CURRICULUM VITAE · 2020. 6. 15. · 07/05/2018 1 CURRICULUM VITAE Name: Yu -Long Li, M.D. Ph.D. Campus Address: DRC-I 6047, Department of Emergency Medicine, University of Nebraska

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CURRICULUM VITAE

Name: Yu-Long Li, M.D. Ph.D.

Campus Address: DRC-I 6047, Department of Emergency Medicine, University of Nebraska Medical Center,

Omaha, NE 68198-5850, USA

Phone: 1-402-559-3016

Fax: 1-402-559-9659 or 402-559-4438

E-mail: [email protected]

EDUCATIONS:

09/1991 - 06/1994 Ph.D. Cardiovascular Physiology, Hebei Medical University, China

08/1984 - 07/1987 M.S. Cardiovascular Pharmacology, Hebei Medical University, Hebei, China

09/1979 - 07/1984 M.D. Clinical Medicine, Hebei Medical University, Hebei, China

EMPLOYMENTS:

07/2018 - present Professor, Department of Emergency Medicine, University of Nebraska Medical Center,

Omaha, NE, USA

07/2018 - present Courtesy Professor, Department of Cellular & Integrative Physiology, University of

Nebraska Medical Center, Omaha, NE, USA

07/2011 - 06/2018 Associate Professor, Department of Emergency Medicine, University of Nebraska

Medical Center, Omaha, NE, USA

07/2011 - 06/2018 Courtesy Associate Professor, Department of Cellular & Integrative Physiology,

University of Nebraska Medical Center, Omaha, NE, USA

07/2007 - 06/2011 Assistant Professor, Department of Emergency Medicine, University of Nebraska

Medical Center, Omaha, NE, USA

07/2007 - 06/2011 Courtesy Assistant Professor, Department of Cellular & Integrative Physiology,

University of Nebraska Medical Center, Omaha, NE, USA

01/2007 - 06/2007 Research Assistant Professor, Department of Cellular & Integrative Physiology,

University of Nebraska Medical Center, Omaha, NE, USA

07/2004 - 12/2006 Instructor, Department of Cellular & Integrative Physiology, University of Nebraska

Medical Center, Omaha, NE, USA

01/2003 - 06/2004 Research Associate, Department of Physiology & Biophysics, University of Nebraska

Medical Center, Omaha, NE, USA

01/2002 - 12/2002 Postdoctoral Research Associate, Department of Physiology & Biophysics, University

of Nebraska Medical Center, Omaha, NE, USA

GRANTS:

Current

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1. NIH/NHLBI, 1R01HL144146-01 (PI, Yulong Li). Potential therapies to improve ventricular vagal

function in type 2 diabetes. 07/01/2018 to 06/30/2023. Role: PI.

2. NIH/NHLBI, 1R01HL137832-01 (PI, Yulong Li). Mechanisms of cardiac sympathetic hyperactivity in

chronic heart failure. 07/01/2017 to 06/30/2022. Role: PI.

3. USAMRAA grant from Department of Defense, W81XWH-17-1-0037 (PI, Yulong Li). Optimized

liposomal dexamethasone therapy improves functional outcome of post-traumatic skeletal muscle and

neuromuscular junction. 03/01/2017-02/28/2020. Role: PI.

4. NIH/NIDDK, 1R01DK114663-01 (PI, KP Patel and H Zheng). Novel target mechanism (renal

denervation) to reduce sodium retention in chronic heart failure. 08/15/2017-04/30/2022. Role:

Co-investigator.

5. NIH/NHLBI, 1R43HL137545-01 (PI, EC Unger and TR Porter). Dodecafluoropentane prevents

ischemia reperfusion injury in contemporary acute myocardial infarction management.

04/01/2017-09/30/2018. Role: Co-investigator.

Previous

1. NIH/NHLBI, R01HL116608-01A1 (PI, IH Zucker). Molecular and cellular determinants of the

exercise pressor reflex in CHF. 08/01/2013 to 06/30/2018. Role: Co-Investigator.

2. Grant-in-Aid from American Heart Association, 15GRANT24970002 (PI, Yulong Li). Role of

ventricular vagal dysfunction in ventricular arrhythmogenesis in heart failure. 07/01/2015-06/30/2017.

Role: PI.

3. NIH/NHLBI, R01HL098503-01A1 (PI, Yulong Li). Dysfunction of baroreceptor neurons in heart

failure: cellular and molecular mechanisms. 07/01/2010 to 06/30/2015. Role: PI.

4. National Institutes of Health; NIH - PPG grant. Project II (PI, PK Patel). The role of excitatory input

into the PVN on increased sympathetic drive in heart failure. 07/01/2009 to 6/30/2014. Role:

Co-Investigator.

5. Nebraska Bankers Association Equipment Grant (PI, Yulong Li). Optimize limb salvage in battlefield

medicine with tourniquet. 06/01/2012-05/31/2013. Role: PI.

6. Scientist Development Grant from American Heart Association, 0730108N (PI, Yulong Li). Blunted

excitability of baroreceptor neurons in diabetes: role of HCN channels and potential signaling

pathways. 01/01/2007-12/31/2010. Role: PI.

7. Nebraska Redox Biology Center, 3P20RR017675 (PI, HD Schultz). O2 sensing in the carotid body: in

search of membrane hemoproteic sensor that modulates K+ channel function. 03/01/2004 to

02/28/2007, Role: Co-Investigator.

TEACHING EXPERIENCE:

08/1987 - 07/1989 Assistant, Department of Pharmacology, Hebei Medical University, Hebei, China. Course

taught: Medical Pharmacology and Pharmacological Lab for Medical Students

07/1989 - 08/1991 Lecturer, Department of Pharmacology, Hebei Medical University, Hebei, China. Course

taught: Medical Pharmacology and Pharmacological Lab for Medical Students

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07/1994 - 12/1995 Associate Professor, Department of Physiology, Hebei Medical University, Hebei, China.

Course taught: Medical Physiology for Medical Students and Advanced Cardiovascular

Physiology for Graduate Student

02/2004 - 12/2010 Course 253-provided lectures to undergraduate students on respiratory physiology,

University of Nebraska Medical Center, NE, USA

02/2011 - 12/2016 Course 353-respiratory physiology, University of Nebraska Medical Center, NE

09/2011 - CIP 916 (Advanced Cardiovascular Physiology) for Ph.D. students

Primary advisor for Ph.D graduate student: 01/2018 - present Junliang Qian to pursue his Ph.D. student. Graduate Student Supervisory Committees: 09/2010 - 11/2013 Doctoral dissertation committee for Jianxun Xia (Department of Pharmacology &

Experimental Neuroscience, Mentor: Huangui, Xiong). 02/2013 - 12/2014 M.S. advisory committee for Mina E. Hanna (Department of Cellular &

Integrative Physiology). 05/2016 - present Doctoral dissertation committee for Gang Zhao (Department of Pharmaceutical

Sciences, Mentor: Dong Wang).

