase gene of nuclear factor κB shRNA in nodose ganglia improves aortic baroreceptor function in
heart failure rats. Hypertension 2014; 63: 88-95. PMID: 24101667
07/05/2018
11
73. Zheng H, Liu X, Li YL, Mishra PK, Patel KP. Attenuated Dopaminergic Tone in the Paraventricular
Nucleus Contributing to Sympatho-Excitation in Rats with Type 2 Diabetes. Am J Physiol Regul Integr
Comp Physiol 2014; 306: R138-R148. PMID: 24305061
74. Zhang D, Liu J, Zheng H, Tu H, Muelleman RL, Li YL. Effect of angiotension II on voltage-gated sodium
currents in aortic baroreceptor neurons and arterial baroreflex sensitivity in heart failure rats. J Hypertens
2015; 33: 1401-1410. PMID:25827427, PMCID: PMC4702522
75. Tian C, Li Y, Huang Y, Wang Y, Chen D, Liu J, Deng X, Sun L, Anderson K, Qi X, Li YL, Mosley RL,
Chen X, Huang J, Zheng JC. Selective generation of dopaminergic precursors from mouse fibroblasts by
direct lineage conversion. Sci Rep 2015; 5: 12622. PMID: 26224135, PMCID: PMC4519786
76. Liu J, Zhang D, Tu H, Muelleman RL, Wang WZ, Li YL. Nicotinic acetylcholine receptors and cardiac
vagal activity in rats with type 2 diabetes. J Diabetes & Metabolism 2015; S13: 012.
77. Zheng H, Liu X, Sharma NM, Li YL, Pliquett R, Patel KP. Urinary proteolytic activation of renal
epithelial Na+ channel in chronic heart failure. Hypertension 2016; 67: 197-205. PMID: 26628676,
PMCID: PMC4679598.
78. Li YL, Zhang D, Tu H, Muelleman RL. Altered ENaC is associated with aortic baroreceptor dysfunction
in chronic heart failure. Am J Hypertens 2016; 29: 582-9. PMID: 26297031.
79. Zhang D, Wang D, Pipinos II, Muelleman RL, Li YL. Dexamethasone promotes long-term functional
recovery of neuromuscular junction in a murine model of tourniquet-induced ischemia-reperfusion. Acta
Physiol (Oxf) 2017; 219: 453-464. PMID: 27306588 (Topic of an Editorial Focus. Acta Physiol (Oxf),
2017; 219: 343-345).
80. Tu H, Zhang D, Corrick RM, Muelleman RL, Wadman MC, Li YL. Morphological regeneration and
functional recovery of neuromuscular junctions after tourniquet-induced injuries in mouse hindlimb. Front
Physiol 2017; 8: 207. PMID: 28428759, PMCID: PMC5382216.
81. Zhang D, Tu H, Wang C, Cao L, Muelleman RL, Wadman MC, Li YL. Correlation of ventricular
arrhythmogenesis with neuronal remodeling of cardiac postganglionic parasympathetic neurons in the late
stage of heart failure after myocardial infarction. Front Neurosci 2017; 11: 252. PMID: 28533740,
PMCID: PMC5420597.
82. Zheng H, Liu X, Li YL, Patel KP. A hypothalamic leptin-glutamate interaction in the regulation of
sympathetic nerve activity. Neural Plast 2017; 2017: 2361675. PMID: 28845307, PMCID: PMC5560058.
83. Li DP, Li YL, Li J, Wang S. Neural mechanisms of autonomic dysfunction in neurological diseases.
Neural Plast 2017; 2017: 2050191. PMID: 29445550, PMCID: PMC5763130.
84. Zhang D, Tu H, Cao L, Zheng H, Muelleman RL, Wadman MC, Li YL. Reduced N-type Ca++ channels in
atrioventricular ganglion neurons are involved in ventricular arrhythmogenesis. J Am Heart Assoc 2018; 7:
e007457. PMID: 29335317, PMCID: PMC5850164.
