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Atnial natriuretic peptide, tubular site ofaction, anesthesia and (dogs), 707
Atropine
antihistamines and local anesthetics, ax-cess tachycardia (dogs), 367
gastrointestinal effects of hyperserotoni-nemia and (dogs), 536
Autoradiography
benzodiazepine receptors, regulation, im-
aging (rats), 739localization of delta opioid receptors,
brain (rats), 720
Badr, M. Z., Belinsky, S. A., Kauffman, F.C. and Thurman, R. G.: Mechanismof hepatotoxicity to periportal re-
gions of the liver lobule due to a!lylalcohol: Role ofoxygen and lipid per-oxidation, 1138
Bath, M. Z., see Be!insky, S. A., 1132Banner, W., Jr., see Hynes, M. R., 100Barbaz, B., see Rinehart, R. K., 178Barbital, central nervous system depres-
sant, long- and short-sleep (mice),1028
Barbiturates
anesthetic and convulsant, y-aminobu-tyric acid-stimulated chloride flux
inhibition of hippocampus (rats), 564Bardales, R. M., see Shapiro, B. H., 68Barium chloride, jejunal contractility, after
chronic ablation, myenteric plexus(rats), 372
Barnes, J. G., see Schwertsch!ag, U., 653Barnes, P. J., see Grandordy, B. M., 273
Barrett, J. E., Witkin, J. M., Mansbach, R.S., Skolnick, P. and Weissman, B. A.:Behavioral studies with anxio!yticdrugs. III. Antipunishment actions of
buspirone in the pigeon do not in-volve benzodiazepine receptor mech-anisms, 1009
Basilar artery, vasoconstnictor neurotrans-mitter in, serotonin as (rabbits), 880
Bass, P., see Fox, D. A., 372
Bay K 8644, dihydropyridine derivativesand, vascular and cardiac effects(rabbits, guinea pigs), 670
Begaud, B., see Chel!y, J. E., 665Behavior
anticonvulsant drug effects, modulationby external discriminative stimulus
Bouboutou, R., see Bourgoin, S., 360Bourgoin, S., Le Bars, D., Artaud, F., Clot,
A.-M., Bouboutou, R., Fournie-Zalu-ski, M.-C., Roques, B. P., Hamon, M.
and Cesselin, F.: Effects of kelator-phan and other peptidase inhibitorson the in vitro and in vivo release ofmethionine-enkephalin-like materialfrom the rat spinal cord, 360
Bousquet, P., see Solaro, R. J., 502Brady, J. V., see Lukas, S. E., 924
tetrahydropynidine, monoamine oxi-dase and (rats), 648
localization of delta opioid receptors, au-toradiography (rats), 720
muscaninic acetylcholine receptors, N-methylscopolamine binding to (rats),
554sigma and phencyclidine receptor binding
sites, autoradiography (rats), 739
Breaux, S. P., see Maderazo, E. G., 453Breeding, genetically prone or resistant to
seizures, ethanol withdrawal (mice),170
Breese, G. R., see Duncan, G. E., 758Brenner, D., see Nielson, C. P., 19Brody, T. M., see Berlin, J. R., 632Brown, J. H. and Goldstein, D.: Analysis of
cardiac muscarinic receptors selec-tively recognized by nonquaternarybut not by quaternary ligands, 580
Brown, J. H., see McDonough, P. M., 612Bruckert, J. W., see Mills, E., 1014Buchan, P., see Wei, E. T., 783
Bumetanide, inhibition of electrical flux,renal thick limbs (mice), 407
Bu#{241}ag, R. D., see Mattila, J., 232Bunney, B. S., see Grace, A. A., 1092Burks, T. F., see Galligan, J. J., 594Burks, T. F., see Koslo, R. J., 62Buspirone
drugs (monkeys), 522Chapman, K. L., see Marwood, J. F., 267Chelly, J. E., Doursout, M.-F., Begaud, B.,
Tsao, C. C. and Hartley, C. J.: Effectsof hydralazine on regional blood flowin conscious dogs, 665
Chiu, A. T., McCall, D. E., Thoolen, M. J.M. C. and Timmermans, P. B. M.M.: Ca4� utilization in the constric-tion of rat aorta to full and partialalpha-i adrenoceptor agonists, 224
Chloral hydrate, central nervous system de-pressant, long- and short-sleep(mice), 1028
Cohen, M. L., Carpenter, R., Schenck, K.,Wittenauer, L. and Mason, N.: Effectof nitrendipine, diltiazem, trifluoper-azine and pimozide on serotonin2 (5-HT2) receptor activation in the ratuterus and jugular vein, 860
Cohen, M. L., Shuman, R T., Osborne, J.J. and Gesellchen, P. D.: Opioid ag-onist activity of IC! 174864 and itscarboxypeptidase degradation prod-uct, LY281217, 769
Conjugation, pharmacokinetic studies, ac-etaminophen disposition, maternal-placental-fetal unit (sheep), 198
Contreras, P. C., Johnson, S., Freedman, R.,Hoffer, B., Olsen, K., Rafferty, M. F.,Lessor, R. A., Rice, K. C., Jacobson,A. E. and O’Donohue, T. L.: Mets-phit, an acylating ligand for phency-clidine receptors: Characterization ofin vivo actions in the rat, 1101
Corcoran, G. B. and Wong, B. K.: Role ofglutathione in prevention of acetami-nophen-induced hepatotoxicity by N-
acetyl-L-cysteine in vivo: Studieswith N-acetyl-D-cysteine in mice, 54
Corsini, G. U., Pintus, S., Bocchetta, A.,Piccardi, M. P. and Del Zompo, M.:A reactive metabolite of 1-methyl-4-
