787 INDEX Volume 222, July-September, 1982 Abe, Y., see Miura, K., 246 Abiko, Y., see Ichihara, K., 720 Abraham, D. J., see Fisher, A., 140 Abramson, F. P., see Bai, S. A., 589 Acetaminophen, formation from phenacetin and acetanilide on sulfation kinetics in per- fused liver (rats), 14 Acetanilide, deuterated and non- deuterated, role in formation ofacetaminophen in perfused liver (rats), 14 Acetylcholine antinociception, mediation by opiate receptors via the release of morphine-like ma- terials (mice, guinea pigs), 612 effect on norepinephrine release in cerebral arteries (cats, rabbits), 562 effects on cyclic AMP levels in heart (chicks), 383 endothelium-dependent effects in femoral artery (dogs), 166 in brain, effect of clonidine on physostigmine-induced in- creases of (mice), 595 in brain, effect of ethylcholine mustard aziridiniam ion on (mice), 140 metabolism, during hypoxia, ef- fect of 3,4-diaminopyridine on (mice), 576 synthesis and release in term placenta, effect of choline acetyltransferase on (man), 301 turnover rate in brain, effects of adenosine analogs and theo- phylline on (rats), 550 Acetylcholine release, influence of glycosidic conformation on activity of ademne nucleo- sides as presynaptic inhibi- tors of (guinea pigs), 241 inhibition by streptomycin (frogs), 488 Adenine nucleosides, presynaptic inhibitors of acetyicholine release, influence of glyco- siclic conformation and charge distribution on (guinea pigs), 241 Adenosine presynaptic inhibition of acetyl- choline release by (guinea pigs), 241 -uptake blockade by benzodi- azepines (guinea pigs), 752 Adenosine triphosphate, endothe- lium-dependent effects in femoral artery (dogs), 166 Na,K-Adenosine triphospha- tase, inhibition by vanadate (dogs), 447 Adenylate cyclase, development in heart (mice), 7 Adrenergic receptor, beta, devel- opment in heart (mice), 7 Adrenergic receptors, alpha-i and alpha-2, interactions of imidazolines (guinea pigs), 29 Adrenoceptors alpha adrenergic, effects in- duced by clomdine-like imi- dazolidines (rats), 705, 712 alpha-i, antagonism of ketan- serin by (rats), 227 beta, role in renin release (dogs), 606 beta, -stimulated renin release, effects of indomethacin (dogs), 414 Aerice, M. T., see Talbot, P. A., 87 Aflatoxin B1, effect on hepatic phase I and II transformation (rats), 471 Aghajanian, G. K., see Marwaha, J., 287 Agonists alpha adrenoceptor, role in me- diating sleep-like behavior (chicks, rats), 680 delta opiate, modulation of do- pamine release in striatal slices by (rats), 435 Agonists-antagonists, adrenergic, effects on phosphatidylinosi- tol labeling and contraction in aorta (rabbits), 258 Akera, T., see Takeda, K., 132 Albuterol, stimulation of renin release by (dogs), 606 Alcohol dehydrogenase-depend- ent metabolism of ethanol, role of testosterone (rats), 20 Allyl alcohol, effect on hepatic phase I and II transformation (rats), 471 Alpha-i glyprotein, induction by phenobarbital (dogs), 589 -y-Aminobutyric acid, transmis- sion in medullary depressor region (cats), 517 Aminophylline, antagonism of 2- chloroadenosine renal effects by (rats), 319 Aminoquinolines, interaction with presynaptically acting neurotoxins (mice, rats, guinea pigs, chicks), 43 Aminoxyacetic acid effect on dopamine metabolism in nigrostriatal pathway (rats), 674 role in elevation of y-aminobu- tyriclevels in brain (cats), 517 Amitriptyline effect on fixed-interval re- spending (squirrel monkeys), 215 -induced toxicity, action of di- azepam and sympathomi- metic amines against (cats), 424 suppression of histamine-in- duced adrenocorticotropic hormone release by (rats), 583 2’-AMP, effect on mtrofurantoin- mediated depletion ofred cell reduced glutathione (man), 430 Amphetamine, potentiation of ketamine-induced loss of righting reflex and sleeping time (mice), 122 d-Amphetamine behavioral and cross-tolerance to (rats), 126 self administration, behavioral effects (dogs), 52 Amygdala-kindled seizures, effect on [3H]quinuciclinyl benzi- late binding sites (rats), 670 Analgesia morphine and enkephalins, ef- fect of naloxone (rats), 190 tail-flick, effect of buprenor- phine on opiate receptors during (rats), 198 Analog of prostaglandin, renal vasodi- latory activities of (dogs, rats), 152 prostaglandin endoperoxide, ef- fect on gastric emptying and secretion (monkeys), 379 Analogs, of $-endorphine, role in modification of $-endorphin (rats), 262 Anderson, W., Molina, E., Rentz, J. and Hirschowitz, B. I.: Analysis of the 2-deoxy-D- glucose-induced vagal stimu- lation of gastric secretion and gastrin release in dogs using methionine-enkephalin, mor- phine and naloxone, 617 Antagonists alpha adrenoceptor, inhibition of sleep time induced by al- pha adrenoceptor agonists (chicks, rats), 680 alpha-i and alpha-2, effects on locus ceruleus, dorsal raphe and dorsal lateral gemculate nuclei (rats), 287 calcium, effects on coronary collateral blood flow (dogs), 494 calcium, effects on isotropic ac- tion of vanadate in isOlated heart (rats, guinea pigs), 132 Antidepressant -induced corneal lesions (rats), 282 -induced decline in beta adre- nergic and serotomn2 recep- tor binding in brain, effects of adrenocorticotropic hormone and yohimbine (rats), 566 Antonaccio, M. J., see Taylor, D. G., 517 Aorta effect of alpha-i adrenergic re- ceptor on phosphatidylinosi- tel labeling and contraction in (rabbits), 258 evaluation of alpha-i adrener- gic effects of cirazoline in (guinea pigs), 29 Aprotinin, inhibition of hypoten- sive action of SQ 14,225 by (dogs), 246 1-fl-D-Arabinofuranosylcytosine, liposome-encapsulated and free, distribution and metab- olism of (dogs, mice), 324 Arachidonate, toxicity, sexual dii- ferentiation of (mice), 315 Arachidonic acid endothelium-dependent effects in femoral artery (dogs), 166 mobilization, effects of diuretics on (rats), 306 Argentieri, T. M., see D’Alonzo, A. J., 401 Arteries, cerebral, effect of acetyl- choline on norepinephrine release in (cats, rabbits), 562 Artery coronary, effect of propranolol on stenosis severity in (dogs), 635 ear, contractility induced by serotonin masks desensitiza- tion to norepinephrine in (rabbits), 338 femoral, endothelium-depend- ent effects of acetylcholine, adenosine triphosphate, thrombin and arachidomc acid (dogs), 166 mesenteric, role of nucleosides and nucleotides in neuromus- cular transmission in (rats), 344 radial, termination of responses to sympathetic nerve stimu- lation and to noradrenaline, effects of cocaine and 17-/i- estradiol (cows), 731 Artery constriction, renal, effect on prostaglandin 12 biosyn- thesis and renin release
