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Chapter 16 (Part 3)
Fatty acid Synthesis
ACP vs. Coenzyme A
Fatty Acid Synthesis Occurs in the Cytosol
Citrate synthaseCitrate Lyase
Malate dehydrogenase
Malate EnzymePyruvate
carboxylase
Acetyl-CoA CarboxylaseAcetyl-CoA + HCO3
- + ATP malonyl-CoA + ADP
Acetyl-CoA
Carboxylase
Regulation of Acetyl-CoA Carboxylase (ACCase)
Animal Fatty Acid Synthase
Further Processing of Fatty acids: Desaturation and Elongation
Allosteric regulation of fatty acid synthesis occurs at ACCase and the carnitine acyltransferase