Th P l Lb The Paperless Lab Ed d G th i Edward Guthrie CASU SW Marketing March 31, 2009
Th P l L bThe Paperless Lab
Ed d G th iEdward Guthrie CASU SW Marketing March 31, 2009
Agenda
• Agilent Informatics Portfolio Overview
Introduction to OpenLAB ECM• Introduction to OpenLAB ECM
• Introduction to Environmental Science Corp.
• Paperless Lab Implementation
Agenda
• Agilent Informatics Portfolio Overview
Introduction to OpenLAB ECM• Introduction to OpenLAB ECM
• Introduction to Environmental Science Corp.
• Paperless Lab Implementation
Informatics Solutions
Bioinformatics
LIMS KalabieBioinformatics
• GeneSpring• Pathway Analysis
Preferred Partners• LabVantage• StarLIMS• Labtronics
E t i C t t
Chromatography / Instrumentation /
Spectroscopy Enterprise Content Management
Spectroscopy
• OpenLAB ECM
• ChemStation• EZChrom Elite• OpenLAB ICM• MassHunter• MassHunter
Agenda
• Agilent Informatics Portfolio Overview
• Introduction to OpenLAB ECMIntroduction to OpenLAB ECM
• Introduction to Environmental Science Corp.
Paperless Lab Implementation• Paperless Lab Implementation
• Summary
The Content Explosion
BY
TES
More data will be generated in the next 3 years than the previous40,000 years combined.
PE
TAB
75 % is UNSTRUCTURED
0 C
.E.
S UC B kl S h l f I f tiSource UC Berkley, School of InformationManagement & Systems, 2003.
OpenLAB ECM
• OpenLAB ECM (Enterprise Content Manager) provides a secure, web-based, centralized data storage,
t d hi l ti f i tifimanagement, and archive solution for scientific laboratories, which helps you reduce paper, share information, meet regulatory requirements and save you , g y q ymoney.
• Unlike any other product on the market OpenLAB ECM• Unlike any other product on the market, OpenLAB ECM manages and indexes any type of electronic record, making the data searchable by keyword or by analytical
lt hil idi f ll li f ti litresults, while providing full compliance functionality managed via a single user login.
Centrally Store and Protect All DataManage and organize ALL electronic content regardless of sourceManage and organize ALL electronic content regardless of source
•• Chromatography resultsChromatography results•• Analytical DataAnalytical Data•• Photos and images Photos and images •• PDF files and formsPDF files and forms
S d filS d fil•• Scanned paper filesScanned paper files•• EmailEmail•• Microsoft Office filesMicrosoft Office files•• Electronic reportsElectronic reports•• ANYANY
Electronic ContentElectronic ContentElectronic ContentElectronic Content
OpenLAB ECM—How Does ECM Help You?
• Reduce paper—All of your records can be stored electronicallySo you save money
• Share information—Around the World, via a web browser interfaceSo you are more productivey
• Secure your data—And Meet regulatory requirementsSo you are more confidenty
All with little or no impact on your current workflow!
OpenLAB ECM ScalabilityStart With A Small, Low-cost Solution,
• From a single PC to a multi-lti it t iserver, multi-site enterprise
• Easily add servers and clients as you enterpriseclients as you enterprise grows
ECM Workgroup for 15 users is <$30,000
ECM ith b i dECM can grow with your business needs
OpenLAB ECM Automatic Data UploadsMinimal Impact on Your Current Workflowp
• Scheduling agents watch d t f ld d dddata folders and add content to ECM
• Upload automatically when• Upload automatically when a change occurs or on a fixed schedule
Add fil t ECM h th h dAdd files to ECM whenever they are changed
OpenLAB ECM Powerful Search ToolsBetter Organization of Your Datag
• Simple Google search
• Smart Boolean searches based on dozens of filter keyskeys
• Advanced searches of scientific results
Fi d ll t hi fil dl f th li ti
scientific results
Find all matching files, regardless of the source application
Agenda
• Agilent Informatics Portfolio Overview
• Introduction to OpenLAB ECMIntroduction to OpenLAB ECM
• Introduction to Environmental Science Corp.
Paperless Lab Implementation• Paperless Lab Implementation
Corporate Overview
• Full service environmental laboratory
E bli h d i 1970• Established in 1970
• Certified by NELAC, A2LA , DOE, AIHA & USACE
• Certified and/or accepted in 48 states
• Largest single location environmental lab
Analytical Services
• Groundwater and wastewater
• Waste characterization (TCLP)
• Underground storage tanks
• RCRA/CERLA soil and water
• Bio monitoring - mold, cryptoBio monitoring mold, crypto
• Drinking water - SDWA
• IH and ambient air two methods• IH and ambient air – two methods
Agenda
• Agilent Informatics Portfolio Overview
• Introduction to OpenLAB ECMIntroduction to OpenLAB ECM
• Introduction to Environmental Science Corp.