11
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787
INDEX
Volume 222, July-September, 1982
Abe, Y., see Miura, K., 246Abiko, Y., see Ichihara, K., 720
Abraham, D. J., see Fisher, A.,140
Abramson, F. P., see Bai, S. A.,589
Acetaminophen, formation fromphenacetin and acetanilideon sulfation kinetics in per-fused liver (rats), 14
Acetanilide, deuterated and non-deuterated, role in formationofacetaminophen in perfusedliver (rats), 14
Acetylcholine
antinociception, mediation byopiate receptors via therelease of morphine-like ma-terials (mice, guinea pigs),612
effect on norepinephrinerelease in cerebral arteries(cats, rabbits), 562
effects on cyclic AMP levels inheart (chicks), 383
endothelium-dependent effects
in femoral artery (dogs), 166in brain, effect of clonidine on
physostigmine-induced in-creases of (mice), 595
in brain, effect of ethylcholinemustard aziridiniam ion on(mice), 140
metabolism, during hypoxia, ef-fect of 3,4-diaminopyridine
on (mice), 576synthesis and release in term
placenta, effect of cholineacetyltransferase on (man),301
turnover rate in brain, effects ofadenosine analogs and theo-
phylline on (rats), 550Acetylcholine release, influence of
glycosidic conformation on
activity of ademne nucleo-sides as presynaptic inhibi-
tors of (guinea pigs), 241
inhibition by streptomycin
(frogs), 488Adenine nucleosides, presynaptic
inhibitors of acetyicholine
release, influence of glyco-siclic conformation andcharge distribution on(guinea pigs), 241
ison with maternal ethanoldiet on postnatal develop-ment (mice), 294
Bymaster, F. P., see Wong, D. T.,61
Ca�-dependent slow action po-tentials in skeletal muscle, ef-fects of bepridil and verapa-mil on (frogs), 80
Cadmium, chelation from metal-
lothionein after injection ofcadmium chloride (rats), 699
Cadmium chloride, effect on he-patic phase I and II transfor-mation (rats), 471
Caill#{233},G., see Lambert, C., 232Calcium channel blockers
effects on cardiac output distri-bution (rats), 359
effects on renal renin secretion(dogs), 447
Calcium pools, involvement incontractile activation in iso-lated heart, effect of vana-date (rats, guinea pigs), 132
CaImOdUIin, inhibition by pheno-thiazines (rats), 509
Carbon, C., see Nivoche, Y., 237Carbon tetrachloride
effect on angiotensin convertingenzyme levels in lung (mice),
641effect on hepatic phase I and II
transformation (rats), 471
Cardiovascular dynamics, effectof diltiazem on (rats), 359
Carino, M. A., see Horita, A., 367
Casey, L C., Fletcher, J. R.,Zmudka, M. I. and Ramwell,P. W.: Prevention of endo-
toxin-induced pulmonary by-pertension in primates by theuse of a selective thrombox-ane synthetase inhibitor,Oxy 1581,441
Castration, effect on alcohol de-hydrogenase-dependent me-
tabolism of ethanol (rats), 20Catechola.mines, developmental
effects of a-difluoromethylor-nithine on (rats), 746
dl-Cathinone, behavioral andcross-tolerance to (rats), 126
Caturay, E. M., see Huidobro-
Tore, J. P., 262Cavero, I., see Roach, A. G., 680
Cell, glial, effects of DNA synthe-sin inhibitors on post-trau-matic proliferation of (rats),
1982 Index 789
765
Cellsendothelial, in lung, injury after
carbon tetrachloride admin-istration (mice), 641
Purkinje, sensitivity to ethanol(mice), 480
red, studies on nitrofurantoin-mediated depletion of re-
duced glutathione in (man),430
Cerebellar grafts, ethanol sensi-
tivity of (mice), 480Cerebellum, transplant, sensitiv-
ity of Purkinje cells to de-pressant effects of ethanol in(mice), 480
Chan, C.-C. and Kaisner, S.: Ter-mination of responses to
sympathetic nerve stimula-tion and to noradrenaline ina perfused arterial prepara-tion: The role ofneuronal andextraneuronal uptake, 731
Chan, K. K., see Pang, K. S., 14Chandra, A., see Liii, M. T., 251Chassaing, C., Duchene-Marullaz,
P. and Paire, M.: Mechanismof action of quinidine onheart rate in the dog, 688
Chau, T. T., Izazola-Conde, C. andDewey, W. L.: Evidence forthe existence of peptide andnonpeptide morphine-likematerials in mouse brain: Ef-fect of an analgesic intracere-broventricular dose of acetyl-choline on their levels, 612
Chaung, L.-Y., see Wolf, R. A.,331
Chelation, of cadmium from me-tallothionein (rats), 699
Chen, F.-C. M., Yamamura, H. I.and Roeske, W. R.: Adenyl-ate cyclase and beta adrener-gic receptor development inthe mouse heart, 7
Cheney, D. L., see Murray, T. F.,550
Chloramphemcol, effect on di-uretic response to furosemide(rats), 232
Chiorisnipramine, effect on fixed-interval responding (squirrelmonkeys), 215
2-Chloroadenosine
antagonism by aminoadenosineon renal effects of (rats), 319
effect on adenosine turnoverrate in brain (rats), 550
Chlorpheniramine, effect on his-tamine-induced adrenocorti-
cotropic hormone release
(rats), 583Choline acetyltransferase
in brain, effects of ethylcholinemustard aziridinium ion on(mice), 140
inhibition, effect on acetylcho-
line synthesis and release interm placenta (man), 301
Cherian, M. G. and Rodgers, K.:
Chelation of cadmium from
metallothionein in vivo andits excretion in rats repeat-
edly injected with cadmiumchloride, 699
Chesselet, M. F., see Lubetzki, C.,435
Chromonar, maximal vasodilation
by (dogs), 635Churchill, P. C.: Renal effects of
2-chloroadenosine and theirantagonism by aminophyl-line in anesthetized rats, 319
Cicero, T. J., Newman, K. S.,Schmoeker, P. F. and Meyer,
E. R.: Role of testosterone inethanol and morphine-in-duced increases in the alcoholdehydrogenase -dependentmetabolism of ethanol in themale rat, 20
Cimetidine, effect on histamine-
induced arousal (rats), 37Cinanserin, inhibition of sympa-
thetic nervous discharge(cats), 94
Cirazoline, alpha-i and alpha-2
adrenergic effects of (guineapigs), 29
Cita.lopram, effect on inhibition of
serotonin release by lysergicacid diethylamide (rats), 220
Claeys, M., see De Mey, J. G., 166Clark, M. J., see Leventer, S. M.,
301Clearance, renal, of digoxin, effect
of quinidine (dogs), 49
Clementi, W. A., McNay, J. L.,Talseth, T., Haegele, K. D.,Ludden, T. M. and Musgrave,G. E.: Endogenous genera-tion of hydralazine from la-bile hydralazine hydrazones.
