2017 PRODUCT CATALOG - Macrocyclics, chelating … your order: or (469) 786-6060 Product List Magnetic Resonance Reagents Page M-145 Tm-DOTA 23 M-147 Gd-DOTA 23 M-155 Tm-DOTP

Molecular Innova on for Medicine

2017 PRODUCT CATALOG

Place your order: www.macrocyclics.com or (469) 786-6060

Macrocyclics has been the global leader in chelating agent technologies for medicine since 1995. The Macrocyclics team is dedicated to providing its clients with both established and innovative chelating agents and services to meet the challenges of molecular imaging and nuclear medicine.

SERVICES

Nuclear Medicine Process chemistry and ligand design Feasibility studies for process optimization Bioconjugation development and cGMP production Custom design, manufacture, and cGMP production of chelates Identification and selection of appropriate chelating agent and specific applications

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ABOUT MACROCYCLICS Macrocyclics, a manufacturer of customized chelating agents, is dedicated to leading-edge development of new chelation chemistry platforms critical for advancement of diagnostic and therapeutic medicine. Our strong commitment to customer service and quality products are key components in our ongoing pursuit of excellence.

ABOUT YOUR ORDER

SHIPPING Most of the compounds we sell are stable under normal laboratory conditions. It is not necessary to refrigerate our compounds during short-distance transportation. Therefore, we ship our compounds via FedEx Air, unless otherwise specified by the customer. If the compound requires special shipping conditions (such as dry ice) you will be notified in advance.

STORAGE CONDITIONS

We recommend storing Macrocyclics’ products in the freezer at –20°C.

TECHNICAL QUESTIONS

If you have a technical question about a product you have received, or would like to know more before you place an order, please contact us: [email protected] or (469) 786-6060.

SAFETY DATA SHEETS SDSs are available on our website under the

Individual product pages. We can also fax a hardcopy if you prefer. Please mention your request on the purchase order.

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PRODUCT ANALYSIS Macrocyclics’ expertise in ligand synthesis is complemented by our quality control systems, guaranteeing the highest possible quality for all our products.

CERTIFICATE OF ANALYSIS

Certificates of analysis will be sent with your products if requested. The C of A provides the test method used and the results. If you need further information about a compound, please contact us and we will try to accommodate your request.

HOW TO ORDER

If you are new customer placing your first order, please provide: Purchase order or credit card number Shipping and billing addresses Phone and fax numbers Email address

Once your order is processed, you will receive a confirmation by fax or email.

Online: By Fax: By Phone: Payment:

www.macrocyclics.com and click on “online catalog” Please fax your order to (469) 814-9116. Call in your order with the information listed above: (469) 786-6060. We accept VISA, MasterCard, and American Express. There is a $20 service charge for international bank transfers. Please see Macrocyclics bank information on your original invoice.

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Product List

Bifunctional Chelators (BFCs) Page B-110 p-NO2-Bn-Cyclen .......................................................... 7 B-170 DOTAM-mono-acid ....................................................... 7 B-199 p-NO2-Bn-DOTA .......................................................... 7 B-200 p-NH2-Bn-DOTA ........................................................... 8 B-201 p-NH2-Bn-DOTA-tetra(t-Bu ester) ................................. 8 B-205 p-SCN-Bn-DOTA .......................................................... 8 B-260 DOTA-tris (t-Bu ester) ................................................... 8 B-264 DOTAGA-tetra (t-Bu ester) ........................................... 9 B-270 DOTA-mono-NHS-tris (t-Bu ester) ................................ 9 B-271 Maleimido-mono-amide-DOTA-tris (t-Bu ester) ............ 9 B-272 Maleimido-mono-amide-DOTA ..................................... 9 B-275 Fmoc-L-Lys-mono-amide-DOTA-tris (t-Bu ester) ........ 10 B-276 Butyne-DOTA-tris(t-butyl ester) .................................. 10 B-277 2-Aminoethyl-mono-amide DOTA-tris (t-Bu ester) ...... 10 B-278 3-Azidopropyl-mono-amide-DOTA-tris(t-Bu ester) ...... 10 B-279 4-Aminobutyl-DOTA-tris (t-butyl ester) ........................ 11 B-280 DOTA-NHS-ester ........................................................ 11 B-281 DO3A-Thiol ................................................................. 11 B-286 Butyne-DOTA .............................................................. 11 B-288 3-Azidopropyl-mono-amide-DOTA .............................. 12 B-289 4-Aminobutyl-DOTA .................................................... 12 B-300 p-NH2-Bn-DTPA .......................................................... 12 B-301 p-NH2-Bn-DTPA-penta (t-Bu ester) ............................. 12 B-305 p-SCN-Bn-DTPA ......................................................... 13 B-351 p-NH2-Bn-CHX-A″-DTPA ............................................ 13 B-355 p-SCN-Bn-CHX-A″-DTPA ........................................... 13 B-365 DTPA-tetra (t-Bu ester) ............................................... 13 B-372 Maleimido-mono-amide-DTPA .................................... 14 B-401 p-NH2-Bn-PCTA .......................................................... 14 B-405 p-SCN-Bn-PCTA ......................................................... 14 B-501 p-NH2-Bn-oxo-DO3A ................................................... 14 B-505 p-SCN-Bn-oxo-DO3A .................................................. 15 B-601 p-NH2-Bn-NOTA.......................................................... 15

