Education: General Practitioner - FK.UNHAS 1994 Pediatrician – FK.UNHAS 2003 Fellowship Pediatric respirologist 2005 -FK-UI/RSCM Diploma In Immunology 2007 -FK-UGM in collaboration with Vrije Universiteit Amsterdam Bioinformatics course –Eijkman Institute 2008 International Board Certified Lactation Consultant – IBCLE 2008 Organization: Head of respirology division, Pediatrics dept, Curriculum Vitae Dr. Bob Wahyudin, SpAK, IBCLC Pediatric respirologist Lactation Consultant Pediatric dept, Fac. of Medicine, Hasanuddin University
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Education: General Practitioner - FK.UNHAS 1994 Pediatrician – FK.UNHAS 2003 Fellowship Pediatric respirologist 2005 -FK-UI/RSCM Diploma In Immunology.
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Education: General Practitioner - FK.UNHAS 1994 Pediatrician – FK.UNHAS 2003 Fellowship Pediatric respirologist 2005 -FK-UI/RSCM Diploma In Immunology 2007 -FK-UGM in collaboration with Vrije Universiteit Amsterdam Bioinformatics course –Eijkman Institute 2008 International Board Certified Lactation Consultant – IBCLE
2008 Organization:
Head of respirology division, Pediatrics dept, FK.UNHAS/RSWS Makassar
Secretary of IDAI Sulawesi Selatan Member of Asian Strategic Alliance for Pneumococcal Disease (
ASAP )
Curriculum VitaeCurriculum VitaeDr. Bob Wahyudin, SpAK, IBCLCPediatric respirologistLactation ConsultantPediatric dept, Fac. of Medicine, Hasanuddin University
TB VACCINE: PRESENT AND FUTURE
Bob Wahyudin
Why Vaccinated
Burden of disease: 2 billions infected 14 million total case 9.1 million new cases/yr, 250.000 children 1,7 million died/yr, 100.000 children
Emergence of MDR-TB WHO declared “global emergency” Vaccination might reduce
*indicates candidates that have been in clinical trials in the past, but are not currently being tested in clinical trialsSource: Tuberculosis Vaccine Candidates – 2009; Stop TB Partnership Working Group on New TB Vaccines
As of November 2009
AERAS-422Aeras
Mtb [∆lysA ∆panCD ∆secA2] Albert Einstein College of Medicine
MTBVAC01 [∆phoP, ∆fad D26]
University of Zaragoza, Institute Pasteur, TuBerculosis Vaccine Initiative (TBVI)
HBHAInstitute Pasteur of Lille, INSERM, TBVI
Hybrid 56Statens Serum Institute (SSI), Aeras, Intercell, TBVI
HG85 A/BShanghai H&G Biotech
Prime
Boost
Post-infection
ImmunotherapyPreclinical vaccine candidates are not yet in clinical trials, but have been manufactured under Good
Manufacturing Practice (GMP) for clinical use and have undergone some preclinical testing that meets regulatory standards.
Route of vaccination
Injection: IC Costly Safety concerns (needle handling) Not natural infection route Does not elicit mucosal immunity
Oral/nasal (under development) Least expensive Mimic natural infection More vigorous immune response (under
evaluation)
Impact prediction of the new vaccine strategies
Goal: Halves prevelance & mortalities by 2015
new case < 1/million by 2050 Reduction prediction on incidence:
Preexposure vaccines : 39-52 % reduction New drugs: 10 -27% New diagnostic measures: 13-42% Combined: 71% Combined + mass vaccination campaigns +
new post exposure vaccines + drugs for LTBI : 94 %