527 INDEX Volume 208, January-March 1979 Abstinence syndrome, morphine, rats, effects of antipsychotic and antianxiety drugs, 63 Acara, M., see Koschier, F. J., 287 Activator, calcium-dependent, of cyclic nucleotide phosphodi- esterase, selective binding of antipsychotics and other psy- choactive agents to, 454 Adenosine triphosphatase, catecholamine-sensitive, in mouse brain, effects of acute and continuous morphine treatment, 80 Adenylate cyclase, ganglionic, stimulation by catechol- amines, 31 Adler, C. H., see Klemfuss, H., 91 Adler, M. W. see Klemfuss, H., 91 see Baldino, F., Jr., 63 Adrenal gland phenylethanolamine N-meth- yltransferase, effects of SK&F 28661,24 steroids, indirectly modulating morphine and fl-endorphin effects, 176 Adrenergic mechanisms, domi- nance in mediating hypoten- sive drug-induced renin release in conscious rat, 303 Age, relationship to metabolism and protein binding of di- goxin in sheep, 263 Alkadhi, K., see Quenzer, L., 31 Alloxan, selectivity for fl-cells of islets of Langerhans, effect of pH, 184 Alphaprodine, intravenous, rela- tive potency and duration of action with respect to respi- ratory depression in man, 73 Alward, C. T., see Baiie, M. D., 298 y-Aminobutyric acid, neurons in caudatus, pallidus and nigra, effects of opioids and dopa- mine agonists, 190 Aminopyrine N-demethylase, cy- tochrome P-450-dependent, in rat brain, comparison with hepatic aminopyrine N-de- methylation, 271 d-Amphetamine, anorexic effect, tolerance to, effect of deple- tion of brain dopamine by 6- hydroxydopamine, 134 Analgesia, morphine-induced, dif- ferential effects of leucine and methionine enkephalin, 86 Anesthesia, effect on cardiovas- cular and renal function in newborn piglet, 298 Anorexic effect, of d-ampheta- mine and fenfluramine in rats, tolerance to, effect of de- pletion of brain dopamine by 6-hydroxydopamine, 134 Antianxiety drugs, effects on mor- phine abstinence syndrome in rats, 63 Anticholinergic actions, stereo- specific, of enantiomers of CTC, cyproheptadine deriv- ative, 460 Anticonvulsant drugs, protein binding in serum of dog and man, 429 Anticonvulsant effects of benzhydryl piperazines on maximal electroshock sei- zures in rats, 480 of ropazine in rat, 236 Antidopaminergic actions, stereo- specific, of enantiomers of CTC, cyproheptadine deny- ative, 460 Antihypertensive effects, of MK- 447, 148 Antihypertensive treatment, ef- fects on systolic blood pres- sure and renin experimental hypertension in rats, 310 Antimeperidine antibodies, speci- ficity and reactivity with opioid peptides, 498 Antimorphine antibodies, speci- ficity and reactivity with opioid peptides, 498 Antinociception, mediated by spinal serotonin terminal sys- tem, 446 Antipsychotic drugs effects on morphine absti- nence syndrome in rats, 63 selective binding to calcium-de- pendent activator of cyclic nucleotide phosphodiester- ase, 454 Antitubulin agent, nocodazole, ac- tion on tubulin assembly, ax- onal ultrastructure and fast axonal transport, 411 Antitumor activity, of BCNU, CCNU and PCNU, effect of phenobarbital pretreatment, Aorta, strips, isolated, rabbit, con- tractile response to unsatu- rated fatty acid peroxides, 347 Aqleh, K. A., see Kaufman, R. D., 73 Arbel, E. R. and Glick, G.: Effects of veratnine on the in situ dog heart: Evidence for increased ventricular fibrillation threshold, 314 Arceneaux, J. E. L., see Pitt, C. G., 12 Anrhythmias, ventricular, digi- taIls-induced, role of fore- brain noradrenergic mecha- nisms, 57 Arteries, renal, canine, tension and 45Ca fluxes, differing ac- tions of nitroprusside and D- 600 on, 155 Asano, M. and Hidaka, H.: Con- tractile response of isolated rabbit aortic strips to unsat- urated fatty acid peroxides, 347 Autonomic nervous system, influ- ence on production of cere- brospinal fluid in cat, 341 Ayala, J. M., see Nascimento, L., 522 Baer, P. G., Kauker, M. L. and McGiff, J. C.: Prostacyclin ef- fects on renal hemodynamic and excretory functions in the rat, 294 Baiie, M. D., Alward, C. T., Saw- yer, D. C. and