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Product List Bifunctional Chelators (BFCs) Page B-605 p-SCN-Bn-NOTA .........................................................15 B-616 NO2A-Butyne-bis (t-Bu ester) .....................................15 B-620 NOTA-bis (t-Bu ester) .................................................16 B-622 Maleimido-mono-amide-NOTA ...................................16 B-626 NO2A-Butyne ..............................................................16 B-628 NO2A-Azide ................................................................16 B-705 p-SCN-Bn-Deferroxamine ...........................................17 B-772 Deferroxamine-maleimide ...........................................17 B-1005 p-SCN-Bn-TCMC ........................................................17 S-100 Bifunctional Starter Pack .............................................17

Macrocyclic Ligands Page C-100 DOTA-Biotin-Sarcosine ...............................................18 C-210 DO3A-Serotonin ..........................................................18 C-220 DOTATATE .................................................................18

Macrocyclic Ligands Page M-090 TACN ..........................................................................19 M-100 Cyclen .........................................................................19 M-125 DO2A ..........................................................................19 M-135 DO3A ..........................................................................20 M-140 DOTA ..........................................................................20 M-150 DOTP ..........................................................................20 M-160 DOTMA .......................................................................20 M-170 TETA ...........................................................................21 M-180 DOTAM .......................................................................21

M-190 DiAmSar ......................................................................21

M-200 CB-Cyclam ..................................................................21 M-220 CB-TE2A .....................................................................22 M-400 DOTA-4AMP ...............................................................22 M-600 NOTA ..........................................................................22 M-650 NOTP ..........................................................................22

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Product List Magnetic Resonance Reagents Page M-145 Tm-DOTA .................................................................... 23 M-147 Gd-DOTA .................................................................... 23 M-155 Tm-DOTP .................................................................... 23 M-165 Tm-DOTMA ................................................................ 24 M-503 Eu-DOTA 4AmC ......................................................... 24 X-205 Tm-p-SCN-Bn-DOTA ................................................. 24 X-207 Gd-p-SCN-Bn-DOTA .................................................. 24 X-209 Ho-p-SCN-Bn-DOTA .................................................. 25 X-275 Tm-Maleimido-DOTA ................................................. 25 X-279 Ho-Maleimido-DOTA .................................................. 25 X-287 Gd-DO3A-Butylamine ................................................. 25

Reactive Intermediates Page M-120 DO2A-tert-butyl ester .................................................. 26 M-130 DO3A-tert-butyl ester .................................................. 26 I-121 Bis-CBZ-Cyclen........................................................... 26 I-131 Tris-Boc-Cyclen........................................................... 27 I-623 NO2A-(t-Bu ester) ....................................................... 27

Fluorescent Probes Page D-100 EAM-1 ......................................................................... 28 D-110 EAM-2 ......................................................................... 28

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www.macrocyclics.com (469) 786-6060

Item #10

FW:CAS Number:Purity:

Formula:

Bifunctional Chelators (BFCs)