Paperless Lab Implementation• Paperless Lab Implementation
Paperless Review Facts & Objectives
• 100 + Chemstation GC, GCMS, ICP, ICPMS & HPLC
50 + F ll ti Ch i t /A l t• 50 + Full time Chemists/Analysts
• Estimated paper savings > $200K /yr
• Improvement of process work flow - TAT
• Easy access to data: chromatograms and reporting
Historical Records Storage
( 2001)(pre 2001)
Current Records Storage
ECM
Three Tier Web Server-Db Architecture
Client(s)Laptop computerIBM Compatible
Client(s)
Application Server(s)
IBM Compatible
Data DataData Store(s)
Three Tier Client-Server Architecture
• Platform – Redhat Linux and Oracle 9i
• Hardware - HP Proliant servers – AMD Opteron
• Web and File servers – ESX VmWare Server
• Database and File Storage – EMC Clariion SAN
ECM - Version 3.2
LCDF St tLCDF Structure
Dept.Analysis
ComputerInstrumentInstrument
Schedulers binarySchedulers – binary data
ChemStation with ECM
Chemstation with ECM
Chromatography Review Work Flow: Analyst
• Analyst reviews data on instrument computer
• Analyst exports data into LIMS and ECM
• Quant.csv file , PDFs
Chromatography Review Work Flow: Analyst
• .Net application for reviewing results from ChemStation - EnviroquantChemStation Enviroquant
• quant.csv , qedit macro, pdf files
S ik l d t l li it f LIMS• Spike values and control limits from LIMS
• Calibration and tune criteria
Chromatography Review Work Flow
Typical Data Package for Review
Sequence Log
Quant Report
Chromatogram
Full Data Package - Organics
• Bookmarks
• Color coding of outliers
• Higher end service
• 10 –20 % hsurcharge
• Higher data integrity
Chromatography Review Work Flow: QC Review
• Second level reviewer notified by analyst - PDFs are available for review
• Reviewer check-out of PDF from ECM and displays it on one computer screen LIMS on second screenone computer screen, LIMS on second screen
• Approval of data in LIMS and Check-In to ECM -eSignatures stamps noteseSignatures, stamps, notes
On-Screen Paperless Review: Dual LCD
LIMS
ECM
Quality Control Criteria
• Precision - DuplicatespRPD
• Accuracy Spikes LCS• Accuracy – Spikes, LCS%Rec
Surrogates%R%Rec
• False Positives - Blanks
QC Report Levels
• LEVEL 1 – Results summary onlyLEVEL 1 Results summary only
• LEVEL 2 – Batch level QC precision and accuracy data
• LEVEL 3 Instrument run QC initial calibration tunes• LEVEL 3 – Instrument run, QC, initial calibration, tunes, CCCs
• LEVEL 4 – All raw dataLEVEL 4 All raw data
Laboratory Deliverables
• Contains documents for each step the sample takes within the laboratory to demonstrate that all method yrequirements have been met and all calculations can be recalculated and verified.
• ECM database serves as a digital repository for all these documents.
Th i di id l d t th b f t h d• These individual documents can then be fetched, merged, bookmarked into a digital document and page numbers added
Full Deliverables
ProgramLIMS
ProgramList of
sequences
ECMCollate
D tDataPackets
Final Document
SQL Statement
FINDING THE PDF FILE IN CERITY ECM
select distinct location from se ect d st ct ocat o ofiles,metadata2,folders where folders.name = :INSTRUMENT_FOLDER and files FOLDERID = folders id andfiles.FOLDERID = folders.id and metadata2.fileID = files.id and files.displayname = :PACKETNAME% and islatestrevision = 1
SQL Statement
Surrogate Summary Report
QA/QC Validation
• Third party interpretation: Meets DQOs retrace raw data l l ticalculations
• Results are usable, complete, estimated values – MDL RDL Results J ValuesRDL Results – J Values
• Data Qualifiers, flags, case narratives
Summary: OpenLAB Solves Customer ProblemsElectronic versus Paper Data Storagep g
• Moving away from paper can save time, money, and storage space
• ESC’s experience:
• The paper based lab produced 15 tons of paper annually (>$200k/yr)
PaperStorage
tons of paper annually (>$200k/yr)• Data storage requirements went
from a rented warehouse space to a single server rooma single server room
• Reduced the review and approval cycle time by 50%
• Turned paper report storage area El t iTurned paper report storage area into productive lab space
ElectronicStorage
Acknowledgements
• Environmental Science Corp.Mt. Juliet, TN
• Tom WhiteTechnical Director, ESC
Scientific Computing – Readers’ Choice Awards
Data MangementGold OpenLab Agilent TechnologiesGold OpenLab, Agilent Technologies
Questions