Hook, J. B.: Effect of anesthesia on car- diovascular and renal func- tion in the newborn piglet, 298 Baines, A. D., Craan, A., Chan, W. and Morgunov, N.: Tubular secretion and metabolism of dopamine, norepinephnne, methoxytyramine and nor- metanephnne by the rat kid- ney, 144 Baldino, F., Jr., Cowan, A., Geller, E. B. and Adler, M. W.: Ef- fects of antipsychotic and an- tianxiety drugs on the mor- phine abstinence syndrome in rats, 63 Baldoni, F., see Tallanida, G., 319 Baquero, R. A., see Nascimento, L., 522 Barkai, A. I.: Serotonin turnover in the intact rabbit brain: Re- lationship to extracellular proteins and modification by pentobarbital or haloperidol, 44 Barlow, T. S., see Vogel, R. A., 161 Barnes, D. W., Morahan, P. 5., Loveless, S. and Munson, A. E.: The effects of maleic an- hydnide-divinyl ether (MVE) copolymers on hepatic micro- somal mixed-function oxi- dases and other biologic ac- tivities, 392 Behavioral effects of chlorpromazine alone and in combination with different morphine treatments in rats, 67 of LSD on learning measured by classical conditioning of rabbit nictitating membrane response, 330 of methadone during pregnancy in rat offspring, 106 thyrotropin-releasing hormone on locomotor activit, operant performance and ingestive behavior, 161 Bell, R. D., see Cicero, T. J., 210 Bellin, S. I., see Edmonds, H. L., Jr., 236 Beilville, J. W., see Kaufman, R. D., 73 Benzhydryl piperazines, anticon- vulsant effects on maximal electroshock seizures in rats, 480 Berman, W., Jr. and Musselman, J.: The relationship of age to the metabolism and protein binding of digoxin in sheep, 263 Bernstein, S. P., see Deneke, S. M., 377 Bile excretion of [‘4Cjphenytoin in rat, effect of pregnancy, 257 excretion of sulfobromophthal- em, rat, effect of inhibition of enzymatic activity of ligan- din, by organometals, 248 Biotransformation, of BCNU, ef- fect of phenobarbital pre- treatment, 1 1,3-Bis (2-chioroethyl) 1-nitrosou- rea (BCNU), antitumor ac- tivity and plasma pharmaco- kinetics and biotransforma- tion, effect of phenobarbital pretreatment, 1 Blatnick, R. A., see Pace, N. L., 254 Blood pressure, systolic in exper- imental hypertension in rats, effects of antihypertensive treatment, 310 Blunden, M., see Vore, M., 257 Bohidar, N. R., see Scriabine, A., 148 Bondinell, W., see Pendleton, R. G., 24 Bordetella pertussis vaccine, del- eterious effect on metabolism and disposition of phenytoin, 267 Bradycardia, prostaglandin E1-in- duced, in rats, effects of brain serotonin alterations, 232
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527
INDEX
Volume 208, January-March 1979
Abstinence syndrome, morphine,
rats, effects of antipsychoticand antianxiety drugs, 63
Acara, M., see Koschier, F. J., 287
Activator, calcium-dependent, of
cyclic nucleotide phosphodi-esterase, selective binding ofantipsychotics and other psy-choactive agents to, 454
Adenosine triphosphatase,catecholamine-sensitive, in
mouse brain, effects of acuteand continuous morphinetreatment, 80
Adenylate cyclase, ganglionic,stimulation by catechol-
amines, 31
Adler, C. H., see Klemfuss, H., 91
Adler, M. W.see Klemfuss, H., 91
see Baldino, F., Jr., 63
Adrenal gland
phenylethanolamine N-meth-yltransferase, effects of
SK&F 28661,24steroids, indirectly modulating
morphine and fl-endorphin
effects, 176Adrenergic mechanisms, domi-
nance in mediating hypoten-sive drug-induced renin
release in conscious rat, 303Age, relationship to metabolism
and protein binding of di-
goxin in sheep, 263
Alkadhi, K., see Quenzer, L., 31
Alloxan, selectivity for fl-cells of
islets of Langerhans, effect ofpH, 184
Alphaprodine, intravenous, rela-
tive potency and duration of
action with respect to respi-ratory depression in man, 73
Alward, C. T., see Baiie, M. D.,298
y-Aminobutyric acid, neurons in
caudatus, pallidus and nigra,effects of opioids and dopa-mine agonists, 190
Aminopyrine N-demethylase, cy-tochrome P-450-dependent,in rat brain, comparison withhepatic aminopyrine N-de-
methylation, 271