Junior Faculties:

Dongze Zhang Instructor (01/2017-present)

Huiyin Tu Instructor (01/2017-present)

Medical Residents:

Ryan Corrick 05/2016 - 06/2017

Mesloh Miranda 07/2017 -

Postdoctoral Fellows & Research Associate:

Huiyin Tu 2008-2013 (now professor in Department of Physiology, Zhengzhou University,

China)

Libin Zhang 2008-2010 (now associate professor in Department of Physiology, Xinxiang Medical

College, China)

Jinxu Liu 2010-2015

Dongze Zhang 2011-2016

Huiyin Tu 2016-2016

Liang Cao 2016-2017

Medical Student Fellows:

Chad Agnew (2007)

Peilin (Max) Song (2014)

Chaojun Wang (2016-2017)

Undergraduate Students:

Chad Agnew (2005, 2006)

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Katie Langenfeld (2007)

Richard Akromis (2007)

Elizabeth Spartz (2011)

Christen Badee (2013)

HONOR AND AWARD:

1990 Award of Scientific and Technological Contribution, Health Department of Hebei Province, China.

1991 Award of Scientific and Technological Contribution, Health Department of Hebei Province, China.

1995 Outstanding Youth Award, Shijiazhuang, Hebei, China.

1995 Young Physiologist Award, Chinese Physiological Society.

1997 Award of Scientific and Technological Contribution, Hebei Provincial Government, China.

2008 Neural Control and Autonomic Regulation Section Research Recognition Award, American

Physiological Society.

2011 New Investigator Award, University of Nebraska Medical Center.

ASSOCIATION:

2002- present Member, American Physiological Society

2002- present Member, Nebraska Physiological Society

2008- present Member, American Heart Association

CONSULTING POSITIONS

Reviewer for journals:

1993 - 1995 Acta Pharmacologica Sinica

2001 - present Cardiovascular Research

2005 - present Am J Physiol-Cell Physiol

2005 - present Am J Physiol-Heart Physiol

2006 - present Hypertension

2008 - present Int J Biomed Sci

2009 - present Am J Physiol-Regu Phsyiol

2010 - present Eur J Pharmacol

2010 - present J Neurophysiol

2010 - present Clin Exp Pharmacol Physiol

2010 - present J Diabetes & Metabolism

2011 - present Pflug Arch - Eur J Physiol

2012 - present Mol Neurodegner

2012 - present Plos ONE

2012 - present Clin Pharmacol Curr Res

2012 - present J Vasc Res

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2012 - present CNS Neurosci Ther

2013 - present Cardiovasc Diabetol

2013 - present J Appl Physiol

2013 - present Acta Physiologica

2014 - present Cell Mol Neurobiol

2014 - present Life Science

2014 - present J Clin Invest

2014 - present Am J Hypert

2015 - present Neuropharmacol

2015 - present Oxid Med Cell Longev

2017 - present Auton Neurosci

2017 - present J Renin Angiotensin Aldosterone Syst

Editorial boards:

2010 - present J Diabetes & Metabolism

2013 - present Eur J Pharmacol

2014 - present World J Cardiol

2015 - present Associate Editor, Section of Autonomic Neuroscience, Frontiers in Neuroscience, Frontiers in

Neurology, and Frontiers in Physiology (3 Journals)

2017 - Guest Editor in Special Issue on neural mechanisms of autonomic dysfunction in neurological

diseases, Neural Plasticity

2018 - Guest Editor in Special Issue on regulation of autonomic nervous system, Neuroscience Bulletin

Member of review committees:

Nebraska Cardiovascular Research Symposium (UNMC, 2006)

Reviewer for UNMC graduate student’s fellowship (UNMC, 2011)

Reviewer for UNMC graduate student’s fellowship (UNMC, 2015)

Reviewer for UNMC graduate student’s fellowship (UNMC, 2017)

Reviewer for UNMC graduate student’s fellowship (UNMC, 2018)

Ad hoc reviewer, NIH, ESTA study section (2016/02)

Ad hoc reviewer, Al Jalila Foundation (2017/06)

PUBLICATIONS:

Original papers

1. Li YL, Fu SX, Li YS. Prophylactic effects of m-nisoldipine and nisoldipine on reperfusion arrhythmia in

hearts of rats. Acta Pharmacol Sin 1988; 9: 542-547.

2. Li YL, Fu SX, Li YS. Prophylactic effects of m-nisoldipine and nisoldipine on reperfusion arrhythmias

exacerbated by free radical generating system in Langendorff heart of rat. Acta Pharmacol Sin 1989;

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10: 310-315.

3. Li YL, Fu SX, Li YS. Influences of perfusate ion concentration on reperfusion arrhythmias in

Langendorff heart of rats. Chin Pharmacol Bull 1989; 5: 95-97.

4. Li YL, Fu SX, Li YS. Investigation on experimental model of reperfusion arrhythmias in rats. Chin J

Pharmacol Toxicol 1990; 4: 159-160.

5. Li YL, He RR. Hemodynamic effects of adenosine and its analogue 2-chloroadenosine in anesthetized

rats. Chin J Physiol Sci 1993; 9: 31-43.

6. Li YL, He RR. Electrophysiological effects of N6-cyclopentyladenosine and

[-]-N6-phenylisopropyladenosine on pacemaker cells in sinoatrial node of guinea pigs. Acta Pharmacol

Sin 1993; 14: 414-417.

7. Li YL, He RR. Effects of 8-phenyltheophylline and glibenclamide on cardiovascular responses to

adenosine and [-]-N6(phenylisopropyl)-adenosine in anesthetized rats. Chin J Physiol Sci 1994; 10:

97-104.

8. Wu HY, Li YL. Recording and application of action potential in sino-atrial node of guinea-pigs. J Hebei

Medical University (Acta Acad Med Hebei) 1994; 15: 167-168.

9. Li YL, He RR. Endogenous adenosine and ATP-sensitive potassium channel modulate anoxia-induced

electrophysiological changes of pacemaker cells in sinoatrial node of guinea pigs. Acta Pharmacol Sin

1995; 16: 42-46.

10. Li YL, He RR. Effects of N6-cyclopentyladenosine on afterdepolarizations and triggered activity induced

by isoproterenol in guinea pig papillary muscle. Acta Pharmacol Sin 1995; 16: 163-168.

11. Li YL, He RR. Protective effect of preconditioning on ischemic heart and characterization of adenosine

receptors in ischemic rabbit hearts. Acta Pharmacol Sin 1995; 16: 505-508.

12. Wei YJ, Tian Q, Li QH, Li YL, Chang JK, Tang J, Ho SY. Hemodynamic effects of centrally

administered adrenomedullin (13-52) in anesthetized rats. Biological Signals 1995; 4: 338-344.

13. Zhang Z, Li YL, Ho SY. Effects of endothelin on the electrical activity of sino-atrial pacemaker cells of

rabbit. Acta Physiol Sin 1996; 48: 53-58.

14. Zhang Z, Sun GQ, Li YL, He RR. Endothelin and ATP-sensitive potassium channel mediate

electrophysiological changes induced by hypoxia in rabbit sinoatrial node. Acta Physiol Sin 1996; 48:

235-42.

15. Ding YF, Li YL, Ho SY. Ischemic preconditioning and exogenous L-arginine reduce infarct size in rabbit

heart. Acta Physiol Sin 1996; 48: 564-70.

16. Zhang Z, Li YL, He RR. Effects of endothelin on electrophysiological and contractile activity of guinea

pig papillary muscles. Chin J Physiol Sci 1996; 12: 129-134.

17. Zhang Z, Li YL, He RR. Effects of endothelin on electrophysiological and contractile activity of guinea

pig papillary muscles. Acta Physiol Sin 1997; 49: 146-52.

18. Peng YX, Ma SP, Li YL, Yang LM. Changes of -adrenoreceptors in peripheral lymphocytes in patients

with essential hypertension. Chin J Hypertension 1998; 6: 39-41.

19. Peng YX, Ma SP, Li YL, Yang LM, Li CY. Regulative characteristics of -adrenoreceptor subtypal

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function in patients with essential hypertension by chronic -selective antagonist. Chin J Cardiol 1998;

26: 337-339.

