Molecular Innova on for Medicine
2017 PRODUCT CATALOG
Place your order: www.macrocyclics.com or (469) 786-6060
Macrocyclics has been the global leader in chelating agent technologies for medicine since 1995. The Macrocyclics team is dedicated to providing its clients with both established and innovative chelating agents and services to meet the challenges of molecular imaging and nuclear medicine.
SERVICES
Nuclear Medicine Process chemistry and ligand design Feasibility studies for process optimization Bioconjugation development and cGMP production Custom design, manufacture, and cGMP production of chelates Identification and selection of appropriate chelating agent and specific applications
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ABOUT MACROCYCLICS Macrocyclics, a manufacturer of customized chelating agents, is dedicated to leading-edge development of new chelation chemistry platforms critical for advancement of diagnostic and therapeutic medicine. Our strong commitment to customer service and quality products are key components in our ongoing pursuit of excellence.
ABOUT YOUR ORDER
SHIPPING Most of the compounds we sell are stable under normal laboratory conditions. It is not necessary to refrigerate our compounds during short-distance transportation. Therefore, we ship our compounds via FedEx Air, unless otherwise specified by the customer. If the compound requires special shipping conditions (such as dry ice) you will be notified in advance.
STORAGE CONDITIONS
We recommend storing Macrocyclics’ products in the freezer at –20°C.
TECHNICAL QUESTIONS
If you have a technical question about a product you have received, or would like to know more before you place an order, please contact us: [email protected] or (469) 786-6060.
SAFETY DATA SHEETS SDSs are available on our website under the
Individual product pages. We can also fax a hardcopy if you prefer. Please mention your request on the purchase order.
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PRODUCT ANALYSIS Macrocyclics’ expertise in ligand synthesis is complemented by our quality control systems, guaranteeing the highest possible quality for all our products.
CERTIFICATE OF ANALYSIS
Certificates of analysis will be sent with your products if requested. The C of A provides the test method used and the results. If you need further information about a compound, please contact us and we will try to accommodate your request.
HOW TO ORDER
If you are new customer placing your first order, please provide: Purchase order or credit card number Shipping and billing addresses Phone and fax numbers Email address
Once your order is processed, you will receive a confirmation by fax or email.
Online: By Fax: By Phone: Payment:
www.macrocyclics.com and click on “online catalog” Please fax your order to (469) 814-9116. Call in your order with the information listed above: (469) 786-6060. We accept VISA, MasterCard, and American Express. There is a $20 service charge for international bank transfers. Please see Macrocyclics bank information on your original invoice.
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Product List
Bifunctional Chelators (BFCs) Page B-110 p-NO2-Bn-Cyclen .......................................................... 7 B-170 DOTAM-mono-acid ....................................................... 7 B-199 p-NO2-Bn-DOTA .......................................................... 7 B-200 p-NH2-Bn-DOTA ........................................................... 8 B-201 p-NH2-Bn-DOTA-tetra(t-Bu ester) ................................. 8 B-205 p-SCN-Bn-DOTA .......................................................... 8 B-260 DOTA-tris (t-Bu ester) ................................................... 8 B-264 DOTAGA-tetra (t-Bu ester) ........................................... 