Copyright 2006 © Mattioli Engineering All rights reserved TRANSDERMAL DELIVERY OF A SUBSTANCE COMPOSED BY HYALURONIC ACID AND AMINO ACIDS C. De Iulio, M. Mariotti, A. Massirone, N. Tamburlin, M. Triulzi
Copyright 2006 © Mattioli Engineering All rights reserved TRANSDERMAL DELIVERY OF A SUBSTANCE COMPOSED BY HYALURONIC ACID AND AMINO ACIDS C. De Iulio,
Dec 23, 2015
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Copyright 2006 © Mattioli Engineering All rights reserved
TRANSDERMAL DELIVERY OF A SUBSTANCE COMPOSED BY HYALURONIC
ACID AND AMINO ACIDS
C. De Iulio, M. Mariotti, A. Massirone, N. Tamburlin, M. Triulzi
Copyright 2006 © Mattioli Engineering All rights reserved
Needle therapy and alternative methods
Nearby the traditional needle therapy there are new developing alternative methods that allow the transdermal
delivery of ionic drugs and active substances without the use of
needles.
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Face and decolleté Bio Revitalization
Bio Revitalization is one of the most requested treatments in esthetic medicine.
Some patients hardly stand the needle therapy.
Face Bio Revitalization performed through alternative methods is raising a great interest.
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Face Bio Revitalization with hyaluronic acid and amino acids through
Dermoelectroporation®
Our protocol was carried out using hyaluronic acid transdermally delivered without needles.
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Hyaluronic Acid
Very Hygroscopic. Responsible of skin moisturizing. Basic substance for the stabilization
of collagen and elastic fibres. Basic substance for metabolic
exchanges and for process of repair and remodelling.
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Hyaluronic Acid enriched with Amino Acids
Ampoule: - Sodium Hyaluronate - water for injection
Freeze-dried bottle: - Glycine - L-Proline - L-Lysine Monohydrochloride - Leucine
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Dermoeletctroporation®Transdermal Drug Delivey
Dermoelectroporation® is a method for
transdermal drug delivery that foresees:
1. A preventive microdermoabrasion with corundum crystals in order to lower the skin impedance in the interested part and to ease the transdermal transfer.
2. The following delivery of the chosen substance through a pulsed iontophoresis with electrical waves similar to electroporation but with a lower and controlled intensity.
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Experimental analysis of the efficacy of transdermal delivery of hyaluronic acid
through Dermoelectroporation®Università Degli Studi di FirenzeD.ssa S. Pacini, Dr. M. Ruggero
Rat skin treated by Dermoelectroporation® and fluorescent hyaluronic acid.
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Performed Protocol
10 patients – age between 30 and 59 years old
1 treatment per week for 4 weeks
1 treatment: microdermabrasion on the interested area + delivery of 3 ml hyaluronic acid enriched with amino acids.
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Evaluation DiagramMoisturizing Elasticity Tone Compactness
Before After Before After Before After Before After
Pt. 1 ++ +++ ++ +++ + ++ ++ ++
Pt. 2 +++ +++++
+++ ++++ +++ ++++ ++ +++
Pt. 3 ++ ++++ ++ +++ ++ +++ +++ ++++
Pt. 4 +++ +++++
+++ ++++ ++ ++++ +++ ++++
Pt. 5 ++ +++ + ++ ++ +++ ++ +++
Pt. 6 +++ ++++ +++ ++++ +++ ++++ ++ +++
Pt. 7 +++ ++++ ++ +++ ++ +++ ++ +++
Pt. 8 ++++ +++++
+++ ++++ ++++ +++++
+++ ++++
Pt.9 +++ ++++ +++ ++++ ++ +++ ++ +++
Pt. 10 ++++ +++++
+++ ++++ +++ ++++ +++ ++++ Evaluations carried out also with the aid of a skin check up system
Very good = +++++ Good = ++++ Medium = +++ Sufficient = ++ Poor = +
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Before After
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Before After
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Results
In all patients we could notice a brighter and more tonic skin.
Patients were satisfied both for the results and for the pleasantness of the treatment, also thanks to the
relaxing vibratory massage made by the probe delivering the impulses.
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Conclusions
The combined action of microdermabrasion, together with the revitalizing action of hyaluronic acid delivered through
dermoelectroporation without the use of needles, obtained more interesting results compared to the use of the same
substance with needle therapy.
1. The peeling performed with microdermabrasion eases the transfer of hyaluronic acid and increases the quality and
brightness of the skin.
2. The probe for the delivery of hyaluronic acid allows the delivery of the substance in an uniform way.
The method was pleasant for the patient, easy to perform and without consequences like bruises, redness, irritations and
pain.
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