phenyl-1,2,3,6-tetrahydropyridine is
formed in rat brain in vitro by type
B monoamine oxidase, 648Corticosterone, kappa opioid receptor ef-
Costa,M.,seeGalligan,J.J., 1114Coughenour, L. L., see Ryan, M. J., 473Covey, J. B., see Duncan, G. E., 758
Crabbe, J. C., see Kosobud, A., 170Creese, I., see Hess, E. J., 846Cniswell, H., see Duncan, G. E., 758
Cubeddu, L. X, see Hoffmann, I. S., 437
Cubells, J. F., Blanchard, J. S., Smith, D.M. and Makman, M. H.: In vivo ac-tion of enzyme-activated irreversibleinhibitors of glutamic acid decarbox-ylase and ‘y-aminobutynic acid trans-aminase in retina vs. brain, 508
Curtis, A. L. and Marwah, J.: Evidence foralpha adrenoceptor modulation of thenociceptive jaw-opening reflex in ratsand rabbits, 576
Cuss, F. M., see Grandordy, B. M., 273
Cyclazocine, psychopharmacology of keto-cyclazocine compared with, 960
Cyclic AMPactivation of DA1 receptors, dopamine or
fenoldopam (rats), 547carbachol and forskolin interaction, car-
Davidenko, J., Delmar, M., Oates, R. andJalife, J.: Electrophysiological ac-
tions ofdantrolene sodium in isOlated
sinoatrial and atrioventricular nodes
and in a model of ischemia, 206Davis, B. B., see Danon, A., 95, 125, 457Defoin, R., see Guentert, T. W., 295DeForrest, J. M., see Antonaccio, M. J., 378
Delmar, M., see Davidenko, J., 206
Del Zompo, M., see Corsini, G. U., 648Dennis, T., see Claustre, Y., 693Depolarization-dependent binding, calcium
De Vivo, M. and Maayani, S.: Characteri-zation of the 5-hydroxytryptamine1Areceptor-mediated inhibition of for-skolin-stimulated adenylate cyclaseactivity in guinea pig and rat hippo-campal membranes, 248
Drazen, J. M., see Rossing, T. H., 874Drug pI(, pH potentiation, sodium channel
blockade, ventricular myocardium
(guinea pigs), 159
1986 Index 1149
Duckles, S. P., see Hynes, M. R., 100Duckles, S. P., see Levitt, B., 880Duffey, M. E., see Ferriola, P. C., 912Duffy, T., see Kalivas, P. W., 1126Duggan, D. E., see Lin, J. H., 978Duncan, G. E., Breese, G. R., Criswell, H.,
Stumpf, W. E., Mueller, R. A. andCovey, J. B.: Effects of antidepres-sent drugs injected into the amygdalaon behavioral responses of rats in theforced swim test, 758
Dunham, E. W. and Vince, R.: Hypotensiveand renal vasodilator effects of car-bocyclic adenosine (anisteromycin) inanesthetized spontaneously hyper-tensive rats, 954
Dunwiddie, T. V., Worth, T. S. and Olsen,R. W.: Facilitation of recurrent inhi-bition in rat hippocampus by barbi-
turate and related nonbarbiturate de-pressant drugs, 564
Electricwala, A., Emeis, J. J. and Atkinson,T.: Evaluation of epithelial tissueplasminogen activator as a thrombo-lytic agent in a rabbit model of ye-nous thrombosis, 254
Electrolytes, plasma, sodium-dependent by-pertension and vasopressin (rats),492
Electrophysiology, bumetanide action, renal
thick limbs (mice), 407El-Fakahany, E. E., see Cioffi, C. L., 916El-Fakahany, E. E., Ramkumar, V. and Lai,
W. S.: Multiple binding affinities ofN-methylscopolamine to brain mus-
caninic acetyicholine receptors: Dif-ferentiation from M, and M2 receptorsubtypes, 554
Emeis, J. J., see Electricwala, A., 254Enantiomers, 2-arylpropionic acid, disposi-
tion, 2-phenylpropionic acid (rab-bits), 280, 288
Endoplasmic reticulum, cytosolic calcium,
hepatocytes exposed to carbon tetra-chloride (rats), 186
Eskinder, H. and Gross, G. J.: Differentialinhibition of Alpha-i us. alpha-2 ad-renoceptor-mediated responses in ca-nine saphenous vein by nitroglycerin,515
Ethanolcentral nervous system depressant, long-
and short-sleep (mice), 1028withdrawal, selective breeding, geneti-
cally prone or resistant to seizures(mice), 170
Ethionine, hepatic energy state, conjugationand (rats), 457
Forced swim test, antidepressant drug injec-tion and, amygdala (rats), 758
Formyl-methionyl-leucyl-phenylalanine,hypoxia induced by, ibuprofen and
methylprednisolone effects on (rab-
bits), 453Forskolin
carbachol interaction, cyclic GMP lower-
ing agent LY83583, cardiac prepara-tions (rabbits), 313
stimulation of fat cells, cyclic AMP andlipolysis relations in (rats), 659
F#{246}rstermann, U., Goppelt-Strube, M., Fr#{246}l-ich, J. C. and Busse, R.: Inhibitors ofacyl-coenzyme A:!ysolecithin-acyl-transferase activate the production of
lipid peroxidation and toxicity, diphenyl-phenylenediamine effects, renal cor-
tex (rats), 83
transport, renal epithelial cell line, 1071Gerber, J. G., see Schwertschlag, U., 653Gesellchen, P. D., see Cohen, M. L., 769
Gibb, J. W., see Sonsalla, P. K., 932Gilbeau, P. M., Hosobuchi, Y. and Lee, N.
