Neoplasia 3

• 1.NEOPLASIA 3
  Fe A. Bartolome, MD, FPASMAP
  Department of Pathology
  Our Lady of Fatima University
  

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Fundamental Changes in Cell Physiology That Determine Malignant Phenotype
Self-sufficiency in growth signals
Insensitivity to growth-inhibiting signals
Evasion of apoptosis
Limitless replicative potential
Sustained angiogenesis
Ability to invade and metastasize
Defects in DNA repair
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Evasion of apoptosis
Review of Apoptosis

• Programmed cell death

4. Triggers: range from DNA damage to loss of adhesion to the basement membrane (anoikis) 5. Two pathways: extrinsic (via death receptor CD95/Fas) and intrinsic (mitochondrial)