Th P l L bThe Paperless Lab · • Paperless Lab Implementation. Agenda ... •• Microsoft Office files Microsoft Office files ... Paperless Review Facts & Objectives • 100 +

Th P l L bThe Paperless Lab

Ed d G th iEdward Guthrie CASU SW Marketing March 31, 2009

Agenda

• Agilent Informatics Portfolio Overview

Introduction to OpenLAB ECM• Introduction to OpenLAB ECM

• Introduction to Environmental Science Corp.

• Paperless Lab Implementation

Agenda

• Agilent Informatics Portfolio Overview

Introduction to OpenLAB ECM• Introduction to OpenLAB ECM

• Introduction to Environmental Science Corp.

• Paperless Lab Implementation

Informatics Solutions

Bioinformatics

LIMS KalabieBioinformatics

• GeneSpring• Pathway Analysis

Preferred Partners• LabVantage• StarLIMS• Labtronics

E t i C t t

Chromatography / Instrumentation /

Spectroscopy Enterprise Content Management

Spectroscopy

• OpenLAB ECM

• ChemStation• EZChrom Elite• OpenLAB ICM• MassHunter• MassHunter

Agenda

• Agilent Informatics Portfolio Overview

• Introduction to OpenLAB ECMIntroduction to OpenLAB ECM

• Introduction to Environmental Science Corp.

Paperless Lab Implementation• Paperless Lab Implementation

• Summary

The Content Explosion

BY

TES

More data will be generated in the next 3 years than the previous40,000 years combined.

PE

TAB

75 % is UNSTRUCTURED

0 C

.E.

S UC B kl S h l f I f tiSource UC Berkley, School of InformationManagement & Systems, 2003.

OpenLAB ECM

• OpenLAB ECM (Enterprise Content Manager) provides a secure, web-based, centralized data storage,

t d hi l ti f i tifimanagement, and archive solution for scientific laboratories, which helps you reduce paper, share information, meet regulatory requirements and save you , g y q ymoney.

• Unlike any other product on the market OpenLAB ECM• Unlike any other product on the market, OpenLAB ECM manages and indexes any type of electronic record, making the data searchable by keyword or by analytical

lt hil idi f ll li f ti litresults, while providing full compliance functionality managed via a single user login.

Centrally Store and Protect All DataManage and organize ALL electronic content regardless of sourceManage and organize ALL electronic content regardless of source

•• Chromatography resultsChromatography results•• Analytical DataAnalytical Data•• Photos and images Photos and images •• PDF files and formsPDF files and forms

S d filS d fil•• Scanned paper filesScanned paper files•• EmailEmail•• Microsoft Office filesMicrosoft Office files•• Electronic reportsElectronic reports•• ANYANY

Electronic ContentElectronic ContentElectronic ContentElectronic Content

OpenLAB ECM—How Does ECM Help You?

• Reduce paper—All of your records can be stored electronicallySo you save money

• Share information—Around the World, via a web browser interfaceSo you are more productivey

• Secure your data—And Meet regulatory requirementsSo you are more confidenty

All with little or no impact on your current workflow!

OpenLAB ECM ScalabilityStart With A Small, Low-cost Solution,

• From a single PC to a multi-lti it t iserver, multi-site enterprise

• Easily add servers and clients as you enterpriseclients as you enterprise grows

ECM Workgroup for 15 users is <$30,000

ECM ith b i dECM can grow with your business needs

OpenLAB ECM Automatic Data UploadsMinimal Impact on Your Current Workflowp

• Scheduling agents watch d t f ld d dddata folders and add content to ECM

• Upload automatically when• Upload automatically when a change occurs or on a fixed schedule

Add fil t ECM h th h dAdd files to ECM whenever they are changed

OpenLAB ECM Powerful Search ToolsBetter Organization of Your Datag

• Simple Google search

• Smart Boolean searches based on dozens of filter keyskeys

• Advanced searches of scientific results

Fi d ll t hi fil dl f th li ti

scientific results

Find all matching files, regardless of the source application

Agenda

• Agilent Informatics Portfolio Overview

• Introduction to OpenLAB ECMIntroduction to OpenLAB ECM

• Introduction to Environmental Science Corp.

Paperless Lab Implementation• Paperless Lab Implementation

Corporate Overview

• Full service environmental laboratory

E bli h d i 1970• Established in 1970

• Certified by NELAC, A2LA , DOE, AIHA & USACE

• Certified and/or accepted in 48 states

• Largest single location environmental lab

Analytical Services

• Groundwater and wastewater

• Waste characterization (TCLP)

• Underground storage tanks

• RCRA/CERLA soil and water

• Bio monitoring - mold, cryptoBio monitoring mold, crypto

• Drinking water - SDWA

• IH and ambient air two methods• IH and ambient air – two methods

Agenda

• Agilent Informatics Portfolio Overview

• Introduction to OpenLAB ECMIntroduction to OpenLAB ECM

• Introduction to Environmental Science Corp.