Item #40B-110

$381.00500 mg $1,706.00FW: 307.4100 mg

S-2-(4-Nitrobenzyl)-1,4,7,10-tetraazacyclododecane

CAS Number: 116052-96-9Purity: 94%

N N

NN NO2H

HH

H

Formula:C H N O

p-NO2-Bn-Cyclen

Item #45B-170

$350.00500 mg $990.00FW: 401.5100 mg

1,4,7,10-Tetraazacyclododecane-1,4,7-tri(carbamoylmethyl)-10-acetic acid

CAS Number: N/APurity: 95%

N N

NN

H2N NH2

H2N OH

O O

O O

Formula:C H N O

DOTAM-mono-acid

Item #50B-199

$269.00100 mg $430.00FW: 685.450 mg

S-2-(4-Nitrobenzyl)-1,4,7,10-tetraazacyclododecane tetraacetic acid


N N

NN NO2

HO OH

HO OH

O O

O O4HCl

Formula:C H N O ·4HCl

p-NO2-Bn-DOTA

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Item #60B-200

$265.00100 mg $424.00FW: 655.450 mg

500 mg $1,712.00

S-2-(4-Aminobenzyl)-1,4,7,10-tetraazacyclododecane tetraacetic acid


N N

NN NH2

HO OH

HO OH

O O

O O4HCl


p-NH -Bn-DOTA

Item #70B-201

$313.00500 mg $1,410.00FW: 848.0100 mg

S-2-(4-Aminobenzyl)-1,4,7,10-tetraazacyclododecane tetra-tert-butylacetate


N N

NN NH2

O OtBu

O OtBu

O O

O OTFA

tBuO

OtBu

Formula:C H N O ·TFA

p-NH -Bn-DOTA-tetra(t-Bu ester)

Item #80B-205

$330.00100 mg $502.00FW: 687.850 mg

500 mg $2,023.00

S-2-(4-Isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane tetraacetic acid


N N

NN NCS

HO OH

HO OH

O O

O O2.5HCl

2.5H2O

Formula:C H N O S·2.5HCl·2.5H

p-SCN-Bn-DOTA

Item #90B-260

$281.001 g $439.00FW: 572.7

500 mg

5 g $1,976.00

1,4,7,10-Tetraazacyclododecane-1,4,7-tris-tert-butyl acetate-10-acetic acid


N N

NN

O OtBu

O OH

O O

O O

tBuO

OtBu

Formula:C H N O

DOTA-tris (t-Bu ester)

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Item #94B-264

$290.00500 mg $660.00FW: 700.9100 mg

1 g $995.00

2-[1,4,7,10-Tetraazacyclododecane-4,7,10-tris(t-butyl acetate)]-pentanedioic acid-1-t-butyl ester


N N

NN

O OtBu

O OtBu

O O

O O

tBuO

OtBuO

OHFormula:C H N O

DOTAGA-tetra (t-Bu ester)

Item #100B-270

$100.00500 mg $438.00FW: 815.8100 mg

1 g $818.00

1,4,7,10-Tetraazacyclododecane-1,4,7-tris-tert-butyl acetate-10-succinimidyl acetate


N N

NN

O OtBu

O O

O O

O O

tBuO

OtBuN

O

O

HPF6 Formula:C H N O ·HPF

DOTA-mono-NHS tris (t-Bu ester)

Item #101B-271

$202.00100 mg $322.00FW: 840.850 mg

500 mg $952.00

1,4,7,10-Tetraazacyclododecane-1,4,7-tris-tert-butyl acetate-10-maleimidoethylacetamide


N N

NN

O OtBu

O NH

O O

O O

tBuO

OtBu

HPF6

N

O

OFormula:C H N O ·HPF

Maleimido-mono-amide-DOTA-tris (t-Bu ester)

Item #102B-272

$228.00100 mg $348.00FW: 786.550 mg

500 mg $1,039.00

1,4,7,10-Tetraazacyclododecane-1,4,7-tris-acetic acid-10-maleimidoethylacetamide


N N

NN

HO OH

HO NH

O O

O O

HPF6

N

O

OTFA Formula:C H N O ·HPF ·TFA

Maleimido-mono-amide-DOTA

9


Item #105B-275

$198.00100mg $311.00FW: 1069.150mg

500mg $946.00

1,4,7,10-Tetraazacyclododecane-1,4,7-tris-tert-butyl acetate-10-(N-a-Fmoc-N-e-acetamido-L-lysine)


N N

NN

O OtBu

O NH

O O

O O

tBuO

OtBu (CH2)4

HPF6

NHFmoc

HOO

Formula:C H N O ·HPF

Fmoc-L-Lys-mono-amide-DOTA-tris(t-Bu ester)

Item #106B-276

$202.00500 mg $796.00FW: 769.8100 mg

1,4,7,10-Tetraazacyclododecane-1,4,7-tris(t-butyl acetate)-10-(3-butynylacetamide)


HPF6

N N

NN

O OtBu

O NH

O O

O OOtBu

tBu


Butyne-DOTA-tris(t-Bu ester)

Item #107B-277

$359.001 g $645.00FW: 695.7

500 mg

5 g $2,563.00

1,4,7,10-Tetraazacyclododecane-1,4,7-tris(t-butyl-acetate)-10-(aminoethylacetamide)


