Brain Mechanisms of HPA Axis Regulation: Neurocircuitry and Feedback in Context Richard Kvetnansky Lecture James P. Herman 1,2,3 , Nawshaba Nawreen 1 , Marissa Smail 1 , Evelin Cotella 1,3 1 Department of Pharmacology and Systems Physiology, University of Cincinnati, Cincinnati OH, 45267 2 Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati OH, 45267 3 Cincinnati Veterans Administration Medical Center Abstract Regulation of stress reactivity is a fundamental priority of all organisms. Stress responses are critical for survival, yet can also cause physical and psychological damage. This review provides a synopsis of brain mechanisms designed to control physiological responses to stress, focusing primarily on glucocorticoid secretion via the hypothalamo-pituitary-adrenocortical (HPA) axis. The literature provides strong support for multi-faceted control of HPA axis responses, involving both direct and indirect actions at paraventricular nucleus (PVN) corticotropin releasing hormone neurons driving the secretory cascade. The PVN is directly excited by afferents from brainstem and hypothalamic circuits, likely relaying information on homeostatic challenge. Amygdala subnuclei drive HPA axis responses indirectly via disinhibition, mediated by GABAergic relays onto PVN-projecting neurons in the hypothalamus and bed nucleus of the stria terminalis (BST). Inhibition of stressor-evoked HPA axis responses is mediated by an elaborate network of glucocorticoid receptor (GR)-containing circuits, providing a distributed negative feedback signal that inhibits PVN neurons. Prefrontal and hippocampal neurons play a major role in HPA axis inhibition, again mediated by hypothalamic and BST GABAergic relays to the PVN. The complexity of the regulatory process suggests that information on stressors is integrated across functional disparate brain circuits prior to accessing the PVN, with regions such as the BST in prime position to relay contextual information provided by these sources into appropriate HPA activation. Dysregulation of the HPA in disease is likely a product of inappropriate checks and balances between excitatory and inhibitory inputs ultimately impacting PVN output. * =corresponding author: Address for correspondence: James P. Herman, PhD, Flor van Maanen Professor, Chair, Department of Pharmacology and Systems Physiology, Director, Neurobiology Research Center, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267-0576. Submitted for the Special Issue: 12 th International Symposium on Catecholamines and Other Neurotransmitters in Stress Declaration of Interest The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. HHS Public Access Author manuscript Stress. Author manuscript; available in PMC 2021 April 09. Published in final edited form as: Stress. 2020 November ; 23(6): 617–632. doi:10.1080/10253890.2020.1859475. Author Manuscript Author Manuscript Author Manuscript Author Manuscript
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Brain Mechanisms of HPA Axis Regulation: Neurocircuitry and Feedback in Context Richard Kvetnansky Lecture
James P. Herman1,2,3, Nawshaba Nawreen1, Marissa Smail1, Evelin Cotella1,3
1Department of Pharmacology and Systems Physiology, University of Cincinnati, Cincinnati OH, 45267
2Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati OH, 45267
3Cincinnati Veterans Administration Medical Center
Abstract
Regulation of stress reactivity is a fundamental priority of all organisms. Stress responses are
critical for survival, yet can also cause physical and psychological damage. This review provides a
synopsis of brain mechanisms designed to control physiological responses to stress, focusing
primarily on glucocorticoid secretion via the hypothalamo-pituitary-adrenocortical (HPA) axis.
The literature provides strong support for multi-faceted control of HPA axis responses, involving
both direct and indirect actions at paraventricular nucleus (PVN) corticotropin releasing hormone
neurons driving the secretory cascade. The PVN is directly excited by afferents from brainstem
and hypothalamic circuits, likely relaying information on homeostatic challenge. Amygdala
subnuclei drive HPA axis responses indirectly via disinhibition, mediated by GABAergic relays
onto PVN-projecting neurons in the hypothalamus and bed nucleus of the stria terminalis (BST).
Inhibition of stressor-evoked HPA axis responses is mediated by an elaborate network of
glucocorticoid receptor (GR)-containing circuits, providing a distributed negative feedback signal
that inhibits PVN neurons. Prefrontal and hippocampal neurons play a major role in HPA axis
inhibition, again mediated by hypothalamic and BST GABAergic relays to the PVN. The
complexity of the regulatory process suggests that information on stressors is integrated across
functional disparate brain circuits prior to accessing the PVN, with regions such as the BST in
prime position to relay contextual information provided by these sources into appropriate HPA
activation. Dysregulation of the HPA in disease is likely a product of inappropriate checks and
balances between excitatory and inhibitory inputs ultimately impacting PVN output.