9 B-270 DOTA-mono-NHS-tris (t-Bu ester) ................................ 9 B-271 Maleimido-mono-amide-DOTA-tris (t-Bu ester) ............ 9 B-272 Maleimido-mono-amide-DOTA ..................................... 9 B-275 Fmoc-L-Lys-mono-amide-DOTA-tris (t-Bu ester) ........ 10 B-276 Butyne-DOTA-tris(t-butyl ester) .................................. 10 B-277 2-Aminoethyl-mono-amide DOTA-tris (t-Bu ester) ...... 10 B-278 3-Azidopropyl-mono-amide-DOTA-tris(t-Bu ester) ...... 10 B-279 4-Aminobutyl-DOTA-tris (t-butyl ester) ........................ 11 B-280 DOTA-NHS-ester ........................................................ 11 B-281 DO3A-Thiol ................................................................. 11 B-286 Butyne-DOTA .............................................................. 11 B-288 3-Azidopropyl-mono-amide-DOTA .............................. 12 B-289 4-Aminobutyl-DOTA .................................................... 12 B-300 p-NH2-Bn-DTPA .......................................................... 12 B-301 p-NH2-Bn-DTPA-penta (t-Bu ester) ............................. 12 B-305 p-SCN-Bn-DTPA ......................................................... 13 B-351 p-NH2-Bn-CHX-A″-DTPA ............................................ 13 B-355 p-SCN-Bn-CHX-A″-DTPA ........................................... 13 B-365 DTPA-tetra (t-Bu ester) ............................................... 13 B-372 Maleimido-mono-amide-DTPA .................................... 14 B-401 p-NH2-Bn-PCTA .......................................................... 14 B-405 p-SCN-Bn-PCTA ......................................................... 14 B-501 p-NH2-Bn-oxo-DO3A ................................................... 14 B-505 p-SCN-Bn-oxo-DO3A .................................................. 15 B-601 p-NH2-Bn-NOTA.......................................................... 15
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Product List Bifunctional Chelators (BFCs) Page B-605 p-SCN-Bn-NOTA .........................................................15 B-616 NO2A-Butyne-bis (t-Bu ester) .....................................15 B-620 NOTA-bis (t-Bu ester) .................................................16 B-622 Maleimido-mono-amide-NOTA ...................................16 B-626 NO2A-Butyne ..............................................................16 B-628 NO2A-Azide ................................................................16 B-705 p-SCN-Bn-Deferroxamine ...........................................17 B-772 Deferroxamine-maleimide ...........................................17 B-1005 p-SCN-Bn-TCMC ........................................................17 S-100 Bifunctional Starter Pack .............................................17
Macrocyclic Ligands Page C-100 DOTA-Biotin-Sarcosine ...............................................18 C-210 DO3A-Serotonin ..........................................................18 C-220 DOTATATE .................................................................18
Macrocyclic Ligands Page M-090 TACN ..........................................................................19 M-100 Cyclen .........................................................................19 M-125 DO2A ..........................................................................19 M-135 DO3A ..........................................................................20 M-140 DOTA ..........................................................................20 M-150 DOTP ..........................................................................20 M-160 DOTMA .......................................................................20 M-170 TETA ...........................................................................21 M-180 DOTAM .......................................................................21