159Clohisy, D. R., Quintanilla, A. P.
and Gibson, T. P.: Effect ofquinidine on the renal clear-ance of digoxin in the pres-ence of low and high serumdigoxin concentrations, 49
Clonidinebradycardic activities (rats),
712
central and peripheral hypoten-sive activity (rats), 705
-induced sleep time, inhibition
by alpha-2 adrenoceptor an-tagonists (chicks, rats), 680
inhibition of phrenic nerve ac-tivity by (cats), 771
protective effects on physostig-
mine-induced toxicity (mice),595
Cocaine
effect on sympathetic nerve
stimulation and noradrena-line concentration in radialartery (cows), 731
potentiation of ketamine-in-
duced loss of righting reflex
and sleeping time (mice), 122Conanan, L B., see Crutchley, D.
J., 544
Conformation, glycoside, influ-
ence on activity of ademne
nucleosides as presynaptic in-
hibitors of acetylcholinerelease (guinea pigs), 241
Contractile activation, in isolatedheart, involvement of cal-cium pools, effects of vana-
� date (rats, guinea pigs), 132
Contractilityin ear artery, masks desensiti-
zation to norepinephrine
(rabbits), 338myocardial, effects of strepto-
zotocin diabetes and insulin
treatment on (rats), 395
Contractions, of aortic strips, ef-fect of alpha-i adrenergic re-ceptor on (rabbits), 258
Contrepois, A., see Nivoche, Y.,237
Cook, M. A., see Paul, M. L., 24i
Corynanthine, effect on clomdine-induced sleeping time(chicks, rats), 680
Costa, E., see Murray, T. F., 550
Cowan, A., see Tallarida, R. J.,198
Craven, P. A. and DeRubertis, F.R.: Calcium-dependent stirs-ulation of renal medullaryprostaglandin synthesis by
furosemide, 306Cremieux, A.-C., see Nivoche, Y.,
237
Crutchley, D. J., Conanan, L. B.and Maynard, J. R.: Stimu-lation of fibrinolytic activity
in human skin fibroblasts byprostaglandins E1, E� and 12,
544
Cruz-Soto, M. A., see Nova, J. M.
L., 447Cyclic AMP, accumulation in
heart, effects of cholinergic
muscarinic agonists on
(chicks), 383Cyclic GMP, accumulation in
heart, effects of phosphodi-esterase inhibitors on(chicks), 383
Cyclophosphamide, inhibition of
[3H]thymidine incorporationinto DNA (rats), 765
Cyproheptadine, inhibition of
sympathetic nervous dis-
charge (cats), 94Cytosine arabinoside
in central nervous system,pharmacokinetics and me-tabolism of (rabbits), 1
inhibition of DNA synthesisand glial cell proliferation by(rats), 765
Dailey, J. W., see Ko, K. H., 662D’Alonzo, A. J., Argentieri, T. M.
and McArdle, J. J.: Ouabainand tetrodotoxin block themyotonia of skeletal muscle
induced with 20,25-diazacho-lesterol, 401
Daniel, M. A. and Evans, M. A.:Quantitative comparison ofmaternal ethanol and mater-
nal tertiary butanol diet on
postnatal development, 294
Degregorio, C. M., see Shannon,
H. E., 52de Jonge, A., Timmermans, P. B.
M. W. M. and van Zwieten,
P. A.: Quantitative aspects of
alpha adrenergic effects in-duced by clonidine-like imi-dazolidines. I. Central hype-tensive and peripheral hyper-tensive activities, 705
de Jonge, A., Timmermans, P. B.M. W. M. and van Zwieten,P. A.: Quantitative aspects of
alpha adrenergic effects in-duced by clonidine-like imi-dazolidines. II. Central andperipheral bradycardic activ-ities, 712
De Mey, J. G., Claeys, M. andVanhoutte, P. M.: Endothe-lium-dependent inhibitoryeffects ofacetylcholine, aden-osine triphosphate, thrombinand arachidomc acid in thecanine femoral artery, 166
Dentate gyrus, membranes, effectof kindled seizures on [3H]quinucidinyl benzilate bind-
ing sites in (rats), 670Dershwitz, M. and Novak, R. F.:
Studies on the mechanism ofmtrofurantoin-mediated red
cell toxicity, 430DeRubertis, F. R., see Craven, P.