*=corresponding author: Address for correspondence: James P. Herman, PhD, Flor van Maanen Professor, Chair, Department of Pharmacology and Systems Physiology, Director, Neurobiology Research Center, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267-0576.
Submitted for the Special Issue: 12th International Symposium on Catecholamines and Other Neurotransmitters in Stress
Declaration of InterestThe author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
HHS Public AccessAuthor manuscriptStress. Author manuscript; available in PMC 2021 April 09.
Published in final edited form as:Stress. 2020 November ; 23(6): 617–632. doi:10.1080/10253890.2020.1859475.
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Keywords
HPA Axis; glucocorticoids; amygdala; hippocampus; prefrontal cortex; bed nucleus of the stria terminalis
It was a great honor for the senior author to present the inaugural Richard Kvetnansky
lecture at the 12th International Symposium on Catecholamines and Other Neurotransmitters
in Stress, held at Smolenice Castle in the summer of 2019. Richard was a consummate
scientist and a strong advocate for the field of stress biology, and his absence is keenly felt.
The goal of this review is to provide a framework for understanding neurobiological
mechanisms governing glucocorticoid responses to adverse events. For the purposes of
framing the review with respect to the ‘problem’ of stress, we begin with a brief conceptual
introduction. The remainder of this contribution will be directed toward discussion of the
neural basis of neuroendocrine responses to stressors, which has been a prevailing emphasis
of our laboratory’ for the last 30+ years.
The ‘Stress’ Concept: Origin and Evolution
Interest in stress harkens back to the early days of experimental medicine. The concept that
physiological responses drive adaptation originated with Claude Bernard’s early
consideration of the ‘milieu interieur’ in the late 1800’s (Bernard et al., 1865), and was a
driving factor in Walter Cannon’s original exposition of homeostasis (Cannon, 1939). Selye
first popularized the term ‘stress’-borrowed from engineering- to describe the ‘non-specific
responses of the body to any demand upon it’. He based this definition on clinical
observations, where he noted a common spectrum of symptoms present in a variety of
disease conditions. These clinical observations were translated into basic research leading to
a landmark paper published in Nature in 1936, showing that a variety of noxious conditions
presented common physiological reactions, including adrenal hypertrophy, atrophy of
lymphoid organs and gastric ulceration in rats (Selye, 1936). The former two observations
are the result of elevated glucocorticoid secretion, which will be a guiding topic of this
review.
Definition of ‘stress’ emerged some time later (Selye, 1956, 1950). The definition above
specifies that ‘stress’ is defined as a ‘response’, rather than a cause. Over the years this
definition has become clouded, as ‘stress’ had moved from consequence to antecedent in
popular parlance (indeed as fuzzily defined, stress can be both cause and effect). In
deference to Selye’s definition, we will refer to causal factors as ‘stressors’ (rather than
‘stress’).
Selye also noted that pleasurable or appetitive events are able to generate physiological
indices of stress. He subsequently distinguished ‘distress’ and ‘eustress’, with the former
referring to responses to noxious, adverse or aversive stimuli, typical of what is usually
thought of as ‘stress’. ‘Eustress’ essentially refers to responses generated in positive as
opposed to negative contexts, and reinforces the notion that physiological responses are
required to help the organism perform optimally in both conditions. The distress-eustress
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continuum has proven hard to reconcile and difficult for the literature to navigate (Selye,
1975). Indeed, a consensus paper suggests limiting discussion of stress to negative
conditions, so as to minimize ambiguous definitions (Koolhaas et al., 2011).
The distress-eustress distinction underscores the role of both neuroendocrine and autonomic
regulation in energy balance. One can argue that the major so-called ‘stress systems’, the
hypothalamo-pituitary-adrenocortical (HPA) and sympathoadrenomedullary axes, are
primarily concerned with metabolism. Indeed, both systems mobilize energy at the level of
the liver (gluconeogenesis, proteolysis and lipolysis in the case of glucocorticoids,
glycogenolysis and glycolysis in the case of epinephrine), in an attempt to provide resources
allowing the organism to adapt to challenges, be they in a negative or positive context.