d-Amphetamine, anorexic effect,tolerance to, effect of deple-tion of brain dopamine by 6-hydroxydopamine, 134
Analgesia, morphine-induced, dif-
ferential effects of leucineand methionine enkephalin,86
Anesthesia, effect on cardiovas-
cular and renal function in
newborn piglet, 298
Anorexic effect, of d-ampheta-mine and fenfluramine in
rats, tolerance to, effect of de-
pletion of brain dopamine by
6-hydroxydopamine, 134Antianxiety drugs, effects on mor-
phine abstinence syndromein rats, 63
Anticholinergic actions, stereo-
specific, of enantiomers of
CTC, cyproheptadine deriv-ative, 460
Anticonvulsant drugs, protein
binding in serum of dog and
man, 429
Anticonvulsant effects
of benzhydryl piperazines on
maximal electroshock sei-
zures in rats, 480of ropazine in rat, 236
Antidopaminergic actions, stereo-
specific, of enantiomers of
CTC, cyproheptadine deny-ative, 460
Antihypertensive effects, of MK-
447, 148
Antihypertensive treatment, ef-fects on systolic blood pres-
sure and renin experimental
hypertension in rats, 310
Antimeperidine antibodies, speci-ficity and reactivity withopioid peptides, 498
Antimorphine antibodies, speci-
ficity and reactivity with
opioid peptides, 498
Antinociception, mediated by
spinal serotonin terminal sys-tem, 446
Antipsychotic drugs
effects on morphine absti-
nence syndrome in rats, 63selective binding to calcium-de-
pendent activator of cyclic
nucleotide phosphodiester-ase, 454
Antitubulin agent, nocodazole, ac-tion on tubulin assembly, ax-onal ultrastructure and fast
axonal transport, 411
Antitumor activity, of BCNU,CCNU and PCNU, effect ofphenobarbital pretreatment,
Aorta, strips, isolated, rabbit, con-
tractile response to unsatu-rated fatty acid peroxides,347
Aqleh, K. A., see Kaufman, R. D.,
73
Arbel, E. R. and Glick, G.: Effectsof veratnine on the in situ dog
heart: Evidence for increased
ventricular fibrillation
threshold, 314
Arceneaux, J. E. L., see Pitt, C.G., 12
Anrhythmias, ventricular, digi-taIls-induced, role of fore-
tractile response of isolatedrabbit aortic strips to unsat-urated fatty acid peroxides,
347Autonomic nervous system, influ-
ence on production of cere-
brospinal fluid in cat, 341Ayala, J. M., see Nascimento, L.,
522
Baer, P. G., Kauker, M. L. andMcGiff, J. C.: Prostacyclin ef-fects on renal hemodynamicand excretory functions in
the rat, 294
Baiie, M. D., Alward, C. T., Saw-yer, D. C. and Hook, J. B.:
Effect of anesthesia on car-
diovascular and renal func-
tion in the newborn piglet,
298Baines, A. D., Craan, A., Chan, W.
and Morgunov, N.: Tubular
secretion and metabolism of
dopamine, norepinephnne,
methoxytyramine and nor-
metanephnne by the rat kid-
ney, 144Baldino, F., Jr., Cowan, A., Geller,
E. B. and Adler, M. W.: Ef-
fects of antipsychotic and an-
tianxiety drugs on the mor-
phine abstinence syndromein rats, 63
Baldoni, F., see Tallanida, G., 319
Baquero, R. A., see Nascimento,L., 522
Barkai, A. I.: Serotonin turnoverin the intact rabbit brain: Re-lationship to extracellular
proteins and modification by
pentobarbital or haloperidol,44
Barlow, T. S., see Vogel, R. A.,
161
Barnes, D. W., Morahan, P. 5.,Loveless, S. and Munson, A.E.: The effects of maleic an-
hydnide-divinyl ether (MVE)copolymers on hepatic micro-somal mixed-function oxi-
dases and other biologic ac-tivities, 392
Behavioral effects
of chlorpromazine alone and in
combination with differentmorphine treatments in rats,
67
of LSD on learning measuredby classical conditioning of
rabbit nictitating membraneresponse, 330
of methadone during pregnancyin rat offspring, 106
thyrotropin-releasing hormone
on locomotor activit, operant
performance and ingestivebehavior, 161
Bell, R. D., see Cicero, T. J., 210Bellin, S. I., see Edmonds, H. L.,
Jr., 236Beilville, J. W., see Kaufman, R.
D., 73
Benzhydryl piperazines, anticon-
vulsant effects on maximalelectroshock seizures in rats,480
Berman, W., Jr. and Musselman,J.: The relationship of age tothe metabolism and protein
binding of digoxin in sheep,263
Bernstein, S. P., see Deneke, S.