20. Peng YX, Ma SP, Li YL, Yang LM. Changes of left ventricular mass and beta-adrenoreceptors of

peripheral lymphocytes in patients with hypertension. Chin J Pathophysiol 1998; 14: 771-773.

21. Peng YX, Ma SP, Li YL, Yang LM, Bian SH, Zhang SJ. Changes of -adrenoreceptors in peripheral

lymphocytes at different stages of essential hypertension and their clinical significance. Chin J Cardiol

1999; 27: 48-50.

22. Peng YX, Ma SP, Li YL, Yang LM. Correlative study on left ventricular mass and -adrenoreceptor

density of peripheral lymphocytes in patients with essential hypertension. Med J Chin People’s

Liberation Army 1999; 24: 33-34.

23. Li YL, Sato T, Arita M. Bepridil blunts the shortening of action potential duration caused by metabolic

inhibition via blockade of ATP-sensitive K+ channels and Na+-activated K+ channels. J Pharmacol Exp

Ther 1999; 292: 562-68.

24. Peng YX, Ma SP, Zhang SJ, Li YL, Yang LM. Selective -adrenoreceptor blocker blunts the sensitivity

of -adrenoreceptor in patients with hypertension. Chin J Hypertension 2000; 8: 131-133.

25. Zhu Z, Li YL, Li DP, He RR. Effect of anoxic preconditioning on ATP- sensitive Potassium channels in

guinea-pig ventricular myocytes. Pflugers Archiv 2000; 439: 808-13.

26. Ito K, Shigematsu S, Sato T, Abe T, Li YL, Arita M. JTV-519, a novel cardioprotective agent, improves

the contractile recovery after ischemia-reperfusion in coronary perfused guinea-pig ventricular muscles.

Br J Pharmacol 2000; 130: 767-76.

27. Peng YX, Ma SP, Zhang SJ, Li YL, Yang LM, Bian SH. Clinical significance of changes in

beta-adrenoreceptors in peripheral lymphocytes in patients with essential hypertension. Chin Med J

2000; 113: 1064-67.

28. Peng YX, Xue H, Ma SP, Li YL, Yang LM. Regulating characteristics of selective -adrenoreceptor

blocker on the function of -adrenoreceptor subtype in patients with essential hypertension. Chin Med J

2001; 114: 62-66.

29. Peng YX, Xue H, Ma SP, Li YL, Yang LM. Regulatory characteristics of -adrenoreceptor subtype

function in patients with essential hypertension and given a chronic 1-selective blocker. Chin Med J

2001; 114: 117-125.

30. Li YL, Sato T. Dual signaling via protein kinase C and phosphatidylinositol-3’-kinase contributes to

bradykinin B2 receptor-induced cardioprotection in guinea-pig hearts. J Mol Cell Cardiol 2001; 33:

2047-53.

31. Li YL, Sun SY, Overholt JJ, Prabhakar NR, Rozanski GJ, Zucker IH, Schultz HD. Attenuated outward

potassium currents in carotid body glomus cells of heart failure rabbit: involvement of nitric oxide. J

Physiol 2004; 555: 219-229.

32. Sato T, Li YL, Saito T, Nakaya H. Minoxidil opens mitochondrial KATP channels and confers

cardioprotection. Br J Pharmacol 2004; 141: 360-366 (Featured in comment, Br J Pharmacol

141:197-198; 2004).

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33. Gao L, Wang W, Li YL, Schultz HD, Liu D, Cornish KG, Zucker IH. Superoxide mediates

sympathoexcitation in heart failure: roles of angiotensin II and NAD(P)H oxidase. Circ Res 2004; 95(9):

937-44.

34. Gao L, Wang W, Li YL, Schultz HD, Liu D, Cornish KG, Zucker IH. Sympatho-excitation by central

Ang II: The roles for AT1 receptor upregulation and NAD(P)H oxidase in the RVLM. Am J Physiol

Heart Circ Physiol. 2005; 288: H2271-H2279.

35. Li YL, Li YF, Liu DM, Cornish KG, Patel KP, Zucker IH, Channon KM, Schultz HD. Gene transfer of

neuronal nitric oxide synthase to carotid body reverses enhanced chemoreceptor function in heart failure

rabbits. Circ Res 2005; 97(3): 260-267 (Featured in editorial, Circ Res 97: 201-203; 2005).

36. Gao L, Wang W, Li Y L, Schultz HD, Liu D, Cornish KG, Zucker IH. Simvastatin therapy normalizes

sympathetic neural control in experimental heart failure: the roles of AT1 receptors and NAD(P)H oxidase.

Circulation 2005; 112: 1763-1770.

37. Takebayashi S, Li YL, Kaku T, Inagaki S, Hashimoto Y, Kimura K, Miyamoto S, Hadama, T, Ono K.

Remodeling excitation-contraction coupling of hypertrophied ventricular myocytes is dependent on

T-type calcium channels expression. Biochem Biophys Res Commun 2006; 345: 766-773.

38. Li YL, Xia XH, Zheng H, Gao L, Li YF, Liu D, Patel KP, Wang W, Schultz HD. Angiotensin II enhances

carotid body chemoreflex control of sympathetic outflow in chronic heart failure rabbits. Cardiovasc Res

2006; 71: 129-138.

39. Li YL, Schultz HD. Enhanced sensitivity of Kv channels to hypoxia in the carotid body in heart failure:

role of angiotensin II. J Physiol 2006; 575: 215-227 (Featured in perspectives, J Physiol 575: 4; 2006).

40. Gao L, Pan YX, Wang W, Li YL, Schulz HD, Zucker IH, Wang W. Cardiac Sympathetic Afferent

Stimulation Augments the Arterial Chemoreceptor Reflex in Anesthetized Rats. J Appl Physiol. 2007;

102: 37-43.

41. Li S, Li X, Li YL, Shao CH, Bidasee KR, Rozanski GJ. Insulin regulation of glutathione and contractile

phenotype in diabetic rat ventricular myocytes. Am J Physiol Heart Circ Physiol 2007; 292: 1619-1629.

42. Li YL, Gao L, Zucker IH, Schultz HD. NADPH oxidase-derived superoxide mediates angiotensin

II-enhanced carotid body chemoreceptor sensitivity in heart failure rabbits. Cardiovasc Res 2007; 75:

646-554.

43. Ding YF, Li YL, Schultz HD. Downregulation of carbon monoxide as well as nitric oxide contributes to

peripheral chemoreflex hypersensitivity in chronic heart failure rabbits. J Appl Physiol 2008; 105: 14-23

(Featured in editorial, J Appl Physiol 105:1-2; 2008).

44. Li YL, Tran TP, Muelleman R, Schultz HD. Blunted excitability of aortic baroreceptor neurons in

diabetic rats: involvement of hyperpolarization-activated channels. Cardiovasc Res 2008; 79: 715-721.

45. Li YL, Ding Y, Agnew C, Schultz HD. Exercise training improves peripheral chemoreflex function in

chronic heart failure rabbits. J Appl Physiol 2008; 105: 782-790 (Featured in editorial, J Appl Physiol

105:779-781; 2008).

46. Xiong W, Mactaggart J, Knispel R, Worth J, Zhu Z, Li YL, Sun Y, Baxter BT, Johanning J. Inhibition of

reactive oxygen species attenuates aneurysm formation in a murine model. Atherosclerosis 2009; 202:

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128-134.

47. Ding Y, Li YL, Zimmerman MC, Davisson RL, Schultz HD. Role of CuZn-superoxide dismutase on

carotid body function in heart failure rabbits. Cardiovasc Res 2009; 81: 678-685 (Featured in editorial,

Cardiovasc Res 81: 633-634; 2009).