Indeed, this appears to be a principle role for both systems on an hour-to-hour and day-by-
day schedule: their relationship with stressors is but one aspect of their primary function.
Activation of stress effectors can occur in response or anticipation of discrete events (acute
stressors) or in prolonged fashion when confronted with persistent or intermittent stress
exposures (chronic stress). Responses to acute stressors are generally considered adaptive,
having the goal of mobilizing resources to meet bodily needs. In contrast, chronic activation
of stress effectors can trigger or exacerbate pathologies, due to prolonged systemic drive,
alterations in metabolic processes and/or immune dysregulation. As discussed below,
pathways controlling acute and chronic responses to stressors can differ substantially, and
one should not assume that chronic stress is simply the summation of individual acute
responses.
Another important concept in stress is ‘allostasis’, a term defined by (Sterling and Eyer,
1988). ‘Allostasis’ was initially proposed to explain the process of ‘stability through
change’, as opposed to homeostasis, defined as the constant return to balance of the internal
milieu in response to environmental stimuli. They postulated that the parameters proposed to
be constant by the concept of homeostasis, could, in fact, have more than one optimal point
of balance, depending on the external and internal circumstances the individual faces at any
given moment.
This concept was later adopted by Bruce McEwen, who extended it by defining allostatic
load as the cost of chronic exposure to fluctuating or heightened neural or neuroendocrine
response resulting from repeated or chronic environmental challenge’ (McEwen and Stellar,
1993). These concepts contributed to include the cognitive functions of the individual (i.e.
the memory and emotional experience with a particular stressor) as an important component
of the adaptation machinery that is required for allostatic processes (Korte et al., 2005).
It is important here to consider the concept of emotion, since emotions drive both generation
and interpretation of stressors. Early work in the field proposes that the physical responses
are the root cause of emotions (the James-Lange theory of emotion) (James, 1994).
Although subsequently challenged (e.g., by Cannon (Cannon, 1927)), the physiology and
emotion connection remains strong (James, 1994), and indeed has found new life in the
somatic marker hypothesis championed by Damasio, which posits that physiological
reactions can affect decision making (Damasio, 1996). The key feature to consider here is
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that emotions almost certainly occur in the context of stressors, and importantly that the
physiological reactions occurring during stressors can be encoded as part of the interpreted
emotion.
Dynamics of HPA axis regulation
Activation of the HPA axis occurs in a number of contexts. Importantly, the HPA axis
exhibits a marked circadian rhythm, with peak secretion generally corresponding with the
onset of the active part of the day-night cycle (e.g., onset of the light cycle in diurnal
animals, onset of the dark cycle in nocturnal animals) (see (Cascio et al., 1987; Jacobson et
al., 1988)). The circadian rise is thought to be important for mobilizing energy to meet the
energetic needs of an awake, behaving organism. Glucocorticoids also rise in anticipation of
meals (Feillet et al., 2006). The circadian peak is guided by input from the suprachiasmatic
nucleus, based on endogenous rhythmicity and/or light cues (Cascio et al., 1987). Note that
neither circadian nor metabolic release of glucocorticoids necessarily reflect a response to
‘stressors’ per se, but rather fulfill the metabolic function of the of HPA axis (putting the
‘gluco(se)’ in ‘glucocorticoid’ through glyconeogenesis, promoting release of free fatty
acids and amino acids by lipolysis and proteolysis, respectively).
Activation by stressors co-opts this important metabolic system to introduce glucocorticoids
in order to meet external or internal challenges, real or perceived (Myers et al., 2014b). The
important consideration here is that the HPA axis is NOT a canonical ‘stress system’, but
rather a bodily system recruited by stressors. Consequently, all measures of HPA activation
need to be weighed with respect to both stressor-elicited secretion and endogenous release
patterns. The most striking need is consideration of circadian timing, which is critical to
appreciating the meaning of baseline glucocorticoid changes in the context of stress and
disease. Indeed, the current gold standard for measurement of human HPA axis reactivity is
the cortisol awakening response (CAR), timed across a narrow window corresponding to
awakening rather than clock time (Stalder et al. 2016; Federenko et al. 2004). Unfortunately,
a sizable literature on human stress biology emerged prior to appreciation of the significance
of the CAR, and we have not even begun to tackle the significance of anything resembling
the CAR in animal models. Moreover, these concerns call the value of single-point
assessment of HPA axis hormones into question, particularly during the active phase of the
circadian cycle.