Paperless Lab Implementation• Paperless Lab Implementation

Paperless Review Facts & Objectives

• 100 + Chemstation GC, GCMS, ICP, ICPMS & HPLC

50 + F ll ti Ch i t /A l t• 50 + Full time Chemists/Analysts

• Estimated paper savings > $200K /yr

• Improvement of process work flow - TAT

• Easy access to data: chromatograms and reporting

Historical Records Storage

( 2001)(pre 2001)

Current Records Storage

ECM

Three Tier Web Server-Db Architecture

Client(s)Laptop computerIBM Compatible

Client(s)

Application Server(s)

IBM Compatible

Data DataData Store(s)

Three Tier Client-Server Architecture

• Platform – Redhat Linux and Oracle 9i

• Hardware - HP Proliant servers – AMD Opteron

• Web and File servers – ESX VmWare Server

• Database and File Storage – EMC Clariion SAN

ECM - Version 3.2

LCDF St tLCDF Structure

Dept.Analysis

ComputerInstrumentInstrument

Schedulers binarySchedulers – binary data

ChemStation with ECM

Chemstation with ECM

Chromatography Review Work Flow: Analyst

• Analyst reviews data on instrument computer

• Analyst exports data into LIMS and ECM

• Quant.csv file , PDFs

Chromatography Review Work Flow: Analyst

• .Net application for reviewing results from ChemStation - EnviroquantChemStation Enviroquant

• quant.csv , qedit macro, pdf files

S ik l d t l li it f LIMS• Spike values and control limits from LIMS

• Calibration and tune criteria

Chromatography Review Work Flow

Typical Data Package for Review

Sequence Log

Quant Report

Chromatogram

Full Data Package - Organics

• Bookmarks

• Color coding of outliers

• Higher end service

• 10 –20 % hsurcharge

• Higher data integrity

Chromatography Review Work Flow: QC Review

• Second level reviewer notified by analyst - PDFs are available for review

• Reviewer check-out of PDF from ECM and displays it on one computer screen LIMS on second screenone computer screen, LIMS on second screen

• Approval of data in LIMS and Check-In to ECM -eSignatures stamps noteseSignatures, stamps, notes

On-Screen Paperless Review: Dual LCD

LIMS

ECM

Quality Control Criteria

• Precision - DuplicatespRPD

• Accuracy Spikes LCS• Accuracy – Spikes, LCS%Rec

Surrogates%R%Rec

• False Positives - Blanks

QC Report Levels

• LEVEL 1 – Results summary onlyLEVEL 1 Results summary only

• LEVEL 2 – Batch level QC precision and accuracy data

• LEVEL 3 Instrument run QC initial calibration tunes• LEVEL 3 – Instrument run, QC, initial calibration, tunes, CCCs

• LEVEL 4 – All raw dataLEVEL 4 All raw data

Laboratory Deliverables

• Contains documents for each step the sample takes within the laboratory to demonstrate that all method yrequirements have been met and all calculations can be recalculated and verified.

• ECM database serves as a digital repository for all these documents.

Th i di id l d t th b f t h d• These individual documents can then be fetched, merged, bookmarked into a digital document and page numbers added

Full Deliverables

ProgramLIMS

ProgramList of

sequences

ECMCollate

D tDataPackets

Final Document

SQL Statement

FINDING THE PDF FILE IN CERITY ECM

select distinct location from se ect d st ct ocat o ofiles,metadata2,folders where folders.name = :INSTRUMENT_FOLDER and files FOLDERID = folders id andfiles.FOLDERID = folders.id and metadata2.fileID = files.id and files.displayname = :PACKETNAME% and islatestrevision = 1

SQL Statement

Surrogate Summary Report

QA/QC Validation

• Third party interpretation: Meets DQOs retrace raw data l l ticalculations

• Results are usable, complete, estimated values – MDL RDL Results J ValuesRDL Results – J Values

• Data Qualifiers, flags, case narratives

Summary: OpenLAB Solves Customer ProblemsElectronic versus Paper Data Storagep g

• Moving away from paper can save time, money, and storage space

• ESC’s experience:

• The paper based lab produced 15 tons of paper annually (>$200k/yr)

PaperStorage

tons of paper annually (>$200k/yr)• Data storage requirements went

from a rented warehouse space to a single server rooma single server room

• Reduced the review and approval cycle time by 50%

• Turned paper report storage area El t iTurned paper report storage area into productive lab space

ElectronicStorage

Acknowledgements

• Environmental Science Corp.Mt. Juliet, TN

• Tom WhiteTechnical Director, ESC

Scientific Computing – Readers’ Choice Awards

Data MangementGold OpenLab Agilent TechnologiesGold OpenLab, Agilent Technologies

Questions