85. Corrick RM, Tu, H, Zhang D, Muelleman RL, Wadman MC, Li YL. Dexamethasone protect against
tourniquet-induced acute ischemia-reperfusion injury in mouse hindlimb. Front Physiol 2018; 9: 244.
PMID: 29615933, PMCID: PMC5870039.
Review papers and Books
07/05/2018
12
1. Li YL, Fu SX, Li YS. Free radicals and reperfusion arrhythmia. Chin Pharmacol Bull 1988; 4:
135-139.
2. Li YL. Cardiovascular Drugs. Complete Collection of Chinese Pharmaceutics. 1990; chapter 23~27:
367-443. People’s Medicine and Health Press (Chief Editor: Hu XM).
3. Li YL, He RR. Role of ATP sensitive K(+)- channels in cardiovascular system. Progress Physiol Sci
1994; 25: 212-216.
4. Li YL. Cardiovascular effects and underlying mechanisms of adenosine and its analogues. Progress
Physiol Sci 1996; 27: 238-40.
5. Ding YF, Li YL, Ho SY. Role of adenosine on ischemic preconditioning-induced cardioprotection. J
Hebei Medical University (Acta Acad Med Hebei) 1996; 17(1): 11-14.
6. Ding YF, Li YL, Ho SY. NO and Ischemic preconditioning. J Hebei Medical University (Acta Acad
Med Hebei) 1997; 18: 1-6.
7. Schultz HD, Li YL. Carotid body function in heart failure. Resp Physiol Neurobi 2007; 157; 171-185.
8. Schultz HD, Li YL, Ding YF. Arterial chemoreceptors and sympathetic function: Implications for
hypertension and heart failure. Hypertension 2007; 50: 6-13 (Figure from paper chosen for cover).
9. Li YL. Cardiovascular autonomic dysfunction in diabetes as a complication: cellular and molecular
mechanisms. In: Type I Diabetes Complications. Wagner D (Ed.). Intech Press, Rijeka, Dec. 2011, pp.
167-194.
10. Li YL. Angiotensin II-superoxide signaling and arterial baroreceptor function in type-1 diabetes
mellitus. J Diabetes & Metabolism 2013; S12: 1-6. PMID: 24567847, PMCID: PMC3932051.
11. Li YL. Single-cell neuronal dissociation for electrophysiological studies. In: Current Laboratory
Methods in Neuroscience Research. Xiong H and Gendelman HE (Eds.). Springer, New York, 2014, pp.
105-113.
12. Zhang D, Muelleman RL, Li YL. Angiotensin II-superoxide-NFkB sigmaling and aortic baroreceptor
dysfunction in chronic heart failure. Front Neurosci 2015; 9: 382. PMID: 26528122, PMCID:
PMC4607814.
13. Zhang D, Tu H, Wadman MC, LI YL. Substrates and potential therapeutics of ventricular arrhythmias
in heart failure. Eur J Pharmacol 2018; 833: 349-356. PMID: 29940156.
14. Tu H, Zhang D, Li YL. Cellular and molecular mechanisms underlying arterial baroreceptor
remodeling in cardiovascular diseases and diabetes. Neurosci Bull 2018 (in press)
Abstracts
1. Ito K, Sato T, Abe T, Li YL, Arita M. Effects of JTV-519 on the ischemic-induced stunning of right
ventricular muscles of guinea pigs. Jpn Circ J 1998; 62(Suppl. I): 150.
2. Li YL, Sato T, Arita M. Protective effect of bepridil on shortening of action potential duration induced
by metabolic inhibition via blocking of ATP sensitive potassium channels and sodium activated
potassium channels. Japanese J Electrocardiol 1998; 18: 669.
3. Li YL, Sato T, Abe T, Arita M. Bradykinin protects the heart from ischemic myocardial stunning in
isolated guinea pig ventricular wall preparations. J Mol Cell Cardiol 1998; 30(11): A310.