Activation of the HPA axis is mediated by a discrete population of neuroendocrine
corticotropin-releasing hormone (CRH) neurons in the paraventricular nucleus of the
hypothalamus (PVN) (Antoni, 1986; Herman et al., 2016). These neurons produce other
neuropeptides (e.g., arginine vasopressin (AVP) that enhance the efficacy of down-stream
CRH action (Gillies et al., 1982). Hypophysiotrophic PVN CRH neurons project to the
external lamina of the median eminence, whereby CRH and co-stored peptides/transmitters
are released into portal veins and subsequently access anterior pituitary corticotropes to
drive adrenocorticotropic hormone (ACTH) release. ACTH then travels to the adrenal cortex
via the systemic circulation, driving synthesis and secretion of glucocorticoids and
completing what is effectively a three-step amplification process (fg/ml CRH to pg/ml
ACTH to ng/ml glucocorticoids) (Herman et al., 2016). It is important to note that the
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amplification process is subject to adjustment at both the pituitary and adrenal. For example,
glucocorticoid feedback (below) can block pituitary release of ACTH (Keller-Wood and
Dallman, 1984), and sympathetic activation can enhance adrenal glucocorticoid production
(Jasper and Engeland, 1997; Ulrich-Lai et al., 2006), respectively. Local effects at both the
pituitary and adrenal are powerful modifiers of HPA output, and are unfortunately
incompletely understood.
Glucocorticoids signal via interaction with two primary receptors, the mineralocorticoid
receptor and glucocorticoid receptor (MR and GR)(see (de Kloet et al., 1998). These
receptors act via any of several mechanisms: as ligand activated transcription factors to drive
or inhibit gene transcription; as intranuclear inhibitors of other transcription factors; or as
membrane receptors providing for rapid glucocorticoid signaling (de Kloet et al., 2018; Oitzl
et al., 1997). The array of signaling mechanisms provides for HPA axis influence on target
systems in the time-frame of minutes (membrane) to days or even weeks (transcription) (de
Kloet et al., 2008). The MR is extensively bound by relative low levels of glucocorticoids,
with nuclear-signaling receptors saturated at low circadian levels of glucocorticoids and
leading some to suggest that it is important in rhythmic actions of hormone (Bradbury et al.,
1991; De Kloet and Reul, 1987). Recent evidence suggests that the affinity of the
membrane-bound receptor may be substantially lower, allowing it to operate at higher, stress
levels of glucocorticoid secretion (Joëls, 2006). The GR is traditionally thought to govern
the metabolic and stress actions of glucocorticoids, as this receptor is extensively occupied
only at the circadian peak or following stress activation of hormone release (Reul and de
Kloet, 1985). There is some evidence to suggest that the two receptors heterodimerize in the
cell nucleus, which may affect which genes are expressed or inhibited (Trapp et al., 1994),
although this has been debated of late (Pooley et al., 2020). Of note, RNAseq studies
indicate that despite the high homology present in the DNA binding domain of MR and GR,
occupation of the respective receptors produces vastly different patterns of gene
transcription (e.g., see (Van Weert et al., 2017)).
Glucocorticoid receptors are widely (but not ubiquitously) expressed in the CNS (Ahima and
Harlan, 1990; Herman, 1993), and have physiological actions in nearly every region tested,
ranging from the brainstem to prefrontal cortex. Similarly, MR is also expressed in a variety
of regions (Ahima et al., 1991), including several where colocalization with GR is
documented (e.g., hippocampus) (see (de Kloet et al., 1998)) or highly likely.
It is important to note that corticosteroids are released from the adrenal in a pulsatile
manner, with a frequency of roughly 3 hours, entrained in accordance with pulsatile pituitary
ACTH release (Sarabdjitsingh et al., 2012; Windle et al., 2013). The net impact of a stressor
on corticosteroid release is dependent on pulsatility, as imposition on the rising phase of a
pulse will enhance net secretion of steroid, whereas the opposite is true on the falling phase
(Lightman et al., 2020). Pulsatile release is critical for appropriate glucocorticoid signaling,
as blocking pulsatile release by constant delivery of glucocorticoids impairs GR nuclear
translocation and thereby modifies glucocorticoid actions on transcription (Russell et al.,
2015; Sarabdjitsingh et al., 2010).