N N

NN

O OtBu

O NH

O O

O O

tBuO

OtBu NH2

HBr

Formula:C H N O ·HBr

2-Aminoethyl-mono-amide-DOTA-tris(t-Bu ester)

Item #108B-278

$202.00500 mg $806.00FW: 735.8100 mg

1 g $1,464.00

1,4,7,10-Tetraazacyclododecane-1,4,7-tris-tert-butyl acetate-10-(azidopropyl ethylacetamide)


N N

NN

O OtBu

O NH

O O

O O

tBuO

OtBu

HBr

N3

Formula:C H N O ·HBr

Azido-mono-amide-DOTA-tris(t-Bu ester)

10


Item #109B-279

$214.00500 mg $734.00FW: 788.8100 mg

1,4,7,10-Tetraazacyclododecane-1,4,7-tris(t-butyl acetate)-10-(4-aminobutyl)acetamide


HPF6

N N

NN

O OtBu

O NH

O O

O OOtBu

tBu

NH2


4-Aminobutyl-DOTA-tris (t-Bu ester)

Item #110B-280

$125.00500 mg $491.00FW: 761.5100 mg

1 g $927.00

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid mono-N-hydroxysuccinimide ester


N N

NN

HO OH

HO O

O O

O ON

O

O

HPF6TFA Formula:C H N O ·HPF ·CF CO

DOTA-NHS-ester

Item #111B-281

$836.00500 mg $2,836.00FW: 691.6100 mg

1,4,7,10-Tetraazacyclododecane-1,4,7-tris(acetic acid)-10-(2-thioethyl)acetamide


N N

NN

HO OH

HO NH

O O

O OSH

2TFAFormula:C H N O S·2CF CO H

DO3A-Thiol

Item #116B-286

$290.00500 mg $1,130.00FW: 683.6100 mg

1,4,7,10-Tetraazacyclododecane-1,4,7-tris(acetic acid)-10-(3-butynylacetamide)


N N

NN

HO OH

HO NH

O O

O O

2TFA Formula:C H N O ·2CF CO H

Butyne-DOTA

11


Item #118B-288

$283.00500 mg $1,128.00FW: 595.9100 mg

1 g $2,050.00

1,4,7,10-Tetraazacyclododecane-1,4,7-tris(acetic acid)-10-(azidopropyl ethylacetamide)


N N

NN

HO OH

HO NH

O O

O O

3HCl

N3


Azido-mono-amide-DOTA

Item #119B-289

$311.00500 mg $1,214.00FW: 766.4100 mg

1,4,7,10-Tetraazacyclododecane-1,4,7-tris(acetic acid)-10-(4-aminobutyl)acetamide


N N

NN

HO OH

HO NH

O O

O O

HPF6

NH2

4HClFormula:C H N O ·HPF ·4HCI

4-Aminobutyl-DOTA

Item #120B-300

$157.00500 mg $678.00FW: 644.3100 mg

S-2-(4-Aminobenzyl)-diethylenetriamine pentaacetic acid


NN N

NH2

OH

OHHO

HOO O

O OOOH

4HClFormula:C H N O ·4HCl

p-NH -Bn-DTPA

Item #121B-301

$1,336.00FW: 779.0

1g

S-2-(4-Aminobenzyl)-diethylenetriamine penta-tert-butyl acetate


NN N

NH2

OtBu

OtBuO

OO O

O OOOtBu

tBuO

tBuOFormula:C H N O

p-NH -Bn-DTPA-penta (t-Bu ester)

12


Item #125B-305

$193.00500 mg $852.00FW: 649.9100 mg

S-2-(4-Isothiocyanatobenzyl)-diethylenetriamine pentaacetic acid


NN N

NCS

OH

OHHO

HOO O

O OOOH

3HClFormula:C H N O S·3HCl

p-SCN-Bn-DTPA

Item #171B-351

$391.00500 mg $1,514.00FW: 661.5100 mg

[(R)-2-Amino-3-(4-aminophenyl)propyl]-trans-(S,S)-cyclohexane-1,2-diamine-pentaacetic acid


NN N

NH2

OH

OHHO

HOO O

O OOOH

2HCl2H2O

Formula:C H N O ·2HCl·2H O

p-NH -Bn-CHX-A"-DTPA

Item #175B-355

$289.00100 mg $440.00FW: 704.050 mg

500 mg $1,618.00

[(R)-2-Amino-3-(4-isothiocyanatophenyl)propyl]-trans-(S,S)-cyclohexane-1,2-diamine-pentaacetic acid