07/05/2018
13
4. Ito K, Sato T, Abe T, Li YL, Arita M. Anti-stunning effects of JTV-519 in coronary perfused guinea pig
ventricular muscles. J Mol Cell Cardiol 1998; 30(11): A324.
5. Li YL, Sato T, Abe T, Arita M. Improving effects of bradykinin on ischemic-reperfusion injury in
isolated guinea pig ventricular wall preparations. J Jpn Physiol 2000; 62(4): 108.
6. Li YL, Sato T, Arita M. Bradykinin improves post-ischemic myocardial contractile recovery via
activation of mitochondrial KATP channels. J Mol Cell Cardiol 2000; 32(11): A96.
7. Kyosue T, Abe T, Li YL, Sato T, Arita M. Intracelllular Na+ accumulation in ventricular cells and the
opening of sodium activated potassium channels under metabolic inhibition. J Jpn Physiol 2001; 63(4):
150.
8. Li YL, Sato T. Bradykinin-induced cardioprotection is mediated by dual signaling via protein kinase C
and phosphatidylinositol-3’-kinase in guinea-pig hearts. Jpn Circ J 2001; 65(Suppl. I): 176.
9. Li YL, Sato T, Kyosue T, Ono K. Bradykinin but not adenosine triggered the cardioprotection of
ischemic preconditioning. J Jpn Physiol 2002; 64(4): 191.
10. Takebayashi S, Li YL, Ono K. Protein expression and function of T-type calcium channels in
monocrotaline-induced right heart failure of rats. J Jpn Physiol 2002; 64(4): 192.
11. Li YL, Sato T, Kyosue T, Ono K. Ischemic preconditioning was mediated by protein kinase C but not
phosphatidylinositol-3’-kinase in guinea-pig hearts. Jpn Circ J 2002; 66(Suppl. I): 696.
12. Takebayashi S, Li YL, Ono K. Contractility of hypertrophied right ventricle is dependent on the T-type
Ca++ channel. Japanese J Electrocardiol 2002; 22: 412.
13. Takebayashi S, Li YL, Kaku T, Ono K. Abnormal expression of T-Type Ca++ channel modulates
contractility in hypertrophied ventricular myocytes. J Mol Cell Cardiol 2002; 34(10): A24.
14. Takebayashi S, Li YL, Kaku T, Ono K. Ca++ influx and contraction in hypertrophied ventricular
myocytes aer dependent on the T-type Ca++ channel. Circulation 2002; 106 (19): II-227.
15. Li YL, Schultz HD. Blunted Ca2+-dependent potassium current in carotid body glomus cells of heart
failure rabbit: Involvement of nitric oxide. FASEB J 2003; 17 (4): A401.
16. Zeng YC, Li YL, Schultz HD. Oxidative stress and cardiac afferents in diabetes. FASEB J 2003; 17 (4):
A886.
17. Li YL, Xia XH, Li YF, Patel KP, Schultz HD. Upregulation of angiotensin II mediates the enhanced
peripheral chemoreceptor sensitivity in heart failure rabbits. Circulation 2003; 108 (17): IV-241.
18. Li YL, Li YF, Wang W, Cornish KG, Patel KP, Zucker IH, Schultz HD. Attenuation of chemoreceptor
sensitivity by transfection of Ad.nNOS in carotid body of heart failure rabbits. FASEB J 2004; 18:
A1277.
19. Li YL, Li YF, Wang W, Cornish KG, Patel KP, Zucker IH, Schultz HD. Effect of Ad.nNOS transfection
on outward potassium currents in carotid body glomus cells from heart failure rabbits. FASEB J 2004;
18: A1277.
20. Li YL, Gao L, Wang W, Zucker IH, Schultz HD. NADPH oxidase-derived superoxide anion mediates
the angiotensin II-enhanced peripheral chemoreceptor sensitivity in heart failure rabbits. Circulation
2004; 110(17): III-265.