A., 306Desensitization
of d-nicotine (rats), 463to norepinephrine, role of con-
tractility in ear artery on(rabbits), 338
Desipramine, suppression of his-tamine-induced adrenocorti-cotropic hormone release by(rats), 583
Desmethylimipramine
effect on fixed-interval re-sponding (squirrel monkeys),215
effect on melatonin concentra-tion in pineal gland (rats), 534
Dewey, W. L, see Chau, T. T.,612
Diabetes, streptozotocin, effect onmyocardial sodium pump andcontractility of heart (rats),
3953,4-Diaminopyridine, effect on be-
havior and acetylcholine me-
tabolism (mice), 576
20,25-Diazacholesterol-inducedmyotonia of skeletal muscle,
effects of ouabain and tetro-dotoxin (rats), 401
Diazepam
effect on dopamine metabolismin mgrostriatal pathway(rats), 674
-induced sensitization of atriato adenosine (guinea pigs),752
protective action against ansi-triptyline-induced toxicity(cats), 424
suppression of histamine-in-
duced adrenocorticotropic
790 Index Vol. 222
hormone release by (rats),583
Dichloroacetate, metabolic and
toxic effects, comparison with
2-chloropropionate (rats,
mice), 501i,i-Dichloroethylene, effect on
hepatic phase I and II tram-formation (rats), 47i
Diet, maternal ethanol and ma-temal t-butanol, comparison
in central nervous system, ef-fect on seizure intensity
(rats), 662
metabolism, drug-induced
changes (rats), 674
-opiate interaction in pedal gan-
glia (molluscs), 759
protective action against aim-
triptyline-induced toxicity
(cats), 424
release in striatal slices, modu-
lation by delta opiate ago-
nists (rats), 435Doxepin, suppression of hista-
mine-induced adrenocortico-
tropic hormone release by
(rats), 583
Drugs
alpha and beta adrenergic,
stimulation of fl-endorphin
release from pituitary (rats),
103
tricycic antidepressant and an-
ticholinergic, effects on fixed-
interval responding (squirrel
monkeys), 215
Dubois, A., see Shea-Donohue, P.
T., 379Duchene-Marullaz, D., see Chas-
saing, C., 688Duckles, S. P. and Kennedy, C.
D.: Cerebral blood vessels:Effects of exogenous acetyl-
choline and field stimulationon norepinephrine release,562
Duman, R., see Kendall, D. A.,
566
Dunnette, J. H., see Woodson, L.C., 174
du Souich, P., see Lambert, C.,
232
Dynorphin, effect on kappa opi-ate receptors in ileum (guinea
pigs), 71
Electrophysiology, cardiac, effects
of enflurane on (guinea pigs),405
Electrophysiological study, on ef-fects of alpha-i and alpha-2antagonists (rats), 287
Elimination, of inulin and galla-mine (dogs), 389
Ellens, H., Rustum, Y., Mayhew,E. and Ledesma, E.: Distri-bution and metabolism oflipsome-encapsulated andfree i-$-D-arabinofuranosyl-cytosine (Ara-C) in dog andmouse tissues, 324
fl-Endorphin, release from pitui-tary, adrenergic control
(rats), 103Endothelium-dependent effects of
acetylcholine, adenosine tn-phosphate, thrombin and ar-achidomc acid in femoral ar-tery (dogs), 166
Endotoxin
-induced fever, role of norepi-nephrine-cycic AMP link on(rats), 251
-induced pulmonary hyperten-sion, prevention with OXY
1581 (baboons), 441
End-plate currents, inhibition by
streptomycin (frogs), 488
Enflurane, effect on papillarymuscle (guinea pigs), 405
lation of autonomic gangliaby isopropylamine (dogs),116
Garcia, J. C., see Nova, J. M. L.,
447GarcIa-Suinz, J. A., see Villalobos-
Molina, R., 258Gastrin release, effects of methi-
onine-enkephalin, morphineand naloxone on 2-deoxy-D-glucose-induced vagal stimu-
lation of (dogs), 617Gastrointestinal activity, effects
of thyrotropin releasing hor-
mone on (rabbits), 66Gastrointestinal transit, stimula-
tion by thyrotropin-releasinghormone (rabbits), 367
Gemba, M., see Matsushima, Y.,
452Gentamicin, binding to renal
brush border membranes(rats), 350
Gerber, J. G., see Olson, R. D., 606
Gerkens, J. F., see Jackson, E. K.,
410, 414Gibson, G. E., see Peterson, C.,
576
Gibson, T. P., see Clohisy, D. R.,49
Gioannini, T. L, see Howells, R.
1982 Index 791
D., 629Gland, pituitary, adrenergic con-
trol of $-endorphin releasefrom (rats), 103
Gleason, J. G., see Weichman, B.
M., 202Glowinski, J., see Lubetzki, C., 435Glutathione, reduced, in red cells,
studies on mtrofurantoin-me-
diated depletion of (man),430
Glycine, metabolism, benzoate-in-duced changes in (man), 572
Goldman, S., Olajos, M. and Mor-
kin, E.: Effects of verapamilon positive inotropic stimu-lation in the left atrium andventricle of conscious dogs,
270
Gomem, R, see Roach, A. G., 680Gormley, J. M., see Richter, J. A.,
778
Gregus, Z., Watkins, J. B.,Thompson, T. N. and Klaas-
son, C. D.: Resistance of somephase II biotransformationpathways to hepatotoxins,
471
Gnignolo, A., see Slotkin, T. A.,
746
Gross, G. J., Buck, J. D., Warltier,D. C. and Hardman, H. F.:
Role of autoregulation in thebeneficial action of propran-olol on ischemic blood flowdistribution and stenosis se-verity in the canine myocar-dium, 635
Gross, G. J., see Zyvoloski, M. G.,494
Guanfacine-induced sleep time,
inhibition by alpha-2 adre-noceptor antagonists (chicks,rats), 680
Haegele, K. D., see Clementi, W.A., 159
Haigler, H. J., see O’Neffl, T. P.,555
Halopenidol, effect on histamine-
induced arousal (rats), 37Hanin, I., see Fisher, A., 140Harden, T. K. and McCarthy, K.
