In-Vitro-Market.pptx

In Vitro Market

In Vitro Market2013 Market AnalysisHistorical Trends2013 Market Analysis

Historical InformationIn Vitro, of Latin origin, literally means in glass due to the initial administration of drugs and biological specimens via a small glass tube.

In Vitro takes place in a test tube, culture dish, or elsewhere outside of a living organism.

Source: http://en.wikipedia.org/wiki/In_vitro

Historical InformationCommon examples of in vitro experiments include work that uses:Cells derived from multicellular organisms (cell culture or tissue culture)

Subcellular components (e.g. mitochondria or ribosomes)

Cellular or subcellular extracts (e.g. wheat germ or reticulocyte extracts)

Purified molecules in the test tube (often proteins, DNA, or RNA, either individually or in combination).Source: http://en.wikipedia.org/wiki/In_vitroHistorical InformationLiving organisms are extremely complex functional systems that are made up of, at a minimum, many tens of thousands of genes, protein molecules, RNA molecules, small organic compounds, inorganic ions and complexes in an environment that is spatially organized by membranes and, in the case of multicellular organisms, organ systems

Source:http://en.wikipedia.org/wiki/In_vitro

Historical InformationIn short, living organisms are very complex, but In Vitro allows simplicity.

Advantages and Disadvantages of In Vitro 2013 Market Analysis

Advantages of In VitroDisadvantages of In VitroThe primary advantage of in vitro work is that it permits an enormous level of simplification of the system under study, so that the investigator can focus on a small number of componentsThe primary disadvantage of in vitro is that it can sometimes be very challenging to extrapolate from the results of in vitro work back to the biology of the intact organism. Source:http://en.wikipedia.org/wiki/In_vitro

Example of In Vitro Advantages

The identity of proteins of the immune system (e.g. antibodies), and the mechanism by which they recognize and bind to foreign antigens would remain very obscure if not for the extensive use of in vitro work to:Isolate the proteinsIdentify the cells and genes that produce themStudy the physical properties of their interaction with antigens andIdentify how those interactions lead to cellular signals that activate other components of the immune system.Source:http://en.wikipedia.org/wiki/In_vitro

Examples of In Vitro Disadvantages

Scientists developing a new viral drug to treat an infection with a pathogenic virus (e.g. HIV-1) may find that a candidate drug functions to prevent viral replication in an in vitro setting (typically cell culture). However, before this drug is used in the clinic, it must progress through a series of in vivo trials to determine if it is safe and effective in intact organisms (typically small animals, primates and humans in succession).

Typically, most candidate drugs that are effective in vitro prove to be ineffective in vivo because of issues associated with delivery of the drug to the affected tissues, toxicity towards essential parts of the organism that were not represented in the initial in vitro studies, or other issues.

Source: http://en.wikipedia.org/wiki/In_vitro

Examples of In Vitro testing and uses2013 Market Analysis

Examples of In Vitro testing and usesPolymerase chain reaction is a method for selective replication of specific DNA and RNA sequences in the test tube. Source: http://en.wikipedia.org/wiki/In_vitro

Examples of In Vitro testing and usesProtein purification involves the isolation of a specific protein of interest from a complex mixture of proteins, often obtained from homogenized cells or tissues.

Source: http://en.wikipedia.org/wiki/In_vitro

Examples of In Vitro testing and usesIn vitro fertilization is used to allow spermatozoa to fertilize eggs in a culture dish before implanting the resulting embryo or embryos into the uterus of the prospective mother.

Source: http://en.wikipedia.org/wiki/In_vitro

Examples of In Vitro testing and usesIn vitro diagnostics refers to a wide range of medical and veterinary laboratory tests that are used to diagnose diseases and monitor the clinical status of patients using samples of blood, cells or other tissues obtained from a patient.