M-190 DiAmSar ......................................................................21
M-200 CB-Cyclam ..................................................................21 M-220 CB-TE2A .....................................................................22 M-400 DOTA-4AMP ...............................................................22 M-600 NOTA ..........................................................................22 M-650 NOTP ..........................................................................22
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Product List Magnetic Resonance Reagents Page M-145 Tm-DOTA .................................................................... 23 M-147 Gd-DOTA .................................................................... 23 M-155 Tm-DOTP .................................................................... 23 M-165 Tm-DOTMA ................................................................ 24 M-503 Eu-DOTA 4AmC ......................................................... 24 X-205 Tm-p-SCN-Bn-DOTA ................................................. 24 X-207 Gd-p-SCN-Bn-DOTA .................................................. 24 X-209 Ho-p-SCN-Bn-DOTA .................................................. 25 X-275 Tm-Maleimido-DOTA ................................................. 25 X-279 Ho-Maleimido-DOTA .................................................. 25 X-287 Gd-DO3A-Butylamine ................................................. 25
Reactive Intermediates Page M-120 DO2A-tert-butyl ester .................................................. 26 M-130 DO3A-tert-butyl ester .................................................. 26 I-121 Bis-CBZ-Cyclen........................................................... 26 I-131 Tris-Boc-Cyclen........................................................... 27 I-623 NO2A-(t-Bu ester) ....................................................... 27
Fluorescent Probes Page D-100 EAM-1 ......................................................................... 28 D-110 EAM-2 ......................................................................... 28
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Item #10
FW:CAS Number:Purity:
Formula:
Bifunctional Chelators (BFCs)
Item #40B-110
$381.00500 mg $1,706.00FW: 307.4100 mg
S-2-(4-Nitrobenzyl)-1,4,7,10-tetraazacyclododecane
CAS Number: 116052-96-9Purity: 94%
N N
NN NO2H
HH
H
Formula:C H N O
p-NO2-Bn-Cyclen
Item #45B-170
$350.00500 mg $990.00FW: 401.5100 mg
1,4,7,10-Tetraazacyclododecane-1,4,7-tri(carbamoylmethyl)-10-acetic acid
CAS Number: N/APurity: 95%
N N
NN
H2N NH2
H2N OH
O O
O O
Formula:C H N O
DOTAM-mono-acid
Item #50B-199
$269.00100 mg $430.00FW: 685.450 mg
S-2-(4-Nitrobenzyl)-1,4,7,10-tetraazacyclododecane tetraacetic acid
CAS Number: 116052-88-1Purity: 94%
N N
NN NO2
HO OH
HO OH
O O
O O4HCl
Formula:C H N O ·4HCl
p-NO2-Bn-DOTA
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Item #60B-200
$265.00100 mg $424.00FW: 655.450 mg
500 mg $1,712.00
S-2-(4-Aminobenzyl)-1,4,7,10-tetraazacyclododecane tetraacetic acid
CAS Number: 181065-46-3Purity: 94%
N N
NN NH2
HO OH
HO OH
O O
O O4HCl
Formula:C H N O ·4HCl
p-NH -Bn-DOTA
Item #70B-201
$313.00500 mg $1,410.00FW: 848.0100 mg
S-2-(4-Aminobenzyl)-1,4,7,10-tetraazacyclododecane tetra-tert-butylacetate
CAS Number: N/APurity: 94%
N N
NN NH2
O OtBu
O OtBu
O O
O OTFA
tBuO
OtBu
Formula:C H N O ·TFA
p-NH -Bn-DOTA-tetra(t-Bu ester)
Item #80B-205
$330.00100 mg $502.00FW: 687.850 mg
500 mg $2,023.00
S-2-(4-Isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane tetraacetic acid
CAS Number: 127985-74-4Purity: 94%
N N
NN NCS
HO OH
HO OH
O O
O O2.5HCl
2.5H2O
Formula:C H N O S·2.5HCl·2.5H
p-SCN-Bn-DOTA