D.: Identification of the beta
adrenergic receptor subtypeon astroglia from rat brain,600
Hardman, H. F., see Gross, G. J.,635
Harris, R A., see Yount, E. A.,
501Hauser, G., see Pappu, A. S., 109Heart
adenylate cyclase and beta ad-renergic receptor develop-ment in (mice), 7
development of ornithine de-carboxylase and polyasninesin (rats), 74i
effects of benzodiazepines onsensitization of atnia to aden-osine (guinea pigs), 752
effects of enflurane on myocar-dial action potentials (guineapigs), 405
effects of propranolol on is-
chemic blood flow and ste-nosis severity in (dogs), 635
effects of streptozotocin diabe-tes and insulin treatment on
sodium pump and contractil-ity of (rats), 395
effects of verapamil on ino-
tropic stimulation of leftatrium and left ventricle in(dogs), 270
ischemic, effect of diltiazem onmyocardial pH in (dogs), 720
glycerin on transmural en-ergy metabolism in (dogs),694
Heart rate, mechanism of actionof quinidine on (dogs, guineapigs), 688
Hemodynamicseffects of calcium antagonists
(dogs), 494
of kidney, effects of adenosineon (rats), 319
of myocardial metabolites, ef-fects of nitroglycerin (dogs),
694renal, effect of vanadate on
(dogs), 447
Henthorn, T. K., Avram, M. J.Frederiksen, M. C. and At-kinson, A. J., Jr.: Heteroge-neity of interstitial fluid
space demonstrated by si-multaneous kinetic analysisof the distribution and elimi-nation of inulin and galla-mine, 389
Hepatocytes, isolated, effect onmetabolism of phenytoin
(rats), 658Hepatotoxins, resistance of some
Phase H biotransformationpathways to (rats), 471
Hermansson, J., see von Bahr, C.,458
Herzer, W. A., see Jackson, E. K.,
414
Heydorn, W. E., Brunswick, D. J.and Fraser, A.: Effect oftreatment of rats with anti-depressants on melatoninconcentrations in the pinealgland and serum, 534
Higuchi, M.: Effects of nitroglyc-em on transmural energymetabolism in the underper-fused canine heart, 694
Hiller, J. M., see Howells, R. D.,629
Hippurate, production in kidney
effect of benzoate (man), 572Hirschowitz, B. I., see Anderson,
w., 617
Histamine
-induced adrenocorticotropichormone release, inhibitionby antihistamines and anti-depressants (rats), 583
Souich, P.: Nonrenal clear-ance of furosemide as a causeof diuretic response vaniabil-ity in the rat, 232
Langer, S. Z. and Moret, C.: Ci-talopram antagonizes the
stimulation by lysergic acid
diethylamide of presynapticinhibitory serotonin autore-
ceptors in the rat hypothala-mus, 220
Lapollo, J., see Vanderwende, C.,122
Lateral geniculate, nucleus, ef-fects of alpha-i and alpha-2
antagonists on (rats), 287Le Breton, G. C., see Parise, L. V.,
276
Ledesma, E., see Ellens, H., 324Lee, N. M., see Huidobro-Toro, J.
P., 262Lee, N. M., see Yoshimura, K., 7i
Lef#{232}vre-Borg, F., see Roach, A.G., 680
Lerea, G. A., see Slotkin, T. A.,
741, 746
Leukotriene-mediated broncho-constriction, in vitro and in
vivo mechanisms (guineapigs), 202
Leventer, S. M., Rowell, P. P. and
Clark, M. J.: The effect ofcholine acetyltransferase in-hibition on acetylcholine syn-thesis and release in term hu-
man placenta, 301Liii, M. T., Wu, J. J., Chandra, A.
and Tsay, B. L.: A norepi-nephrine-cycic AMP link inthe hypothalamic pathways
which mediate fever inducedby endotoxin and prostaglan-
din E2 in the rat, 251
Lind, M., see von Bahr, C., 458Linden, J., Vogel, S. and Spere-
lakis, N.: Sensitivity of Ca-de-
pendent slow action poten-tials to methacholine is in-
duced by phosphodiesteraseinhibitors in embryonic chick
ventricles, 383Ling, N., see Huidobro-Toro, J.
P., 262Lisuride, effect on sympathetic
nervous discharge (cats), 94
Liverdistribution and metabolism of
lipsome-encapsulated andfree 1-$-D-arabrnofuranosyl-cytosine in (dogs, mice), 324
metabolism of furosemide by
(rats), 232microsomal metabolism of
phenytoin (rats), 658microsomes, oxidation of (R)-
and (S)-propranolol in (man,
dogs), 458
Vol. 222
mince, propranolol effects onlipids (rats), 109
perfused, effect of trans-stil-bene oxide on excretion ofmorphine (rats), 526
perfused, formation of acet-aminophen from phenacetinand acetanilide on sulfationkinetics in (rats), 14
Locus ceruleus, nucleus, effects ofalpha-i and alpha-2 antago-nists on (rats), 287
Loh, H. H., see Hudiobro-Toro, J.P., 262
Loh, H. H., see Yoshimura, K., 7iLubetzki, C., Chesselet, M. F. and
Glowinski, J.: Modulation ofdopamine release in rat stria-tal slices by delta opiate ag-onists, 435
Ludden, T. M., see Clementi, W.A., 159
Lukacsko, P. and Blumberg, A.:Modulation of the vasocon-
stnictor response to adrener-gic stimulation by nucleo-sides and nucleotides, 344
Lum, B. K. B., see Foilmer, C. H.,424
Lungangiotensin converting enzyme
levels, effect of carbon tetra-chloride (mice), 641
parenchymal strips, effects ofindomethacin and meclofen-amic acid on leukotriene-in-duced contractions in (guineapigs), 202
LY135252, inhibition of norepi-
nephnine uptake in brain by(rats), 61
Lynch, C., HI, Vogel, S., Pratila,M. G. and Sperelakis, N.: En-flurane depression of myocar-
dial slow action potentials,405
Lysergic acid diethylamide, inhi-bition of serotonin release(rats), 220
Malik, K. U., see Homma, T., 623Mandel, H. G., see Bilhingsley, M.
L., 765Mantione, C. R., see Fisher, A.,
140
Martinez-Maldonado, M., see
Nova, J. M. L., 447Marwaha, J. and Aghajanian, G.
