Microbiology - Pathogens of the Digestive System Pathogens of the Digestive System Chapter 25 1. Diseases that enter via the digestive Tract A. Gastroenteritis i. Preformed Bacterial Toxins ii. Noninvasive Bacteria iii. Intracellular Invasion B. Systemic or Neurological Infections C. Oral Lesions 2. Bacteria of Diseases via. Preformed Bacterial Toxins A. Staphylococcus aureus (pp. 711 - 712) i. General Information (p. 318) a. Carriers b. Locations c. Nosocomial Infections ii. Diseases a. Staphylococcal Food Poisoning • Growth Factors • Heat-stable Enterotoxin Page 1
18
Embed
€¦ · Web viewBiofilm • Dental Plaque • Metabolic Pathways (see handout) * Dextran (Glycocalyx) * Lactic Acid. ii. Diseases (pp. 708 - 709) a. Dental caries. b.
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Transcript
Microbiology - Pathogens of the Digestive System
Pathogens of the Digestive System
Chapter 25
1. Diseases that enter via the digestive Tract
A. Gastroenteritis
i. Preformed Bacterial Toxins
ii. Noninvasive Bacteria
iii. Intracellular Invasion
B. Systemic or Neurological Infections
C. Oral Lesions
2. Bacteria of Diseases via. Preformed Bacterial Toxins
A. Staphylococcus aureus (pp. 711 - 712)
i. General Information (p. 318)
a. Carriers
b. Locations
c. Nosocomial Infections
ii. Diseases
a. Staphylococcal Food Poisoning
• Growth Factors
• Heat-stable Enterotoxin
• Symptoms
b. Prevention
B. Bacillus cereus (pp. 720 - 721)
Page 1
Microbiology - Pathogens of the Digestive System
i. General Information
a. Environment
b. Endospores
c. Disease Symptoms
d. Prevention
ii. Toxins
a. Heat-Labile
b. Heat-Stable
C. Clostridium botulinum (pp. 616 - 619)
i. General Information (p. 316)
a. Obligate anaerobe
b. Endospores
c. Exotoxin
• Types A, B, and E
• Heat Susceptibility
• Cases
* Europe
* United States
* Farm Animals
ii. Diseases
a. Botulism
Page 2
Microbiology - Pathogens of the Digestive System
• Flaccid Paralysis
b. Infant Botulism
c. Wound Botulism
ii. Therapy
a. Trivalent Antitoxin
b. Supportive Care
D. Clostridium perfringens (p. 720)
i. General Information
a. Toxin
b. Wound infections and food poisoning
• Contamination
• Gas Gangrene (P. 646)
* Ischemia Necrosis and Anaerobic
ii. Clostridium perfringens Gastroenteritis
a. Contamination
3. Bacterial Diseases of the Mouth
A. Streptococcus mutans (pp. 706 - 709) (see handout)
i. Etiology
Page 3
Microbiology - Pathogens of the Digestive System
a. Biofilm
• Dental Plaque
• Metabolic Pathways (see handout)
* Dextran (Glycocalyx)
* Lactic Acid
ii. Diseases (pp. 708 - 709)
a. Dental caries
b. Gingivitis
c. Periodontitis
4. Fungal Diseases via. Preformed Toxins
A. Aspergillus flavus (p. 443)
i. Disease
a. Mycotoxicosis
• Liver Damage
• Cirrhosis
• Liver Carcinoma
ii. Virulence Factor
a. Mycotoxin
• Aflatoxin
5. Non-invasive toxin producing Bacteria
A. Escherichia coli (p. 310; pp. 717 - 718)
i. E. coli Strains
a. Enterotoxigenic E. coli (ETEC)
Page 4
Microbiology - Pathogens of the Digestive System
• Colonizing Factors
* Fimbriae
• Toxins
* LT (Heat Labile Toxin)
* ST (Heat Stable Toxin)
b Enteroinvasive E. coli (EIEC)
• General Information
* Outbreaks
c. Enterohemorrhagic E. coli (EHEC)
• General Information
* Outbreaks
* Fimbrial Adhesion
* Two shiga like toxins
* Serotype: 0157:H7
• Hemolytic Uremic Syndrome
• Control
B. Vibrio cholerae (pp. 716 - 717)
i. General Characteristics
a. Bacteria
b. Epidemics
ii. Disease
Page 5
Microbiology - Pathogens of the Digestive System
a. Cholera
• Fecal-oral route