Item #90B-260
$281.001 g $439.00FW: 572.7
500 mg
5 g $1,976.00
1,4,7,10-Tetraazacyclododecane-1,4,7-tris-tert-butyl acetate-10-acetic acid
CAS Number: 137076-54-1Purity: 95%
N N
NN
O OtBu
O OH
O O
O O
tBuO
OtBu
Formula:C H N O
DOTA-tris (t-Bu ester)
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Item #94B-264
$290.00500 mg $660.00FW: 700.9100 mg
1 g $995.00
2-[1,4,7,10-Tetraazacyclododecane-4,7,10-tris(t-butyl acetate)]-pentanedioic acid-1-t-butyl ester
CAS Number: 306776-79-4Purity: 94%
N N
NN
O OtBu
O OtBu
O O
O O
tBuO
OtBuO
OHFormula:C H N O
DOTAGA-tetra (t-Bu ester)
Item #100B-270
$100.00500 mg $438.00FW: 815.8100 mg
1 g $818.00
1,4,7,10-Tetraazacyclododecane-1,4,7-tris-tert-butyl acetate-10-succinimidyl acetate
CAS Number: 819869-77-7Purity: 94%
N N
NN
O OtBu
O O
O O
O O
tBuO
OtBuN
O
O
HPF6 Formula:C H N O ·HPF
DOTA-mono-NHS tris (t-Bu ester)
Item #101B-271
$202.00100 mg $322.00FW: 840.850 mg
500 mg $952.00
1,4,7,10-Tetraazacyclododecane-1,4,7-tris-tert-butyl acetate-10-maleimidoethylacetamide
CAS Number: N/APurity: 94%
N N
NN
O OtBu
O NH
O O
O O
tBuO
OtBu
HPF6
N
O
OFormula:C H N O ·HPF
Maleimido-mono-amide-DOTA-tris (t-Bu ester)
Item #102B-272
$228.00100 mg $348.00FW: 786.550 mg
500 mg $1,039.00
1,4,7,10-Tetraazacyclododecane-1,4,7-tris-acetic acid-10-maleimidoethylacetamide
CAS Number: 1006711-09-5Purity: 94%
N N
NN
HO OH
HO NH
O O
O O
HPF6
N
O
OTFA Formula:C H N O ·HPF ·TFA
Maleimido-mono-amide-DOTA
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Item #105B-275
$198.00100mg $311.00FW: 1069.150mg
500mg $946.00
1,4,7,10-Tetraazacyclododecane-1,4,7-tris-tert-butyl acetate-10-(N-a-Fmoc-N-e-acetamido-L-lysine)
CAS Number: 479081-06-6Purity: 94%
N N
NN
O OtBu
O NH
O O
O O
tBuO
OtBu (CH2)4
HPF6
NHFmoc
HOO
Formula:C H N O ·HPF
Fmoc-L-Lys-mono-amide-DOTA-tris(t-Bu ester)
Item #106B-276
$202.00500 mg $796.00FW: 769.8100 mg
1,4,7,10-Tetraazacyclododecane-1,4,7-tris(t-butyl acetate)-10-(3-butynylacetamide)
CAS Number: N/APurity: 94%
HPF6
N N
NN
O OtBu
O NH
O O
O OOtBu
tBu
Formula:C H N O ·HPF
Butyne-DOTA-tris(t-Bu ester)
Item #107B-277
$359.001 g $645.00FW: 695.7
500 mg
5 g $2,563.00
1,4,7,10-Tetraazacyclododecane-1,4,7-tris(t-butyl-acetate)-10-(aminoethylacetamide)
CAS Number: N/APurity: 94%
N N
NN
O OtBu
O NH
O O
O O
tBuO
OtBu NH2
HBr
Formula:C H N O ·HBr
2-Aminoethyl-mono-amide-DOTA-tris(t-Bu ester)
Item #108B-278
$202.00500 mg $806.00FW: 735.8100 mg
1 g $1,464.00
1,4,7,10-Tetraazacyclododecane-1,4,7-tris-tert-butyl acetate-10-(azidopropyl ethylacetamide)
CAS Number: N/APurity: 94%
N N
NN
O OtBu
O NH
O O
O O
tBuO
OtBu
HBr
N3
Formula:C H N O ·HBr
Azido-mono-amide-DOTA-tris(t-Bu ester)
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Item #109B-279
$214.00500 mg $734.00FW: 788.8100 mg
1,4,7,10-Tetraazacyclododecane-1,4,7-tris(t-butyl acetate)-10-(4-aminobutyl)acetamide
CAS Number: N/APurity: 94%
HPF6
N N
NN
O OtBu
O NH
O O
O OOtBu
tBu
NH2
Formula:C H N O ·HPF
4-Aminobutyl-DOTA-tris (t-Bu ester)
Item #110B-280
$125.00500 mg $491.00FW: 761.5100 mg
1 g $927.00
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid mono-N-hydroxysuccinimide ester
CAS Number: 170908-81-3Purity: 90%
N N
NN
HO OH
HO O
O O
O ON
O
O
HPF6TFA Formula:C H N O ·HPF ·CF CO
DOTA-NHS-ester
Item #111B-281
$836.00500 mg $2,836.00FW: 691.6100 mg
1,4,7,10-Tetraazacyclododecane-1,4,7-tris(acetic acid)-10-(2-thioethyl)acetamide
CAS Number: 865470-67-3Purity: 94%
N N
NN
HO OH
HO NH
O O
O OSH
2TFAFormula:C H N O S·2CF CO H
DO3A-Thiol
Item #116B-286
$290.00500 mg $1,130.00FW: 683.6100 mg
1,4,7,10-Tetraazacyclododecane-1,4,7-tris(acetic acid)-10-(3-butynylacetamide)
CAS Number: N/APurity: 94%
N N
NN
HO OH
HO NH
O O
O O
2TFA Formula:C H N O ·2CF CO H
Butyne-DOTA
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Item #118B-288
$283.00500 mg $1,128.00FW: 595.9100 mg