NN N

NCS

OH

OHHO

HOO O

O OOOH

3HCl

Formula:C H N O S·3HCl

p-SCN-Bn-CHX-A"-DTPA

Item #185B-365

$706.001 g $1,299.00FW: 617.8

500 mg

Diethylenetriamine-N,N,N",N"-tetra-tert-butyl acetate-N'-acetic acid


NN NOtBu

OtBuO

OO O

O OOOH

tBuO

tBuOFormula:C H N O

DTPA-tetra (t-Bu ester)

13


Item #192B-372

$340.00100 mg $544.00FW: 857.550 mg

500 mg $1,855.00

Diethylenetriamine-N,N,N",N"-tetraacetic acid-N'-maleimidoethylacetamide


NN NOH

OHHO

HOO O

O OONH

NO

O

3CF3COOH

Formula:C H N O ·3CF CO H

Maleimido-mono-amide-DTPA

Item #221B-401

$378.00100 mg $549.00FW: 594.550 mg

3,6,9,15-Tetraazabicyclo[9.3.1] pentadeca-1(15),11,13-triene-4-S-(4-aminobenzyl)-3,6,9-triacetic acid


NN N

N

NH2

2HCl2H2O

O

OH

OHO

OHO


p-NH -Bn-PCTA

Item #305B-405

$462.00100 mg $625.00FW: 637.050 mg

3,6,9,15-Tetraazabicyclo[9.3.1] pentadeca-1(15),11,13-triene-4-S-(4-isothiocyanatobenzyl)-3,6,9-triacetic acid


NN N

N

NCS

3HClO

OH

OHO

OHO


p-SCN-Bn-PCTA

Item #401B-501

$378.00100 mg $549.00FW: 561.550 mg

1-Oxa-4,7,10-tetraazacyclododecane-5-S-(4-aminobenzyl)-4,7,10-triacetic acid


ON N

N

NH2

2HCl2H2O

O

OH

OHO

OHO


p-NH -Bn-oxo-DO3A

14


Item #405B-505

$450.00100 mg $609.00FW: 603.950 mg

1-Oxa-4,7,10-tetraazacyclododecane-5-S-(4-isothiocyantobenzyl)-4,7,10-triacetic acid


ON N

N

NCS

3HClO

OH

OHO

OHO


p-SCN-Bn-oxo-DO3A

Item #501B-601

$242.00100 mg $398.00FW: 517.450 mg

2-S-(4-Aminobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid


N NN

HO OHO O

NH2HOO

4HClFormula:C H N O ·2HCl·2H O

p-NH2-Bn-NOTA

Item #505B-605

$350.00100 mg $528.00FW: 559.950 mg

2-S-(4-Isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid


N NN

HO OHO O

NCSHOO

3HClFormula:C H N O S·3HCl

p-SCN-Bn-NOTA

Item #516B-616

$796.00500 mg $2,703.00FW: 466.6100 mg

1,4,7-Triazacyclononane-1,4-bis(t-butylacetate)-7-(3-butynylacetamide)

CAS Number: N/APurity:

NNNO

OO

OtBu

HNO

tBu

Formula:C H N O

NO2A-Butyne-bis (t-Bu ester)

15


Item #520B-620

$198.00500 mg $817.00FW: 415.5100 mg

1 g $1,136.00

1,4,7-Triazacyclononane-1,4-bis-tert-butyl acetate-7-acetic acid


NNNO

OO

OtBu

OHO

tBu

Formula:C H N O

NOTA-bis(t-Bu ester)

Item #522B-622

$468.00500 mg $1,362.00FW: 539.5100 mg

1,4,7-Triazacyclononane-1,4-bis-acetic acid-7-maleimidoethylacetamide


NNNO

HOO

OH

HNO

NO

OCF3CO2H

Formula:C H N O •CF CO H

Maleimido-mono-amide-NOTA

Item #526B-626

$1,153.00500 mg $4,034.00FW: 354.4100 mg

1,4,7-Triazacyclononane-1,4-bis(acetic acid)-7-(3-butynylacetamide)


NNNO

HOO

OH

HNO

Formula:C H N O

NO2A-Butyne

Item #528B-628

$490.00500 mg $1,424.00FW: 494.8100 mg

1,4,7-Triazacyclononane-1,4-bis(acetic acid)-7-(3-azidopropylacetamide)