Source: http://en.wikipedia.org/wiki/In_vitro

Worldwide players2013 Market Analysis Source:Worldwide PlayersBio-Rad LaboratoriesSource:

Worldwide PlayersBio-RadFounded in 1952 in Berkley, CaliforniaManufacturer and supplier of:Life science researchHealthcareAnalytical chemistryOther markets with products and systems used to separate complex chemical and biological materials and to identify, analyze, and purify their componentsSource: http://www.bio-rad.com/Worldwide PlayersBio-Rad operates in six industry segments: Life Science ResearchClinical DiagnosticsProcess SeparationsFood ScienceSpectroscopyLife Science Education

Source: http://www.bio-rad.com/Worldwide PlayersAll segments operate worldwide. Bio-Rads customers include:HospitalsUniversitiesMajor research institutionsBiotechnologyPharmaceutical companiesSecondary and tertiary academic institutionsSource:http://www.bio-rad.com/Worldwide PlayersBio-Rad is the number one specialty diagnostics company in the world.

The Clinical Diagnostics Group develops, manufactures, sells and supports a large portfolio of products for medical screening and diagnostics. Source: http://en.wikipedia.org/wiki/Bio-Rad_LaboratoriesWorldwide PlayersBio-Rad holds leadership positions in diabetes monitoring and quality control (QC) systems.

Bio-Rad is well known for:Blood virus testing and detectionBlood typingAutoimmune and genetic disorders testingInternet-based software products.

Source: http://en.wikipedia.org/wiki/Bio-Rad_LaboratoriesWorldwide PlayersBio-Rad's Clinical Diagnostics segment encompasses a broad array of technologies incorporated into a variety of products used to detect, identify, monitor, and quantify substances in patient and donor blood, other bodily fluids, and tissue samples.The vast majority of these tests are performed in vitro (outside the body)Source: http://en.wikipedia.org/wiki/Bio-Rad_LaboratoriesWorldwide PlayersThe market is split into several sub-segments consisting of:Clinical chemistryImmunoassayMicrobiology HematologyMolecularCoagulationBlood bankingBlood typing

Source: http://en.wikipedia.org/wiki/Bio-Rad_LaboratoriesWorldwide PlayersBio-Rad has significant positions in:Blood virus testing (blood banking and immunoassay)Immunohematology (blood typing)Hemoglobin A1c testing for diabetes monitoring (clinical chemistry and immunoassay)Autoimmune disease testing (immunoassay)Quality control (crossing all sub-segments).

Source: http://en.wikipedia.org/wiki/Bio-Rad_Laboratories

Worldwide PlayersOne medically significant product is Bio-Rads rapid dengue test, called the NS1 antigen test, which allows for dengue detection the first day of fever, rather than when antibodies rise some five or more days later.Source: http://en.wikipedia.org/wiki/Bio-Rad_LaboratoriesWorldwide PlayersBeckman CoulterSource:

Worldwide PlayersBeckman CoulterFounded in 1935 as National Technical Laboratories to commercialize a pH meter

Headquarters in Brea, California.

Locations worldwide:AmericasEuropeAfricaMiddle EastPacificAsia

Source: https://www.beckmancoulter.comWorldwide PlayersBeckman CoulterDevelops, manufactures, and markets products that simplify, automate and innovate complex biomedical testing. Beckman Coulter diagnostic systems are found in hospitals and other critical care settings around the world and produce information used by physicians to diagnose disease, make treatment decisions and monitor patients.Life science research instruments are used to study complex biological problems including causes of disease and potential new therapies or drugs.

Source: https://www.beckmancoulter.comWorldwide PlayersBeckman Coulters core customers:Core clinical diagnostic customers are: Hospital laboratories

Core life science customers are:Pharmaceutical and biotechnology companiesUniversitiesMedical schoolsResearch institutions.

Source: https://www.beckmancoulter.com

Worldwide PlayersBeckman Coulter Analytical MachinesAn-50 Ti and An-60 Ti RotorsAn-50 TIAnalytical rotor with an eight-place titanium rotor (painted black), rated for 50,000 RPM. Seven holes are for sample cells and the eighth is for the counterbalance; all are parallel to the axis of rotation.An-60 TiAnalytical rotor with a four-place titanium rotor (painted black), rated for 60,000 RPM. Three holes are for sample cells and the fourth is for the counterbalance; all are parallel to the axis of rotation. Source: https://www.beckmancoulter.com/wsrportal/techdocs?docname=LXLA-TB-003Worldwide PlayersBoth rotors cell holes are numbered for easy identification, together with the windows in the cells, allow light to pass through the cells for analysis of the material being processed.