M., 377Bile
excretion of [‘4Cjphenytoin inrat, effect of pregnancy, 257
excretion of sulfobromophthal-em, rat, effect of inhibition ofenzymatic activity of ligan-
din, by organometals, 248Biotransformation, of BCNU, ef-
fect of phenobarbital pre-treatment, 1
1,3-Bis (2-chioroethyl) 1-nitrosou-rea (BCNU), antitumor ac-tivity and plasma pharmaco-kinetics and biotransforma-tion, effect of phenobarbitalpretreatment, 1
Blatnick, R. A., see Pace, N. L.,254
Blood pressure, systolic in exper-imental hypertension in rats,
effects of antihypertensivetreatment, 310
Blunden, M., see Vore, M., 257Bohidar, N. R., see Scriabine, A.,
148
Bondinell, W., see Pendleton, R.G., 24
Bordetella pertussis vaccine, del-eterious effect on metabolismand disposition of phenytoin,267
Bradycardia, prostaglandin E1-in-
duced, in rats, effects of brainserotonin alterations, 232
528 Index
Bradykinin, intra-arterial injec-tion in rabbit hindlimb, car-diovascular and respiratory
chemoreflexes, 319
Brainy-aminobutyric acid neurons in
caudatus, pallidus and mgra,
effects of opioids and dopa-
mine agonists, 190dopamine, depletion by 6-hy-
droxydopamine, effect on tol-erance to anorexic effect of d-
amphetamine and fenflura-
mine in rats, 143
guanosine 3’,5’-monophosphate
content, change by thyrotro-pin-releasing hormone, 169
homogenates, rat, tele-methyl-histamine oxidation by type
B monoamine oxidase, 422intact, rabbit, relationship of
serotonin turnover to extra-cellular proteins and modi.fl-cation by phenobarbital orhaloperidol, 44
mouse, catecholamine-sensitiveadenosine triphosphatase,effects of acute and continu-ous morphine administration,
80rat, comparison of cytochrome
P-450-dependent aminopy-
rime N-demethylase with he-patic aminopyrine N-de-methylation, 271
rat, morphine persistence aftersingle doses, 228
rat striatum, endogenous phos-phorylation on synaptic
plasma membrane proteins,effect of morphine, 96
regional concentrations of do-pamine and dihydroxyphen-ylacetic acid, effects of drugs,
44noradrenergic mechanisms, role
in digitalis-induced arrhyth-miss, 57
serotonin alterations, effects onprostaglandin E1-inducedbradycardia in rats, 232
Braswell, L., see Savarese, J. J.,436
Breese, G. R.see Hollister, A. S., 37
see Mailman, R. B., 169see Vogel, R. A., 161
Brindisi, F., see Tallarida, G., 319Bronchodilator, new (pirbuterol),
pharmacokinetics and cardi-opulmonary effects in dogs,371
Butanol, tertiary, physical de-pendence in mice, quantita-tively compared with ethanol
and correlated with lipid sol-ubiity, 113
Byers, B. R., see Pitt, C. G., 12
Byington, K. H. and Hansbrough,E.: Inhibition of the enzy-
matic activity of ligandin byorganogermanium, organo-
lead or organotin compounds
and the biiary excretion ofsulfobromophthalein by the
rat, 248Byrd, A., see Levin, V. A., 1
Calcium-dependent activator of
cyclic nucleotide phosphodi-esterase, selective binding ofantipsychotics and other psy-
choactive agents to, 454
Calcium-45, fluxes in canine renalarteries, differing actions of
nitroprusside and D-600, 155
Cangiano, J. L., RodrIguez-Sar-
gent, C. and MartInez-Mal-
donado, M.: Effects of anti-hypertensive treatment onsystolic blood pressure and
renin in experimental hyper-tension in rats, 310
Cardiopulmonary effects, of sub-
lingual pirbuterol, new bron-chodilator, in dogs, 371
Cardiovascular function, in new-born piglet, effect of anesthe-sia, 298
regional brain concentrations,effects of drugs, 44
release mechanisms, differen-tially affected by dopaminetransport inhibitor nomifen-sine, 195
synthesis, in striatal synapto-somes, effect of haloperidol,468
tubular secretion and metabo-ham by rat kidney, 144
Dopamine agonists, effects on y-
aminobutyric acid neurons incaudatus, palhidus and nigra,190
Dopaminergic systems, develop-ment of functional depend-ence on ethanol, 216
Dvorchick, B. H., see Marietta,
M. P., 271
Eaton, D. L and Klaassen, C. D.:Effects of microsomal en-zyme inducers on carrier-me-diated transport systems inisolated rat hepatocytes, 381
Edmonds, H. L, Jr., Stark, L G.,Stark, D. M., McCormack, C.R., Sylvester, D. M. and Bel-lin, S. I.: The anticonvuLsantactivity of ropizine in the rat,236
$-Endorphineffects, indirectly modulated by
adrenal steroids, 176effects on -y-aminobutyric acid
neurons in caudatus, pallidusand nigra, 190
Enzymatic activity, ligandin, in-
hibition by organometals, oreffect on biiary excretion of
sulfobromophthalein in rat,
248Enzyme
inducers, microsomal, effects oncarrier-mediated transportsystems in isolated rat hepa-
tocytes, 381therapy, immune response in-
duced by enzyme- and buffer-loaded liposomes in C3H/HeJ Gus mice, 507
Esteratic cholinoceptive sites, ac-
tion of phenylene diacryloylbis-cholinium esters, 436
and tyrosine hydroxylase instriatal synaptosomes, 468
effects on morphine abstinencesyndrome in rats, 63
modification of serotonin turn-over in intact rabbit brain,relationship to extracellularproteins, 44
Halushka, P. V., see Hsu, C. Y.,
366Hansbrough, E., see Byington, K.