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Feedback Control of the HPA Axis
Activation of the HPA axis is limited by glucocorticoid negative feedback inhibition at
several levels, ranging from peripheral tissues (e.g., fat) to brain (de Kloet and Herman,
2018; Myers et al., 2012). Negative feedback is best thought of as a multifaceted process,
with glucocorticoid signals communicated largely by GR binding in target cells. Similarly,
GR in pituitary corticotropes reduce expression of ACTH, limiting the capacity of the brain
to drive the HPA axis, and as we shall see below, GR acts in the brain (e.g., hypothalamus,
hippocampus, prefrontal cortex, etc) to limit activation of HPA axis responses to stressors
(Ding et al., 2019; Herman et al., 2016; Keller-Wood and Dallman, 1984; Levin et al., 1988).
Finally, glucocorticoids can also regulate the HPA axis via peripheral mechanisms: for
example, our group has shown that deletion of GR in adipocytes inhibits the HPA axis,
likely through actions of end-products generated by GR action (e.g., free fatty acids
generated by lipolysis) (de Kloet and Herman, 2018).
Glucocorticoid feedback acts across multiple time domains via multiple mechanisms
(Keller-Wood and Dallman, 1984). Traditional genomic effects occur at relatively long
latencies (hours) and can initiate transcriptional and functional changes that persist beyond
the period of active glucocorticoid secretion. Transcriptional actions can involve direct DNA
binding to either increase (glucocorticoid response elements (GREs)) or decrease (negative
or nGREs) gene transcription, and perhaps are the most commonly studied. Ultimate
transcriptional actions of GR (or MR) will depend on interactions with nuclear coactivators
(e.g., Src) that control histone acetylation/deacetylation and ultimately associations with the
transcriptional machinery (Lachize et al., 2009; Meijer et al., 2005). Additional evidence
supports the ability of GR to bind other nuclear transcription factors (e.g., AP1, NFkB
complexes) and modulate their transcriptional actions, providing for non-GRE dependent
effects on gene expression (McKay and Cidlowski, 1998; Yang-Yen et al., 1990).
A wealth of data dating back to early studies by Dallman indicates the ability of
glucocorticoids to inhibit HPA axis drive within minutes, so-called ‘fast feedback’ (Dallman
and Yates, 1969). In vitro electrophysiological studies from the Tasker group found that
PVN neurons are inhibited by glucocorticoids at the level of the membrane, accomplished
via G-protein dependent release of endocannabinoids and nitric oxide, which inhibit
glutamatergic and enhance GABAergic synaptic currents, respectively, in the PVN (Di et al.,
2003). Our group subsequently verified endocannabinoid-mediated membrane fast feedback
inhibition in vivo as well (Evanson et al., 2010). Glucocorticoid fast feedback is blocked by
PVN deletion of GR in vitro and in vivo, indicating that actions are likely mediated by
membrane-associated GRs (Nahar et al., 2015; Solomon et al., 2015). While
immunohistochemical studies support the existence of GR (or GR-like) molecules at or near
the cell membrane (Jafari et al., 2012; Johnson et al., 2005), the exact nature of the signaling
process is unknown. Rapid GR action is also observed at the level of the corticotropes,
where fast feedback appears to be mediated by annexin 1A signaling (Buckingham et al.,
2003).
Recent data suggests that GR may also signal via ligand-independent mechanisms. Use of
non-membrane-permeant GR ligands (dexamethasone-bovine serum albumin conjugate
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(DEX-BSA)) have revealed the ability of membrane-bound GR to elicit Akt mediated
nuclear translocation of unliganded GR. Nuclear GR translocated as a result of DEX-BSA
treatment does not appear to directly drive transcription via binding to consensus
glucocorticoid response elements (GREs) and promotes transcription of genes distinct those
regulated by DEX alone, implying interaction with alternative transcription mechanisms
(Rainville et al., 2019). The data indicate further complexities associated with cellular GR
signaling as a result of membrane GR binding.