NN

NO

HO

O

OH

HN

ON3


NO2A-Azide

16


Item #605B-705

$268.00100 mg $423.00FW: 752.950 mg

500 mg $1,462.00

1-(4-isothiocyanatophenyl)-3-[6,17-dihydroxy-7,10,18,21-tetraoxo-27-(N-acetylhydroxylamino)- 6,11,17, 22- tetraazaheptaeicosine] thiourea


O

NHNO

OH

NOOH

NH

NH N O

OH

O

S

NH

NCS

Formula:C H N O S

p-SCN-Bn-Deferoxamine

Item #672B-772

$222.00100mg $351.00FW: 711.850mg

500mg $1,211.00

N-(3,11,14,22,25,33-hexaoxo-4,10,15,21,26,32-hexaaza-10,21,32- trihydroxytetratriacontane)maleimide


ON

HNO

OH

NOOH

NH

NH N O

OH

O

O

NO

O

Formula:C H N O

Deferoxamine-maleimide

Item #705B-1005

$350.00100 mg $648.00FW: 693.550 mg

S-2-(4-Isothiocyanatobenzyl)-1,4,7,10-tetraaza-1,4,7,10-tetra(2-carbamoylmethyl)cyclododecane


N N

NN NCS

H2N NH2

H2N NH2

O O

O O4HCl


p-SCN-Bn-TCMC

Item #798S-100

FW:100 mg

$848.00

Samples of our most popular bifunctional chelators

CAS Number:Purity:

Formula:

Bifunctional Starter Pack

50 mg100 mg100 mg50 mg

B-205B-280B-305B-355

p-SCN-Bn-DOTA DOTA-NHS-ester p-SCN-Bn-DTPA p-SCN-Bn-CHX-A"-DTPA

17


Item #799


Formula:

Conjugates

Item #800C-100

$412.0050 mg $864.00FW: 915.920 mg

100 mg $1,684.00

(N-methyl-N-(hexahydro-2-oxo-1H-thieno[3,4-d]-imidazol-4-yl)-oxopentyl)glycyl-2-(S)-(4-aminobenzyl)-1,4,7,10-tetraacetic acid-1,4,7,10-tetraazacyclododecane


S

HN NHO

ON O

N

N N

N

NH

HO

HO

OH

OH

O

O

O

O

2HCl2H2O Formula:C H N O S·2HCl·2H O

DOTA-Biotin-Sarcosine

Item #910C-210

$408.00500 mg $1,642.00100 mg

1-(5-Hydroxyindole-3-ethylacetamide)-4,7,10-triacetic acid-1,4,7,10-tetraazacyclododecane

Formula:C H N O •2CF CO H FW: 790.7CAS Number: N/APurity: 94%

N N

NN

HO OH

HO NH

O O

O O

NH

HO

.2TFA

DO3A-Serotonin

Item #920C-220

$550.001 mg

DOTA-d-Phe-Cys-Tyr-d-Trp-Lys-Thr-Cys-Thr

Formula:C H N O S •3TFA•3H O FW: 1831.7CAS Number: 177943-89-4 Purity: 95%

ONH

OOH

NH

HN

NHOOS

S

HN

O

NH

HN

O

NH

NH2

NH

OOHOHO

OH

O

NN

NN

COOH

HOOC

HOOC

3 CF3CO2H3 H2O

DOTATATE

18


Item #1010


Formula:

Macrocyclic Ligands

Item #1100M-090

$128.005 g $585.00FW: 129.21 g

1,4,7-Triazacyclononane


N NN

HH

H

Formula:C H N

TACN

Item #1101M-100

$245.0010 g $484.00FW: 172.35 g

25 g $1,075.00

1,4,7,10-Tetraazacyclododecane

CAS Number: 294-90-6Purity: Crystalline

N N

NNH

HH

H

Formula:C H N

Cyclen

Item #1125M-125

$481.001 g $871.00FW: 434.2

500 mg

1,4,7,10-Tetraazacyclododecane-1,7-diacetic acid

CAS Number: 112193-75-6Purity: N/A

N N

NN

H

H

HO

OH

O

O

4HCl


DO2A

19


Item #1135M-135

$371.001 g $648.00FW: 448.4

500 mg

1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid trisodium salt


N N

NNH

NaO ONa

NaO

O O

O

2H2O

Formula:C H N O Na ·2H O

DO3A

Item #1140M-140

$144.005 g $613.00FW: 512.51 g

25 g $2,537.00

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid


N N

NN

HO OH

HO OH

O O

O O

6H2O

Formula:C H N O ·6H O

DOTA

Item #1150M-150

$87.005 g $278.00FW: 548.31 g

10 g $516.00

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetra(methylene phosphonic acid)