48. Tu H, Zhang L, Tran TP, Muelleman RL, Li YL. Diabetes alters protein expression of

hyperpolarization-activated cyclic nucleotide-gated channel subunits in rat nodose ganglion cells.

Neuroscience 2010; 165: 39-52.

49. Zhang L, Tu H, Li YL. Angiotensin II enhances hyperpolarization-activated currents in rat aortic

baroreceptor neurons: involvement of superoxide. Am J Physiol Cell Physiol 2010; 298: C98-C106.

50. Ding Y, Li YL, Zimmerman MC, Schultz HD. Elevated mitochondrial superoxide contributes to enhanced

chemoreflex in heart failure rabbits. Am J Physiol Regul Integr Comp Physiol 2010; 298: R303-R311

(Article commentary in editorial focus, Am J Physiol Regul Integr Comp Physiol 2010, 298: R301-R302).

51. Gao L, Li YL, Schultz HD, Wang WZ, Wang W, Finch M, Smith L, Zucker IH. Down regulated Kv4.3

expression in the RVLM as a potential mechanism of sympatho-excitation in chronic heart failure rats. Am

J Physiol Heart Circ Physiol 2010; 298: H945-H955.

52. Marcus N, Li YL, Bird C, Schultz HD, Morgan B. Chronic intermittent hypoxia augments chemoreflex

control of sympathetic activity: role of the angiotensin II type 1 receptor. Resp Physiol Neurobi 2010; 171:

36-45.

53. Yin JX, Yang RF, Li S, Renshaw A, Li YL, Schultz HD, Zimmerman MC. Mitochondria-produced

superoxide mediates angiotensin II-induced inhibition of neuronal potassium current. Am J Physiol Cell

Physiol 2010; 298: C857-C865.

54. Li YL, Zheng H, Ding Y, Schultz HD. Expression of neuronal nitric oxide synthase in rabbit carotid body

glomus cells regulates Ca++ dependent potassium currents. J Neurophysiol 2010; 103: 3027-3033.

55. Tu H, Zhang L, Tran TP, Muelleman RL, Li YL. Reduced expression and activation of voltage-gated

sodium channels contributes to blunted baroreflex sensitivity in heart failure rats. J Neurosci Res 2010; 88:

3337-3349.

56. Wang HJ, Li YL, Gao L, Zucker IH, Wang W. Alteration in skeletal muscle afferents in rats with

chronic heart failure. J Physiol 2010; 588: 5033-5047.

57. Tran TP, Tu H, Pipinos II, Muelleman RL, Albadawi H, Li YL. Tourniquet-induced acute

ischemia-reperfusion injury in mouse skeletal muscles: involvement of superoxide. Eur J Pharmacol

2011; 650: 328-334. PMID: 21036124

58. Yang RF, Yin JX, Li YL, Zimmerman MC, Schultz HD. Angiotensin-(1-7) increases neuronal

potassium current via a nitric oxide-dependent mechanism. Am J Physiol Cell Physiol 2011; 300:

C58-64.

59. Ding YF, Li YL, Schultz HD. Role of blood flow in carotid body chemoreflex function in heart failure. J

Physiol 2011; 589: 245-258.

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60. Wang HJ, Li YL, Zhang LB, Zucker IH, Gao L, Zimmerman MC, Wang W. Endogenous reactive oxygen

species modulates voltage-gated sodium channels in dorsal root ganglia of rats. J Appl Physiol 2011; 110:

1439-1447.

61. Li YL. Elevated angiotensin II in rat nodose ganglia primes diabetes-blunted arterial baroreflex

sensitivity: involvement of NADPH oxidase-derived superoxide. J Diabetes & Metabolism 2011; 2(6):

135 (1-5). pii: 1000135. PMID: 22308229

62. Li YL, Zheng H. Angiotensin II-NADPH oxidase-derived superoxide mediates diabetes-attenuated cell

excitability of aortic baroreceptor neurons. Am J Physiol Cell Physiol 2011; 301: C1368-1377. PMID:

21940665

63. Tu H, Liu J, Zhu Z, Pipinos II, Li YL. Mitochondria-derived superoxide and voltage-gated sodium

channels in baroreceptor neurons from chronic heart failure rats. J Neurophysiol 2012; 107: 591-602.

PMID: 22072507

64. Liu J, Zhang L, Tu H, Li YL. Angiotensin II induces protein overexpression of

hyperpolarization-activated cyclic nucleotide-gated channels in primary cultured nodose neurons.

Neurosci Lett 2012; 515: 168-173. PMID: 22465246

65. Liu J, Tu H, Zheng H, Zhang L, Tran TP, Muelleman RL, Li YL. Alterations of calcium channels and cell

excitability in intracardiac ganglion neurons from type 2 diabetic rats. Am J Physiol Cell Physiol 2012;

302: C1119-C1127. PMID: 22189553

66. Wang HJ, Li YL, Zucker IH, Wang W. Exercise training reverses skeletal muscle afferent sensitization in

rats with chronic heart failure. Am J Physiol Regul Integr Comp Physiol 2012; 302: R1260-R1270. PMID:

22496362

67. Liu J, Tu H, Zhang D, Li YL. Changes of calcium channel mRNA, protein and current in NG108-15 cells

after cell differentiation. Biochem Biophys Res Commun 2012; 423: 55-59. PMID: 22627136

68. Marcus NJ, Philippi NR, Bird CE, Li YL, Schultz HD, Morgan BJ. Effect of AT1 receptor blockade on

intermittent hypoxia-induced endothelial dysfunction. Respir Physiol Neurobiol 2012; 183: 67-74. PMID:

22728949

69. Tran TP, Tu H, Liu J, Muelleman RL, Li YL. Mitochondria-derived superoxide links to

tourniquet-induced apoptosis in mouse skeletal muscle. PLoS One 2012; 7: e43410. PMID: 22912870

70. Liu J, Tu H, Zhang D, Zheng H, Li YL. Voltage-gated sodium channel expression and action potential

generation in differentiated NG108-15 cells. BMC Neurosci 2012; 13: 129. PMID: 23095258

71. Tu H, Liu J, Zhang D, Zheng H, Patel KP, Cornish KG, Wang WZ, Muelleman RL, Li YL. Heart

failure-induced changes of voltage-gated Ca++ channels and cell excitability in rat cardiac postganglionic

neurons. Am J Physiol Cell Physiol 2014; 306: C132-C142. PMID: 24025863 (Topic of an Editorial

Focus, Am J Physiol Cell Physiol, 2014: 306: C121-C122).

72. Zhang D, Liu J, Tu H, Muelleman RL, Cornish KG, Li YL. In vivo transfection of manganese superoxide

dismutase gene of nuclear factor κB shRNA in nodose ganglia improves aortic baroreceptor function in

heart failure rats. Hypertension 2014; 63: 88-95. PMID: 24101667

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73. Zheng H, Liu X, Li YL, Mishra PK, Patel KP. Attenuated Dopaminergic Tone in the Paraventricular

Nucleus Contributing to Sympatho-Excitation in Rats with Type 2 Diabetes. Am J Physiol Regul Integr

Comp Physiol 2014; 306: R138-R148. PMID: 24305061

74. Zhang D, Liu J, Zheng H, Tu H, Muelleman RL, Li YL. Effect of angiotension II on voltage-gated sodium

currents in aortic baroreceptor neurons and arterial baroreflex sensitivity in heart failure rats. J Hypertens

2015; 33: 1401-1410. PMID:25827427, PMCID: PMC4702522

75. Tian C, Li Y, Huang Y, Wang Y, Chen D, Liu J, Deng X, Sun L, Anderson K, Qi X, Li YL, Mosley RL,

Chen X, Huang J, Zheng JC. Selective generation of dopaminergic precursors from mouse fibroblasts by

direct lineage conversion. Sci Rep 2015; 5: 12622. PMID: 26224135, PMCID: PMC4519786

76. Liu J, Zhang D, Tu H, Muelleman RL, Wang WZ, Li YL. Nicotinic acetylcholine receptors and cardiac

vagal activity in rats with type 2 diabetes. J Diabetes & Metabolism 2015; S13: 012.