H., 248Hartman, R. D., see Marietta, M.
P., 271
Harvey, J. A., see Gimpl, M. P.,
330Haywood, J. R. and Vogh, B. P.:
Some measurements of au-
tonomic nervous system in-fluence on production of cere-brospinal fluid in the cat, 341
Heart, ventricular arrhythmias,digitalis-induced, role of fore-brain noradrenergic mecha-nisms, 57
Heffner, T. G. and Seiden, L. S.:The effect of depletion ofbrain dopamine by 6-hydrox-ydopamine on tolerance tothe anorexic effect of d-am-phetamine and fenfluraminein rats, 134
Helke, C. J., Zavadil, A. P., III andGills, R. A.: Forebrain nor-adrenergic mechanisms and
Immune response, induced by en-zyme- and buffer-loaded Ii-posomes in C3H/HeJ Gus
mice, 507
Intoccia, A., see Pendleton, R. G.,24
Iron, overload, treatment, selec-tion and evaluation of new
chelating agents, 12
Islets of Langerhans, fl-cells, ef-
feet of pH on selectivity ofalloxan for, 184
James, M. 0., see Pritchard, J. B.,
280
Jenkins, B., see Pendleton, R. G.,24
Kapatos, G. and Zigmond, M. J.:
Effect of haloperidol on do-pamine synthesis and tyro-
sine hydroxylase in striate!synaptosomes, 468
Kaufman, R. D., Aqleh, K. A. andBeIlville, J. W.: Relative po-
tencies and durations of ac-
tion with respect to respira-
tory depression of intrave#{149}nous meperidine, fentanyland alphaprodine in man, 73
Kauker, M. L., see Baer, P. G..294
Keeton, T. K. and Pettinger, W.A.: The domanance of adren-ergic mechanisms in mediat-ing hypotensive drug-in-duced renin release in theconscious rat, 303
Kidneyfunction in newborn piglet, ef-
fect of anesthesia, 298hemodynamics and excretory
functions in rat, prostacyclineffects, 194
isolated, perfused, rat, trans-
port of 2,4,5-trichlorophen-oxyacetate, 287
rabbit, metabolism of organic
compounds, demonstrationof separate pathways, 418
rat, levo-methadone distribu-tion during postnatal devel-
opment, 491rat, tubular secretion and me-
tabolism by dopamine, nor-epinephrine, methoxytyra-
mine and normetanephrine,144
tubular secretion of furosemide,related to sa!uretic effect, 515
winter flounder, handling of 2,4-dichlorophenylacetic acid,280
Kitz, R. J., see Savarese, J. J., 436Klaassen, C. D., see Eaton, D. L.,
381Klemfuss, H., Tallarida, R J., Ad-
ler, C. H. and Adler, M. W.:Morphine-induced mydriasis
and fluctuation in the rat:Time and dose relationships,91
Knapp, D. R., see Hsu, C. Y., 366Koch, R. L. and Goldman, P.: The
anaerobic metabolism ofmetronidazole forms N-(2-
hydroxyethyl)-oxamic acid,
406
Koschier, F. J. and Acara, M.:Transport of 2,4,5-trichloro-phenoxyacetate in the iso-lated, perfused rat kidney,287
Kramer, R. E., Greiner, J. W.,Rumbaugh, R. C., Sweeney,T. D. and Colby, H. D.: Re-quirement of the pituitarygland for gonadal hormoneeffects on hepatic drug me-tabolism in rats, 19
Law,P-Y.,seeHoladay,J.W., 176
Lau, C. and Slotkin, T. A.: Accel-erated development of ratsympathetic neurotransmis-
sion caused by neonatal tri-iodothyronine administra-
tion, 485Leander, J. D., see Lucot, J. B., 67Learning, effects of LSD mea-
sured by classical condition-ing ofrabbit nictitating mem-brain response, 330
Lettieri, J. T. and Fung, H-L.:Dose-dependent pharmaco-
kinetics and hypnotic effectsof sodium y-hydroxybutyratein the rat, 7
Leucine enkephalin, effects onmorphine-induced analgesia,acute tolerance and depend-ence, comparison with methi-onine enkephalin, 76
Levi, G., see Raiteri, M., 195
Levis, R. M. and Weiss, B.: Selec-tive binding of antipsychoticsand other psychoactiveagents to the calcium-depen-
dent activator of cyclic nu-cleotide phosphodiesterase,454
Levis, V. A., Stearns, J., Byrd, A.,Finn, A. and Weinkam, R. J.:The effect of phenobarbitalpretreatment on the antitu-mor activity of 1,3-bis-(2-chloroethyl)- 1-nitrosourea(BCNU), 1-(2-chloroethyl)-3-cyclohexyl- 1-nitrosourea(CCNU) and 1-(2-chloro-ethyl)-3-(2,6-dioxo-3-piperi-dyl)-1-nitrosourea (PCNU),and on the plasma pharma-cokinetics and biotransfor-mation of BCNU, 1