K.: Relative potencies of al-pha-1 and alpha-2 antago-rnsts in the locus ceruleus,dorsal raphe and dorsal lat-eral geniculate nuclei: Anelectrophysiological study,
287
Matsushima, Y. and Gemba, M.:Stimulatory action of vera-pamil on transport of organicacids in rat kidney corticalslices, 452
Mayhew, E., see Ellens, H., 324Maynard, J. R., see Crutchley, D.
J., 544McCall, R B. and Humphrey, S.
J.: Involvement of serotoninin the central regulation ofblood pressure: Evidence for
1982 Index 793
a facilitating effect on sym-pathetic nerve activity, 94
McArdle, J. J., see Argentieri, T.
M., 401
McCarthy, K. D., see Harden, T.K., 600
McCrimmon, D. R. and Lalley, P.M.: Inhibition of respiratoryneural discharges by clom-dine and 5-hydroxytrypto-phan, 771
McKearney, J. W.: Effects of tri-cyclic antidepressant and an-ticholinergic drugs on fixed-
interval responding in thesquirrel monkey, 2i5
McNamara, J. 0., see Savage, D.D., 670
McNay, J. L., see Clementi, W.A., 159
Meclofenamate, effect on pan-
creatic blood flow and exo-crine excretion (dogs), 623
Meclofenamic acid, effect on
leukotriene-induced bron-choconstriction in vitro andin vivo (guinea pigs). 202
Melatonin, in pineal gland, effectof antidepressants on (rats),534
Mepyramine, effect on histamine-
induced adrenocorticotropin
hormone release (rats), 58316-Mercaptoethanol, inhibition of
norepinephrine accumula-tion in sympathetic nerveendings by (mice, rats), 419
Metabolism
dopamine, effect of morphine(mice), 182
of acetylcholine, during hy-poxia, effect of 3,4-diamino-pyridine on (mice), 576
of 1-$-D-arabinofuranosylcyto-sine (dogs, mice), 324
of arachidomc acid (dogs), 166of cytosine arabinoside in cen-
tral nervous system (rabbits),
of dopamine (rats), 674of dopamine, effects of mu and
delta opiate agonists (rats),435
of ethanol, alcohol dehydroge-nase-dependent, role of tea-tosterone (rats), 20
of furosemide by liver (rats),232
of glycine and urea, benzoate-induced changes in (man),572
of hydralazine (rats, rabbits),159
ofmorphine, effect of trans-stil-bane oxide on (rats), 526
of phenytoin by isolated hepa-tocytes and hepatic micro-somes (rats), 658
of phospholipid, effects of pro-pranolol (rats), 109
of polyphosphoinositide, in-volvement of alpha noradre-nergic receptors in mediation
of (rats), 209of propranolol in liver (man,
dogs), 458of transported drugs, (rats), 372
transmural energy, in heart, ef-fects of nitroglycerin on(dogs), 694
Metallothionein, chelation of cad-mium from (rats), 699
Metergoline, inhibition of sym-
pathetic nervous discharge(cats), 94
Methacholine, effects on cyclic
AMP levels in heart (chicks),
383
Methionine-Enkephalin, effect ongastric secretion and gastrin
release (dogs), 617Methiothepin, effect on inhibition
by lysergic acid diethylamideof serotonin release (rats),220
5-Methoxydimethyltryptamine,
effect on sympathetic nerv-ous discharge (cats), 94
a-Methylnorepinephnine
-induced sleep time, inhibitionby alpha-2 adrenoceptor an-tagonists (chicks, rats), 680
isomers, alpha adrenergic ef-fects of (guinea pigs), 645
Methysergide, inhibition of sym-pathetic nervous discharge(cats), 94
Meyer, E. R., see Cicero, T. J., 20Mianserin, suppression of hista-
pretreatment, effect on potencyof f1-endorphin (rats), 262
Muccitelli, R. M., see Weichman,B. M., 202
Mueller, G. P., see Pettibone, D.J., 103
Muller, J. E., see Wolf, R. A., 331Muramatsu, I., see Ikushima, S.,
463Murray, T. F., Blaker, W. D., Che-
ney, D. L and Costa, E.: In-hibition of acetylcholineturnover rate in rat hippo-campus and cortex by intra-ventricular injection of aden-osine analogs, 550
Muscimol, effect on dopaminemetabolism in nigrostriatalpathway (rats), 674
Muscle
papillary, cardiac, depression
by enflurane (guinea pigs),405
skeletal, effects of bepridil andverapamil on Ca�-depend-ent slow action potentials in(frogs), 80
skeletal, effects of ouabain andtetrodotoxin on myotonia of(rats), 401
Musgrave, G. E., see Clementi, W.A., 159
Myers, A., Papadopoulos, A.,O’Day, D., Ramey, E., Ram-well, P. and Penhos, J.: Sex-ual differentiation of arachi-donate toxicity in mice, 315
Myers, L., see Shea-Donohue, P.T., 379
Myocardial ischemia
effects of diltiazem and nifedi-pine (dogs), 494
effect of hyaluromdase on(dogs, rats, man), 331
Myotonia, of skeletal muscle, ef-fects of ouabain and tetrodo-toxin on (rats), 401
Naloxoneantagonism of analgesic effects
of morphine and enkephalins(rats), 190
antagonism of dynorphin
(guinea pigs), 71
antagonism of $-endorphin(rats), 262
effect on gastric secretion and
gastrin release (dogs), 617
a-Naphthylisothio-cyanate, effecton hepatic phase I and IItransformation (rats), 471
ing, interaction with amino-quinolines (mice, rats, guinea
pigs, chicks), 43Neurotransmission, synaptic, ef-
fects of primidone and phen-ylethylmalonamide (frogs),
87
Neurotransmitter release, nerve-evoked, at neuromuscularjunction, effect of primidone
and phenylethylmalonamide(frogs), 87
Newman, K. S., see Cicero, T. J.,20
Nialamide, effect on melatoninconcentration in pineal gland(rats), 534
d-Nicotine, effects on nicotinic re-ceptors (rats), 463
