Cell Damage Cell Damage Cell DamageCell Damage
EARLY ALLERGIC RESPONSE
LATE ALLERGIC RESPONSEWheezingUrticariaSneezingRhinorrhoeaConjunctivitis
Further WheezingSustained Nasal BlockageEczema
Allergen
MHC-
II
Dusts, Plant Pollens, DustMites, Animals, MoldSpores, Drugs, Foods,
Smoke
TCR
IL-18
IL-4
IL-5
lgE
FcεRI
lgERlgEFcεRIlgER
lgEFcεRIlgER
IL-4, IL-13
IL-4IL-9
IL-10 IL-4IL-13
IL-13
, Leu
kotri
enes
IL-3IL-5PGD-2
IL-9IL-13
GMCSFIL-5IL-3
IL-4, IL-33
APC
IL-5IL-3IL-8
TNF
Histamine
Naive CD4+
T Cell
Mast cell
Bone Marrow
EosinophilRelease
lgE lgE
B Cell
lgE
lgElgE
lgE
Eos Recruitment
Eos Migration andActivation
CytokineLipids
TSLP
MucusHypersecretion
FIBROSISTH2 Cell
Ecp EPO EDN MBP
Basophil
Mast cell
Allergen
lgE
Histamine
CD63
CD203c
Neutrophil
Histamine
Histamine
CytokinesEotaxin
IL-4, IL-6, IL-9, IL-13
Allergic Response Pathway
antibody and ELISA experts
Activation
Indirect Activation
Binding
Expression
-------------
Enzyme Catalysis
Inhibition
Leads to
Modification
Membership
Proteolysis
Reaction (Uni)
Reaction (Bi)
Related Pathway
Translocation
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