77. Zheng H, Liu X, Sharma NM, Li YL, Pliquett R, Patel KP. Urinary proteolytic activation of renal

epithelial Na+ channel in chronic heart failure. Hypertension 2016; 67: 197-205. PMID: 26628676,

PMCID: PMC4679598.

78. Li YL, Zhang D, Tu H, Muelleman RL. Altered ENaC is associated with aortic baroreceptor dysfunction

in chronic heart failure. Am J Hypertens 2016; 29: 582-9. PMID: 26297031.

79. Zhang D, Wang D, Pipinos II, Muelleman RL, Li YL. Dexamethasone promotes long-term functional

recovery of neuromuscular junction in a murine model of tourniquet-induced ischemia-reperfusion. Acta

Physiol (Oxf) 2017; 219: 453-464. PMID: 27306588 (Topic of an Editorial Focus. Acta Physiol (Oxf),

2017; 219: 343-345).

80. Tu H, Zhang D, Corrick RM, Muelleman RL, Wadman MC, Li YL. Morphological regeneration and

functional recovery of neuromuscular junctions after tourniquet-induced injuries in mouse hindlimb. Front

Physiol 2017; 8: 207. PMID: 28428759, PMCID: PMC5382216.

81. Zhang D, Tu H, Wang C, Cao L, Muelleman RL, Wadman MC, Li YL. Correlation of ventricular

arrhythmogenesis with neuronal remodeling of cardiac postganglionic parasympathetic neurons in the late

stage of heart failure after myocardial infarction. Front Neurosci 2017; 11: 252. PMID: 28533740,

PMCID: PMC5420597.

82. Zheng H, Liu X, Li YL, Patel KP. A hypothalamic leptin-glutamate interaction in the regulation of

sympathetic nerve activity. Neural Plast 2017; 2017: 2361675. PMID: 28845307, PMCID: PMC5560058.

83. Li DP, Li YL, Li J, Wang S. Neural mechanisms of autonomic dysfunction in neurological diseases.

Neural Plast 2017; 2017: 2050191. PMID: 29445550, PMCID: PMC5763130.

84. Zhang D, Tu H, Cao L, Zheng H, Muelleman RL, Wadman MC, Li YL. Reduced N-type Ca++ channels in

atrioventricular ganglion neurons are involved in ventricular arrhythmogenesis. J Am Heart Assoc 2018; 7:

e007457. PMID: 29335317, PMCID: PMC5850164.

85. Corrick RM, Tu, H, Zhang D, Muelleman RL, Wadman MC, Li YL. Dexamethasone protect against

tourniquet-induced acute ischemia-reperfusion injury in mouse hindlimb. Front Physiol 2018; 9: 244.

PMID: 29615933, PMCID: PMC5870039.

Review papers and Books

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1. Li YL, Fu SX, Li YS. Free radicals and reperfusion arrhythmia. Chin Pharmacol Bull 1988; 4:

135-139.

2. Li YL. Cardiovascular Drugs. Complete Collection of Chinese Pharmaceutics. 1990; chapter 23~27:

367-443. People’s Medicine and Health Press (Chief Editor: Hu XM).

3. Li YL, He RR. Role of ATP sensitive K(+)- channels in cardiovascular system. Progress Physiol Sci

1994; 25: 212-216.

4. Li YL. Cardiovascular effects and underlying mechanisms of adenosine and its analogues. Progress

Physiol Sci 1996; 27: 238-40.

5. Ding YF, Li YL, Ho SY. Role of adenosine on ischemic preconditioning-induced cardioprotection. J

Hebei Medical University (Acta Acad Med Hebei) 1996; 17(1): 11-14.

6. Ding YF, Li YL, Ho SY. NO and Ischemic preconditioning. J Hebei Medical University (Acta Acad

Med Hebei) 1997; 18: 1-6.

7. Schultz HD, Li YL. Carotid body function in heart failure. Resp Physiol Neurobi 2007; 157; 171-185.

8. Schultz HD, Li YL, Ding YF. Arterial chemoreceptors and sympathetic function: Implications for

hypertension and heart failure. Hypertension 2007; 50: 6-13 (Figure from paper chosen for cover).

9. Li YL. Cardiovascular autonomic dysfunction in diabetes as a complication: cellular and molecular

mechanisms. In: Type I Diabetes Complications. Wagner D (Ed.). Intech Press, Rijeka, Dec. 2011, pp.

167-194.

10. Li YL. Angiotensin II-superoxide signaling and arterial baroreceptor function in type-1 diabetes

mellitus. J Diabetes & Metabolism 2013; S12: 1-6. PMID: 24567847, PMCID: PMC3932051.

11. Li YL. Single-cell neuronal dissociation for electrophysiological studies. In: Current Laboratory

Methods in Neuroscience Research. Xiong H and Gendelman HE (Eds.). Springer, New York, 2014, pp.

105-113.

12. Zhang D, Muelleman RL, Li YL. Angiotensin II-superoxide-NFkB sigmaling and aortic baroreceptor

dysfunction in chronic heart failure. Front Neurosci 2015; 9: 382. PMID: 26528122, PMCID:

PMC4607814.

13. Zhang D, Tu H, Wadman MC, LI YL. Substrates and potential therapeutics of ventricular arrhythmias

in heart failure. Eur J Pharmacol 2018; 833: 349-356. PMID: 29940156.

14. Tu H, Zhang D, Li YL. Cellular and molecular mechanisms underlying arterial baroreceptor

remodeling in cardiovascular diseases and diabetes. Neurosci Bull 2018 (in press)

Abstracts

1. Ito K, Sato T, Abe T, Li YL, Arita M. Effects of JTV-519 on the ischemic-induced stunning of right

ventricular muscles of guinea pigs. Jpn Circ J 1998; 62(Suppl. I): 150.

2. Li YL, Sato T, Arita M. Protective effect of bepridil on shortening of action potential duration induced

by metabolic inhibition via blocking of ATP sensitive potassium channels and sodium activated

potassium channels. Japanese J Electrocardiol 1998; 18: 669.

3. Li YL, Sato T, Abe T, Arita M. Bradykinin protects the heart from ischemic myocardial stunning in

isolated guinea pig ventricular wall preparations. J Mol Cell Cardiol 1998; 30(11): A310.

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4. Ito K, Sato T, Abe T, Li YL, Arita M. Anti-stunning effects of JTV-519 in coronary perfused guinea pig

ventricular muscles. J Mol Cell Cardiol 1998; 30(11): A324.

5. Li YL, Sato T, Abe T, Arita M. Improving effects of bradykinin on ischemic-reperfusion injury in

isolated guinea pig ventricular wall preparations. J Jpn Physiol 2000; 62(4): 108.

6. Li YL, Sato T, Arita M. Bradykinin improves post-ischemic myocardial contractile recovery via

activation of mitochondrial KATP channels. J Mol Cell Cardiol 2000; 32(11): A96.