Levine, W. G. and Finkelstein, T.T.: A role for liver glutathi-one in the hepatobiiary fateof N,N-dimethyl-4-amino-azobenzene, 399
Li, C. H., see Holaday, J. W., 176
Lieberman, M. M., see Pace, N.L., 254
Ligandin, enzymatic activity, in-hibition by organometals, ef-feet on biiary excretion ofsulfobromophthalein, 248
Lin,M.,seeRosen,T.S., 118
Lin, M. T.: Effects of brain sero-tonin alterations on prosta-
glandin E1-induced bradycar-dia in rats, 232
Lipid solubility, correlation withphysical dependence on ter-tiary butanol and ethanol inmice, 113
Liposomes, enzyme- and buffer-loaded, immune response inC3H/HeJ Gus mice, 507
Liveraminopyrine N-demethylation,
comparison with cytochromeP450-dependent aminopy-rise N-demethylase in rat
brain, 271drug metabolism, rats, role of
pituitary gland in gonadalhormone effects, 19
glutathione, role in hepatobili-ary fate of N,N-dimethyl-4-aminoazobenzene, 399
microsomal mixed-function ox-idases, effects of maleic an-hydride-divinyl ether cops!-ymers, 392
necrosis, thioacetamide-in-duced, rat, 386
rat, carrier-mediated transport
systems, effects of micro-somal enzyme inducers, ‘381
rat, levo-methadone distribu-tion during postnatal devel-opment, 491
Locomotor activity, i�-dihydroxy-
phenylalanine-stimulated,role of monoamine neuralsystems, 37
Loh, H. H., see Holaday, J. W.,176
L#{246}scher,W.: A comparative studyof the protein binding of an-ticonvulsant drugs in serum
of dog and man, 429
Loveless, S., see Barnes, D. W.,392
LSD, effects on learning mea-sured by classical condition-ing ofrabbit mctitating mem-brane response, 330
Lucot, J. B., McMillan, D. E. andLeander, J. D.: The behav-ioral effects of chlorproma-zine alone and in combina-tion with different morphinetreatments in rats, 67
Ludden, C. T., see Scriabine, A.,
148Lung
rat, levo-methadone distribu-tion during postnatal devel-opment, 491
rat, toxic effects of95 to 97% 02,enhancement by disulfiram,
377
Mailman, R. B., Frye, G. D.,Mueller, R. A. and Breese, 0.R: Change in brain gua-nosine 3’,5’-monophosphate(cGMP) content by thyrotro-pin-releasing hormone, 169
Maleic anhydride-divinyl ethercopolymers, effects on he-patic microsomal mixed-function oxidases and otherbiologic activities, 392
Malthe-Sorenssen, D., see Robin-son, S. E., 476
Manplatelet aggregation, effects of
alpha adrenergic agents, 366serum, protein binding of anti-
convulsant drugs, 429
Marietta, M. P., Vesell, E. S.,Hartman, R D., Weiss, J. andDvorchik, B. H.: Characteri-zation of cytochrome P-450-dependent aminopyrine N-demethylase in rat brain:Comparison with hepatic am-inopyrine N-demethylation,271
Martinez-Maldonado, M.see Cangiano, J. L., 310see Nascimento, L., 522
McComb, J. A. and Goldstein, D.B.: Quantitative comparisonof physical dependence ontertiary butanol and ethanolin mice: Correlation withlipid solubility, 113
McCormack, C. R., see Edmonds,H. L., Jr., 236
McGiff, J. C., see Baer, P. G., 294Mcllhenny, H. M., see Constan-
tine, J. W., 371
McKendry, M. A., see Chine-schmidt, B. V., 460
McMillan, D. E., see Lucot, J. B.,67
Meperidine, intravenous, relative
potency and duration of ac-tion with respect to respira-tory depression in man, 73
Metabolismand protein binding of digoxin
in sheep, relationship to age,
263anaerobic, of metromdazole
forms N-(2-hydroxyethyl)-oxamic acid, 406
hepatic drug, rats, role of pitui-tary gland in gonadal hor-mone effects, 19
hepatobiiary, of N,N-dimethyl-4-aminoazobenzene, role for
liver glutathione, 399of glucose and phosphate in
anesthetized dog, effects ofchonidine, 243
of levo-methadone during post-natal development in rat, 491
of organic compounds in rabbitkidney, demonstration of sep-
Pitt, C. G., Gupta, G., Estes, W.E., Rosenkrantz, H., Metter-ville, J. J., Crumbliss, A. L.,Palmer, R. A., Nordquest, K.W., Sprinkle Hardy, K. A.,Whitcomb, D. R, Byers, B.