Hypothalamic Mechanisms of HPA Axis Regulation
In general, glucocorticoid feedback directly or indirectly inhibits PVN neurons driving the
neuroendocrine cascade. Electrophysiological studies show that neurons in the PVN are
inhibited, as indicated by a reduction in mEPSC frequency and enhanced mIPSC frequency
during the rapid negative feedback of the HPA axis (Di et al., 2003; Joëls, 2006). Lesion and
implant studies suggest strong hypothalamic involvement in feedback, e.g., local implants of
glucocorticoid pellets in the region of the PVN can attenuate corticosterone and ACTH
responses to stressors (corticosterone) (Feldman et al., 1992). In addition, local
dexamethasone implants inhibit enhanced CRH and AVP immunoreactivity (Kovacs and
Mezey, 1987) and mRNA expression driven by adrenalectomy (Sawchenko, 1987).
Conversely, conditional knockdown of GR in PVN (and SON) neurons (using Sim1-driven
expression of Cre recombinase to delete exon 1C-2 or exon3) enhanced both basal and
stress-induced ACTH and corticosterone release in male mice (Laryea et al., 2013). Results
in females are more variable, depending on the exon targeted for deletion: females with
deletion of exon 1C-2 exhibit minimal HPA axis dysfunction, whereas the impact of exon 3
deletion is equivalent to males, suggesting a potential sex difference in the importance of GR
(Laryea et al., 2013; Solomon et al., 2015). As noted above, Sim1-mediated deletion of GR
blocks rapid inhibitory effects of glucocorticoids on PVN neurons (Nahar et al., 2015),
suggesting that fast feedback actions may be linked to GR in or near the cell membrane.
Overall, actions at the PVN are clearly glucocorticoid negative feedback effects.
Drive of the HPA axis may also be inhibited by input from PVN-projecting hypothalamic
neurons. A large proportion of hypothalamic neurons are GABAergic, and more than 50% of
synaptic inputs on PVN neurons are inhibitory, suggesting a prominent role for local
inhibition on HPA axis regulation (Decavel and Van Den Pol, 1990). Indeed, the PVN is
surrounded by a shell of GABAergic neurons. These local circuit neurons are in the
projection fields of afferents from regions such as the hippocampus, lateral septum and
raphe nuclei (Herman et al., 2002). Blockade of ionotropic glutamate receptors in this peri-
PVN region increases corticosterone responses to stress (Ziegler and Herman, 2000),
suggesting that these local neurons may be involved in mediating trans-synaptic inhibition
by relaying extrahypothalamic input (Fig. 1).
Several nuclei within the hypothalamus act to modulate HPA axis drive, including the
medial preoptic area (mPOA), dorsomedial hypothalamic (DMH) and posterior
hypothalamic (PH) nuclei (Fig. 1). Lesion studies suggest that the medial preoptic area plays
a role in inhibition of the HPA axis following stress exposure. This hypothalamic region is
rich in gonadal steroid receptors, and is thought to mediate the inhibitory effects of
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testosterone on HPA axis reactivity (Viau and Meaney, 1996). The DMH sends both
glutamatergic and GABAergic inputs to the PVN (Bailey and Dimicco, 2001; Roland and
Sawchenko, 1993), and indeed, its role in HPA axis integration appears to vary by subregion:
inhibition of the ventromedial component reduces corticosterone responses to stressors,
glucose deprivation) but not stressors of a more psychogenic nature (restraint, footshock,
swim) (Bundzikova-Osacka et al., 2015; Flak et al., 2014; Gaillet et al., 1993, 1991; Ritter et
al., 2003), suggesting stressor specificity. Notably this specificity does not extend to NTS
GLP-1 neurons, which modulate responses to psychogenic as well as physical stressors
(Ghosal et al., 2017). Overall, the literature indicates that direct NTS projections to the PVN
stimulate HPA axis responses to acute stressors (Fig. 2) in a neuronal cell type-specific
manner.
The NTS also mediates HPA axis responses to chronic stress exposure. Chronic variable
stress (CVS) promotes drive of TH mRNA and protein expression in NTS catecholaminergic
neurons, but markedly reduces expression of the GLP-1 precursor preproglucagon (GCG)
(Zhang et al., 2010). Despite presumptive increases in biosynthesis, lesions of ascending
NTS NE and E neurons do not attenuate enhanced HPA axis drive following CVS (Flak et
al., 2014). In contrast, intracerebroventricular supplementation of GLP-1 in rat enhances
HPA axis drive following CVS. In contrast, infusion of a GLP-1 receptor antagonists of
selective deletion of the GLP-1 receptor in the PVN block CVS potentiation of HPA axis
stress responses (Tauchi et al., 2008). Thus, GLP-1 but not catecholamine neurons appear to
be required for chronic stress-induced HPA axis sensitization (Fig. 3).