07/05/2018
14
21. Li YL, Zheng H, Li YF, Patel KP, Schultz HD. Angiotensin II-superoxide signaling pathway potentiates
the sensitivity of outward K+ channels to hypoxia in carotid and NG108-15 cells. FASEB J 2005; 19(5):
A1291.
22. Li YL, Zheng H, Li YF, Patel KP, Schultz HD. Involvement of superoxide production on angiotensin
II-blunted outward K+ channels in NG108-15 cells. FASEB J 2005; 19(5): A1291.
23. Gao L, Wang W, Li YL, Schultz HD, Cornish KG, Zucker IH. Chronic central infusion of losartan
down-regulates the expression of AT1 receptor and NAD(P)H oxidase subunits in RVLM in rabbits
with heart failure. FASEB J 2005; 19 (5): A1291-A1292.
24. Gao L, Wang W, Li YL, Schultz HD, Cornish KG, Zucker IH. Simvastatin therapy normalizes
sympathetic neural control in experimental heart failure: The roles of AT1 receptors and NAD(P)H
oxidase. FASEB J 2005; 19 (5): A1292.
25. Li YL, Tek V, Kim H, Ragsdale SW, Schultz HD. Oxygen sensitivity of K+ channels in rat carotid body
type I cells: Involvement of cGMP in a hemoxygenase-carbon monoxide signaling pathway. Program
No. 636.8. 2005 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2005.
Online.
26. Li YL, Agnew C, Schultz HD. Endogenous nNOS and AT1 receptor do not mediate the enhanced
peripheral chemoreflex function in early stage of chronic heart failure rabbits. FASEB J 2006; 20(5):
A1203-A1204.
27. Ding YF, Li YL, Schultz HD. Downregulation of Carbon Monoxide as well as Nitric Oxide Contributes
to Peripheral Chemoreflex Hypersensitivity in Heart Failure Rabbits. FASEB J 2006; 20(5): LB35.
28. Gao L, Wang W, Mann E, Finch M, Li YL, Liu D, Schultz HD, Zucker IH. Sympathoexcitation in
chronic heart failure: Ang II induced inhibition of voltage-gated K+ channel, an in vivo and in vitro
study. FASEB J 2006; 20(5): A1202-A1203.
29. Wang WZ, Pan YX, Gao L, Zucker IH, Li YL, Schultz HD, Wang W. Activation of the cardiac
sympathetic afferent reflex enhances the neuronal chemosensitivity in the nucleus tractus solitarius in
rats with chronic heart failure. Circulation 2006; 114 (18): II-309.
30. Li YL, Schultz HD. Role of NADPH oxidase-derived superoxide anion on angiotensin II-enhanced
sensitivity of potassium channels to hypoxia in carotid body of congestive heart failure rabbits. FASEB J
2007; 21(5): 910.12.
31. Ding YF, Li YL, Cornish KG, Schultz HD. Reduced blood flow in carotid arteries is a trigger
contributing to peripheral chemoreflex hypersensitivity in chronic heart failure rabbits. FASEB J 2007;
21(5): 910.13.
32. Li YL, Ding YF, Agnew C, Schultz HD. Exercise training normalizes enhanced peripheral chemoreflex
function in chronic heart failure rabbits. FASEB J 2008; 22: 952.10.
33. Li YL, Tran TP, Muelleman R, Schultz HD. Hyperpolarization-activated cyclic nucleotide-gated
channels mediate blunted excitability of aortic baroreceptor neurons in diabetic rats. FASEB J 2008; 22:
1171.22.
34. Ding YF, Li YL, Davisson RL, Schultz HD. Gene Transfer of Cu-Zn Superoxide Dismutase to the
07/05/2018
15
Carotid Body Reverses Enhanced Chemoreceptor Function in Heart Failure Rabbits. FASEB J 2008; 22:
741.2.
35. Yin JX, Li YL, Xiao L, Schultz HD, Zimmerman MC. Cytoplasmic and mitochondrial-produced
superoxide mediates angiotensin II (AngII)-induced inhibition of K+ current in CATH.a neurons. FASEB
J 2008; 22: LB150.