• Non-invasive
• Mortality
iii. Virulence Factors
a. Choleragen
iv. Control
a. Sanitation
b. Vaccine
v. Treatment
a. Antibiotics
b. Rehydration
C. Campylobacter jejuni (p. 718)
i. General Information
a. Reservior
b. Transmission
c. Disease: Campylobacteriosis (Campylobacter
Gastroenteritis)
Page 6
Microbiology - Pathogens of the Digestive System
D. Helicobacter pylori (pp. 718 - 720)
i. Stomach Review
ii. Mechanism of Disease
iii. Chemotherapy
6. Bacteria that Invade and Grow Intracellularly
A. Shigella sp. (p. 712)
i. General Information
a. Reservoir
b. Symptoms
c. Species
Page 7
Microbiology - Pathogens of the Digestive System
ii. Disease
a. Bacillary Dysentery (or Shigellosis)
b. Transmission
c. Invasiveness
e. Dysentery
iii. Virulence Factor
a. Shiga Toxin
b. Lysogenic Conversion
iv. Control
B. Enteroinvasive E. coli (p. 717)
i. Invasiveness
ii. Disease
iii. Lysogenic Conversion
C. Salmonella sp. (pp. 712 - 714)
i. General Information
a. Peritrichious flagella
b. Reservoir
ii. Pathogenesis of Salmonellosis
a. Transmission
• Cases
Page 8
Microbiology - Pathogens of the Digestive System
• Associations
• Eggs
b. Etiology
iii. Control
a. “Scramble or Gamble”
b. Industrial Issues
iv. Symptoms
D. Salmonella typhi (pp. 714 - 716)
i. General Information
a. Transmission
b. Acid resistant
ii. Typhoid Fever
a. Invasivemess
b. Gall Bladder
c. Symptoms
d. Chronic Carriers
• “Typhoid Mary”
e. Vaccine
Page 9
Microbiology - Pathogens of the Digestive System
E. Listeria monocytogenes (pp. 614 - 615)
i. General Information
• Transmision
• Source
• Growth
ii. Reservior
iii. Diseases
a. Listeriosis
b. Meningitis
c. Still birth
d. Carriers
F. Bacteroides fragilis
i. Diseases
a. Intraabdominal Abscesses
b. Lung Abscesses
c. Bacteroides Bacteremia
7. Protozoal Diseases of the Digestive Tract
A. Entamoeba histolytica (p. 348; 731 - 732)
i. General Information
ii. Disease
Page 10
Microbiology - Pathogens of the Digestive System
a. Amebic Dysentery (Amoebiasis)
b. Carriers
B. Naegleria fowlerii (p. 629)
i. Disease
a. Primary Amebic Meningoencephalitis
C. Balantidium coli (p. 354)
i. Disease
a. Balantidiasis
D. Giardia lamblia (p. 730)
i. Disease
a. Giardiases
E. Toxoplasma gondii (p 661 - 663)
i. Introduction
ii. Stages
a. Acute
b. Chronic
iii. Forms
iv. Life Cycle
v. Disease
Page 11
Microbiology - Pathogens of the Digestive System
a. Toxoplasmosis
• Congenital Toxoplasmosis
• Toxoplasma Encephalitis (TE)
iv. Treatment and Prevention
a. AIDS patients
• Acute Stage Therapy
• Maintenance Treatment
b. Immunocompromized Patients and Pregnant Women
c. Prevention
8. Parasitic (Multicellular Euchariotic) Diseases of the Digestive Tract
A. Taenia saginata (pp. 356 - 358; 732 - 733)
i. General Information
a. Definitive Host
b. Intermediate Host
ii. Life Cycle
iii. Disease
a. Symptoms
b. Psychological Distress
c. Control
Page 12
Microbiology - Pathogens of the Digestive System
B. Taenia solium (pp. 356 - 358; 732 - 733)
i. General Information
a. Definitive Host
b. Intermediate Host
i. Disease
a. Cysticercosis
C. Trichinella spiralis (pp. 736 - 737)
i. Life Cycle
ii. Disease
a. Trichinosis
D. Enterobius vermicularis (pp. 360; 734 - 735)
i. Disease
a. Pinworm
9. Enteric Viruses That Cause Disease
A. Polio
i. Disease
a. Poliomyletis (pp. 620 - 622)
Page 13
Microbiology - Pathogens of the Digestive System
ii. Vaccine
a. Salk vaccine
b. Sabin vaccine
• Disadvantages
iii. World Elimination of Polio
A. Hepatitis A Virus (HAV) (infectious hepatitis) (pp.721 - 723)