M.: Dynorphin effects on plasmaconcentrations of anterior pituitary
1150 Index Vol. 238
hormones in the nonhuman primate,974
Gillis, C. N., see Turrin, M., 14Ginsburg, R., see Rosenbaum, J. S., 396Giuliani, S., see Maggi, C. A., 259, 341Glial cells, LRM55, substance P receptors
On, 389
Glomerular filtration rate, a-hANP, tubularsite of action (dogs), 707
Glucuronidation, pharmacokinetic studies,
acetaminophen disposition, mater-nal-placental-fetal unit (sheep), 198
Glutamic acid decarboxylase, enzyme mac-tivation, retina vs. brain (rats), 508
Glutathioneconjugation, reduced hepatic energy state
effects (rats), 457
prevention of acetaminophen-inducedhepatotoxicity, N-acetyl-L-cysteine
(mice), 54Goldfarb, S., see Weiss, J., 969Goldstein, D. see Brown, J. H., 580Goppelt-Strube, M., see F#{246}rstermann, U.,
352Goto, K., see Saito, 713Grace, A. A. and Bunney, B. S.: Induction
of depolarization block in midbraindopamine neurons by repeated ad-ministration of haloperidol: Analysisusing in vivo intracellular recording,1092
Grandordy, B. M., Cuss, F. M., Sampson, A.S., Palmer, J. B. and Barnes, P. J.:
Phosphatidylinositol response to
cholinergic agonists in airway smoothmuscle: Relationship to contractionand muscaninic receptor occupancy,273
Grant, A. 0., see Moorman, J. R., 159Greenberg, D. A., Carpenter, C. L. and
Griffiths, R. R., see Lukas, S. E., 924Gross, G. J. and Daemmgen, J. W.: Benefi-
cia! effects of two specific brady-cardic agents AQ-A39 (Falipamil)and AQ-AH 208 on reversible myo-cardial reperfusion damage in anes-thetized dogs, 422
Gross, G. J., see Eskinder, H., 515Gross, G. J., see Pelc, L. R., 113Grover, G. J., Tierney, M. A. and Weiss, H.
R.: Beta adrenoceptor control of themicrovascular reserve in rabbit myo-cardium, 868
Gruetter, C. A. and Lemke, S. M.: Compar-ison of endothelium-dependent re-laxation in bovine intrapulmonaryartery and vein by acetylcholine and
A23187, 1055
Guentert, T. W., Schmitt, M. and Defoin,R.: Acceleration of the elimination oftenoxicam by cholestyramine in thedog, 295
Gulya, K., Gehlert, D. R., Wamsley, J. K.,Mosberg, H., Hruby, V. J. and Ya-mamura, H. I.: Light microscopic au-toradiographic localization of delta
opioid receptors in the rat brain using
a highly selective bis-pencillaminecyclic enkephalin analog, 720
Gundlach, A. L., see Largent, B. L., 739
Haertzen, C. A., see Kumor, K. M., 960
Hall, G. E. and Kenny, A. D.: Bone resorp-tion induced by parathyroid hormoneand dibutyryl cyclic AMP: Role ofcarbonic anhydrase, 778
Hamed, A. T., Jandhyala, B. S. and Lok-handwala, M. F.: Evaluation of therole of alpha-i and a�pha-2 adre-noceptors in the maintenance of neu-rogenic tone to the hindlimb vascu-lature, 599
Hamon, M., see Bourgoin, S., 360a-hANP, see Human atrial natriuretic poly-
peptide
Hansen, D. K. and Billings, R. E.: Effectsof nitrous oxide on macromolecu!arcontent and DNA synthesis in ratembryos, 985
Hanson, G. R., see Sonsalla, P. K., 932Harris, R. A., see Allan, A. M., 763Harrison, J. H., Jr. and Jollow, D. J.: Role
of aniline metabolites in aniline-in-duced hemolytic anemia, 1045
Harsing, L. G., Jr., see Vizi, E. S., 701Hartley, C. J., see Chelly, J. E., 665Hartmann, A., see Kiil, F., 327Hattori, Y., Nakaya, H., Tohse, N. and
Kanno, M.: Vascular and cardiac ef-fect�s of a new dihydropynidine deriv-ative, YC-170: A comparison withBay K 8644, 670
Haywood, J. R., see Hinojosa, C., 492H2 blocker, pharmacological comparison, ci-
hypertension and (rats), 492Helgeson, E. A., see Newball, H. H., 839
Hemolytic anemia, aniline-induced, anilinemetabolites role in (rats), 1045
Hepatocytes, exposed to carbon tetrachlo-ride, cytosolic calcium (rats), 186
Hepatotoxicityacetaminophen-induced, glutathione role
in prevention, N-acetyl-L-cysteine(mice), 54
ally! alcohol, liver lobule (rats), 1132, 1138Hess, E. J., Albers, L. J., Le, H. and Creese,
E.: Effects of chronic SCH23390
treatment on the biochemical and be-havioral properties of D1 and D2 do-pamine receptors: Potentiated be-havioral responses to a D2 dopamineagonist after selective D1 dopaminereceptor upregulation, 846
Hoffer, B., see Contreras, P. C., 1101Hoffman, B. B., see Rosenbaum, J. S., 396Hoffmann, I. S., Talmaciu, R. K. and Cu-
beddu, L. X.:Interactions betweenendogenous dopamine and dopamineagonists at release modulatory recep-tars: Multiple effects of neuronal up-take inhibitors on transmitter re-lease, 437
Holck, M., see Kozlowski, R., 1084
Holthe, M. R., see Ku!, F., 327Holtzman, S. G., see Finn, I. B., 542Holtzman, S. G., see Locke, K. W., 990,997Hori, R., see Saito, H., 1071
Hosobuchi, Y., see Gilbeau, P. M., 974Hruby, V. J., see Gulya, K., 720Hubel, K. A. and Renquist, K. S.: Effect of
neuropeptide Y on ion transport bythe rabbit ileum, 167
Huffman, W., see Mann, W. A., 401a-Human atnial natriuretic polypeptide,
synthetic, tubular site of action(dogs), 707
Hydralazine, regional blood flow and, con-scious state (dogs), 665
Kappa opiate agonists modulate thehypothalamic-pituitary-adrenocorti-cal axis in the rat, 429
Iyengar, S., see Rinehart, R. K., 178
Jacobson, A. E., see Contreras, P. C., 1101Jaffe, B. M., Ferrara, A. and Sherlock, D.