36. Tran TP, Li YL, Ilir Frrokaj, Robert Muelleman, Pipinos II. Superoxide production and
mitochondiopathy in a murine model of acute hind limb ischemia reperfusion. Acad Emerg Med 2008;
15(S1): S26.
37. Dopp JM, Marcus NJ, Bird CB, Phillipi N, Moran JJM., Olson B, Schultz HD, Li YL, Morgan BJ.
Xanthine oxidase inhibition attenuates hypoxia-induced changes in chemoreceptor sensitization
pathways. American College of Clinical Pharmacy, Annual Meeting in Louisville, Oct 19-22, 2008.
38. Tran TP, Casale G, Li YL, Pipinos II. Mitochondrial manganese superoxide dismutase in a murine
model of acute hind limb ischemia reperfusion. Ann Emerg Med 2008; 52(4): S64-S64.
39. Li YL, Tran TP, Muelleman R, Schultz HD. Diabetes enhances activation of hyperpolarization-activated
cyclic nucleotide-gated channels in aortic baroreceptor neurons: involvement of angiotensin II. Ann
Emerg Med 2008; 52(4): S64-S65.
40. Renshaw AO, Yin JX, Li YL, Schultz HD, Zimmerman MC. Overexpression of mitochondria-targeted
superoxide dismutase modulates angiotensin II signaling in neurons. Hypertension 2008; 52(4): E120.
41. Li YL, Tran TP, Muelleman RL, Schultz HD. Elevated angiotensin II in rat nodose ganglia mediates
diabetes-blunted arterial baroreflex sensitivity. Circulation 2008; 118(18): S360.
42. Tu H, Li YL, Tran TP. A murine model of acute hindlimb ischemia/reperfusion injury. FASEB J 2009;
23: 763.1.
43. Zhang L, Tran TP, Muelleman RL, Li YL. Involvement of NADPH oxidase-derived superoxide anion in
diabetes-blunted aortic baroreceptor neuron excitability. FASEB J 2009; 23: 785.2.
44. Ding Y, Li YL, Yin J, Zimmerman MC, Schultz HD. Adenovirus-mediated gene transfer of Mn
Superoxide dismutase to carotid body normalizes enhanced chemoreceptor function in heart failure
rabbits. FASEB J 2009; 23: 957.2.
45. Marcus NJ, Li YL, Bird CB, Olson EB, Smith SS, Sorenson KI, Schultz HD, Morgan BJ. Chronic
intermittent hypoxia alters chemoreflex control of lumbar sympathetic nerve activity and carotid body
protein expression. FASEB J 2009; 23: 1008.1.
46. Yin J, Li YL, Ding Y, Schultz HD. Interplay of angiotensin 1-7 and angiotensin II in the regulation of
voltage-gated potassium current in the glomus cells of carotid body. FASEB J 2009; 23: 1009.12.
47. Tran P, Tu H, Muelleman R, Li YL. Function of electron transport chain of nodose ganglia is impaired
in heart failure. Acad Emerg Med 2009; 16 (S1): S118-119.
48. Tu H, Zhang L, Tran P, Muelleman R, Li YL. A novel approach to normalize the blunted baroreflex in
diabetes. Acad Emerg Med 2009; 16(S1): S119.
49. Tran TP, Tu H, Muelleman RL, Albadawi H, Pipinos II, Li YL. Tourniquet-induced acute
ischemia-reperfusion injury is associated with oxidative stress and mitochondrial dysfunction. Eur J
07/05/2018
16
Emerg Med 2009; 16: 291.
50. Tu H, Zhang L, Tran TP, Muelleman RL, Li YL. Lowered activation of voltage-gated sodium channels
contributes to blunted baroreflex sensitivity in heart failure rats. FASEB J 2010; 24: 1051.4.