Catecholaminergic and GLP-1 neurons in the NTS express GR (Harfstrand et al., 1986;
Rinaman, 2011), suggesting the potential for glucocorticoid regulation of output. Local
implants of pellets containing the GR antagonist mifepristone increase drive of the HPA axis
by an acute stressor, whereas implants of corticosterone reduce stress-induced corticosterone
secretion. Moreover, local mifepristone implants increase resting corticosterone secretion
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following chronic stress and potentiate HPA axis sensitization following CVS (Bechtold et
al., 2009; Ghosal et al., 2014), consistent with blockade of negative feedback effects on the
NTS. These data are consistent with GR-mediated feedback inhibition of HPA axis
responding via the NTS. Given that 1) GLP-1 neurons are differentially implicated in
potentiation of responses to chronic stress, and 2) GCG mRNA expression and GLP-1
immunoreactivity are decreased by CVS exposure (Ghosal et al., 2017; Zhang et al., 2010),
it is plausible that effects of GR are mediated by attenuation of GLP-1 drive to PVN
neurons.
The role of the NTS in both physical vs. psychogenic stress is somewhat at odds with the
notion of specific circuitry mediating two distinct classes of stressors, a hypothesis put
forward by our group and Paul Sawchenko’s in the late 1990s (Herman et al., 1998; Li et al.,
1996). The newer data suggest that the NTS may instead be a common conduit of stress
integration of multiple modalities, with psychogenic stressor responses and chronic stress
reactivity likely controlled by non-catecholaminergic neurons, perhaps via descending inputs
from limbic projection regions (such as the ventromedial prefrontal cortex and central
amygdaloid nuclei (Schwaber et al., 1982; van der Kooy et al., 1984).
Putting It All Together: Role of the Bed Nucleus of the Stria Terminalis
One common feature shared by all of the above regions is a connection with the BST (Figs.
1–3). The BST is known to play a role in anxiety processing (as opposed to fear), becoming
important in generation of responses to stimuli that do not necessarily predict a defined
outcome (Avery et al., 2016; Walker et al., 2003) (a function well connected with general
conceptualization of stress). Recent work highlights a role for the BST in the development
and expression of contextual conditioning, implicating the BST as an interpreter of
contextual information (Goode and Maren, 2017; Luyck et al., 2020), a process consistent
with generating responses in anticipation of potential threat.
The BST is intimately involved in control of HPA axis responses to stressful stimuli. Early
work from our group demonstrated a complex role for the BST in stress: lesions of the
anteromedial divisions of the BST inhibit HPA axis responses to stress, whereas lesion of
posterior nuclei enhanced HPA axis stressor reactivity (Choi et al., 2007). Recent work
further identifies a specified role for the anterolateral region in HPA axis activation,
conferring inhibition of stressor responses via PL projections (Radley et al., 2009; Radley
and Johnson, 2018). Notably, the role of the anteromedial region appears to change under
conditions of chronic drive, becoming stress-inhibitory rather than stress-excitatory (Choi et
al., 2008). The mechanism underlying this switch is unclear but could be related to the
complex neurotransmitter content of BST-PVN connections, which express both GABA and
CRH, the latter a predominantly excitatory neuropeptide. As neuropeptides are generally
secreted at more intense levels of stimulation than classical transmitters (Mains and Eipper,
1999), it is possible that alterations in BST drive in acute vs. chronic stress may differential
favor downstream activation or inhibition of PVN neurons. It is also important to consider
that chronic stress and/or corticosterone administration can reverse the chloride gradient in
PVN neurons, causing GABA to be excitatory rather than inhibitory (Bains et al., 2015;
Inoue and Bains, 2014).
