Sebaceous gland - Saylor Academy...Sebaceous gland 2 Sebum Sebaceous glands secrete the oily, waxy substance called sebum (Latin, meaning fat or tallow) that is made of fat (lipids),

Sebaceous gland 1

Sebaceous gland

Sebaceous gland

Schematic view of hair follicle & sebaceous gland.

Cross-section of all skin layers. A hair follicle with associated structures. (Sebaceous glands labeled at center left.)

Latin glandula sebacea

Gray's subject #234 1069 [1]

MeSH Sebaceous+glands [2]

The sebaceous glands are microscopic glands in the skin which secrete an oily/waxy matter, called sebum, tolubricate the skin and hair of mammals.[3] In humans, they are found in greatest abundance on the face and scalp,though they are distributed throughout all skin sites except the palms and soles.[4] In the eyelids, meibomiansebaceous glands secrete a special type of sebum into tears. There are several related medical conditions, including:acne, sebaceous cysts, hyperplasia, sebaceous adenoma and sebaceous gland carcinoma (see section below:Pathology).

Locations and morphologyA branched type of acinar gland, the sebaceous glands exist in humans throughout the skin except in the palms of thehands and soles of the feet.Sebaceous glands can usually be found in hair-covered areas, where they are connected to hair follicles (see image attop). The glands deposit sebum on the hairs, and bring it to the skin surface along the hair shaft. The structureconsisting of hair, hair follicle, arrector pili muscle, and sebaceous gland is known as a pilosebaceous unit.Sebaceous glands are also found in non-haired areas (glabrous skin) of eyelids, nose, penis, labia minora, andnipples. Here, the sebum traverses ducts which terminate in sweat pores on the surface of the skin.At the rim of the eyelids, meibomian glands are a specialized form of sebaceous gland. They secrete a form of sebum(called meibum) onto the eye, slowing the evaporation of tears.

Sebaceous gland 2

SebumSebaceous glands secrete the oily, waxy substance called sebum (Latin, meaning fat or tallow) that is made of fat(lipids), wax, and the debris of dead fat-producing cells.[5] In the glands, sebum is produced within specialized cellsand is released as these cells burst; sebaceous glands are thus classified as holocrine glands.Sebum is odorless, but its bacterial breakdown can produce odors. Sebum is the cause of some people experiencing"oily" hair,[6] as in hot weather or if not washed for several days. Earwax is partly composed of sebum. Excesssebum has been linked to eating red meats, fried, oily or other foods, but studies are not conclusive.

FunctionAlthough it is commonly believed that sebum acts to protect and waterproof hair and skin, scientists have contendedthat "low levels of sebaceous gland activity are not correlated with dry skin" and it may serve little or no purpose inmodern humans.[7]

CompositionThe composition of sebum varies between species. In humans, the lipid content is as follows:[8]

Percent composition Substance

25% wax monoesters

41% triglycerides

16% free fatty acids

12% squalene

Sapienic acid is a sebum fatty acid that is unique to humans.

ControlThe following treatments have been shown to reduce sebum secretion rates:• Isotretinoin[9]

• SMT D002[10]

• Spironolactone[11] (suitable for females only)

Changes during developmentThe sebaceous glands of a human fetus in utero secrete a substance called Vernix caseosa, a "waxy" or "cheesy"white substance coating the skin of newborns.The activity of the sebaceous glands increases during puberty because of heightened levels of androgens. In males,sebaceous glands begin to appear predominantly on the penis, on the shaft and around the rim of the penile headduring and after puberty. This is however normal, not to be confused with an STD. In females, they appearpredominantly in the labia minora.