J.: Comparative effects of ketanserin,atropine and methysergide on thegastrointestinal effects of hypersero-toninemia in the awake dog, 536
Jalife, J., see Davidenko, J., 206James, D. W., see Ward, S. J., 625
James, M. 0., see Shiverick, K. T., 1108
Jandhyala, B.S., see Hamed, A. T., 599Jardine, I., see Low, J. E., 39Jasinski, D., see Kumor, K. M., 960Jaw-opening reflex, -nociceptive, alpha ad-
renoceptor modulation of (rats, rab-bits), 576
Jejunum, contractility, after chronic abla-tion, myenteric plexus (rats), 372
Jim, K. F., Macia, R. A. and Matthews, W.D.: Role of receptor reserve in the
inhibition of alpha-i adrenoceptor-
mediated pressor responses by cal-cium antagonists in the pithed rat, 89
Johnson, J. D., see Solaro, R. J., 502
Johnson, K. M., see Snell, L. D., 938
Johnson, M. D., Wang, J. K. T., Morgan, J.I. and Spector, S.: Downregulation of[3H]RO5-4864 binding sites after ex-posure to peripheral-type benzodi-azepines in vitro, 855
Johnson, R. E., see Kumor, K. M., 960
Johnson, S., see Contreras, P. C., llOiJollow, D. J., see Harrison, J. J., Jr., 1045Jones, M. E., see Meffin, P. J., 280Jones, M. E., Sallustio, B. C., Purdie, Y. J.
and Meffin, P. J.: Enantioselectivedisposition of 2-arylpropionic acidnonsteroidal anti-inflammatorydrugs. II. 2-Phenylpropionic acid pro-tein binding, 288
Josepovitz, C., see Ramsammy, L. S., 83Joshi, U., see Atchison, W. D., 618
Kalivas, P. W., Richardson-Carlson, R andDuffy, T.: Neuromedin N mimics theactions of neurotensin in the ventraltegmental area but not in the nucleusaccumbens, 1126
Kanda, A., see Yorikane, R., 334Kangawa, K., see Yukimura, T., 707Kanno, M., see Hattoni, Y., 670
Kaplan, H. R., see Ryan, M. J., 473Kapocsi, J., see Vizi, E. S., 701Katona, P. G., see Rigel, D. F., 367Katz, L. B., Scott, C. K. and Shriver, D. A.:
Pharmacological comparison of ORF
17910, a potent, long-acting hista-
mine H2-receptor agonist, to cimeti-dine and ranitidine, 587
Kau, S. T., see Li, J. H.-Y., 415Kauffman, F. C., see Bath, M. Z., 1138Kauffman, F. C., see Belinsky, S. A., 7835Kauker, M. L. and Nasjletti, A.: Segmental
nephron function in rats treated withaprotinin, an inhibitor of kallikrein,i55
tial cells (rabbits), 125segmental nephron function, aprotinin
treatment (rats), 155sodium/potassium-ATPase, transport
rate, transcellular NaCl reabsorption(dogs), 327
tubules, bumetanide action in (mice), 407Xii!, F., Hartmann, A., Langberg, H., Se-
jersted, 0. M. and Holthe, M. R:Renal Na,K-adenosine triphospha-tase transport rate limits transcel!u-lar NaCI reabsorption in distal neph-rons of volume-expanded dogs, 327
Killam, E. K., see Paule, M. G., 32Kim, H. S., see Iyengar, S., 429Kimura, S., see Saito, A., 713Kimura, T., see Yorikane, R, 334
King, L. W., see Lertora, J. J. L., 893Kinins, segmental nephron function, apro-
tinin treatment (rats), 155Kinter, L. B., see Mann, W. A., 401Klaassen, C. D., see Dulls, R. L, 463Klemfuss, H. and Adler, M. W.: Autonomic
mechanisms for morphine and am-phetamine mydriasis in the rat, 788
Kobayashi, M., Kondo, S., Yasumoto, T.and Ohizumi, Y.: Cardiotoxic effectsof maitotoxin, a principal toxin ofseafood poisoning, on guinea pig andrat cardiac muscle, 1077
Kocher, T., see Kumor, K. M., 960Kondo, S., see Kobayashi, M., 1077
Koslo, R. J., Burks, T. F. and Porreca, F.:
1152 Index Vol. 238
Centrally administered bombesin a!-fects gastrointestinal transit and co-lonic bead expulsion through supra-spinal mechanisms, 62
Kosobud, A. and Crabbe, J. C.: Ethanolwithdrawal in mice bred to be genet-ically prone or resistant to ethanolwithdrawal seizures, 170
Kozlowski, R., Ehrhard, P., Fischli, W., Os-terrieder, W. and Holck, M.: o-Iso-thiocyanate dihydropynidine (oNCS-DHP), a long-acting reversible inhib-itor of the Ca� channel, 1084
Kraemer, F. B. and Spilman, S. D.: Effectsof ketoconazole in cholesterol syn-thesis, 905
Kragh, R., see Carroll, M. E., 1Kroeger, E. A., see Bergen, J., 679
Kumor, K. M., Haertzen, C. A., Johnson, R.E., Kocher, T. and Jasinski, D.: Hu-man psychopharmacology of ketocy-
clazocine as compared with cyclazo-cine, morphine and placebo, 960
Kwang, J. K. T., see Johnson, M. D., 855
Lac, S. T., see Carroll, M. E., 1Lai, W. S., see El-Fakahany, E. E., 554Lakshmi, V. M., see Spry, L., 457Lambert, C., Vermeulen, M., Cardinal, R.
