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HISTOPATOLOGI GLOMERULOPATI Noza Hilbertina, dr, M.Biomed, SpPA Bagian Patologi Anatomi Fak.Kedokteran UNAND 1 1
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glomerulopati, 2015

Oct 01, 2015

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GLMERULOPATI & ISK

HISTOPATOLOGI GLOMERULOPATINoza Hilbertina, dr, M.Biomed, SpPABagian Patologi AnatomiFak.Kedokteran UNAND111ARSIP 012THOPEDICMINGGU 3 BLOK 3.4ReferensiRobbins and Cotran Pathologic Basis of Disease, 9th ed, 2015General and Systematic Pathology : JCE Underwood, 4th edPathology Illustrated : Peter S. Macfarlane : 5th edPractical Renal pathology : Donna J.Lager : 20132Histologi ginjal normal3

TubulusGlomerulusp.darah4

TerminologiGlomerulopati : lesi pd glomerulus primer, sekunderTerminologi lokasi jejas glomerulus :Difusa : semua glomerulusFokal : sbgn glomerulusGlobal : semua bgn pd satu glomerulusSegmental : sebagian dari satu glomerulus5Klasifikasi : etiologi, rx imunologi, pola histologiKebanyakan glomerulopati tdk diketahui penyebabnya srg klasifikasi bdsrkan histologi

6Penyakit Glomerulus Primerminimal change diseasefocal segmental glomerulosclerosismembranous nephropathyIgA nephropathymembranoproliferative glomerulonephritisacute post infectious glomerulonephritisPenyakit Glomerulus Sekunder1. Yang berhubungan dengan penyakit sistemik :diabetic nephropathylupus nephritisparaprotein-associated renal diseaseHIV-associated nephropathyanti-GBM antibody-mediated diseasepauci immune necrotizing and cresentic glomerulonehritis2. Fibrillary glomerulonephritis3. immunotactoid glomerulopathy4. thrombotic microangiopathythrombotic thrombocytopenic purpurahemolytic-uremic syndromeTampilan klinis penyakit ginjalAzotemia : peninggian kadar urea nitrogen dan kreatinin darah sindrom nefritik : hematuria, azotemia, hipertensi, proteinuria sub nefrotiksindroma nefrotik : proteinuria berat, hipoalbuminemia, edema, hiperlipidemia, dan lipiduriahematuria atau proteinuria asimptomatikjejas ginjal akut : penurunan GFR secara cepat 10 penyakit ginjal kronik : penurunan GFR menetap