Sebaceous gland 3

PathologySebaceous glands are involved in skin problems such as acne and keratosis pilaris. In the skin pores, sebum andkeratin can create a hyperkeratotic plug called a "microcomedone". The prescription drug isotretinoin significantlyreduces the amount of sebum produced by the sebaceous glands, and is used to treat acne.The extreme use (up to 10 times doctor-prescribed amounts) of anabolic steroids by bodybuilders, for muscle gaincan cause acne. The sebaceous gland is stimulated due to some steroids conversion into dihydrotestosterone. Thismay cause serious acne on the face, neck, chest, back and shoulders.A blocked sebaceous gland can result in a sebaceous cyst.A condition involving enlarged sebaceous glands is known as sebaceous hyperplasia.Sebaceous gland carcinoma is a rare and aggressive form of cancer involving the sebaceous glands; sebaceousadenoma is a more benign neoplasm of the sebaceous glands.Sebum can also build up around body piercings.[12]

Importance to other animals

Demodex mite

Certain species of Demodex mites feed on sebum and are commonlyfound in the sebaceous glands of mammals, including those of humans.

The preputial glands of mice and rats are large modified sebaceousglands that produce pheromones.

Additional images

Pilosebaceous unit Base of pilosebaceous unit Insertion of sebaceous glands into hair shaft

Sebaceous gland 4

Sagittal section through theupper eyelid.

A hair follicle with associated structures.

References[1] http:/ / education. yahoo. com/ reference/ gray/ subjects/ subject?id=234#p1069[2] http:/ / www. nlm. nih. gov/ cgi/ mesh/ 2007/ MB_cgi?mode=& term=Sebaceous+ glands[3] Dellmann's textbook of veterinary histology (405 pages), Jo Ann Coers Eurell, Brian L. Frappier, 2006, p.29, weblink: Books-Google-RTOC

(http:/ / books. google. com/ books?id=FnS4uiOlRT0C& pg=PA29& lpg=PA29).[4] James, William D.; Berger, Timothy; Elston, Dirk M. (2006). Andrews' diseases of the skin: clinical dermatology. Saunders Elsevier. p. 7.

ISBN 978-0-7216-2921-6.[5] "Exercise 15: Hair", VT.edu, 2008, webpage: Vetmed-lab15 (http:/ / education. vetmed. vt. edu/ Curriculum/ VM8054/ Labs/ Lab15/ Lab15.

htm).[6] "Hair Care: An Illustrated Dermatologic Handbook", Zoe Diana Draelos, Zoe Kececioglu Draelos, 2005, p.26, web: Books-Google-5QC

(http:/ / books. google. com/ books?id=Z2rHHGQc-5QC& pg=PA26& lpg=PA26): oily hair & detergents.[7] Downing DT, Stewart ME, Wertz PW, Colton SW, Abraham W, Strauss JS (March 1987). "Skin lipids: an update". The Journal of

Investigative Dermatology 88 (3 Suppl): 2s–6s. doi:10.1111/1523-1747.ep12468850. PMID 2950180.[8] Cheng JB, Russell DW (September 2004). "Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a

member of the acyltransferase enzyme family" (http:/ / www4. utsouthwestern. edu/ moleculargenetics/ pdf/ dr_cur_res/ JBiolChem2004-II.pdf). The Journal of Biological Chemistry 279 (36): 37798–807. doi:10.1074/jbc.M406226200. PMID 15220349. PMC 2743083. .

[9] Farrell LN, Strauss JS, Stranieri AM (December 1980). "The treatment of severe cystic acne with 13-cis-retinoic acid. Evaluation of sebumproduction and the clinical response in a multiple-dose trial". Journal of the American Academy of Dermatology 3 (6): 602–11.doi:10.1016/S0190-9622(80)80074-0. PMID 6451637.

[10] http:/ / www. summitplc. com/ uploads/ RNSSeborrhoeatrialFINAL. pdf[11] Goodfellow A, Alaghband-Zadeh J, Carter G, et al. (August 1984). "Oral spironolactone improves acne vulgaris and reduces sebum

excretion". The British Journal of Dermatology 111 (2): 209–14. doi:10.1111/j.1365-2133.1984.tb04045.x. PMID 6235834.[12] Playe, Stephen J (July 2002). "Infectious Complications of Body Art: Infection is reported in about 1% of tattoos and in up to 45% of

piercings, depending on the technique employed, body location, and after care" (http:/ / journals. lww. com/ em-news/ Citation/ 2002/ 07000/Infectious_Complications_of_Body_Art__Infection_is. 7. aspx). Emergency Medicine News 24 (7): 10–3.doi:10.1097/01.EEM.0000334232.52899.06 (inactive 2010-06-14). .

