“Knowledge Management in Biomedical Translational Research” HIKM-ACW HIKM ---- 1 Feb 2012 Fernando J. Martin-Sanchez Professor and Chair of Health Informatics Melbourne Medical School Faculty of Medicine, Dentistry & Health Sciences & Director, Health and Biomedical Informatics Research (HBIR) Unit
Presentation given at Health Informatics and Knowledge Management conference (http://publichealth.curtin.edu.au/HIKM/), as part of Australasian Computer Science Week 2012. http://www.cs.rmit.edu.au/acsw2012/
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“Knowledge Management in Biomedical Translational
Research”
HIKM-ACW
HIKM ---- 1 Feb 2012
Fernando J. Martin-Sanchez Professor and Chair of Health Informatics
Melbourne Medical School Faculty of Medicine, Dentistry & Health Sciences
& Director, Health and Biomedical Informatics Research (HBIR) Unit
Outline
• Biomedical translational research • The role of knowledge management • HBIR@UniMelb
Biomedical
Translational Research
---The ultimate goal of translational medicine is the development of new treatments and insights towards the improvement of health across populations.---
Woolf, SH. JAMA 2008
USA: 7 NCBC + 60 CTSA + 1 new NCATS
www.ScienceTranslationalMedicine.org 6 July 2011 Vol 3 Issue 90
Transdisciplinary paths – research teams
Bench (Bioscientist)
WHAT Bedside (Clinician)
Population (Epidemiologist)
HOW Society at large (Health services researcher)
WHY
KN
OW
LED
GE
MA
NA
GE
ME
NT
Translate basic research findings into clinical solutions
Facilitate structured, standardized, anonymized clinical data sets for research Evaluate the efficacy of
Interventions across communities
Assess impact on health policies
Biomedical Informatics: Biomedical Information processing from particle to population
Altman RB, Balling R, Brinkley JF, Coiera E, Consorti F, Dhansay MA, Geissbuhler A, Hersh W, Kwankam SY, Lorenzi NM, Martin-Sanchez F, Mihalas GI, Shahar Y, Takabayashi K, Wiederhold G. "Commentaries on Informatics and medicine: from molecules to populations". Methods Inf Med. 2008;47(4):296-317.
Multilevel modeling, ontologies, data integration, data mining, …
The role of Knowledge
management
The role of knowledge management to facilitate translational research
• Update researchers and clinicians on the latest developments within relevant areas
• Data integration (putting into context molecular information from the patient with existing biomedical knowledge on the web)
• Assess the clinical relevance of biomarkers
• Supporting decision making through new clinical guidelines, and alerting systems which take into account genetic data from patients
• Education of patients and health professionals in genomics and informatics
• What are the main features of the disease? • Are there any drugs for the disease? • Are there any gene therapies or clinical trials for the disease? • What laboratories perform genetic tests for the disease? • What genes cause the disease? • On which chromosomes are these genes located? • What mutations have been found in these genes? • What names are used to refer to these genes? • What are the proteins coded by these genes? • What are the functions of the gene product? • What is the 3D structure for these proteins? • What are the enzymes associated to these proteins?
DiseaseCard
• DiseaseCard • Collaboration with
University of Aveiro • Integrates information
from 20 reference databases
• 2000+ genetic diseases
http://www.diseasecard.org
Dias GS, Oliveira JL, Vicente J, Martin-Sanchez F. “Integrating medical and genomic data: a successful example for rare diseases”. Stud. Health Technol. Inform. 2006;124:125-30.
Support of specific activities Liaison with medical specialties
Foundational Contributing member
Research
• Three main areas: – Informatics - personalized
medicine – Informatics - simulation,
modeling and sensors – Informatics – e-health
• All of them aim at: – Improving health services – Facilitating translational
research – Contributing to professional
development
Education
• Health students and professionals, Engineers & informaticians
• Experts in the field (Master, PhD in HBI)
• Undergrad – Bachelor of Biomed, Science • Postgrad New MD – Across the
Curriculum • MSc - Offer an elective subject: “eHealth
and Biomedical Informatics Systems” – MSc Information Science, MSc
Bioinformatics, MSc Biomedical Engineering, MSc Public Health, …
• 2nd Elective subject (eHealth and Biomedical Informatics Methods)
• 4 subjects stream within an existing MSc • Master and PhD degrees
Collaborative Health Informatics Research Seminar & Social (CHIRSS) Focus on the future of healthcare and new opportunities that are emerging for collaborative R&D in
Health and Biomedical Informatics. Once a month. CHIRSS is supported by the Institute for a Broadband Enabled Society and Victorian eResearch
Strategic Initiative Partnerships Journal club A new Health and Biomedical Informatics journal club has started up, with a focus on strategies for
publishing health informatics research. We meet from 12.00 to 1.00 on the second Tuesday of the month in the ICT Building, 111 Barry Street, level 4, room 9.
Bulletins “Liaisons” with Clinical specialties Web page