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The BST receives input from all the purported stress regulatory regions listed above. The
distribution of inputs can vary somewhat by BST subregion. For example, the CeA heavily
innervates the anterolateral and anteroventral regions of the BST, whereas the MeA projects
heavily to posterior subnuclei (Dong et al., 2001). In some cases, inputs from limbic regions
can innervate the same BST neurons: in fact, dual tracing studies suggest direct innervation
of individual BST neurons by both PL and SUBv projectors, consistent with the ability of
BST neurons to summate influences from different HPA regulatory pathways (Radley and
Sawchenko, 2011). Connections between the IL/PL and BST are thought to mediate
inhibition of HPA axis responses to acute stressors (Radley et al., 2009; Spencer et al.,
2005). Moreover, the anterior BST has extensive interactions with the NTS, being a major
target of both catecholaminergic and GLP-1ergic neurons (Bundzikova-Osacka et al., 2015;
Ghosal et al., 2013; Maniscalco and Rinaman, 2017). Thus, the BST is at a crossroads for
handling of information from a variety of stress effector systems.
The intrinsic organization of the BST is itself complex. Anterior subnuclei are generally
associated with anxiety and emotional responses, including HPA axis activation, and appear
to mediate BST potentiation of fear and drug relapse and reinstatement (Miles and Maren,
2019; Ressler et al., 2011), whereas the posterior BST subnuclei have rich connections with
structures linked with agonistic and social behavior (e.g., MeA) (Dong et al., 2001). In
addition, the BST also has intrinsic interconnections across subnuclei that may differentially
interface with input from prefrontal and amygdala projections (Gungor and Paré, 2016).
The BST is known to play a major role in processing of emotional responses to context.
Prior studies indicate that the BST plays a major role in non-associative sensitization of
startle (Davis et al., 2010; Walker and Davis, 1997) and in expression of contextual fear (Ali
et al., 2012; Sullivan et al., 2004; Zimmerman and Maren, 2011).The BST is also critical for
reinstatement of contextual fear responses following extinction (Goode et al., 2015; Waddell
et al., 2006). Finally, activation of the BST is required for stress-related relapse of drug and
alcohol self-administration (see reviews of (Centanni et al., 2019; Goode and Maren, 2019)).
Together the data suggest that the BST is involved in processing information on the overall
significance of stressors, integrating inputs from corticolimbic as well as hindbrain
structures involved in determining the stimulus significance and salience. The net output of
the BST then broadly affects how the organism responds to stress, adjusting behavioral,
autonomic as well as HPA axis reactions in accordance with its ‘interpretation’ of the
summated neuronal input
Summary
Regulation of the HPA axis is of critical importance to the organism, given the behavioral
and energetic signal carried by glucocorticoid hormones. Glucocorticoids act in a variety of
body compartments and by numerous neuronal systems to achieve a net signaling level that
optimizes the response of the organism to stressors. Secretion is regulated by diverse somatic
and psychological signals and held in check by a diverse feedback system designed to ‘dial
in’ responses to best meet the real or perceived challenge. The checks and balances system is
by no means perfect, and disruption by chronic drive or disease can move response
magnitude and/or signaling capacity into either inadequate or over-reactive ranges, with
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potentially important consequences. In some cases, responses to stressors may be ‘adaptive’
in nature: for example, habituation of stressor responses limits potential damage associated
with glucocorticoid over-reactivity, and one can argue that sensitization of HPA axis
responses to chronic stress may promote readiness of the organism to cope with a ‘now
hostile’ world. In contrast, inappropriate secretory activity resulting from developmental
adversity, aging or disease may result in out-of-context hypo- or hypersecretion, generating
‘stress’ reactions under conditions where stress responses are not beneficial (or even
harmful, i.e. allostatic overload). Overall, the weight of evidence indicates that management
of stress is above all a network problem, requiring integration of a substantial array of
signals that link psychological responses to the internal state of the organism. Consequently,
convergent inputs from regions such as the BST, hypothalamic nuclei and perhaps the NTS
send sensory-processed and salience-adjusted information to the PVN, where it is integrated
into a go- no go response. This response is then adjusted by neuronal and hormonal
feedback signals designed to provide temporal control of the responses. It is this exquisite
balance of appropriate drive and hormonal/neuronal inhibition that provides life-long
efficiency of stressor responses and limits disruptions in physiology and behavior.
Funding details:
This work was supported by a Veterans Administration Merit Award to JPH (I01BX003858) and National Institutes of Health grants MH049698, MH101729 and MH119814
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Figure 1. Neural mechanisms of acute stress inhibition. As noted, the CRH containing region of the