7. Kyosue T, Abe T, Li YL, Sato T, Arita M. Intracelllular Na+ accumulation in ventricular cells and the

opening of sodium activated potassium channels under metabolic inhibition. J Jpn Physiol 2001; 63(4):

150.

8. Li YL, Sato T. Bradykinin-induced cardioprotection is mediated by dual signaling via protein kinase C

and phosphatidylinositol-3’-kinase in guinea-pig hearts. Jpn Circ J 2001; 65(Suppl. I): 176.

9. Li YL, Sato T, Kyosue T, Ono K. Bradykinin but not adenosine triggered the cardioprotection of

ischemic preconditioning. J Jpn Physiol 2002; 64(4): 191.

10. Takebayashi S, Li YL, Ono K. Protein expression and function of T-type calcium channels in

monocrotaline-induced right heart failure of rats. J Jpn Physiol 2002; 64(4): 192.

11. Li YL, Sato T, Kyosue T, Ono K. Ischemic preconditioning was mediated by protein kinase C but not

phosphatidylinositol-3’-kinase in guinea-pig hearts. Jpn Circ J 2002; 66(Suppl. I): 696.

12. Takebayashi S, Li YL, Ono K. Contractility of hypertrophied right ventricle is dependent on the T-type

Ca++ channel. Japanese J Electrocardiol 2002; 22: 412.

13. Takebayashi S, Li YL, Kaku T, Ono K. Abnormal expression of T-Type Ca++ channel modulates

contractility in hypertrophied ventricular myocytes. J Mol Cell Cardiol 2002; 34(10): A24.

14. Takebayashi S, Li YL, Kaku T, Ono K. Ca++ influx and contraction in hypertrophied ventricular

myocytes aer dependent on the T-type Ca++ channel. Circulation 2002; 106 (19): II-227.

15. Li YL, Schultz HD. Blunted Ca2+-dependent potassium current in carotid body glomus cells of heart

failure rabbit: Involvement of nitric oxide. FASEB J 2003; 17 (4): A401.

16. Zeng YC, Li YL, Schultz HD. Oxidative stress and cardiac afferents in diabetes. FASEB J 2003; 17 (4):

A886.

17. Li YL, Xia XH, Li YF, Patel KP, Schultz HD. Upregulation of angiotensin II mediates the enhanced

peripheral chemoreceptor sensitivity in heart failure rabbits. Circulation 2003; 108 (17): IV-241.

18. Li YL, Li YF, Wang W, Cornish KG, Patel KP, Zucker IH, Schultz HD. Attenuation of chemoreceptor

sensitivity by transfection of Ad.nNOS in carotid body of heart failure rabbits. FASEB J 2004; 18:

A1277.

19. Li YL, Li YF, Wang W, Cornish KG, Patel KP, Zucker IH, Schultz HD. Effect of Ad.nNOS transfection

on outward potassium currents in carotid body glomus cells from heart failure rabbits. FASEB J 2004;

18: A1277.

20. Li YL, Gao L, Wang W, Zucker IH, Schultz HD. NADPH oxidase-derived superoxide anion mediates

the angiotensin II-enhanced peripheral chemoreceptor sensitivity in heart failure rabbits. Circulation

2004; 110(17): III-265.

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21. Li YL, Zheng H, Li YF, Patel KP, Schultz HD. Angiotensin II-superoxide signaling pathway potentiates

the sensitivity of outward K+ channels to hypoxia in carotid and NG108-15 cells. FASEB J 2005; 19(5):

A1291.

22. Li YL, Zheng H, Li YF, Patel KP, Schultz HD. Involvement of superoxide production on angiotensin

II-blunted outward K+ channels in NG108-15 cells. FASEB J 2005; 19(5): A1291.

23. Gao L, Wang W, Li YL, Schultz HD, Cornish KG, Zucker IH. Chronic central infusion of losartan

down-regulates the expression of AT1 receptor and NAD(P)H oxidase subunits in RVLM in rabbits

with heart failure. FASEB J 2005; 19 (5): A1291-A1292.

24. Gao L, Wang W, Li YL, Schultz HD, Cornish KG, Zucker IH. Simvastatin therapy normalizes

sympathetic neural control in experimental heart failure: The roles of AT1 receptors and NAD(P)H

oxidase. FASEB J 2005; 19 (5): A1292.

25. Li YL, Tek V, Kim H, Ragsdale SW, Schultz HD. Oxygen sensitivity of K+ channels in rat carotid body

type I cells: Involvement of cGMP in a hemoxygenase-carbon monoxide signaling pathway. Program

No. 636.8. 2005 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2005.

Online.

26. Li YL, Agnew C, Schultz HD. Endogenous nNOS and AT1 receptor do not mediate the enhanced

peripheral chemoreflex function in early stage of chronic heart failure rabbits. FASEB J 2006; 20(5):

A1203-A1204.

27. Ding YF, Li YL, Schultz HD. Downregulation of Carbon Monoxide as well as Nitric Oxide Contributes

to Peripheral Chemoreflex Hypersensitivity in Heart Failure Rabbits. FASEB J 2006; 20(5): LB35.

28. Gao L, Wang W, Mann E, Finch M, Li YL, Liu D, Schultz HD, Zucker IH. Sympathoexcitation in

chronic heart failure: Ang II induced inhibition of voltage-gated K+ channel, an in vivo and in vitro

study. FASEB J 2006; 20(5): A1202-A1203.

29. Wang WZ, Pan YX, Gao L, Zucker IH, Li YL, Schultz HD, Wang W. Activation of the cardiac

sympathetic afferent reflex enhances the neuronal chemosensitivity in the nucleus tractus solitarius in

rats with chronic heart failure. Circulation 2006; 114 (18): II-309.

30. Li YL, Schultz HD. Role of NADPH oxidase-derived superoxide anion on angiotensin II-enhanced

sensitivity of potassium channels to hypoxia in carotid body of congestive heart failure rabbits. FASEB J

2007; 21(5): 910.12.

31. Ding YF, Li YL, Cornish KG, Schultz HD. Reduced blood flow in carotid arteries is a trigger

contributing to peripheral chemoreflex hypersensitivity in chronic heart failure rabbits. FASEB J 2007;

21(5): 910.13.

32. Li YL, Ding YF, Agnew C, Schultz HD. Exercise training normalizes enhanced peripheral chemoreflex

function in chronic heart failure rabbits. FASEB J 2008; 22: 952.10.

33. Li YL, Tran TP, Muelleman R, Schultz HD. Hyperpolarization-activated cyclic nucleotide-gated

channels mediate blunted excitability of aortic baroreceptor neurons in diabetic rats. FASEB J 2008; 22:

1171.22.

34. Ding YF, Li YL, Davisson RL, Schultz HD. Gene Transfer of Cu-Zn Superoxide Dismutase to the

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Carotid Body Reverses Enhanced Chemoreceptor Function in Heart Failure Rabbits. FASEB J 2008; 22:

741.2.

35. Yin JX, Li YL, Xiao L, Schultz HD, Zimmerman MC. Cytoplasmic and mitochondrial-produced

superoxide mediates angiotensin II (AngII)-induced inhibition of K+ current in CATH.a neurons. FASEB

J 2008; 22: LB150.

36. Tran TP, Li YL, Ilir Frrokaj, Robert Muelleman, Pipinos II. Superoxide production and

mitochondiopathy in a murine model of acute hind limb ischemia reperfusion. Acad Emerg Med 2008;

15(S1): S26.