1 g $2,050.00
1,4,7,10-Tetraazacyclododecane-1,4,7-tris(acetic acid)-10-(azidopropyl ethylacetamide)
CAS Number: 1227407-76-2Purity: 94%
N N
NN
HO OH
HO NH
O O
O O
3HCl
N3
Formula:C H N O ·3HCl
Azido-mono-amide-DOTA
Item #119B-289
$311.00500 mg $1,214.00FW: 766.4100 mg
1,4,7,10-Tetraazacyclododecane-1,4,7-tris(acetic acid)-10-(4-aminobutyl)acetamide
CAS Number: N/APurity: 94%
N N
NN
HO OH
HO NH
O O
O O
HPF6
NH2
4HClFormula:C H N O ·HPF ·4HCI
4-Aminobutyl-DOTA
Item #120B-300
$157.00500 mg $678.00FW: 644.3100 mg
S-2-(4-Aminobenzyl)-diethylenetriamine pentaacetic acid
CAS Number: 102650-29-3Purity: 94%
NN N
NH2
OH
OHHO
HOO O
O OOOH
4HClFormula:C H N O ·4HCl
p-NH -Bn-DTPA
Item #121B-301
$1,336.00FW: 779.0
1g
S-2-(4-Aminobenzyl)-diethylenetriamine penta-tert-butyl acetate
CAS Number: 205956-41-0Purity: 94%
NN N
NH2
OtBu
OtBuO
OO O
O OOOtBu
tBuO
tBuOFormula:C H N O
p-NH -Bn-DTPA-penta (t-Bu ester)
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Item #125B-305
$193.00500 mg $852.00FW: 649.9100 mg
S-2-(4-Isothiocyanatobenzyl)-diethylenetriamine pentaacetic acid
CAS Number: 102650-30-6Purity: 94%
NN N
NCS
OH
OHHO
HOO O
O OOOH
3HClFormula:C H N O S·3HCl
p-SCN-Bn-DTPA
Item #171B-351
$391.00500 mg $1,514.00FW: 661.5100 mg
[(R)-2-Amino-3-(4-aminophenyl)propyl]-trans-(S,S)-cyclohexane-1,2-diamine-pentaacetic acid
CAS Number: 1105741-38-5Purity: 94%
NN N
NH2
OH
OHHO
HOO O
O OOOH
2HCl2H2O
Formula:C H N O ·2HCl·2H O
p-NH -Bn-CHX-A"-DTPA
Item #175B-355
$289.00100 mg $440.00FW: 704.050 mg
500 mg $1,618.00
[(R)-2-Amino-3-(4-isothiocyanatophenyl)propyl]-trans-(S,S)-cyclohexane-1,2-diamine-pentaacetic acid
CAS Number: 157380-45-5Purity: 94%
NN N
NCS
OH
OHHO
HOO O
O OOOH
3HCl
Formula:C H N O S·3HCl
p-SCN-Bn-CHX-A"-DTPA
Item #185B-365
$706.001 g $1,299.00FW: 617.8
500 mg
Diethylenetriamine-N,N,N",N"-tetra-tert-butyl acetate-N'-acetic acid
CAS Number: 174267-71-1Purity: 94%
NN NOtBu
OtBuO
OO O
O OOOH
tBuO
tBuOFormula:C H N O
DTPA-tetra (t-Bu ester)
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Item #192B-372
$340.00100 mg $544.00FW: 857.550 mg
500 mg $1,855.00
Diethylenetriamine-N,N,N",N"-tetra- acetic acid-N'-maleimidoethylacetamide
CAS Number: N/APurity: 94%
NN NOH
OHHO
HOO O
O OONH
NO
O
3CF3COOH
Formula:C H N O ·3CF CO H
Maleimido-mono-amide-DTPA
Item #221B-401
$378.00100 mg $549.00FW: 594.550 mg
3,6,9,15-Tetraazabicyclo[9.3.1] pentadeca-1(15),11,13-triene-4-S-(4-aminobenzyl)-3,6,9-triacetic acid
CAS Number: N/APurity: 94%
NN N
N
NH2
2HCl2H2O
O
OH
OHO
OHO
Formula:C H N O ·2HCl·2H O
p-NH -Bn-PCTA
Item #305B-405
$462.00100 mg $625.00FW: 637.050 mg
3,6,9,15-Tetraazabicyclo[9.3.1] pentadeca-1(15),11,13-triene-4-S-(4-isothiocyanatobenzyl)-3,6,9-triacetic acid
CAS Number: N/APurity: 94%
NN N
N
NCS
3HClO
OH
OHO
OHO
Formula:C H N O S·3HCl
p-SCN-Bn-PCTA
Item #401B-501
$378.00100 mg $549.00FW: 561.550 mg
1-Oxa-4,7,10-tetraazacyclododecane-5-S-(4-aminobenzyl)-4,7,10-triacetic acid
CAS Number: N/APurity: 94%
ON N
N
NH2
2HCl2H2O
O
OH
OHO
OHO
Formula:C H N O ·2HCl·2H O
p-NH -Bn-oxo-DO3A
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Item #405B-505
$450.00100 mg $609.00FW: 603.950 mg
1-Oxa-4,7,10-tetraazacyclododecane-5-S-(4-isothiocyantobenzyl)-4,7,10-triacetic acid
CAS Number: N/APurity: 94%
ON N
N
NCS
3HClO
OH
OHO
OHO
Formula:C H N O S·3HCl
p-SCN-Bn-oxo-DO3A
Item #501B-601
$242.00100 mg $398.00FW: 517.450 mg
2-S-(4-Aminobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid
CAS Number: 142131-37-1Purity: 94%
N NN
HO OHO O
NH2HOO
4HClFormula:C H N O ·2HCl·2H O
p-NH2-Bn-NOTA
Item #505B-605
$350.00100 mg $528.00FW: 559.950 mg
2-S-(4-Isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid
CAS Number: 147597-66-8Purity: 94%
N NN
HO OHO O
NCSHOO
3HClFormula:C H N O S·3HCl
p-SCN-Bn-NOTA
Item #516B-616
$796.00500 mg $2,703.00FW: 466.6100 mg