N N

NNPO3H2

PO3H2H2O3P

H2O3P

Formula:C H N O P

DOTP

Item #1160M-160

$168.00500 mg $526.00FW: 620.5100 mg

1 g $940.00

(1R, 4R, 7R, 10R)- , ’, ”, ’”-Tetramethyl-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid tetrasodium salt


N N

NN

NaO ONa

NaO ONa

O O

O O

4H2OFormula:C H N O Na ·4H O

DOTMA

20


Item #1170M-170

$492.001 g $897.00FW: 650.4

500 mg

5 g $3,745.00

1,4,8,11-Tetraazacyclotetradecane-1,4,8,11-tetraacetic acid


N N

NN

HO OH

HO OH

O O

O O4H2O

4HClFormula:C H N O ·4H O·4HCl

TETA

Item #1180M-180

$53.001 g $98.00FW: 400.5

500 mg

5 g $459.00

1,4,7,10-Tetrakis(carbamoylmethyl)-1,4,7,10-tetraazacyclododecane


N N

NN

H2N NH2

H2N NH2

O O

O O

Formula:C H N O O

DOTAM

Item #1190M-190

$306.00500 mg $1,007.00FW: 404.6100 mg

1,8-Diamino-3,6,10,13,16,19-hexaazabicyclo[6,6,6]-eicosane

CAS Number: 91002-72-1Purity: Crystalline

N N

NNH

HH

H

N NH2N NH2HH

5H2O

Formula:C H N ·5H O

DiAmSar

Item #1200M-200

$429.001 g $666.00FW: 226.4

500 mg

1,4,8,11-Tetraazabicyclo[6.6.2]hexadecane


N N

NN

H

H

Formula:C H N

CB-Cyclam

21


Item #1220M-220

$113.00500 mg $451.00FW: 448.3100 mg

1,4,8,11-Tetraazabicyclo[6.6.2]hexadecane-4,11-diacetic acid


N N

NN

OH

HO

O

O


CB-TE2A

Item #1400M-400

$367.00500 mg $949.00FW: 893.4100 mg

1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(acetamido-methylenephosphonic acid)


NN

N NO

O

O

O

HN PO3H2

NH

NHH2O3P

HN

PO3H2

H2O3P

HBr2H2O

Formula:C H N O P ·2H O·HBr

DOTA-4AMP

Item #1600M-600

$518.001 g $748.00FW: 412.7

500 mg

1,4,7-Triazacyclononane-1,4,7-triacetic acid


NNNO

HO

OHO

OOH

3HCl


NOTA

Item #1650M-650

$199.005g $847.00FW: 411.21g

1,4,7-Triazacyclononane-1,4,7-tri(methylene phosphonic acid)


NNN

P

PO

HO

O

HO

PO

OH

OH

OHOH

Formula:C H N O P

NOTP

22


Item #2690


Formula:

Magnetic Resonance Reagents

Item #2845M-145

$219.001 g $403.00FW: 642.4

500 mg

Thulium (III) 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetate


N N

NN

HO O-

-O O-

O O

O O

4H2OTm3+

Formula:TmC H N O ·4H O

Tm-DOTA

Item #2847M-147

$196.001 g $345.00FW: 652.7

500 mg

Gadolinium (III) 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetate

CAS Number: N/APurity: N/A

N N

NN

-O ONa

-O O-

O O

O O

4H2OGd3+

Formula:GdC H N O Na·4H O

Gd-DOTA

Item #2855M-155

$156.0010 g $1,281.00FW: 914.21 g

100 g $11,845.00

Thulium (III) 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetra(methylenephosphonate)


N N

NNPO3Na

PO3NaNaO3P

Na2O3P

Tm3+ 5H2O Formula:TmC H N O P Na ·5H O

Tm-DOTP

23


Item #2865M-165

$817.001 g $1,273.00FW: 698.5

500 mg

Thulium (III) (1R, 4R, 7R, 10R)- , ’, ”, ’”-Tetramethyl-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid


N N

NN

HO O-

-O O-

O O

O O

4H2OTm3+Formula:TmC H N O ·4H O

Tm-DOTMA

Item #3303M-503

$159.00100 mg $282.00FW: 943.750 mg

500 mg $648.00

Europium (III) 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrakis(acetamidoacetic acid)