and Nadeau, R.: Effect of the induc-tion of amiodarone biotransforma-tion on ventricular refractory periods
in rats, 307Lane, B. P., see Ramsammy, L. S., 83Langberg, H., see Kiil, F., 327Lanosterol, synthesis, ketoconazole effects,
905Largent, B. L., Gundlach, A. L. and Snyder,
S. H.: Pharmacological and autora-diographic discrimination of sigmaand phencyclidine receptor bindingsites in brain, with (+)-[3H]SKF10,047, (+)-[3HJ-3-[3-hydroxy-
Larrey, D., see Letteron, P., 685Le, H., see Hess, E. J., 846Le Bars, D., see Bourgoin, S., 360Loch, G. M., see Shapiro, B. H., 68Lee, N. M., see Fang, F. G., 1039Lee, N. M., see Gilbeau, P. M., 974Leibold, L., see Picker, M., 529Lemke, S. M., see Gruetter, C. A., 1055Lepore, R. D., see Perrone, M. H., 389Lertora, J. J. L. and King, L. W.: Cardio-
vascular actions and pharmacoki-
netics of desethyl-N-acetylprocain-amide in the dog, 893
Lessor, R. A., see Contreras, P. C., 1101Letteron, P., Descatoire, V., Larrey, D., Ti-
nel, M., Geneve, J. and Pessayre, D.:
Inactivation and induction of cyto-chrome P-450 by various psoralen de-rivatives in rats, 685
Leukocyteschloroquine, mechanisms of cell associa-
tion, 302polymorphonuclear, oxygen metabolite
generation, doxorubicin and doxo-rubicinol-induced alterations, 19
Leukotrienes, lung mediator release, re-
duced oxygen tension, 8Levitt, B. and Duckles, S. P.: Evidence
against serotonin as a vasoconstric-
tor neurotransmitter in the rabbitbasilar artery, 880
Li, J. H.-Y., Zuzack, J. S. and Kau, S.T.:Effects of detergents on sodium
transport in toad urinary bladder,415
Liang, B. T. and Molinoff, P. B.: Beta ad-renergic receptor subtypes in theatria: Evidence for close coupling ofbeta-i and beta-2 adrenergic recep-tors to adenylate cyclase, 886
Lichtenstein, L. M., see Peters, S. P., 8Lidocaine, pH potentiation, drug pK, so-
chum channel blockade in ventricular
myocardium (guinea pigs), 159Lin, J. H., Ulm, E. H. and Duggan, D. E.:
Possible mechanisms for reduced
plasma clearance of diflunisal in ratexperimental renal failure, 978
Ling, K.-Y., see Ramsammy, L. S., 83Lipid peroxides, hepatotoxicity and, liver
lobule (rats), 1138
Lipids, peroxidation and toxicity, gentami-cm-induced, diphenyl-phenylenedi-
Locke, K. W. and Holtzman, S. G.: Behav-ioral effects of opioid peptides selec-tive for mu or delta receptors. I. Mor-phine-like discriminative stimuluseffects, 990
Locke, K. W. and Holtzman, S. G.: Behav-ioral effects of opioid peptides selec-tive for mu or delta receptors. II. Lo-comotor activity in nondependentand morphine-dependent rats, 997
Locomotor activity
chronic SCH23390, dopamine receptors
and (rats), 846
opioid peptide effects (rats), 990,997stimulation, caffeine and (rats), 542
Lokhandwala, M. F., see Alkadhi, K. A., 547
Lokhandwala, M. F., see Hamed, A. T., 599London, E. D., see Szikszay, M., 192Long, R. M. and Moore, L: Elevated cyto-
solic calcium in rat hepatocytes ex-posed to carbon tetrachloride, 186
Longhurst, P. A. and Belis, J. A.: Abnor-malities of rat bladder contractilityin streptozotocin-induced diabetesmellitus, 773
LoPresti, D., see Ward, S. J., 625Low, J. E. and Jardine, I.: A novel cyclo-
sporine binding assay, 39Lucchesi, B. R., see Simpson, P. J., 497Lukas, S. E., Brady, J. V. and Griffiths, R
R.: Comparison of opioid seif-injec-tion and disruption of schedule-con-trolled performance in the baboon,924
Lund, D. D., see Schmid, P. G., 447
Lungangiotensin-converting enzyme inhibitor,
uptake of N-[i(S)-carboxy-(4-OH-3-‘�I-phenyl)ethyl-L-ala-L-pro (rab-bits), 14
Major, T. C., see Ryan, M. J., 473Makman, M. H., see Cubells, J. F., 508
Mann, W. A., Stassen, F., Huffman, W. andKinter, L. B.: Mechanism of actionand structural requirements of vaso-pressin analog inhibition of trans-
1986 Index 1153
epithelial water flux in toad urinary
bladder, 401
Mansbach, R. S., see Barrett, J. E., 1009Manzini, S., see Maggi, C. A., 341Marley, R. J., Miner, L. L., Wehner, J. M.
and Collins, A. C.: Differential effectsof central nervous system depres-
sants in long-sleep and short-sleepmice, 1028
Marwah, J., see Curtis, A. L., 576Marwood, J. F., Chapman, K. L. and Stokes,
G. S.: Studies that question the exist-
ence of a4,ha-2 adrenoceptors in tailarteries of normotensive Sprague-
Dawley rats, 267Masaki, T., see Saito, A., 713
Mason, N., see Cohen, M. L., 860Mast cells, histamine release, organophos-
phate-induced (rats), 839
Mathias, N. P., see Ryan, M. J., 473Matsuo, H., see Yukimura, T., 707Matthews, W. D., see Jim, K. F., 89Mattila, J. and Bu#{241}ag,R. D.: Sympathetic
vasoconstriction and renin secretion
cause pressor responses to thyrotro-
pin-releasing hormone in rats, 232
Mayersohn, M., see Woodworth, J. R., 900Mays, J. B., see Hinson, J. A., 106McCall, D. E., see Chiu, A. T., 224McDonough, P. M., Wetzel, G. T. and
Brown, J. H.: Further characteriza-tion ofthe presynaptic alpha-i recep-
tar modulating [3HJACh release fromrat atnia, 612
McGiff, J. C., see Quilley, J., 606
McGonigle, P., see Neve, K. A., 46McLean, M. J. and Macdonald, R. L.: Car-
bamazepine and 10,11-epoxycarba-
mazepine produce use- and voltage-dependent limitation of rapidly firingaction potentials of mouse centralneurons in cell culture, 727
Meffin, P. J., Sallustio, B. C., Purdie, Y. J.and Jones, M. E.: Enantioselectivedisposition of 2-arylpropionic acid
nonsteroidal anti-inflammatory
drugs. I. 2-Phenylpropionic acid dis-position, 280
Meffin, P. J., see Jones, M. E., 288Meli, A., see Maggi, C. A., 259, 341Mertz, T. E., see Ryan, M. J., 473Messing, R. 0., see Greenberg, D. A., 1021Metabolic/excretory coupling, renal, nitro-
furothiazole carcinogens (rats), 457
Metaphit, acy!ating ligand for receptors(rats), 1101