1,4,7-Triazacyclononane-1,4-bis(t-butylacetate)-7-(3-butynylacetamide)
CAS Number: N/APurity:
NNNO
OO
OtBu
HNO
tBu
Formula:C H N O
NO2A-Butyne-bis (t-Bu ester)
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Item #520B-620
$198.00500 mg $817.00FW: 415.5100 mg
1 g $1,136.00
1,4,7-Triazacyclononane-1,4-bis-tert-butyl acetate-7-acetic acid
CAS Number: 1161415-28-6Purity: 95%
NNNO
OO
OtBu
OHO
tBu
Formula:C H N O
NOTA-bis(t-Bu ester)
Item #522B-622
$468.00500 mg $1,362.00FW: 539.5100 mg
1,4,7-Triazacyclononane-1,4-bis-acetic acid-7-maleimidoethylacetamide
CAS Number: N/APurity: 94%
NNNO
HOO
OH
HNO
NO
OCF3CO2H
Formula:C H N O •CF CO H
Maleimido-mono-amide-NOTA
Item #526B-626
$1,153.00500 mg $4,034.00FW: 354.4100 mg
1,4,7-Triazacyclononane-1,4-bis(acetic acid)-7-(3-butynylacetamide)
CAS Number: N/APurity: 94%
NNNO
HOO
OH
HNO
Formula:C H N O
NO2A-Butyne
Item #528B-628
$490.00500 mg $1,424.00FW: 494.8100 mg
1,4,7-Triazacyclononane-1,4-bis(acetic acid)-7-(3-azidopropylacetamide)
CAS Number: N/APurity: 94%
NN
NO
HO
O
OH
HN
ON3
3HClFormula:C H N O ·3HCl
NO2A-Azide
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Item #605B-705
$268.00100 mg $423.00FW: 752.950 mg
500 mg $1,462.00
1-(4-isothiocyanatophenyl)-3-[6,17-dihydroxy-7,10,18,21-tetraoxo-27-(N-acetylhydroxylamino)- 6,11,17, 22- tetraazaheptaeicosine] thiourea
CAS Number: 1222468-90-7Purity: 94%
O
NHNO
OH
NOOH
NH
NH N O
OH
O
S
NH
NCS
Formula:C H N O S
p-SCN-Bn-Deferoxamine
Item #672B-772
$222.00100mg $351.00FW: 711.850mg
500mg $1,211.00
N-(3,11,14,22,25,33-hexaoxo-4,10,15,21,26,32-hexaaza-10,21,32- trihydroxytetratriacontane)maleimide
CAS Number: N/APurity: 94%
ON
HNO
OH
NOOH
NH
NH N O
OH
O
O
NO
O
Formula:C H N O
Deferoxamine-maleimide
Item #705B-1005
$350.00100 mg $648.00FW: 693.550 mg
S-2-(4-Isothiocyanatobenzyl)-1,4,7,10-tetraaza-1,4,7,10-tetra(2-carbamoylmethyl)cyclododecane
CAS Number: 282097-63-6Purity: 94%
N N
NN NCS
H2N NH2
H2N NH2
O O
O O4HCl
Formula:C H N O S·4HCl
p-SCN-Bn-TCMC
Item #798S-100
FW:100 mg
$848.00
Samples of our most popular bifunctional chelators
CAS Number:Purity:
Formula:
Bifunctional Starter Pack
50 mg100 mg100 mg50 mg
B-205B-280B-305B-355
p-SCN-Bn-DOTA DOTA-NHS-ester p-SCN-Bn-DTPA p-SCN-Bn-CHX-A"-DTPA
17
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Item #799
FW:CAS Number:Purity:
Formula:
Conjugates
Item #800C-100
$412.0050 mg $864.00FW: 915.920 mg
100 mg $1,684.00
(N-methyl-N-(hexahydro-2-oxo-1H-thieno[3,4-d]-imidazol-4-yl)-oxopentyl)glycyl-2-(S)-(4-aminobenzyl)-1,4,7,10-tetraacetic acid-1,4,7,10-tetraazacyclododecane
CAS Number: N/APurity: 94%
S
HN NHO
ON O
N
N N
N
NH
HO
HO
OH
OH
O
O
O
O
2HCl2H2O Formula:C H N O S·2HCl·2H O
DOTA-Biotin-Sarcosine
Item #910C-210
$408.00500 mg $1,642.00100 mg
1-(5-Hydroxyindole-3-ethylacetamide)-4,7,10-triacetic acid-1,4,7,10-tetraazacyclododecane
Formula:C H N O •2CF CO H FW: 790.7CAS Number: N/APurity: 94%
N N
NN
HO OH
HO NH
O O
O O
NH
HO
.2TFA
DO3A-Serotonin
Item #920C-220
$550.001 mg
DOTA-d-Phe-Cys-Tyr-d-Trp-Lys-Thr-Cys-Thr
Formula:C H N O S •3TFA•3H O FW: 1831.7CAS Number: 177943-89-4 Purity: 95%
ONH
OOH
NH
HN
NHOOS
S
HN
O
NH
HN
O
NH
NH2
NH
OOHOHO
OH
O
NN
NN
COOH
HOOC
HOOC
3 CF3CO2H3 H2O
DOTATATE
18
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Item #1010
FW:CAS Number:Purity:
Formula:
Macrocyclic Ligands
Item #1100M-090
$128.005 g $585.00FW: 129.21 g
1,4,7-Triazacyclononane
CAS Number: 4730-54-5Purity: 95%
N NN
HH
H
Formula:C H N
TACN
Item #1101M-100
$245.0010 g $484.00FW: 172.35 g
25 g $1,075.00
1,4,7,10-Tetraazacyclododecane
CAS Number: 294-90-6Purity: Crystalline
N N
NNH
HH
H
Formula:C H N
Cyclen
Item #1125M-125
$481.001 g $871.00FW: 434.2
500 mg
1,4,7,10-Tetraazacyclododecane-1,7-diacetic acid
CAS Number: 112193-75-6Purity: N/A
N N
NN
H
H
HO
OH
O
O
4HCl
Formula:C H N O ·4HCl
DO2A
19
