Life Sciences Trend Analysis 2013 GERMANY. About Us The following statistical information has been obtained from Biotechgate. Biotechgate is a global,

Life Sciences Trend Analysis 2013

GERMANY

About Us

The following statistical information has been obtained from Biotechgate. Biotechgate is a global, comprehensive, Life Sciences database encompassing the Biotechnology, Pharmaceutical and Medical Device industries. www.biotechgate.com

The German Biotech Database is a part of the global Biotechgate and is brought to you in partnership with BIO NRW - Cluster Biotechnology North Rhine-Westphalia; representing an active, multicentric network developing into a technological pacesetter for NRW’s life science business. www.germanbiotech.com

Biotechgate is owned and operated by Venture Valuation AG, a Zurich based company specializing in independent assessment and valuation of technology-driven companies in high growth industries, such as the Life Sciences (Biotech, Pharma, Medtech), ICT, high-tech, Nanotech, Cleantech and Renewable energy. www.venturevaluation.com

Status of the Sector

2012 Statistics

Germany 2013 Statistics

836 Total Biotech Companies 991

139 Biotech - Therapeutics 162

561 Biotech - R&D Services 661

136 Biotech - Other 168

92% Percentage of SME's 91%

3%Percentage of Publicly Owned

Companies2%

USD 176 M (2011)

Financing/Capital RaisedUSD 261 M

(2012)

329 Licensing Opportunities 411

Key Activities of Biotechnology Companies

Historical DataSubsector 201

32012

Bioinformatics and Bioelectronics

5% 5%

Contract Research and Manufacturing

13% 12%

Diagnostics and Analytical Services

24% 23%

Genomics and Proteomics 8% 8%Other Services and Suppliers 27% 28%Therapeutics 8% 9%Other 15% 15%

Bioinformatics and Bioelec-

tronics5%

Contract Re-search and

Manufacturing13%

Diagnostics and Analytical

Services24%

Genomics and Proteomics

8%

Other Services and Suppliers

27%

Therapeutics8%Other

15%

2013 Data

Company Foundation Timeline

19951996

19971998

19992000

20012002

20032004

20052006

20072008

20092010

20112012

20130

10

20

30

40

50

60

70

913

28

32

22

43 38

24 2316 14

1514

1510

72

1

2

3

8

4

8

44

1 2

5 3

53

2

2

1

16 10 7

12 134 5 5 6 10 8 10 8 5 4 1

Biotechnology - Therapeutics and DiagnosticsBiotechnology / R&D ServicesBiotechnology - other

Year

No.

of

Com

panie

s F

ounded

Company Ownership

Historical DataSubsector 201

3201

2Private/ Independent

84% 85%

Public 2% 2%Subsidiary 14% 13%

Private / inde-pendent

84%

Public2%

Sub-sidiary14%

2013 Data

Sources of Company Foundations

Historical DataCompany Foundation 2013 2012Independent foundation 48% 59%Spin-off from company 2% 3%Spin-off from public institution / NPO 4% 6%Spin-off from university 9% 12%Subsidiary 11% 14%Other 3% 4%

Undisclosed22%

Independent foundation

48%

Merger1% Spin-off from

company2%

Spin-off from public institu-

tion / NPO4%

Spin-off from university

9%Subsidiary

11%

Other3%

2013 Data

Number of Employees

Historical DataNo. of Employees 2013 20121-10 24% 23%11-50 47% 50%51-200 20% 19%Greater than 200 9% 6%

1-10:24%

11-50:47%

51-200:20%

201+:9%

2013 No. of Employees

Products in the Pipeline

2013

2012

2013

2012

2013

2012

2013

2012

Pre

clin

ical

Phase

IPhase

II

Phase

III

0 10 20 30 40 50 60 70

64

66

27

28

65

45

16

15

No. of Products

Financing Rounds in Germany & 3 Major Financing Rounds

Financing for 2012/2013 Private Biotech Companies

Major Financings in 2012/2013

SectorUSD M

Curevac GmbHBiotech – Therapeutics &

Diagnostics103

Brain AG Biotech – Other 77

Affimed Therapeutics AGBiotech – Therapeutics &

Diagnostics20

2007 2008 2009 2010 2011 20120

100200300400500

0510152025

Financing Value Number of Financings

Half Yearly

Fin

an

cin

g V

alu

e

US

D M

Nu

mb

er

of

Fu

nd

-in

g R

ou

nd

s

About Biotechgate

Biotechgate contains over 29’000 high quality company profiles which include company descriptions, contact information, product pipeline information, financing rounds and management details. Profiles are regularly updated by the companies themselves, as well as by an experienced database team, to ensure the accuracy and relevance of the data.

To register for free or learn more about the different subscription options, please visit www.biotechgate.com.

Terms of Use

The “German Life Sciences Trend Analysis” is based on data entered in the Biotechgate Database available at www.biotechgate.com. The statistics and graphs in this presentation are based on figures and information entered in this database and we do not guarantee any accuracy hereof.

The use of the figures and graphs provided in this report is free of charge for any presentations as long as www.biotechgate.com is clearly cited as the source. For all other uses please contact us for terms and conditions.

Biotechgatec/o Venture Valuation VV AGKasernenstrasse 11 +41 (43) 321 86 608004 Zurich [email protected] www.venturevaluation.com