37. Dopp JM, Marcus NJ, Bird CB, Phillipi N, Moran JJM., Olson B, Schultz HD, Li YL, Morgan BJ.

Xanthine oxidase inhibition attenuates hypoxia-induced changes in chemoreceptor sensitization

pathways. American College of Clinical Pharmacy, Annual Meeting in Louisville, Oct 19-22, 2008.

38. Tran TP, Casale G, Li YL, Pipinos II. Mitochondrial manganese superoxide dismutase in a murine

model of acute hind limb ischemia reperfusion. Ann Emerg Med 2008; 52(4): S64-S64.

39. Li YL, Tran TP, Muelleman R, Schultz HD. Diabetes enhances activation of hyperpolarization-activated

cyclic nucleotide-gated channels in aortic baroreceptor neurons: involvement of angiotensin II. Ann

Emerg Med 2008; 52(4): S64-S65.

40. Renshaw AO, Yin JX, Li YL, Schultz HD, Zimmerman MC. Overexpression of mitochondria-targeted

superoxide dismutase modulates angiotensin II signaling in neurons. Hypertension 2008; 52(4): E120.

41. Li YL, Tran TP, Muelleman RL, Schultz HD. Elevated angiotensin II in rat nodose ganglia mediates

diabetes-blunted arterial baroreflex sensitivity. Circulation 2008; 118(18): S360.

42. Tu H, Li YL, Tran TP. A murine model of acute hindlimb ischemia/reperfusion injury. FASEB J 2009;

23: 763.1.

43. Zhang L, Tran TP, Muelleman RL, Li YL. Involvement of NADPH oxidase-derived superoxide anion in

diabetes-blunted aortic baroreceptor neuron excitability. FASEB J 2009; 23: 785.2.

44. Ding Y, Li YL, Yin J, Zimmerman MC, Schultz HD. Adenovirus-mediated gene transfer of Mn

Superoxide dismutase to carotid body normalizes enhanced chemoreceptor function in heart failure

rabbits. FASEB J 2009; 23: 957.2.

45. Marcus NJ, Li YL, Bird CB, Olson EB, Smith SS, Sorenson KI, Schultz HD, Morgan BJ. Chronic

intermittent hypoxia alters chemoreflex control of lumbar sympathetic nerve activity and carotid body

protein expression. FASEB J 2009; 23: 1008.1.

46. Yin J, Li YL, Ding Y, Schultz HD. Interplay of angiotensin 1-7 and angiotensin II in the regulation of

voltage-gated potassium current in the glomus cells of carotid body. FASEB J 2009; 23: 1009.12.

47. Tran P, Tu H, Muelleman R, Li YL. Function of electron transport chain of nodose ganglia is impaired

in heart failure. Acad Emerg Med 2009; 16 (S1): S118-119.

48. Tu H, Zhang L, Tran P, Muelleman R, Li YL. A novel approach to normalize the blunted baroreflex in

diabetes. Acad Emerg Med 2009; 16(S1): S119.

49. Tran TP, Tu H, Muelleman RL, Albadawi H, Pipinos II, Li YL. Tourniquet-induced acute

ischemia-reperfusion injury is associated with oxidative stress and mitochondrial dysfunction. Eur J

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Emerg Med 2009; 16: 291.

50. Tu H, Zhang L, Tran TP, Muelleman RL, Li YL. Lowered activation of voltage-gated sodium channels

contributes to blunted baroreflex sensitivity in heart failure rats. FASEB J 2010; 24: 1051.4.

51. Zhang L, Zheng H, Tu H, Tran TP, Muelleman RL, Zimmerman MC, Li YL. Elevated angiotensin II

attenuates activation of voltage-gated sodium channels in heart failure rats: involvement of

mitochondria-derived superoxide. FASEB J 2010; 24: 1018.5.

52. Yang RF, Yin JX, Li YL, Schultz HD, Zimmerman MC. Amgiotensin-(1-7) inhibirts angiotensin II

intra-neuronal signaling. FASEB J 2010; 24: 1051.12.

53. Yang RF, Yin JX, Li YL, Zimmerman MC, Schultz HD. Angiotensin-(1-7) increases neuronal

potassium current via a nitric oxide-dependent mechanism. FASEB J 2010; 24: 809.19.

54. Tang Y, Ding Y, Li YL, Schultz HD. Enhanced peripheral chemoreflex function in conscious rats with

ligation-induced heart failure. FASEB J 2010; 24: 1050.2.

55. Marcus NJ, Philippi NR, Bird CE, Schultz HD, Li YL, Morgan BJ. Effect of AT1 receptor blockade on

intermittent hypoxia-induced endothelial dysfunction. FASEB J 2010; 24: 1022.7.

56. Tu H, Pipinos II, Muelleman RL, Li YL, Tran TP. Ischemic injury is minimal compared to reperfusion

injury in critical limb syndrome. Acad Emerg Med 2010; 17 (S1): S115.

57. Tu H, Muelleman RL, Li YL, Tran TP. Salutatory effects of urocortin in acute limb ischemia. Ann Emerg

Med 2010; 56 (3): S30 (#89).

58. Schlessinger DI, Cloyd B, Maliszewski J, Huber A, Hernandez H, Keegan B, Sittler D, Thor C, Tu H, Li

YL, Tran TP. Urocortin as an early biomarker of myocardial ischemia for patients presenting to the

emergency department (ED) with angina. Great Plains Regional Society for Academic Emergency

Medicine meeting in Omaha, Sep 17, 2010.

59. Tu H, Tran TP, Muelleman RL, Li YL. Epithelial sodium channels contribute to the blunted sensitivity

of aortic baroreceptors in chronic heart failure rats. FASEB J 2011; 25: 646.9.

60. Liu J, Tu H, Zhang L,Tu H, Li YL. Angiotensin II increases protein expression of

hyperpolarization-activated channels in rat nodose ganglion neurons. FASEB J 2011; 25: 843.10.

61. Wang HJ, Li YL, Gao L, Zucker IH, Wang W. Alteration in skeletal muscle afferents in rats with

chronic heart failure. FASEB J 2011; 25: 1054.10.

62. Wang HJ, Li YL, Zucker IH, Wang W. Exercise training prevents the abnormal sensitization of skeletal

muscle afferents in chronic heart failure. Hypertension 2011; 58: E69.

63. Tu H, Liu J, Li YL. Role of nuclear factor-kappa B in mitochondria-derived superoxide-lowered protein

expression of voltage-gated sodium channels in nodose neurons from heart failure rats. FASEB J 2012;

26: 703.2.

64. Liu J, Tu H, Li YL. Blunted sensitivity of intracardiac ganglion neurons to nicotine in type-2 diabetic

rats. FASEB J 2012; 26: 1091.9.

65. Tu H, Liu J, Li YL. Activation of nuclear factor-kappa B lowers protein expression of voltage-gated

sodium channels in nodose neurons from heart failure rats. Physiologist 2012; 55: C-14.

66. Liu J, Tu H, Li YL. Response of intracardiac ganglion neurons to nicotine in type-2 diabetic rats.

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Physiologist 2012; 55: C23.

67. Li YL, Tu H, Liu J, Zhang D. Superoxide-NFkB signaling pathway lowers protein expression of

voltage-gated sodium channels in nodose neurons from heart failure rats. Acta Physiologica Sinica

2012; 64: 254.

68. Tu H, Liu J, Zhang D, Muelleman RL, Li YL. Involvement of nuclear factor-kappa B in

superoxide-lowered protein expression of voltage-gated sodium channels in nodose ganglia from heart

failure rats. FASEB J 2013; 27: 699.2.

69. Zhang D, Tu H, Liu J, Muelleman RL, Li YL. In-vivo transfection of manganese SOD gene and NFκB

shRNA into nodose ganglia improve blunted baroreflex sensitivity in chronic heart failure rats. FASEB J

2013; 27: 699.3.

70. Liu J, Tu H, Zhang D, Li YL. Alterations of calcium channels and cell excitability in intracardiac and

stellate ganglion neurons from chronic heart failure. FASEB J 2013; 27: 928.1.

71. Zheng H, Liu X, Li YL, Sharma NM, Patel KP. Enhanced levels of proteases in tubular fluid activate

ENaC in chronic heart failure. FASEB J 2013; 27: 698.2.

72. Tu H, Yuan F, Li YL, Wang D. Effective amelioration of tourniquet-induced acute ischemia-reperfusion

injury in mouse skeletal muscles using macromolecularized dexamethasone. American Association of

Pharmaceutical Scientists (AAPS) Annual Meeting 2013. San Antonio, Texas, November, 2013.

73. Zhang D, Yuan F, Tu H, Liu J, Wang D, Muelleman RL, Li YL. Anti-inflammatory effect of PEGylated

Dexamethasone liposome for tourniquet-induced acute ischemia-reperfusion injury in mouse skeletal

muscle. FASEB J 2014; 28: 1102.5.

74. Liu J, Zhang D, Zheng H, Muelleman RL, Li YL. Angiotensin II-induced inhibition of sodium currents

in aortic baroreceptor neurons mediates blunted arterial baroreflex sensitivity in heart failure rats.

FASEB J 2014; 28: 1169.3.

75. Zheng H, Liu X, Li YL, Patel KP. Enhanced leptin-TRPC signaling in the hypothalamus contributes to

the exaggerated sympatho-excitation in type 2 diabetic rats. FASEB J 2014; 28: 1130.9.

76. Li YL, Wang D, Zhang D, Yuan F, Tu H, Liu J, Muelleman RL. Effect of a novel anti-inflammatory

drug (dexamethasone liposome) on long-term recovery of ischemia/reperfusion-injured mouse skeletal

muscle. MHSRS symposium, August, 2014.

77. Li YL, Liu J, Zhang D, Tu H, Muelleman RL. Intracardiac ganglion neuron dysfunction in type 2

diabetes. FASEB J 2015; 29: 651.1

78. Li YL, Zhang D, Liu J, Wang D, Muelleman RL. Dexamethasone promotes neuromuscular recovery in

a murine model of tourniquet-induced ischemia/reperfusion. MHSRS symposium, August, 2015.

79. Zhang D, Wang D, Muelleman RL, Li YL. Dexamethasone promotes the long-term functional recovery

of neuromuscular junction after ischemia/reperfusion injury induced by tourniquet in mouse hindlimb.

FASEB J 2016; 30: 1245.1.

80. Zhang D, Tu H, Zheng H, Muelleman RL, Li YL. Reduced N-type Ca++ channels in ventricular vagal

neurons and ventricular arrhythmogenesis. Circulation 2016; 134 (Suppl 1): A11882.

81. Tu H, Zhang D, Corrick RM, Muelleman RL, Wadman MC, Li YL. Morphological regeneration and

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functional recovery of neuromuscular junctions after tourniquet-induced injuries in mouse hindlimb. FASEB

J 2017; 31: 1022.4.

82. Zhang D, Tu H, Wang C, Muelleman RL, Wadman MC, Li YL. Correlation of ventricular arrhythmogenesis

with neuronal remodeling in cardiac postganglionic parasympathetic neurons during the progression of heart

failure after myocardial infarction. FASEB J 2017; 31: 718.4.

83. Li YL, Corrick RM, Tu H, Zhang D, Muelleman RL, Wadman MC. Protective effect of dexamethasone

against tourniquet-induced acute ischemia-reperfusion injury in mouse hindlimb. MHSRS symposium,

August, 2017.

84. Zhang D, Tu H, Wang C, Muelleman RL, Wadman MC, Li YL. Overactivation of N-type Ca++ channels in

stellate ganglia and ventricular arrhythmogenesis in chronic heart failure. Circulation 2017; 135 (Suppl

1): A14004.

PRESENTATIONS

1. Blunted Ca2+-dependent potassium current in carotid body glomus cells of heart failure rabbit:

Involvement of nitric oxide. Experimental Biology 2003, San Diego, California, April, 2003

2. Upregulation of angiotensin II mediates the enhanced peripheral chemoreceptor sensitivity in heart failure

rabbits. American Heart Association Scientific Sessions 2003, Orlando, Florida, November, 2003

3. Attenuation of chemoreceptor sensitivity by transfection of Ad.nNOS in carotid body of heart failure

rabbits. Experimental Biology 2004, Washington, DC, April, 2004

4. NADPH oxidase-derived superoxide anion mediates the angiotensin II-enhanced peripheral

chemoreceptor sensitivity in heart failure rabbits. American Heart Association Scientific Sessions 2004,

New Orleans, Louisiana, November, 2004

5. Angiotensin II and chemoreflex in heart failure: role of carotid body--one of the angiotensin II-targeted

organs. Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, May,

2006

6. Postconditioning and ischemia-reperfusion injury: intracellular Ca2+, free radicals and mitochondrial

function. Department of Emergency Medicine, University of Nebraska Medical Center, March, 2008

7. Elevated angiotensin II in rat nodose ganglia mediates diabetes-blunted arterial baroreflex sensitivity.

American Heart Association Scientific Sessions 2008, New Orleans, Louisiana, November, 2008

8. Funny current and excitability of baroreceptor neurons in diabetes. Department of Cellular and

Integrative Physiology, University of Nebraska Medical Center, March, 2009

9. Oxygen reactive species, aortic baroreceptor, and baroreflex function in diabetes. Department of

Physiology, Second Military Medical University, Shanghai, China, October, 2010.

10. Response of intracardiac ganglion neurons to nicotine in type-2 diabetic rats. 2012 American

Physiological Society Conference: Autonomic regulation of cardiovascular function in health and disease,

Omaha, Nebraska, July, 2012

11. NFκB, a bridge between superoxide and Nav channels in aortic baroreceptor from heart failure.

Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, September,

2012

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19

12. Superoxide-NFκB signaling pathway lowers protein expression of voltage-gated sodium channels in

nodose neurons from heart failure rats. International Conference of Physiological Science 2012, Suzhou,

China, November, 2012

13. Baroreceptor dysfunction and heart failure. College of Dentistry, University of Nebraska Medical Center,

March, 2014

14. Effect of a novel anti-inflammatory drug (dexamethasone liposome) on long-term recovery of

ischemia/reperfusion-injured mouse skeletal muscle. Military Health System Research Symposium

(MHSRS) 2014, Fort Lauderdale, Florida, August, 2014

15. Dexamethasone promotes neuromuscular recovery in a murine model of tourniquet-induced

ischemia/reperfusion. Military Health System Research Symposium (MHSRS) 2015, Fort Lauderdale,

Florida, August, 2015

16. Reduced N-type Ca++ channels in ventricular vagal neurons and ventricular arrhythmogenesis. American

Heart Association Scientific Sessions 2016, New Orleans, Louisiana, November, 2016

17. Protective effect of dexamethasone against tourniquet-induced acute ischemia-reperfusion injury in mouse

hindlimb. Military Health System Research Symposium (MHSRS), 2017, Kissimmee, Florida, August,

2017

18. Overactivation of N-type Ca++ channels in stellate ganglia and ventricular arrhythmogenesis in chronic

heart failure. American Heart Association Scientific Sessions 2017, Anaheim, California, November, 2017