Nies, A. S., see Olson, R. D., 606Nifedipine
effect on normal and ischemicmyocardium (dogs), 494
effect on renal renin secretion(dogs), 447
Nigrostriatal pathway, actions ofGABAergic agents on dopa-mine metabolism in (rats),674
Ni�rofurantoin-mediated red cell
toxicity, studies on mecha-
ni.�m of (man), 430Nitroglycerin, effects on tram-
mural energy metabolism inheart (dogs), 694
Nivoche, Y., Contrepois, A., Cre-
794 Index Vol. 222
mieux, A-C. and Carbon, C.Vancomycin in rabbits: Phar-macokinetics, extravasculardiffusion, renal excretion andinteractions with furosemide,237
Nompleggi, D., see Shea-Dono-hue, P. T., 379
Noradrenaline, in radial artery,effects of cocaine and 17-�6-
estradiol (cows), 731Norepinephnine
accumulation in sympatheticnerve endings, inhibition bydisulfides (mice, rats) 419
contractility in ear artery masksdesensitization to (rabbits),338
-cyclic AMP link, role in endo-toxin- and prostaglandin E2-induced fever (rats), 251
development in brain and pe-ripheral nerves (rats), 746
effects on polyphosphoinositidemetabolism (rats), 209
-evoked neuronal firing in mes-encephalic reticular forma-
tion, effects of phentolamineand propranolol on (rats), 555
in central nervous system,effect on seizure intensity(rats), 662
isomers, alpha adrenergic ef-fects of (guinea pigs), 645
protective action against ami-
triptyline-induced toxicity
(cats), 424
release in cerebral arteries, ef-fect of acetylcholine (cats,rabbits), 562
Nortriptyline, effect on fixed-in-terval responding (squirrelmonkeys), 215
Nova, J. M. L, Garcia, J. C., Crux-Soto, M. A., i3enabe, J. E.and Martinez-Maldonado,M.: Effect of sodium ortho-vanadate on renal resin se-cretion in vivo, 447
Novak, R. F., see Dershwitz, M.,430
Oates, J. A., see Jackson, E. K.,
414O’Connor, B. L., see Yount, E. A.,
501O’Day, D., see Myers, A., 315O’Hara, D., see Wolf, R A., 331Olajos, M., see Goldman, S., 270Olson, L., see Palmer, M. R., 480Olson, R D., Nies, A. S. and Ger-
bar, J. G.: Beta adrenergicallymediated release of renin inthe dog is not confined to
either beta-i or beta-2 adre-noceptors, 606
O’Neill, T. P. and Haigler, H. J.:Characteristics of adrenocep-tore in a nociceptive pathway
in the mesencephalic reticu-lar formation of the rat, 555
Opiate binding, to buprenorphine
(rats), 198
Opioids, endogenous, release intocerebrospinal fluid frombrain, effects of morphine on
(mice, guinea pigs), 612Organic acids, transport in kidney,
stimulatory action of verapa-
mil on (rats), 452
Ornithine decarboxylaseeffects of inhibition on devel-
opment of nervous system(rats), 746
role in tissue growth and devel-opment (rats), 741
Pang, K. S., Wailer, L, Horning,M. G. and Chan, K. K.: Me-tabolite kinetics: Formation
of acetaminophen from deu-terated and nondeuteratedphenacetin and acetanilideon acetaminophen sulfationkinetics in the perfused ratliver preparation, 14
Papadopoulos, A., see Myers, A.,315
Pappu, A. S. and Hauser, G.:Phospholipid metabolismchanges in rat tissue in vitroafter injections of proprano-lol, 109
Parise, L. V., Venton, D. L andLe Breton, G. C.: Thrombox-ane A2/prostaglandin H2 di-rectly stimulates platelet
shape change independent ofsecreted ADP, 276
Paul, M. L., Miles, D. L and Cook,M. A.: The influence of gly-cosidic conformation andcharge distribution on activ-ity of adenine nucleosides aspresynaptic inhibitors of ace-tylcholine release, 241
Penhos, J., see Myers, A., 315Pentobarbital, inhibition of cho-
line uptake in hippocampusby (rats), 778
Pentobarbital narcosis, effect of
histamine (rats), 37
Peterson, C. and Gibson, G. E.:3,4-Diaminopyridine altersacetylcholine metabolismand behavior during hypoxia,
576
Peterson, R. G., see Yount, E. A.,
501Pettibone, D. J. and Mueller, G.
P.: Adrenergic control ofimmunoreactive �8-endorphinrelease from the pituitary ofthe rat: In vitro and in vivo
studies, 103Pharmacogentics, of thiopurine
methyltransferase (man), 174Pharmacokinetics
of cytosine arabinoside in cen-tral nervous system (rabbits),1
of vancomycin, effect of furo-seaside on (rabbits), 237
Phenacetin, deuterated and non-deuterated, role in formationofacetaminophen in perfused
liver (rats), 14Phencycidine-like effects of nar-
cotics (rats), 146
Phenobarbital, interaction with
propranolol (dogs), 589Phenothiazines, inhibition of cal-
modulin by (rats), 509Phenoxybenzamine
antagonism of central nervousadrenoceptors by (cats),771
inhibition of thyrotropin releas-ing hormone effect on gas-trointestinal activity (rab-bits), 66
mechanism of action on heartrate (dogs, guinea pigs), 688
[3H]Quinucidinyl benzilate, bind-ing sites in dentate gyrus, ef-fect of kindled seizures on(rats), 670
Ramey, E., see Myers, A., 315Ramwell, P., see Myers, A., 315
Ramwell, P. W., see Casey, L C.,441
Raphe, dorsal, nucleus, effects of
alpha-i and alpha-2 antago-nista on (rats), 287
Rapoport, R. M. and Bevan, J. A.:Increased contractility in-duced in rabbit ear artery byprior exposure to serotoninmasks concomitant desensi-tization to norepinephrmne,
338
Rauwoiscine, inhibition of clom-dine-induced sleeping timeby (chicks, rats), 680