A handle is attached for easy lifting of the rotor.Source: https://www.beckmancoulter.com/wsrportal/techdocs?docname=LXLA-TB-003Worldwide PlayersFor over-speed protection, a photoelectric detector in the XL-A/XL-I system monitors the over-speed disk on the bottom of the rotor and shuts down the run if speeds exceeding the rotors rated maximum are detected.Magnets have been inserted in the over-speed disk between cell holes 1 and 4 (An-60 Ti) or 1 and 8 (An-50 Ti). A sensor in the rotor chamber, triggered by these magnets, is used for timing the light sources

Source:https://www.beckmancoulter.com/wsrportal/techdocs?docname=LXLA-TB-003Worldwide PlayersAKSA MedicalSource:

Worldwide PlayersAKSA MedicalLocated in the NetherlandsAn independent distributor in the Benelux. Product range of AKSA Medical consists of the following product groups:Clinical ChemistryImmunochemistryDrugs of AbuseHematologyMicrobiology / VirologyPoint of Care Testing (POCT)HPLC and LCMS/MS reagents, controls, calibrators

Source: http://www.aksamedical.com/Worldwide PlayersAska Products:

General Diagnostic Assays

Infectious Diseases

Life Sciences

Point of care Testing (POCT)

Quality Control

QC software

Laboratory InstrumentsReagents

Special products

Lipoprint

HPLC

LC-MS/MS Applications

Happy Cell / 3D Cell Culture in HCS & HTS

ToxicologieSource: http://www.aksamedical.com/Worldwide PlayersAKSA has 19 suppliers, all of which are displayed below

RandoxQuantimetrix CorporationCisBiotechIVD TechnologiesLTA S.R.LRECIPE Chemical + Instruments GmbH Sentinel DiagnosticsDiaMetraExpress DiagnosticsHIMedia LaboratoriesBioGroup Medical System Pilots PointBIOCRATESBiocroi Ltd.BoditechPrinceton BioMitech CorporationIVD Research Inc. ACCESS BIO, Inc.LifeSign

Source: http://www.aksamedical.com/

Future prospects and growth2013 Market Analysis- European marketSource:European SectorIt is anticipated that the IVD market in Western Europe will grow at a rate of 5% per annum. Germany has the biggest market share with sales of almost Euro 1.6 billion, accounting for 24% of the total European market. Italy has the next highest sales with revenues of Euro 1.1 billion and 18% of the market. After Italy come France, Spain, United Kingdom, Belgium and Switzerland.

Source: http://www.researchandmarkets.com/reports/35139/the_top_100_in_vitro_diagnostics_manufacturingEuropean SectorMarket share in percentagesRevenue growth in billionsEuropean SectorThe global IVD market is worth an estimated EUR 19.5 billion, broken down as follows:

European sector (numbers in millions)Clinical Chemistry- 5,271Infectious Diseases- 5,627Rapid Tests Coagulation Endocrine Testing Glucose-4,209Haematology- 1,253Blood Grouping/TypingSource: http://www.researchandmarkets.com/reports/35139/the_top_100_in_vitro_diagnostics_manufacturing

European SectorThe largest IVD segments are:Infectious diseasesClinical chemistryGlucose

Glucose and rapid tests are the fastest growing tests in the European sector.

Source: The largest IVD segments are infectious diseases, clinical chemistry and glucose. Glucose and rapid tests are the fastest growing.