NN

N NO

O

O

O

HN CO2

-

NH

NHHO2C

HN

9H2OEu3+

CO2-

-O2C

Formula:EuC H N O ·9H O

Eu-DOTA-4AmC

Item #3405X-205

$697.00100 mg $1,189.00FW: 831.650 mg

Thulium (III) S-2-(4-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid


N N

NN NCS

HO O

O O

O O

O O

Tm

TFA.Formula:TmC H N O ·TFA

Tm-p-SCN-Bn-DOTA

Item #3407X-207

$697.00100 mg $1,189.00FW: 819.950 mg

Gadolinium (III) S-2-(4-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid


N N

NN NCS

HO O

O O

O O

O O

Gd

TFA.Formula:GdC H N O ·TFA

Gd-p-SCN-Bn-DOTA

24


Item #3409X-209

$697.00100 mg $1,189.00FW: 827.550 mg

Holmium (III) S-2-(4-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid


N N

NN NCS

HO O

O O

O O

O O

Ho

TFA.Formula:H C H N O ·TFA

Ho-p-SCN-Bn-DOTA

Item #3475X-275

$461.00100 mg $802.00FW: 806.550 mg

Thulium (III) 1,4,7,10-tetraazacyclododecane-1,4,7-tris(acetic acid)-10-maleimidoethylacetamide


N N

NN

O O

O NH

O O

O O N

O

OTm

TFA. Formula:TmC H N O ·TFA

Tm-Maleimido-DOTA

Item #3479X-279

$461.00100 mg $802.00FW: 802.550 mg

Holmium (III) 1,4,7,10-tetraazacyclododecane-1,4,7-tris(acetic acid)-10-maleimidoethylacetamide


N N

NN

O O

O NH

O O

O O N

O

OHo

TFA. Formula:HoC H N O ·TFA

Ho-Maleimido-DOTA

Item #3487X-287

$495.00500 mg $1,928.00FW: 665.2100 mg

Gadolinium (III) 1,4,7,10-Tetraazacyclododecane-1,4,7-tris(acetic acid)-10-(4-aminobutyl)acetamide


N N

NN

O O

O NH

O O

O O

GdNH2

HCl

Formula:GdC H N O ·HCl

Gd-DO3A-Butylamine

25


Item #3602


Formula:

Reactive Intermediates

Item #4120M-120

$170.001 g $262.00FW: 400.6

500 mg

5 g $1,097.00

1,4,7,10-Tetraazacyclododecane-1,7-bis(t-butyl acetate)


N N

NN

H

H

O

OtBu

O

O

tBuO

Formula:C H N O

DO2A-tert-butyl ester

Item #4130M-130

$94.001 g $128.00FW: 514.7

500 mg

5 g $562.00

1,4,7,10-Tetraazacyclododecane-1,4,7-tris(t-butyl acetate)


N N

NNH

O OtBu

O

O O

O

tBuO

OtBu

Formula:C H N O

DO3A-tert-butyl ester

Item #4321I-121

$306.005 g $1,214.00FW: 440.51 g

1,4,7,10-Tetraazacyclododecane-1,7-bis(benzylcarbamide)


N N

NN

H

H OO

OO

Formula:C H N O

Bis-CBZ-Cyclen

26


Item #4331I-131

$169.005 g $760.00FW: 472.61 g

1,4,7,10-Tetraazacyclododecane-1,4,7-tris(t-butoxycarbonyl)


N N

NN

H

OtBuO

OO

OO

tBuO

tBuO

Formula:C H N O

Tris-BOC-Cyclen

Item #4922I-623

$507.001 g $850.00FW: 357.5

500 mg

1,4,7-Triazacyclononane-1,4-bis(t-butyl acetate)


NNNO

OO

OtButBu

H

Formula:C H N O

NO2A-(t-Bu ester)

27


Item #4925


Formula:

Fluorescent Probes

Item #5100D-100

$352.00FW: 393.2

10 mg

N,N,N-Trimethyl-2[(7-nitro-1,2,3-benzoxadiazol-4-yl)amino] ethanaminium iodide


NNO

O2N NH

NI

Formula:C H N O I

EAM-1

Item #5110D-110

$352.00FW: 376.2

10 mg

N,N-Dimethyl-N-(2-hydroxyethyl)-2[(7-nitro-1,2,3-benzoxadiazol-4-yl)amino] ethanaminium bromide


NNO

O2N NH

NBr

OH

+

Formula:C H N O Br

EAM-2

28


29


30

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Plano, TX 75074 - USA

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2017 PRODUCT CATALOG - Macrocyclics, chelating … your order: or (469) 786-6060 Product List Magnetic Resonance Reagents Page M-145 Tm-DOTA 23 M-147 Gd-DOTA 23 M-155 Tm-DOTP

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