R., Arceneaux, J. E. L.,Gaines, C. G. and Sciortino,C. V.: The selection and eval-uation of new chelatingagents for the treatment ofiron overload, 12
Pituitary gland, role in gonadalhormone effects on hepaticdrug metabolsm in rats, 19
Pirbuterol (new bronchodilator),sublingual, pharmacokinetics
and cardiopulmonary effectsin dogs, 371
Platelet aggregation, human, ef-fects of alpha adrenergic
agents, 366Poly(rI . rC), deleterious effect on
metabolism and dispositionof phenytoin, 267
Porter, W. R., Gudzinowicz, M. J.and Neal, R. A.: Thioaceta-mide-induced hepatic necro-sis. II. Pharmacokinetjcs ofthioacetamide and thioacet-amide-S-oxide in the rat, 386
Powell, J. R.: Effects of histamineon vascular sympathetic neu-roeffector transmission, 360
Prange, A. J., Jr., see Vogel, R. A.,161
Pregnancyeffect on biliary excretion of
[‘4Cjphenytoin in rat, 257methadone during, behavioral
effects on rat offspring, 106rat, maternal, fetal and neo-
natal effects of chronic pro-
pranolol, 118
Pregnenolone- 16a-carbonitrile,
effects on carrrier-mediatedtransport systems in isolatedrat hepatocytes, 381
Pritchard, J. B. and James, M. 0.:Determinants of the renalhandling of 2,4-dichlorophen-oxyacetic acid by winterflounder, 280
Propranololchronic administration, in rat,
maternal, fetal and neonataleffects, 118
stimulation-induced release
from adrenergic neurons, 354Prostacyclin, effects on renal he-
modynamics and excretoryfunctions in rat, 294
Prostaglandin E1-induced brady-cardia in rats, effects of brain
serotonin alterations, 232
Protein(s)binding and metabolism of di-
goxin in sheep, relationshipto age, 263
binding, of anticonvulsantdrugs in serum of dog and
man, 429
extracellular, relationship toserotonin turnover in intact
rabbit brain and its modifi-cation by phenobarbital andhaloperidol, 44
synaptic plasma membrane, ratstriatum, endogenous phos-phorylation, effects of mor-phine, 96
Pupil, rat, time and dose relation-ships of morphine-induced
mydriasis and fluctuation, 91
Quenzer, L., Yahn, D., Alkadhi,K. and Voile, R. L.: Tram-mission blockade and stimu-
lation ofganglionic adenylatecyclase by catecholamines, 31
Rabbit(s)hindlimb sensory receptors,
cardiovascular and respira-
tory chemoreflexes evoked
by intra-arterial injection of
bradykinin and other chemi-cal agents, 319
intact brain, relationship of ser-otonin turnover to extracel-
lular proteins and modifica-
tion by phenobarbital or
haloperidol, 44
isolated aortic strips, contrac-tile response to unsaturated
fatty acid peroxides, 347
kidney, metabolism of organiccompounds, demonstrationof separate pathways, 418
nictitating membrane response,
classical conditioning, as
measure of LSD effects on
learning, 330
role ofsulthydryl groups in con-traction of vascular smooth
thesis and tyrosine hydrox-ylase, effect of halperidol, 468
Strijbos, C., see Crabbe, J. C., 128Sulfliydryl groups, role in contrac-
tion of vascular smooth mus-cle, 335
Sulfobromophthalein, biliary ex-cretion, rat, effect of inhibi-tion of enzymatic activity of
ligandin by organometals,248
Sweeney, T. D., see Kramer, R.E., 19
Sweet, C. S., see Scriabine, A., 148
Sylvester, D. M., see Edmonds, H.L., Jr., 236
Sympathetic nerves, transmis-sion, effects of histamine, 360
Sympathetic nervous system, rat,
accelerated developmentcaused by neonatal triiodo-thyronine administration,
485
Synaptic plasma membrane, pro-
teins, rat striatum, effect of
morphine on endogenousphosphorylation, 96
Synaptosomes, striatal, dopaminesynthesis and tyrosine hy-
534 Index
droxylase, effect of haloperi-dol, 468
Synthesisdopamine, in striate.! synapto-
somes, effect of haloperidol,468
Tabakoff, B. and Hoffman, P. L.:Development of functionaldependence on ethanol in do-paminergic systems, 216
Takemori, A. E., see Vaught, J.