Future prospects and growth2013 Market Analysis- China and IndiaSource:

China and IndiaThe IVD markets of China and India, two countries that account for roughly one-third of the worlds population, have demonstrated remarkable growth during the past 15 years.The IVD markets have seen steady growth rates:10-20% per year during the past 15 yearsGrowth in India is starting from a substantially lower point.Pace of growth for both countries has increasedChina 25% growth India 18% growthSource: http://www.ivdtechnology.com/article/china-and-india-comparing-two-fast-growing-ivd-marketsChina and IndiaIncreased prosperity and urbanization in both countries are allowing for a rapid increase of IVD use.Source: http://www.ivdtechnology.com/article/china-and-india-comparing-two-fast-growing-ivd-marketsChina and IndiaMcEvoy & Farmers 2011 report on Chinas IVD market estimates the size of the market to be $2.1 billion with a growth rate of about 25% Source: http://www.ivdtechnology.com/article/china-and-india-comparing-two-fast-growing-ivd-markets

China and IndiaMcEvoy & Farmers 2011 report on Indias IVD market estimates the market size to be $531 million and growing at approximately 18%Source: http://www.ivdtechnology.com/article/china-and-india-comparing-two-fast-growing-ivd-markets

Future Prospects and Growth2013 Market Analysis- US Market

Source:Future Prospects and GrowthCauses of significant market growth:Introduction of the Patient Protection and Affordable Care Act (PPACA) in 2014

This will significantly affect the United States in vitro diagnostics (IVD) market landscape.

Most notably, the implementation of this Act will increase the percentage of people covered by insurance, which will drive test volumes, especially as the US population ages and the demand for IVD increases.

Source: http://www.fiercemedicaldevices.com/press-releases/us-vitro-diagnostics-market-grow-nearly-86-billion-2017#ixzz2M4meCZXp 49

Future Prospects and GrowthCauses of significant market growth (cont..)

The PPACA will also lead to increased centralization of IVD testing as more laboratories, hospitals and care facilities consolidate in the wake of health care reform. Although the rise of centralized labs will leave manufacturers with fewer potential sites for capital sales, these facilities will see high testing volumes and ultimately have the resources to purchase a broader array of diagnostic tests.

Source: http://www.fiercemedicaldevices.com/press-releases/us-vitro-diagnostics-market-grow-nearly-86-billion-2017#ixzz2M4of25cl Future Prospects and GrowthHigh testing volumes at centralized sites will mean that labs will look for vendors that can offer a broad range of instrumentation and automation equipment.

Labs will prefer to purchase all of their equipment from one vendor to improve workflow logistics and reduce costs.

Source: http://www.fiercemedicaldevices.com/press-releases/us-vitro-diagnostics-market-grow-nearly-86-billion-2017#ixzz2M4qaxKgI

Future Prospects and GrowthOverall results of growth:

Majority of market share will be held by a few key multi-segment players, like:

Siemens HealthcareRoche Abbott Laboratories

Source: http://www.fiercemedicaldevices.com/press-releases/us-vitro-diagnostics-market-grow-nearly-86-billion-2017Future Prospects and GrowthLarge multinational companies will likely continue to dominate the market through 2017especially those players with a finger in molecular diagnostics technologies.

This market segment will grow rapidly through 2017, cannibalizing sales from more mature segments such as immunoassay and microbiology testing.

Source: http://www.fiercemedicaldevices.com/press-releases/us-vitro-diagnostics-market-grow-nearly-86-billion-2017

Future Prospects and GrowthThere is still uncertainty surrounding the PPACA and health care reform in the US.

This has caused many facilities to delay purchasing IVD capital equipment

Source: http://www.fiercemedicaldevices.com/press-releases/us-vitro-diagnostics-market-grow-nearly-86-billion-2017Future Prospects and GrowthHowever, the increase in test volumes will outweigh these negative effects, and the US IVD market will see steady growth.

Source: http://www.fiercemedicaldevices.com/press-releases/us-vitro-diagnostics-market-grow-nearly-86-billion-2017

Future Prospects and GrowthOverall growth projections of the In Vitro market:

Nearly $8.6 Billion by 2017 in the U.S.

Source: http://www.fiercemedicaldevices.com/press-releases/us-vitro-diagnostics-market-grow-nearly-86-billion-2017:

Conclusions 2013 In Vitro Market AnalysisSource:ConclusionsThe In Vitro diagnostic market is growing rapidly worldwideRapid growth potential is certain virtually worldwide as developed countries readily use IVD testingAs developing countries become westernized, the use of IVD testing will ensue as well.Source:ConclusionsIt is vital to ensure that Asian and Pacific markets are not ignored as they are rapidly growing as leaders in the usage of IVD tests.Source: