Case study 1
JOANA NOOR RASHIDAHSHAHIDAH WAN NORHIDAYAHNADIA NABILANURLIYANA
The Case
A previously healthy 4-year-old girl presented with a 2-day history of severe nausea, vomiting, and diarrhea. Her symptoms began with severe pain in the mid to upper abdomen by alternating episodes of vomiting and nonbloody diarrhea. Laboratory diagnosis show urease positive. Gram stain and culture show curved gram-negative rod
Symptoms
severe nausea vomiting diarrhea (nonbloody diarrhea ) abdominal pain severe pain mid to upper abdomen
Causative Agent
microaerobic
Gram negative
Urease positive
motile
multiple unipolar-sheathed flagella
Curved rod
shape
microaerophilic
Helicobacter pylori
Mode transmission
Fecal-oral spread
PATHOGENESIS
The Vac A cytotoxin produce protein cause
vacuole.
Vacuole cause pore
formation in human
cells
cagA gene product
injected in host cell
Changes in host cell signaling
Lab diagnosis Endoscopy Urease test of biopsy relatively
sensitive and highly specific . Urea breath test. ELISA Fecal Antigen Test
TREATMENT & PREVENTION Antibiotic Surgery Become more hygienic Avoid uncooked / undercook food