Sebaceous gland 5

External links• Histology at BU 08801loa (http:/ / www. bu. edu/ histology/ p/ 08801loa. htm) - "Integument: scalp"• MeSH Sebaceous+Glands (http:/ / www. nlm. nih. gov/ cgi/ mesh/ 2009/ MB_cgi?mode=& term=Sebaceous+

Glands)

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Article Sources and ContributorsSebaceous gland  Source: http://en.wikipedia.org/w/index.php?oldid=395368752  Contributors: 1st2Bomb, AED, Abdull, Aitias, Andycjp, AnnaP, Arcadian, Auntof6, AxelBoldt, Bansp,Bobo192, CerealBabyMilk, Ceyockey, Chris Capoccia, CommonsDelinker, CrazyInSane, Darklilac, Davewho2, DeadEyeArrow, Divide, Dougluce, Dprady, Dr. Doof, Dreamer.redeemer, Ds13,Edgar181, Evets21, Fences and windows, Fsotrain09, Fuzzbox, Fuzzy901, Geni, Hankwang, Helix84, Hightower 40, Intersofia, Iraqidude, Jchae88, Kajerm, Kjkolb, Lando242, Lichee66,Majorly, MarcoTolo, Mattygabe, Mctt, Mikael Häggström, Mikekearn, Moshe Constantine Hassan Al-Silverburg, My Core Competency is Competency, Neckoneckonecko, Neilbeach, NunoTavares, Oatmeal batman, Obli, OlEnglish, Pablo X, Peter Ellis, Ph.eyes, Pwjb, R sirahata, RDBrown, Rlfb, Rogermw, Rune X2, Saleen1996, Seanmiz, Smulthaup, SofiaSoGood, Sprostini,Steven Walling, Stratuspower88, TLazzo, Taco325i, That Guy, From That Show!, Tjmayerinsf, UnicornTapestry, Vojtech.dostal, Vsion, WLU, Waitak, Wikid77, Wikijens, Wolfkeeper,Writerite, X-Fi6, Yvwv, Zinnmann, 102 anonymous edits

Image Sources, Licenses and ContributorsImage:HairFollicle.png  Source: http://en.wikipedia.org/w/index.php?title=File:HairFollicle.png  License: unknown  Contributors: User:Helix84Image:Skin.jpg  Source: http://en.wikipedia.org/w/index.php?title=File:Skin.jpg  License: Public Domain  Contributors: US-GovImage:Haarbalgmilbe.jpg  Source: http://en.wikipedia.org/w/index.php?title=File:Haarbalgmilbe.jpg  License: Creative Commons Attribution-Sharealike 2.5  Contributors: Blauerauerhahn,EusebiusImage:Pilosebaceous_Unit_4x.JPG  Source: http://en.wikipedia.org/w/index.php?title=File:Pilosebaceous_Unit_4x.JPG  License: unknown  Contributors: User:KilbadImage:Base of Pilosebaceous Unit 10x.JPG  Source: http://en.wikipedia.org/w/index.php?title=File:Base_of_Pilosebaceous_Unit_10x.JPG  License: Public Domain  Contributors: KilbadImage:Insertion_of_sebaceous_glands_into_hair_shaft_x10.jpg  Source: http://en.wikipedia.org/w/index.php?title=File:Insertion_of_sebaceous_glands_into_hair_shaft_x10.jpg  License:Public Domain  Contributors: User:KilbadImage:Gray893.png  Source: http://en.wikipedia.org/w/index.php?title=File:Gray893.png  License: Public Domain  Contributors: Arcadian, 1 anonymous editsImage:Gray944.png  Source: http://en.wikipedia.org/w/index.php?title=File:Gray944.png  License: unknown  Contributors: Keenan Pepper, Lennert B, Man vyi, Omegatron

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