Moore, D. H., Abel, P. W., Rinard, G. A.,Puckett, A. M. and Walter, J. B.:Regional differences in relaxation ofelectric field-stimulated canine air-way smooth muscle by verapamil, iso-proterenol and prostaglandin E,, 76
Moore, L, see Long, R. M., 186
Moorman, J. R., Yes, R., Bjornsson, T.,Starmer, C. F., Grant, A. 0. andStrauss, H. C.: pI( does not predictpH potentiation of sodium channelblockade by lidocaine and W6211 inguinea pig ventricular myocardium,159
Oates, R., see Davidenko, J., 206Obesity, verapamil dynamics and (rats), 642Ode, R. P., see Schmid, P. G., 447O’Donohue, T. L., see Contreras, P. C., 1101Ohiztimi, Y., see Kobayashi, M., 1077
Okamoto, M, Rao, S. and Walewski, J. L.:Effect of dosing frequency on the de-velopment of physical dependenceand tolerance to pentobarbital, 1004
Okamura, T., see Toda, N., 319Olsen, K., see Contreras, P. C., 1101Olsen, R. W., see Dunwiddie, C. W., 564Olson, R. D., see Nielson, C. P., 19Olszewski, B. J., see Ryan, M. J., 473Operant conditioning, anticonvulsant
supraspinal analgesic effects, mu receptoraction (mice), 1039
withdrawal-induced hyposensitivity, nal-oxone, serum LH, male (rats), 1063
Opioid, self-injection, disruption of sched-ule-controlled performance and (ha-boons), 924
Opioid agonistsactivity of IC! 174864 (mice), 769mu- and delta-selective, ileal preparation
and (guinea pigs), 625neurogenic plasma extravasation and,
paw (rats), 783
Opioid peptidesbehavioral effects
morphine-like, 997
mu and delta receptors (rats), 990ORF 17910, pharmacological comparison,
cimetidine and ranitidine (dogs), 587Organophosphate, histamine release in-
duced by, mast cells (rats), 839
Osborne, J. J., see Cohen, M. L., 769Osterrieder, W., see Kozlowski, R., 1084
Ouabainprostatic secretion, drug-modified ion
transport (dogs), 26renal sodium/potassium-ATPase trans-
port rate, tnansce!lu!ar NaCl reab-sorption (dogs), 327
Owens, S. M., see Woodworth, J. R., 900
Palermo, N. J., see Smith, E. R., 26Palmer, J. B., see Grandordy, B. M., 273Palmier, M. 0., see Danon, A., 95Pancreatic islets, insulin release, p-hydrox-
ymercuribenzoic acid-induced (rats),809, 819
Paraldehyde, central nervous system de-pressant, long- and short-sleep(mice), 1028
Parathyroid hormone, bone resorption in-duced by (mice), 778
Paule, M. G. and Killam, E. K.: Behavioraltoxicity of chronic ethosuximide andsodium valproate treatment in theepileptic baboon, Papio papio, 32
Rafferty, M. F., see Contreras, P. C., 1101Raghoebar, M., Peeters, P. A. M., van den
Berg, W. B. and van Ginneken, C. A.M.: Mechanisms of cell association ofch!oroquine to leucocytes, 302
Ramkumar, V., see El-Fakahany, E. E., 554Ramsammy, L. S., Josepovitz, C., Ling, K.-
Y., Lane, B. P. and Kaloyanides, G.J.: Effects of diphenyl-phenylenedi-amine on gentamicin-induced lipidperoxidation and toxicity in rat renalcortex, 83
Ranitidine, pharmacological comparison,
H2 blockers (dogs), 587
Rao, S., see Okamoto, M., 1004Rauwolscine, a!pha-i,2 adrenoceptors, re-
sponse coupling, saphenous and fern-oral veins (dogs), 131
Receptor reservealpha-i and 2 adrenoceptors
effect of cooling, saphenous and femo-ral veins (dogs), 139
Rigel, D. F. and Katona, P. G.: Effects ofantihistamines and local anestheticson excess tachycardia in consciousdogs, 367
Rinard, G. A., see Moore, D. H., 76Rinehart, R. K., Barbaz, B., !yengar, S.,
Ambrose, F., Steel, D. J., Neale, R.F., Petrack, B., Bittiger, H., Wood,P. L. and Williams, M.: Benzodiaze-pine interactions with central thy-roid-releasing hormone binding sites:Characterization and physiologicalsignificance, 178
Rivy, J. P., see Claustre, Y., 693Re 15-1788, antagonism, benzodiazepine-
like drugs (monkeys), 522RO5-4864, 3H-labeled, downregulation of,
peripheral-type benzodiazepines, 855Roques, B. P., see Bourgoin, S., 360
Rosen, M. R., see Spinel!i, W., 794Rosenbaum, J. S., Zera, P., Umans, V. A.,
Ginsburg, R. and Hoffman, B. B.:Desensitization of aortic smoothmuscle contraction in rats harboringpheochromocytoma, 396
Rosenthal, G., see Simpson, P. J., 497Rossing, T. H. and Drazen, J. M.: Effects of
Roth, B. L., Nakaki, T., Chuang, D.-M. andCosta, E.: 5-Hydroxytryptamine2 re-ceptors coupled to phospholipase Cin rat aorta: Modulation of phos-phoinositide turnover by phorbol es-tsr, 480
Rudolph, A. M., see Wang, L. H., 198Ruffolo, R. R., Jr., see Shebuski, R. J., 217
Ryan, J. W., see Turnin, M., 14Ryan, M. J., Bjork, F. A., Cohen, D. M.,
Coughenour, L. L., Major, T. C., Ma-thias, N. P., Marts, T. E., Olszewski,B. J., Singer, R. M., Evans, D. B. andKaplan, H. R.: CI-926 (3-[4-[4-(3-metbylphenyl)-1-piperazinyl]butylj-2,4-imidazolinedione): Antibyperten-sive profile and pharmacology, 473
Sabouni, M. H., see Alkadhi, K. A., 547Saito, A., Ishikawa, T., Masaki, T., Kimura,
S. and Goto, K.: Pharmacologicalanalysis of autonomic innervation ofthe right atria ofrats and guinea pigs:Demonstration of nonadrenergicnoncholinergic nerves, 713
Saito, H., Inui, K.-!. and Honi, R.: Mecha-
nisms ofgentamicin transport in kid-ney epitbe!ial cell line (LLC-PK1),1071
Salhab, A. S., see Shiverick, K. T., 1108
Sallustio, B. C., see Jones, M. E., 288
Sallustio, B. C., see Meffm, P. J., 280
Sampson, A. S., see Grandordy, B. M., 273Santicioli, P., see Maggi, C. A., 259,341
Satoh, S., see Yorikane, R., 334Scatton, B., see Claustre, Y., 693SCH 23390
dopamine or fenoldopam and, cyclic AMPlevels (rats), 547
methamphetamine-induced changes and,
monoamine systems (rats), 932treatment, dopamine receptors and (rats),
846
Schenck, K., see Cohen, M. L., 860Schild plots, limitations, alpha adrenocep-
tors, vascular smooth muscle, 237Schmid, P. G., Whiteis, C. A., Ode, R P.