Read, G. W., Hong, S. M. andKiefer, E. F.: Competitive in-
hibition of48/80-induced his-tamine release by benzalko-
nium chloride and its analogsand the polyamine receptorin mast cells, 652
Receptoracetylcholine, block by strep-
tomycin (frogs), 488alpha adrenergic, effect on
phosphatidylinositol labeling
and contraction in aorta (rab-bits), 258
beta adrenergic, developmentin heart (mice), 7
/3-endorphin, on vas deferens,studies on structural prereq-
uisites for activation of (rats),262
polyamine, inhibition of hista-
mine release (rats), 652Receptors
alpha adrenergic, in mesen-cephalic reticular formation,
characteristics of (rats), 555alpha-i and alpha-2 adrener-
Shea-Donohue, P. T., Nompleggi,D., Myers, L and Dubois, A.:
A prostaglandin endoperox-ide analog increases gastricemptying and suppresses gas-tric secretion in rhesus mon-keys, 379
Sigg, E. B., see Reilly, M. A., 583Simon, E. J., see Howells, R D.,
629Simpson, L L: The interaction
between aminoquinolinesand presynaptically actingneurotoxins, 43
Simpson, L L: Disulfide bond re-
duction inhibits norepineph-rine accumulation in post-
ganglionic sympathetic nerve
endings, 419
Skin fibroblasts, effects of pros-taglandins on fibninolytic ac-
tivity in (man), 544
SL-76002, effect on dopamine
metabolism in nigrostriatalpathway (rats), 674
Sleep, ketamine-induced, poten-tiation by cocaine (mice), 122
Slopis, J., see Kendall, D. A., 566
Slotkin, T. A., Grignolo, A., Whit-more, W. L., Lerea, L., Tre-panier, P. A., Barnes, G. A.,Weigel, S. J., Seidler, F. J.and Bartolome, J.: Impaireddevelopment of central andperipheral catecholamineneurotransmitter systems inpreweanling rats treated with
796 Index
a-difluoromethylornithine, a
specific irreversible inhibitorof onnithine decarboxylase,746
Slotkin, T. A., Seidler, F. J., Tre-panier, P. A., Whitmore, W.L., Lerea, L., Barnes, G. A.,Weigel, S. J. and Bartolome,J.: Ornithine decarboxylaseand polyamines in tissues ofthe neonatal rat: Effects of
Vogel, S., see Linden, J., 383Vogel, S., see Lynch, C., Ill., 405von Bahr, C., Hermanason, J. and
Lind, M.: Oxidation of (R)-and (S)-propranolol in hu-man and dog liver micro-somes. Species differences instereoselectivity, 458
Vonvoigtlander, P. F., Kolaja, G.J. and Block, E. M.: Corneallesions induced by antide-pressanta: A selective effect
upon young Fischer 344 rats,282
Waddell, J. E., see Ruffolo, R. R.,Jr., 29, 645
Walle, T., see Privitera, P. J., 116
Wailer, L, see Pang, K. S., 14Warltier, D. C., see Gross, G. J.,
635
Warltier, D. C., see Zyvoloski, M.
G., 494Wasserman, M. A., see Weich-
man, B. M., 202
Watkins, J. B., see Gregus, Z., 471
Way, E. L., see Huidobro-Toro, J.P., 262
Way, E. L., see Yoshimura, K., 71
Weichman, B. M., Muccitelli, R.
M., Osborn, R R., Holden, D.
A., Gleason, J. G. and Was-serman, M. A.: In vitro andin vivo mechanisms of leu-
kotniene-mediated broncho-constriction in the guinea pig,202
Weigel, S. J., see Slotkin, T. A.,741, 746
Weinberg, J. M., see Sastrasinh,M.,350
Weinshilboum, R M., see Wood-son, L. C., 174
Weiss, B., see Prozialeck, W. C.,509
Whitmore, W. L., see Slotkin, T.
A., 741, 746
Wolf, R A., Chaung, L.-Y.,O’Hara, D., Smith, T. W. and
Muller, J. E.: The serum ki-netics ofbovine testicular hy-
aluronidase in dogs, rats and
humans, 331Wong, D. T., Threlkeld, P. G.,
Best, K. L and Bymaster, F.P.: A new inhibitor of norepi-nephnine uptake devoid of a!-finity for receptors in rat
brain, 61Wood, P. L.: Actions of GA-
BAergic agents on dopaminemetabolism in the nigrostri-atal pathway of the rat, 674
Woodson, L. C., Dunnette, J. H.and Weinshilboum, H. M.:Pharmacogenetics of humanthiopurine methyltransfer-
ase: Kidney-erythrocyte cor-relation and immunotitration
studies, 174Wu, C. H., see Farley, J. M., 488Wu,J.J.,seeLin,M.T.,251
Xylazine-induced sleep time, in-
hibition by alpha-2 adreno-ceptor antagonists (chicks,rats), 680
Yaden, E. L, see Ruffolo, R R,
Jr., 645Yamamoto, K., see Miura, K., 246Yamamura, H. I., see Chen, F.-C.
M., 7
Yohimbine
effect on clonidine-induced pro-tection of physostigmine tox-icity (mice), 595
influence on antidepressant-in-
duced decline in brain neu-rotransmitter receptor bind-
ing (rats), 566inhibition of clonidine-induced
sleeping time by (chicks,rats), 680
Yokotani, Y. S. K., see Ikushima,S., 463
Yoneda, S., see Takahashi, H., 726Yoshimura, K., Huidobro-Toro, J.
P., Lee, N. M., Loh, H. H.
and Way, E. L.: Kappa opioidproperties of dynorphin andits peptide fragments on theguinea-pig ileum, 71
Yoshimura, M., see Takahashi,H., 726
Yount, E. A., Felten, S. Y.,O’Connor, B. L, Peterson, R.G., Powell, R S., Yum, M. N.and Harris, R A.: Compari-son ofthe metabolic and toxiceffects of 2-chloropropionateand dicb.loroacetate, 501
Yum, M. N., see Yount, B. A., 501
Zimmerman, J. B., see Jackson,
E. K., 414Zelis, R., see Flaim, S. F., 359Zmudka, M. I., see Casey, L C.,
441Zukin, H. S., see Stefano, G. B.,
759Zyvoloski, M. G., Brooks, H. L,
Gross, G. J. and Warltier, D.C.: Myocardial perfusion dis-tel to an acute or chronic cor-onary artery occlusion: Ef-fects of diltiazem and nifedi-pine, 494