Cvcofliverandspleen 140720222447-phpapp02-140820043744-phpapp02

Chronic Venous Congestion Of

Lung, Liver and Spleen

INTRODUCTION

Congestion is a hemodynamic i.e. circulatory disorder.

Definition: Congestion is a passive process resulting from reduced outflow of blood from a tissue.

It is also called passive hyperemia .

It can be: 1)Systemic or Local And 2)Acute or chronic

Chronic is more common so it is known as Chronic Venous congestion(CVC).

TYPES OF CVCLocal Systemic

Results from obstruction to venous outflowfrom an organ or part of the body.

Eg: Portal venous obstruction in liver cirrhosis, plasters, tumors, pregnancy and hernia.

This occurs mainly due to engorgement of systemic veins.

Eg: In right and left sided heart failure and diseases of lungs interfering pulmonary blood flow like emphysema and fibrosis.

CONSEQUENCES As a result of increased volumes and

pressures, congestion commonly leads to edema.

In passive long standing congestion, lack of blood flow causes chronic hypoxia potentially resulting in ischemic tissue injury and scarring.

Capillary rupture in chronic congestion can also cause small hemorrhagic foci, subsequent catabolism of extravasated red cells can leave residual tell tale clusters of hemosiderin laden macrophages.

GROSS APPEARANCE

Congested tissue is dusky reddish blue in color due to red cell stasis and accumulation of

deoxygenated hemoglobin.

Mechanisms involved in CVC of different organs :Heart Failure

Right-sided failure Left Sided failure

Pressure transmitted upstream of right heart Pressure transmitted upstream of left heart

Systemic Venous Congestion Pulmonary congestion

CVC of lungCVC liver CVC spleen CVC kidney Congested Leg Veins

CVC OF LUNG

CAUSE:

Left Heart Failure, especially in rheumatoid mitral

stenosis so that there is consequent venous pressure.

GROSS APPEARANCE:

Lungs are heavy and firm in consistency.

Sectioned surface is rusty brown in color due to which is

referred to as “brown induration” of lungs.

Brown induration is due to pigmentation and fibrosis.

Brown induration

Of lung seen in cut

section

HISTOLOGY OF CVC LUNG

Alveolar septa are widened due to interstitial edema as well as due

to dilated and congested capillaries.

Septa mildly thickened due to slight increase in fibrous connective

tissue.

Minute intra-alveolar hemorrhages can be seen due to rupture of

dilated and congested capillaries.

The breakdown of erythrocytes liberates hemosiderin pigment

which is taken up by alveolar macrophages.

The minute structures so formed are called “Heart Failure Cells”,

which can be easily seen in the alveolar lamina.

CVC OF LIVER

CAUSE:

Occurs mainly due to right heart failure and sometimes due to

occlusion of Inferior Venacava and Hepatic Vein .

GROSS APPEARANCE:

The liver is enlarged and the capsule is tense.

Cut surface shows characteristic red and yellow mottled

appearance mainly due to congested centre of lobules and fatty

peripheral zone respectively.

Such an appearance of the liver is called as “Nutmeg Liver”.

Gross appearance of CVC

Liver

1)Nut -meg appearance

2)Peripheral fatty change

NUT-MEG LIVER

HISTOLOGY OF CVC LIVER Changes are more marked in the

centrilobular zone due to severe hypoxia than in the periphery.

Central vein as well as adjacent sinusoids are distended and filled with blood.

The centrilobular hepatocytes undergo degenerative changes , and eventually “centrilobular hemorrhagic necrosis” can be seen.

Long standing cases may show fine centrilobular fibrosis and regeneration of hepatocytes.

The peripheral zone of the lobule is less severely affected by chronic hypoxia and shows some fatty change in the hepatocytes.

CVC OF SPLEEN

CAUSES:

Can occur due to right heart failure and in portal hypertension from liver cirrhosis.

GROSS APPEARANCE:

Spleen in early stage is moderately enlarged(up to 250g as compared to normal 150g.)

In long standing cases there is progressive enlargement and may weigh up to 500 to 1000g.

Organ is deeply congested, tense and cyanotic.

Sectioned surface is gray tan.

Gross appearance

Of CVC spleen

1)Deeply congested

with tense capsule

2)Cut surface shows gray

tan parenchyma

HISTOLOGY OF CVC SPLEEN

Red pulp is enlarged due to congestion and marked sinusoidal dilation and there are many areas of new and old hemorrhages.

Sinusoids may get converted to capillary (capillarisation of sinusoids).

There is hyperplasia of reticuloendothelial cells in the red pulp of the spleen( Splenic macrophages).

There is fibrous thickening of the capsule and the trabeculae.

Some of the hemorrhages overlying fibrous tissue get deposits of the hemosiderin pigment and the calcium salts, these organized structures are called Gamna Gandy bodies or siderofibrotic nodules.

Firmness of spleen in advanced stage is seen more commonly in hepatic cirrhosis(Congestive splenomegaly) and is the most common cause of hypersplenism.