51. Zhang L, Zheng H, Tu H, Tran TP, Muelleman RL, Zimmerman MC, Li YL. Elevated angiotensin II
attenuates activation of voltage-gated sodium channels in heart failure rats: involvement of
mitochondria-derived superoxide. FASEB J 2010; 24: 1018.5.
52. Yang RF, Yin JX, Li YL, Schultz HD, Zimmerman MC. Amgiotensin-(1-7) inhibirts angiotensin II
intra-neuronal signaling. FASEB J 2010; 24: 1051.12.
53. Yang RF, Yin JX, Li YL, Zimmerman MC, Schultz HD. Angiotensin-(1-7) increases neuronal
potassium current via a nitric oxide-dependent mechanism. FASEB J 2010; 24: 809.19.
54. Tang Y, Ding Y, Li YL, Schultz HD. Enhanced peripheral chemoreflex function in conscious rats with
ligation-induced heart failure. FASEB J 2010; 24: 1050.2.
55. Marcus NJ, Philippi NR, Bird CE, Schultz HD, Li YL, Morgan BJ. Effect of AT1 receptor blockade on
intermittent hypoxia-induced endothelial dysfunction. FASEB J 2010; 24: 1022.7.
56. Tu H, Pipinos II, Muelleman RL, Li YL, Tran TP. Ischemic injury is minimal compared to reperfusion
injury in critical limb syndrome. Acad Emerg Med 2010; 17 (S1): S115.
57. Tu H, Muelleman RL, Li YL, Tran TP. Salutatory effects of urocortin in acute limb ischemia. Ann Emerg
Med 2010; 56 (3): S30 (#89).
58. Schlessinger DI, Cloyd B, Maliszewski J, Huber A, Hernandez H, Keegan B, Sittler D, Thor C, Tu H, Li
YL, Tran TP. Urocortin as an early biomarker of myocardial ischemia for patients presenting to the
emergency department (ED) with angina. Great Plains Regional Society for Academic Emergency
Medicine meeting in Omaha, Sep 17, 2010.
59. Tu H, Tran TP, Muelleman RL, Li YL. Epithelial sodium channels contribute to the blunted sensitivity
of aortic baroreceptors in chronic heart failure rats. FASEB J 2011; 25: 646.9.
60. Liu J, Tu H, Zhang L,Tu H, Li YL. Angiotensin II increases protein expression of
hyperpolarization-activated channels in rat nodose ganglion neurons. FASEB J 2011; 25: 843.10.
61. Wang HJ, Li YL, Gao L, Zucker IH, Wang W. Alteration in skeletal muscle afferents in rats with
chronic heart failure. FASEB J 2011; 25: 1054.10.
62. Wang HJ, Li YL, Zucker IH, Wang W. Exercise training prevents the abnormal sensitization of skeletal
muscle afferents in chronic heart failure. Hypertension 2011; 58: E69.
63. Tu H, Liu J, Li YL. Role of nuclear factor-kappa B in mitochondria-derived superoxide-lowered protein
expression of voltage-gated sodium channels in nodose neurons from heart failure rats. FASEB J 2012;
26: 703.2.
64. Liu J, Tu H, Li YL. Blunted sensitivity of intracardiac ganglion neurons to nicotine in type-2 diabetic
rats. FASEB J 2012; 26: 1091.9.
65. Tu H, Liu J, Li YL. Activation of nuclear factor-kappa B lowers protein expression of voltage-gated
sodium channels in nodose neurons from heart failure rats. Physiologist 2012; 55: C-14.
66. Liu J, Tu H, Li YL. Response of intracardiac ganglion neurons to nicotine in type-2 diabetic rats.
07/05/2018
17
Physiologist 2012; 55: C23.
67. Li YL, Tu H, Liu J, Zhang D. Superoxide-NFkB signaling pathway lowers protein expression of
voltage-gated sodium channels in nodose neurons from heart failure rats. Acta Physiologica Sinica
2012; 64: 254.
68. Tu H, Liu J, Zhang D, Muelleman RL, Li YL. Involvement of nuclear factor-kappa B in
superoxide-lowered protein expression of voltage-gated sodium channels in nodose ganglia from heart
failure rats. FASEB J 2013; 27: 699.2.