L., 86
Tallarida, G., Baldoni, F., Peruzzi,0., Brindisi, F., Raimondi, G.
and Sangiorgi, M.: Cardiovas-cular and respiratory chemo-reflexes from the hindlimbsensory receptors evoked byintra-arterial injection ofbradykinin and other chemi-cal agents in the rabbit, 319
Tallarida, R. J., see Klemfuss, H.,
91
Tension, canine renal arteries, dif-fering actions of nitroprus-
side and D-600, 155Testes, steroidogenesis, effects of
ethanol, 210
Thioacetamide-induced hepatic
necrosis in rat, 386Thioridazine, effects on morphine
abstinence syndrome in rats,63
Thyrotropin-releasing hormoneeffects on locomotor activity,
operant performance andingestive behavior, 161
-induced change in brain gua-nosine 3’,5’-monophosphate
content, 169Toadfish, effect of pH on selectiv-
ity of alloxan for fl-cells of
islets of Langerhans, 184
Toleranceacute, morphine, differential ef-
fects of leucine and methio-nine enkephalin, 86
functional, to pentobarbital in
goldfish, 123
rapid development, to hypo-
thermic effect of ethanol inmice, 128
to anorexic effect of d-amphet-
amine and fenfluramine in
rats, effect of depletion ofbrain dopamine by 6-hydrox-ydopamine, 134
Totaro, J. A., see Clineschmidt, B.V., 460
Towey, J. P., see Hutchings, D.E., 106
Toxicity, of 95 to 97% 02 in ratlung, enhancement by disul-
firam, 377
Transmission, blockade, gangli-omc, by catecholamines, 31
2,4,5-Trichlorophenoxyacetate,transport in isolated, per-
fused rat kidney, 287Triiodothyronine, � neonatal, as
cause of accelerated devel-opment of rat neurotransmis-sion, 485
Tyrosine hydroxylase, in striate.!
synaptosomes, effect of halo-peridol, 468
Uijlen, J., see Crabbe, J. C., 128Umezu, K. and Moore, K. E.: Ef-
fects of drugs on regional
brain concentrations of do-pamine and dihydroxyphen-ylacetic acid, 49
Vasoconstriction
rabbit ear arteries, role ofsulfhydryl groups, 335
sympathetic, effects of hista-mine, 360
Vaught, J. L and Takemori, A.E.: Differential effects of leu-cine and methionine enkeph-alin on morphine-induced an-algesia, acute tolerance anddependence, 86
Vesell, E. S., see Marietta, M. P.,271
Vogel, R. A., Cooper, B. R., Bar-low, T. S., Prange, A. J., Jr.,Mueller, R A. and Breese, G.R.: Effects of thyrotropin-re-leasing hormone on locomo-tor activity, operant perform-ance and ingestive behavior,161
Vogh, B. P., see Haywood, J. R.,
341Voile, R. L., see Quenzer, L., 31
Vore, M., Soliven, E. and Blun-den, M.: The effect of preg-nancy on the biliary excretion
of [‘4C]phenytoin in the rat,257
Wainer, B. H., Wung, W. E., Con-nors, M. and Rothberg, R.
M.: The specificity of anti-morphine and antimeperi-dine antibodies and theirreactivity with opioid pep-tides, 498
Walle, T., see Daniell, H. B., 354
Watkins, D., Cooperstein, S. J.and Fiel, S.: Studies on theselectivity of alloxan for thefl-cells of the islets of Langer-
hans: Effect of pH on the invitro action of alloxan, 184
Watson, D., see Samson, F., 411Watson, L S., see Scriabine, A.,
148
Webb, J. G., see Daniell, H. B.,354
Weiner, C., see Pendleton, R 0.,
24
Weinkam, R. J., see Levin, V. A.,
Weiss, B., see Levin, R. M., 454Weiss, G. B., see Hester, R K.,
155
Weisz, J., see Marietta, M. P., 271
Whitcomb, D. R., see Pitt, C. G.,12
Williams� M., see Clineschmidt, B.
V., 460
Williams, N., see O’Callaghan, J.P., 96
Wilson, P. R, see Yaksh, T. L,
446Withdrawal, from ethanolin mice,
suppressed by sodium bro-
mide and sodium valproate,223
Wong, K. C., see Pace, N. L, 254Wood, P. L, see Robinson, S. E.,
476
Wung, W. E., see Wainer, B. H.,498
Yahn, D., see Quenzer, L, 31
Yaksh, T. L. and Wilson, P. R.:Spinal serotonin terminalsystem mediates antinocicep-
tion, 446
Zavadil, A. P., III, see Helke, C.J., 57
Zenser, T. V., Mattammal, M. B.and Davis, B. B.: Demonstra-tion of separate pathways forthe metabolism of organiccompounds in rabbit kidney,418