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Item #1135M-135
$371.001 g $648.00FW: 448.4
500 mg
1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid trisodium salt
CAS Number: 217973-03-0Purity: 95%
N N
NNH
NaO ONa
NaO
O O
O
2H2O
Formula:C H N O Na ·2H O
DO3A
Item #1140M-140
$144.005 g $613.00FW: 512.51 g
25 g $2,537.00
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid
CAS Number: 60239-18-1Purity: 95%
N N
NN
HO OH
HO OH
O O
O O
6H2O
Formula:C H N O ·6H O
DOTA
Item #1150M-150
$87.005 g $278.00FW: 548.31 g
10 g $516.00
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetra(methylene phosphonic acid)
CAS Number: 91987-74-5Purity: 95%
N N
NNPO3H2
PO3H2H2O3P
H2O3P
Formula:C H N O P
DOTP
Item #1160M-160
$168.00500 mg $526.00FW: 620.5100 mg
1 g $940.00
(1R, 4R, 7R, 10R)- , ’, ”, ’”-Tetramethyl-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid tetrasodium salt
CAS Number: 148408-89-3Purity: 95%
N N
NN
NaO ONa
NaO ONa
O O
O O
4H2OFormula:C H N O Na ·4H O
DOTMA
20
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Item #1170M-170
$492.001 g $897.00FW: 650.4
500 mg
5 g $3,745.00
1,4,8,11-Tetraazacyclotetradecane-1,4,8,11-tetraacetic acid
CAS Number: 314041-07-1Purity: 95%
N N
NN
HO OH
HO OH
O O
O O4H2O
4HClFormula:C H N O ·4H O·4HCl
TETA
Item #1180M-180
$53.001 g $98.00FW: 400.5
500 mg
5 g $459.00
1,4,7,10-Tetrakis(carbamoylmethyl)-1,4,7,10-tetraazacyclododecane
CAS Number: 157599-02-5Purity: 95%
N N
NN
H2N NH2
H2N NH2
O O
O O
Formula:C H N O O
DOTAM
Item #1190M-190
$306.00500 mg $1,007.00FW: 404.6100 mg
1,8-Diamino-3,6,10,13,16,19-hexaazabicyclo[6,6,6]-eicosane
CAS Number: 91002-72-1Purity: Crystalline
N N
NNH
HH
H
N NH2N NH2HH
5H2O
Formula:C H N ·5H O
DiAmSar
Item #1200M-200
$429.001 g $666.00FW: 226.4
500 mg
1,4,8,11-Tetraazabicyclo[6.6.2]hexadecane
CAS Number: 130701-19-8Purity: N/A
N N
NN
H
H
Formula:C H N
CB-Cyclam
21
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Item #1220M-220
$113.00500 mg $451.00FW: 448.3100 mg
1,4,8,11-Tetraazabicyclo[6.6.2]hexadecane-4,11-diacetic acid
CAS Number: 313229-90-2Purity: N/A
N N
NN
OH
HO
O
O
4HClFormula:C H N O ·4HCl
CB-TE2A
Item #1400M-400
$367.00500 mg $949.00FW: 893.4100 mg
1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(acetamido-methylenephosphonic acid)
CAS Number: N/APurity: 94%
NN
N NO
O
O
O
HN PO3H2
NH
NHH2O3P
HN
PO3H2
H2O3P
HBr2H2O
Formula:C H N O P ·2H O·HBr
DOTA-4AMP
Item #1600M-600
$518.001 g $748.00FW: 412.7
500 mg
1,4,7-Triazacyclononane-1,4,7-triacetic acid
CAS Number: 56491-86-2Purity: 95%
NNNO
HO
OHO
OOH
3HCl
Formula:C H N O ·3HCl
NOTA
Item #1650M-650
$199.005g $847.00FW: 411.21g
1,4,7-Triazacyclononane-1,4,7-tri(methylene phosphonic acid)
CAS Number: 83834-39-3Purity: 95%
NNN
P
PO
HO
O
HO
PO
OH
OH
OHOH
Formula:C H N O P
NOTP
22
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Item #2690
FW:CAS Number:Purity:
Formula:
Magnetic Resonance Reagents
Item #2845M-145
$219.001 g $403.00FW: 642.4
500 mg
Thulium (III) 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetate
CAS Number: N/APurity: 94%
N N
NN
HO O-
-O O-
O O
O O
4H2OTm3+
Formula:TmC H N O ·4H O
Tm-DOTA
Item #2847M-147
$196.001 g $345.00FW: 652.7
500 mg
Gadolinium (III) 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetate
CAS Number: N/APurity: N/A
N N
NN
-O ONa
-O O-
O O
O O
4H2OGd3+
Formula:GdC H N O Na·4H O
Gd-DOTA
Item #2855M-155
$156.0010 g $1,281.00FW: 914.21 g
100 g $11,845.00
Thulium (III) 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetra(methylenephosphonate)
CAS Number: 30859-88-8Purity: N/A
N N
NNPO3Na
PO3NaNaO3P
Na2O3P
Tm3+ 5H2O Formula:TmC H N O P Na ·5H O
Tm-DOTP
23
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Item #2865M-165
$817.001 g $1,273.00FW: 698.5
500 mg
Thulium (III) (1R, 4R, 7R, 10R)- , ’, ”, ’”-Tetramethyl-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid
CAS Number: N/APurity: 94%
N N
NN
HO O-
-O O-
O O
O O
4H2OTm3+Formula:TmC H N O ·4H O
Tm-DOTMA
Item #3303M-503
$159.00100 mg $282.00FW: 943.750 mg
500 mg $648.00
Europium (III) 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrakis(acetamidoacetic acid)
CAS Number: N/APurity: 95%
NN
N NO
O
O
O
HN CO2
-
NH
NHHO2C
HN
9H2OEu3+
CO2-
-O2C
Formula:EuC H N O ·9H O
Eu-DOTA-4AmC
Item #3405X-205
$697.00100 mg $1,189.00FW: 831.650 mg
Thulium (III) S-2-(4-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid
CAS Number: N/APurity: 94%
N N
NN NCS
HO O
O O
O O
O O
Tm
TFA.Formula:TmC H N O ·TFA
Tm-p-SCN-Bn-DOTA
Item #3407X-207
$697.00100 mg $1,189.00FW: 819.950 mg
Gadolinium (III) S-2-(4-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid
CAS Number: N/APurity: 94%
N N
NN NCS
HO O
O O
O O
O O
Gd
TFA.Formula:GdC H N O ·TFA
Gd-p-SCN-Bn-DOTA
24
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Item #3409X-209
$697.00100 mg $1,189.00FW: 827.550 mg
Holmium (III) S-2-(4-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid
CAS Number: N/APurity: 94%
N N
NN NCS
HO O
O O
O O
O O
Ho
TFA.Formula:H C H N O ·TFA
Ho-p-SCN-Bn-DOTA
Item #3475X-275
$461.00100 mg $802.00FW: 806.550 mg
Thulium (III) 1,4,7,10-tetraazacyclododecane-1,4,7-tris(acetic acid)-10-maleimidoethylacetamide
CAS Number: N/APurity: 94%
N N
NN
O O
O NH
O O
O O N
O
OTm
TFA. Formula:TmC H N O ·TFA
Tm-Maleimido-DOTA
Item #3479X-279
$461.00100 mg $802.00FW: 802.550 mg
Holmium (III) 1,4,7,10-tetraazacyclododecane-1,4,7-tris(acetic acid)-10-maleimidoethylacetamide
CAS Number: N/APurity: 94%
N N
NN
O O
O NH
O O
O O N
O
OHo
TFA. Formula:HoC H N O ·TFA
Ho-Maleimido-DOTA
Item #3487X-287
$495.00500 mg $1,928.00FW: 665.2100 mg
Gadolinium (III) 1,4,7,10-Tetraazacyclododecane-1,4,7-tris(acetic acid)-10-(4-aminobutyl)acetamide
CAS Number: N/APurity: 94%
N N
NN
O O
O NH
O O
O O
GdNH2
HCl
Formula:GdC H N O ·HCl
Gd-DO3A-Butylamine
25
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Item #3602
FW:CAS Number:Purity:
Formula:
Reactive Intermediates
Item #4120M-120
$170.001 g $262.00FW: 400.6
500 mg
5 g $1,097.00
1,4,7,10-Tetraazacyclododecane-1,7-bis(t-butyl acetate)
CAS Number: 162148-48-3Purity: 95%
N N
NN
H
H
O
OtBu
O
O
tBuO
Formula:C H N O
DO2A-tert-butyl ester
Item #4130M-130
$94.001 g $128.00FW: 514.7
500 mg
5 g $562.00
1,4,7,10-Tetraazacyclododecane-1,4,7-tris(t-butyl acetate)
CAS Number: 122555-91-3Purity: 95%
N N
NNH
O OtBu
O
O O
O
tBuO
OtBu
Formula:C H N O
DO3A-tert-butyl ester
Item #4321I-121
$306.005 g $1,214.00FW: 440.51 g
1,4,7,10-Tetraazacyclododecane-1,7-bis(benzylcarbamide)
CAS Number: N/APurity: 95%
N N
NN
H
H OO
OO
Formula:C H N O
Bis-CBZ-Cyclen
26
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Item #4331I-131
$169.005 g $760.00FW: 472.61 g
1,4,7,10-Tetraazacyclododecane-1,4,7-tris(t-butoxycarbonyl)
CAS Number: N/APurity: 95%
N N
NN
H
OtBuO
OO
OO
tBuO
tBuO
Formula:C H N O
Tris-BOC-Cyclen
Item #4922I-623
$507.001 g $850.00FW: 357.5
500 mg
1,4,7-Triazacyclononane-1,4-bis(t-butyl acetate)
CAS Number: 174137-97-4Purity: 95%
NNNO
OO
OtButBu
H
Formula:C H N O
NO2A-(t-Bu ester)
27
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Item #4925
FW:CAS Number:Purity:
Formula:
Fluorescent Probes
Item #5100D-100
$352.00FW: 393.2
10 mg
N,N,N-Trimethyl-2[(7-nitro-1,2,3-benzoxadiazol-4-yl)amino] ethanaminium iodide
CAS Number: 287970-46-1Purity: 94%
NNO
O2N NH
NI
Formula:C H N O I
EAM-1
Item #5110D-110
$352.00FW: 376.2
10 mg
N,N-Dimethyl-N-(2-hydroxyethyl)-2[(7-nitro-1,2,3-benzoxadiazol-4-yl)amino] ethanaminium bromide
CAS Number: N/APurity: 94%
NNO
O2N NH
NBr
OH
+
Formula:C H N O Br
EAM-2
28
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29
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30
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