69. Zhang D, Tu H, Liu J, Muelleman RL, Li YL. In-vivo transfection of manganese SOD gene and NFκB
shRNA into nodose ganglia improve blunted baroreflex sensitivity in chronic heart failure rats. FASEB J
2013; 27: 699.3.
70. Liu J, Tu H, Zhang D, Li YL. Alterations of calcium channels and cell excitability in intracardiac and
stellate ganglion neurons from chronic heart failure. FASEB J 2013; 27: 928.1.
71. Zheng H, Liu X, Li YL, Sharma NM, Patel KP. Enhanced levels of proteases in tubular fluid activate
ENaC in chronic heart failure. FASEB J 2013; 27: 698.2.
72. Tu H, Yuan F, Li YL, Wang D. Effective amelioration of tourniquet-induced acute ischemia-reperfusion
injury in mouse skeletal muscles using macromolecularized dexamethasone. American Association of
Pharmaceutical Scientists (AAPS) Annual Meeting 2013. San Antonio, Texas, November, 2013.
73. Zhang D, Yuan F, Tu H, Liu J, Wang D, Muelleman RL, Li YL. Anti-inflammatory effect of PEGylated
Dexamethasone liposome for tourniquet-induced acute ischemia-reperfusion injury in mouse skeletal
muscle. FASEB J 2014; 28: 1102.5.
74. Liu J, Zhang D, Zheng H, Muelleman RL, Li YL. Angiotensin II-induced inhibition of sodium currents
in aortic baroreceptor neurons mediates blunted arterial baroreflex sensitivity in heart failure rats.
FASEB J 2014; 28: 1169.3.
75. Zheng H, Liu X, Li YL, Patel KP. Enhanced leptin-TRPC signaling in the hypothalamus contributes to
the exaggerated sympatho-excitation in type 2 diabetic rats. FASEB J 2014; 28: 1130.9.
76. Li YL, Wang D, Zhang D, Yuan F, Tu H, Liu J, Muelleman RL. Effect of a novel anti-inflammatory
drug (dexamethasone liposome) on long-term recovery of ischemia/reperfusion-injured mouse skeletal
muscle. MHSRS symposium, August, 2014.
77. Li YL, Liu J, Zhang D, Tu H, Muelleman RL. Intracardiac ganglion neuron dysfunction in type 2
diabetes. FASEB J 2015; 29: 651.1
78. Li YL, Zhang D, Liu J, Wang D, Muelleman RL. Dexamethasone promotes neuromuscular recovery in
a murine model of tourniquet-induced ischemia/reperfusion. MHSRS symposium, August, 2015.
79. Zhang D, Wang D, Muelleman RL, Li YL. Dexamethasone promotes the long-term functional recovery
of neuromuscular junction after ischemia/reperfusion injury induced by tourniquet in mouse hindlimb.
FASEB J 2016; 30: 1245.1.
80. Zhang D, Tu H, Zheng H, Muelleman RL, Li YL. Reduced N-type Ca++ channels in ventricular vagal
neurons and ventricular arrhythmogenesis. Circulation 2016; 134 (Suppl 1): A11882.
81. Tu H, Zhang D, Corrick RM, Muelleman RL, Wadman MC, Li YL. Morphological regeneration and
07/05/2018
18
functional recovery of neuromuscular junctions after tourniquet-induced injuries in mouse hindlimb. FASEB
J 2017; 31: 1022.4.
82. Zhang D, Tu H, Wang C, Muelleman RL, Wadman MC, Li YL. Correlation of ventricular arrhythmogenesis
with neuronal remodeling in cardiac postganglionic parasympathetic neurons during the progression of heart
failure after myocardial infarction. FASEB J 2017; 31: 718.4.
