The Internet Journal of Dermatology 2007 : Volume 5 Number 1 Diagno stic dilem ma: HMB-45 an d Melan - A negative t umor , can it be st il l a m elanom a?: MITF (Microp hthalmia-associated tran scripti on factor) stain m ay confirm the diagnosis Jeff F. W ang M.D. Department of PathologyCreighton University Medical Center Omaha NE USADeba P. Sarma M.D. Department of PathologyCreighton University Medical Center Omaha NE USAPamela Ulmer D.O. Department of PathologyCreighton University Medical Center Omaha NE USACitation: J. F. Wang, D. P. Sarma & P. Ulmer : Diagnostic dilemma: HMB-45 and Melan-A negative tumor, can it be still a melanoma?: MITF (Microphthalmia-associated transcription factor) stain may confirm the diagnosis . The Internet Journal of Dermatology. 2007 Volume 5 Number 1 Keywords: Melanoma | HMB-45 | Melan-A | MITF Abstract We report a case of dermal malignant melanoma that staine d negatively for commonly done immunostains , HMB-4 5, and Melan-A. It stained weakly positiv e for S- 100 protein, a less specific marker for melanocytes. The diagnosis was established by strongly positive immunostaining by MITF ( microphthlmia-associated transcription factor). A briefreview of the MITF and its usefulness in the diagnosis of melanoma are presented. Source of support None Case Report An 82-year-old male presented with a 1-cm raised dermal nodule on the medial side of the right foot that has been
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DR SARMA'S DERMPATH: Diagnostic dilemma: HMB-45 and Melan-A negative tumor, can it be still a melanoma?: MITF (Microphthalmia-associated transcription factor) stain may confirm the
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8/14/2019 DR SARMA'S DERMPATH: Diagnostic dilemma: HMB-45 and Melan-A negative tumor, can it be still a melanoma?: …
The Internet Journal of Dermatology 2007 : Volume 5 Number 1
Diagnostic dilem m a: HMB-45 and Melan-A negative tum or , can it be still a m elanom a?: MITF(Microphthalm ia-associated tran scription factor)stain m ay confirm the diagnosis
Jeff F. W ang M.D.
Department of Pathology
Creighton University Medical Center
Omaha NE USA
Deba P. Sar ma M.D.
Department of Pathology
Creighton University Medical Center
Omaha NE USA
Pam ela Ulmer D.O.
Department of Pathology Creighton University Medical Center
Omaha NE USA
C i t a t i o n : J. F. Wang, D. P. Sarma & P. Ulmer : Diagnostic dilemma: HMB-45 and Melan-A negative tumor, can it be still a melanoma?:
MITF (Microphthalmia-associated transcription factor) stain may confirm the diagnosis . The Internet Journal of Dermatology. 2 0 0 7
Volume 5 Number 1
Keywords: Melanoma | HMB-45 | Melan-A | MITF
Abstract
We report a case of dermal malignant melanoma that stained negatively for commonly done immunostains, HMB-45,
and Melan-A. It stained weakly positive for S-100 protein, a less specific marker for melanocytes. The diagnosis was
established by strongly positive immunostaining by MITF ( microphthlmia-associated transcription factor). A brief
review of the MITF and its usefulness in the diagnosis of melanoma are presented.
Source of support
None
Case Report
An 82-year-old male presented with a 1-cm raised dermal nodule on the medial side of the right foot that has been
8/14/2019 DR SARMA'S DERMPATH: Diagnostic dilemma: HMB-45 and Melan-A negative tumor, can it be still a melanoma?: …