and Lund, D. D.: Presynaptic regu-lation of cardiac sympathetic func-tion in guinea pigs, 447
Schmitt, M., see Guentert, T. W., 295Schmoeker, P. F., see Cicero, T. J., 1063Schnier, R. W., see Schwertschlag, U., 119Schwartz, D. D. and Eikenburg, D. C.: Car-
diovascular responsiveness to sym-pathetic activation after chronic epi-nephrine administration, 148
Scbwertschlag, U., Gerber, J. G., Barnes, J.S. and Nies, A. S.: A dual effect ofnonsteroidal anti-inflammatory
drugs on renal water handling in hu-mans, 653
Schwertschlag, U., Schrier, R W. and Wil-son, P.: Beneficial effects of calciumchannel blockers and CaImOdUlin
binding drugs on in vitro renal cellanoxia, 119
Scott, C. see Katz, L B., 587Sedative hypnotics, long- and short-sleep
with (mice), 1028
Sejersted, 0. M., see Kiil, F., 327Serotonergic system, methamphetamine-in-
duced changes, dopamine receptor
sybtypes in (rats), 932Serotonin
as a vasoconstrictor neurotransmitter,basilar artery (rabbits), 880
and (rats), 480receptor activation, calcium ion channel
antagonists and (rats), 860
Sexual dimorphism, hepatic monooxygen-ase system, persistent defects, pbe-nytoin (rats), 68
Sham, see Perrone, M. H., 389Shapiro, B. H., Lech, G. M. and Bardales,
R. M.: Persistent defects in the he-
patic monooxygenase system of adultrats exposed, perinatally, to mater-nally administered phenytoin, 68
Sharp, B. M. and Beyer, H. S.: Rapid desen-sitization ofthe acute stimulatory ef-
fects of nicotine on rat plasma adre-nocorticotropin and prolactin, 486
Shebuski, R. J., Fujita, T. and Ruffolo, R.
R., Jr.: Evaluation of alpha-i and a!-pha-2 adrenoceptor-mediated vaso-constriction in the in situ, autoper-fused, pulmonary circulation of theanesthetized dog, 217
Sherlock, D. J., see Jaffe, B. M., 536Shiverick, K. T., Swanson, C., Saihab, A. S.
and James, M. 0.: Differential induc-tion of ethoxyresorufm-O-deethylasein tissues of the rat placenta, 1108
Shriver, D. A., see Katz, L. B., 587
Shuman, R T., see Cohen, M. L., 769Simpson, P. J., Smith, C. B., Jr., Rosenthal,
G. and Lucchesi, B. R.: Reduction inthe incidence of thrombosis by thethromboxane synthetase inhibitorCGS 13080 in a canine model of cor-onary artery injury, 497
Singer, R. M., see Ryan, M. J., 473SKF 38393, supersensitivity, apomorphine,
rotational behavior (mice), 242Skolnick, P., see Barrett, J. E., 1009Smith, C. B., Jr., see Simpson, P. J., 497Smith, D. M., see Cubells, J. F., 508Smith, E. R., Miller, T. B., Palermo, N. J.
and Donovan, D. W.: Effects on ca-nine prostatic secretion of somedrugs that modify ion transport, 26
Smith, P. G., see Mills, E., 1014Smith, T. W., see Wei, E. T., 783
Snell, L. D. and Johnson, K. M.: Character-ization of the inhibition of excitatoryamino acid-induced neurotransmit-ter release of the rat striatum byphencycidine-like drugs, 938
Snyder, F. R., see Szikszay, M., 192Snyder, S. H., see Largent, B. L., 739Sodium, transport, detergent effects, un-
Solaro, R. J., Bousquet, P. and Johnson, J.D.: Stimulation of cardiac myofila-
ment force, ATPase activity and tro-ponin C Ca� binding by bepridil, 502
Somogyl, G. T., see Vizi, E. S., 701
Sonsalla, P. K., Gibb, J. W. and Hanson, G.R.: Roles of D1 and D2 receptor sub-types in mediating the methamphe-tamine-induced changes in mono-amine systems, 932
Spealman, R. D., see Wettstein, J. G., 522Spector, S., see Johnson, M. D., 855
Spilman, S. D., see Kraemer, F. B., 905Spinal cord
Spinelli, W. and Rosen, M. R.: Frequency-dependent actions of phenytoin inadult and young canine Purkinje fi-bers, 794
Spry, L., Lakshmi, V. M., Zenser T. andDavis, B.: Metabolism and excretion
1986 Index 1157
of nitrofurothiazole bladder carcino-gens, 457
Starmer, C. F., see Moorman, J. R., 159Stassen, F., see Mann, W. A., 401Steel, D. J., see Rinehart, R. K., 178Sterols, synthesis, ketoconazole effects, 905Stevens, C. W. and Yaksh, T. L.: Dynorphin
A and related peptides administeredintrathecally in the rat: A search forputative kappa opiate receptor activ-ity, 833
Stokes, G. S., see Marwood, J. F., 267Strauss, H. C., see Moorman, J. R., 159Streptozotocin, diabetes mellitus, bladder
dysfunction in (rats), 773Stress
antidepressant drug injection and, amyg-dala (rats), 758
cortical dopamine metabolism and (rats),693
Striatal kainate lesions, benzodiazepine re-ceptors, regulation of (rats), 739
Stumpf, W. E., see Duncan, G. E., 758Stupecky, G. L., Murray, D. L. and Purdy,
R. E.: Vasoconstrictor threshold syn-
ergism and potentiation in the rabbitisolated thoracic aorta, 802
Submucous plexus, neuropeptide Y, effecton ion transport, ileum (rabbits), 167
Substance K, substance P and, neurokininmotor effect, duodenum (rats), 341
Substance Preceptors, see Receptorssubstance K and
like release, spinal cord (rats), 360Thomasson, D. L., see Danon, A., 95, 125Thoolen, M. J. M. C., see Chits, A. T., 224Thornburg, J. E., see Atchison, W. D., 618Threshold synergism, potentiation and, vas-
oconstrictor, thoracic aorta (rabbits),802
Thrombin, artery contraction and, alpha ad-renoceptor agonists and (rabbits),947
pharmacokinetics and dynamics, obesityand (rats), 642
Vermeulen, M., see Lambert, C., 307Vince, R, see Dunham, E. W., 954
Vizi, E. S., Harsing, L. G., Jr., Gas!, J.,Kapocsi, J., Bernath, S. and Somogyi,G. T.: CH-38083, a selective, potent
1158 Index Vol. 238
antagonist of alpha-2 adrenorecep-tors, 701
W6211, pH potentiation, drug pK�, sodiumchannel blockade in ventricular myo-cardium (guinea pigs), 159
Walewski, J. L., see Okamoto, M., 1004
Walker, M. J., see Carroll, M. E., 1Walker, S. T., see Weiss, J., 969Walter, J. B., see Moore, D. H., 76
Wamsley, J. K., see Gulya, K., 720Wang, L. H., Rudolph, A. M. and Benet, L.
Z.: Pharmacokinetic studies of thedisposition of acetaminophen in thesheep maternal-placental-fetal unit,198
Ward, S. J., LoPresti, D. and James, D. W.:
Activity of mu- and delta-selectiveopioid agonists in the guinea pigileum preparation: Differentiationinto peptide and nonpeptide classeswith �-funaltrexamine, 625
Warltier, D. C., see Pelc, L. R., 113Water, transepithelial flux, inhibition by
vasopressin agonists, urinary bladder(rats), 401
Webner, J. M., see Manley, R. J., 1028Wei, E. T., Kiang, J. G., Buchan, P. and
Smith, T. W.: Corticotropin-releas-ing factor inhibits neurogenic plasmaextravasation in the rat paw, 783
Weiss, B., see Winkler, J. D., 242Weiss, H. R., see Grover, G. J., 868
Weiss, J., Walker, S. T., Fallon, M. andGoldfarb, S.: In vivo and in vitro ef-fects ofWR-2721 in experimental by-percalcemia in the rat, 969
Weissman, B. A., see Barrett, J. E., 1009Wettstein, J. G. and Spealman, R. D.: Be-
havioral effects of zopiclone, CL 218,872 and diazepam in squirrel mon-keys: Antagonism by Ro 15-1788 andCGS 8216, 522
Wetzel, G. T., see McDonough, P. M., 612Whiteis, C. A., see Schmid, P. G., 447
Williams, M., see Rinehart, R. K., 178Wilson, P., see Schwertschlag, U., 119Winkler, J. D. and Weiss, B.: Reversal of
supersensitive apomorphine-induced
rotational behavior in mice by con-tinuous exposure to apomorphine,242
Witkin, J. M., see Barrett, J. E., 1009Wittenauer, L., see Cohen, M. L., 860Wong, B. K., see Corcoran, G. B., 54Wood, P. L., see Iyengar, S., 429Wood, P. L., see Rinehart, R. K., 178
Woodwortb, J. R., Mayersohn, M. andOwens, S. M.: Disposition kinetics ofthe monohydroxy metabolites ofphencyclidine in the dog, 900
Woronick, C. L., see Maderazo, E. G., 453
Worth, T. S., see Dunwiddie, C. W., 564WR-2721, experimental hypercalcemia
(rats), 969
Yaksh, T. L., see Stevens, C. W., 833
Yamamoto, K., see Yukimura, T., 707
Yamamura, H. I., see Gulya, K., 720Yamamura, H. I., see Hynes, M. R., 100Yasumoto, T., see Kobayashi, M., 1077
YC-170, vascular and cardiac effects, corn-panison with Bay K 8644 (rabbits,guinea pig), 670
Yee, R, see Moorman, J. R., 159Yohimbine
aipha-2 adrenoceptors, question of exist-ence, tail arteries (rats), 267
Yorikane, R., Kanda, A., Kimura, T. andSatob, S.: Effects ofepinephnine, iso-proterenol and IPS-339 on sympa-thetic transmission to the dog heart:Evidence against the facilitatory roleof presynaptic beta adrenoceptors,
334Young, A. B., see Ciliax, B. J., 749Yukimura, T., Ito, K., Takenaga, T., Ya-
mamoto, K., Kangawa, K. and Mat-suo, H.: Possible tubular site of ac-tion in anesthetized dogs of a syn-thetic a-human atrial natriureticpolypeptide, 707
Zenser, T. V., see Danon, A., 95, 125, 457Zera, P., see Rosenbaum, J. S., 396
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