Cell Damage Cell Damage Cell Damage Cell Damage EARLY ALLERGIC RESPONSE LATE ALLERGIC RESPONSE Wheezing Urticaria Sneezing Rhinorrhoea Conjunctivitis Further Wheezing Sustained Nasal Blockage Eczema Allergen MHC-II Dusts, Plant Pollens, Dust Mites, Animals, Mold Spores, Drugs, Foods, Smoke TCR IL-18 IL-4 IL-5 lgE FcεRI lgER lgE FcεRI lgER lgE FcεRI lgER IL-4, IL-13 IL-4 IL-9 IL-10 IL-4 IL-13 IL-13, Leukotrienes IL-3 IL-5 PGD-2 IL-9 IL-13 GMCSF IL-5 IL-3 IL-4, IL-33 APC IL-5 IL-3 IL-8 TNF Histamine Naive CD4 + T Cell Mast cell Bone Marrow Eosinophil Release lgE lgE B Cell lgE lgE lgE lgE Eos Recruitment Eos Migration and Activation Cytokine Lipids TSLP Mucus Hypersecretion FIBROSIS TH 2 Cell Ecp EPO EDN MBP Basophil Mast cell Allergen lgE Histamine CD63 CD203c Neutrophil Histamine Histamine Cytokines Eotaxin IL-4, IL-6, IL-9, IL-13 Allergic Response Pathway antibody and ELISA experts Activation Indirect Activation Binding Expression ------------- Enzyme Catalysis Inhibition Leads to Modification Membership Proteolysis Reaction (Uni) Reaction (Bi) Related Pathway Translocation Available to order in Europe from