Life Sciences Trend Analysis 2013 CANADA. About Us The following statistical information has been obtained from Biotechgate. Biotechgate is a global,

Life Sciences Trend Analysis 2013

CANADA

About Us

The following statistical information has been obtained from Biotechgate. Biotechgate is a global, comprehensive, Life Sciences database encompassing the Biotechnology,Pharmaceutical and Medical Device industries. www.biotechgate.com

The Canadian Life Sciences Database is a part of the global Biotechgate and is brought to you in partnership with BIOTECanada, the national non-profit association dedicated to building the bio-based economy in Canada. www.canadianlifesciences.com

Biotechgate is owned and operated by Venture Valuation AG, a Zurich based company specializing in independent assessment and valuation of technology-driven companies in high growth industries, such as the Life Sciences (Biotech, Pharma, Medtech), ICT, high-tech, Nanotech, Cleantech and Renewable energy. www.venturevaluation.com

Status of the Sector

2012 Statistics

Canada 2013 Statistics

615 Total Biotech Companies 632

152 Biotech - Therapeutics 159

202 Biotech - R&D Services 201

261 Biotech - Other 272

91% Percentage of SME's 89%

15% Percentage of Publicly Owned Companies 14%

USD 162 M in 2011

Financing/Capital RaisedUSD 67 M in

2012

190 Licensing Opportunities 175

Key Activities of Biotechnology Companies

Historical DataSubsector 201

3201

2AgroBio 9% 9%Environment 12% 12%Contract Research & Manufacturing

9% 9%

Diagnostics and Analytical Services

11% 12%

Food & Nutraceuticals 6% 6%Other Services and Suppliers 20% 21%Therapeutics 14% 14%Other 19% 17%

AgroBio9%

Contract Re-search and

Manufacturing9%

Diagnostics and Analyt-ical Services

11%Environment12%

Food and Nu-traceuticals

6%

Other Services and Suppliers

20%

Therapeutics14%

Other19%

2013 Data

Company Foundation Timeline

19951996

19971998

19992000

20012002

20032004

20052006

20072008

20092010

20112012

20130

5

10

15

20

25

5 4 3 36 6

4 53

8 79

57

3 3 42

48

74

57

8 78

44

2

54

41

2

1

7

6

6 11

98

6 5 66 9

7

44

1

2

Biotechnology - Therapeutics and DiagnosticsBiotechnology / R&D ServicesBiotechnology - other

Year

No.

of

Com

panie

s F

ounded

Company Ownership

Historical DataSubsector 201

32012

Private/ Independent

76% 76%

Public 14% 15%Subsidiary 10% 9%

Private / in-dependent

76%

Public14%

Subsidiary10%

2013 Data

Sources of Company Foundations

Historical DataCompany Foundation 2013 2012Independent foundation 54% 70%Merger 1% 2%Spin-off from company 1% 2%Spin-off from public institution / NPO 1% 2%Spin-off from university 5% 7%Subsidiary 9% 13%Other 3% 4%

Undisclosed26%

Independent foundation

53%

Merger1%

Spin-off from company1% Spin-off from public insti-

tution / NPO1%

Spin-off from university

5%

Subsidiary9%

Other3%

2013 Data

Number of Employees

Historical DataNo. of Employees 2013 20121-10 35% 28%11-50 37% 42%51-200 17% 21%Greater than 200 11% 6%

1-10:35%

11-50:37%

51-200:17%

201+:11%

2013 No. of Employees

Products in the Pipeline

2013

2012

2013

2012

2013

2012

2013

2012

Pre

clin

ical

Phase

IPhase

II

Phase

III

0 20 40 60 80 100 120 140 160

146

149

76

72

89

72

36

22

No. of Products

Financing Rounds in Canada & 3 Major Financing Rounds

Financing for 2012/2013 Private Biotech Companies

Major Financings in 2012/2013

SectorUSD M

Thrasos Therapeutics, Inc.Biotech – Therapeutics &

Diagnostics35

Zymeworks Inc.Biotech – Therapeutics &

Diagnostics11

Plantform CorporationBiotech – Therapeutics &

Diagnostics10

2007 2008 2009 2010 2011 20120

50

100

150

200

024681012

Financing Value Number of Financings

Half YearlyFin

an

cin

g V

alu

e U

SD

M

Nu

mb

er

of

Fu

nd

ing

R

ou

nd

s

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