83. Li YL, Corrick RM, Tu H, Zhang D, Muelleman RL, Wadman MC. Protective effect of dexamethasone
against tourniquet-induced acute ischemia-reperfusion injury in mouse hindlimb. MHSRS symposium,
August, 2017.
84. Zhang D, Tu H, Wang C, Muelleman RL, Wadman MC, Li YL. Overactivation of N-type Ca++ channels in
stellate ganglia and ventricular arrhythmogenesis in chronic heart failure. Circulation 2017; 135 (Suppl
1): A14004.
PRESENTATIONS
1. Blunted Ca2+-dependent potassium current in carotid body glomus cells of heart failure rabbit:
Involvement of nitric oxide. Experimental Biology 2003, San Diego, California, April, 2003
2. Upregulation of angiotensin II mediates the enhanced peripheral chemoreceptor sensitivity in heart failure
rabbits. American Heart Association Scientific Sessions 2003, Orlando, Florida, November, 2003
3. Attenuation of chemoreceptor sensitivity by transfection of Ad.nNOS in carotid body of heart failure
rabbits. Experimental Biology 2004, Washington, DC, April, 2004
4. NADPH oxidase-derived superoxide anion mediates the angiotensin II-enhanced peripheral
chemoreceptor sensitivity in heart failure rabbits. American Heart Association Scientific Sessions 2004,
New Orleans, Louisiana, November, 2004
5. Angiotensin II and chemoreflex in heart failure: role of carotid body--one of the angiotensin II-targeted
organs. Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, May,
2006
6. Postconditioning and ischemia-reperfusion injury: intracellular Ca2+, free radicals and mitochondrial
function. Department of Emergency Medicine, University of Nebraska Medical Center, March, 2008
7. Elevated angiotensin II in rat nodose ganglia mediates diabetes-blunted arterial baroreflex sensitivity.
American Heart Association Scientific Sessions 2008, New Orleans, Louisiana, November, 2008
8. Funny current and excitability of baroreceptor neurons in diabetes. Department of Cellular and
Integrative Physiology, University of Nebraska Medical Center, March, 2009
9. Oxygen reactive species, aortic baroreceptor, and baroreflex function in diabetes. Department of
Physiology, Second Military Medical University, Shanghai, China, October, 2010.
10. Response of intracardiac ganglion neurons to nicotine in type-2 diabetic rats. 2012 American
Physiological Society Conference: Autonomic regulation of cardiovascular function in health and disease,
Omaha, Nebraska, July, 2012
11. NFκB, a bridge between superoxide and Nav channels in aortic baroreceptor from heart failure.
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, September,
2012
07/05/2018
19
12. Superoxide-NFκB signaling pathway lowers protein expression of voltage-gated sodium channels in
nodose neurons from heart failure rats. International Conference of Physiological Science 2012, Suzhou,
China, November, 2012
13. Baroreceptor dysfunction and heart failure. College of Dentistry, University of Nebraska Medical Center,
March, 2014
14. Effect of a novel anti-inflammatory drug (dexamethasone liposome) on long-term recovery of
ischemia/reperfusion-injured mouse skeletal muscle. Military Health System Research Symposium
(MHSRS) 2014, Fort Lauderdale, Florida, August, 2014
15. Dexamethasone promotes neuromuscular recovery in a murine model of tourniquet-induced
ischemia/reperfusion. Military Health System Research Symposium (MHSRS) 2015, Fort Lauderdale,
Florida, August, 2015
16. Reduced N-type Ca++ channels in ventricular vagal neurons and ventricular arrhythmogenesis. American
Heart Association Scientific Sessions 2016, New Orleans, Louisiana, November, 2016
17. Protective effect of dexamethasone against tourniquet-induced acute ischemia-reperfusion injury in mouse
hindlimb. Military Health System Research Symposium (MHSRS), 2017, Kissimmee, Florida, August,
2017
18. Overactivation of N-type Ca++ channels in stellate ganglia and ventricular arrhythmogenesis in chronic
heart failure. American Heart Association Scientific Sessions 2017, Anaheim, California, November, 2017